This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] See more...

Aliases for MAVS Gene

Aliases for MAVS Gene

  • Mitochondrial Antiviral Signaling Protein 2 3 5
  • IPS-1 2 3 4
  • VISA 2 3 4
  • Interferon Beta Promoter Stimulator Protein 1 3 4
  • Putative NF-Kappa-B-Activating Protein 031N 3 4
  • Mitochondrial Antiviral-Signaling Protein 3 4
  • CARD Adapter Inducing Interferon Beta 3 4
  • Virus-Induced Signaling Adaptor 2 3
  • Virus-Induced-Signaling Adapter 3 4
  • CARD Adaptor Inducing IFN-Beta 2 3
  • IFN-B Promoter Stimulator 1 2 3
  • KIAA1271 2 4
  • Cardif 2 4
  • IPS1 3 4
  • CARDIF 3
  • MAVS 5

External Ids for MAVS Gene

Previous GeneCards Identifiers for MAVS Gene

  • GC20P003783
  • GC20P003784

Summaries for MAVS Gene

Entrez Gene Summary for MAVS Gene

  • This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAVS Gene

MAVS (Mitochondrial Antiviral Signaling Protein) is a Protein Coding gene. Diseases associated with MAVS include Hepatitis C and Hepatitis. Among its related pathways are Ovarian tumor domain proteases and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding and CARD domain binding.

UniProtKB/Swiss-Prot Summary for MAVS Gene

  • Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763).

Gene Wiki entry for MAVS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAVS Gene

Genomics for MAVS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAVS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003845 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 611.6 0.0 -45 3.3 SP1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 IKZF1 ZNF692 POLR2A NFRKB MAVS CDC25B AP5S1 CENPB PANK2 PANK2-AS1 HSPA12B lnc-CENPB-2
GH20J003844 Enhancer 0.5 ENCODE 600.7 -1.9 -1891 0.1 RUNX3 BATF SOX6 CREM IKZF2 MAVS AP5S1 CDC25B CENPB PANK2 PANK2-AS1 HSPA12B lnc-CENPB-2
GH20J003848 Enhancer 0.3 dbSUPER 600.7 +2.0 1975 0.5 ZNF600 POLR2A MAVS AP5S1 CDC25B CENPB PANK2 PANK2-AS1 piR-57564
GH20J003780 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.1 -62.4 -62441 6.9 BRCA1 HNRNPL CREB1 GATAD2A CTCF TEAD4 ZNF629 REST RFX1 SIX5 SPEF1 CDC25B VPS16 MAVS UBOX5 C20orf27 CENPB NONHSAG031162.2 lnc-SPEF1-1
GH20J003795 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -42.1 -42128 19.3 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST CDC25B LINC01730 PANK2-AS1 VPS16 PCED1A SPEF1 UBOX5 ADAM33 C20orf194 PTPRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAVS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAVS

Top Transcription factor binding sites by QIAGEN in the MAVS gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • FOXJ2
  • FOXJ2 (long isoform)
  • Fra-1
  • JunB
  • JunD
  • RFX1

Genomic Locations for MAVS Gene

Genomic Locations for MAVS Gene
chr20:3,846,799-3,876,123
(GRCh38/hg38)
Size:
29,325 bases
Orientation:
Plus strand
chr20:3,827,446-3,856,770
(GRCh37/hg19)
Size:
29,325 bases
Orientation:
Plus strand

Genomic View for MAVS Gene

Genes around MAVS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAVS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAVS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAVS Gene

Proteins for MAVS Gene

  • Protein details for MAVS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z434-MAVS_HUMAN
    Recommended name:
    Mitochondrial antiviral-signaling protein
    Protein Accession:
    Q7Z434
    Secondary Accessions:
    • A8K6X0
    • B2BD33
    • B2BD34
    • F5H6C8
    • M1P2Z0
    • Q2HWT5
    • Q3I0Y2
    • Q5T7I6
    • Q86VY7
    • Q9H1H3
    • Q9H4Y1
    • Q9H8D3
    • Q9ULE9

    Protein attributes for MAVS Gene

    Size:
    540 amino acids
    Molecular mass:
    56528 Da
    Quaternary structure:
    • Self-associates and polymerizes (via CARD domains) to form 400 nM long three-stranded helical filaments on mitochondria, filament nucleation requires interaction with DDX58/RIG-I whose CARD domains act as a template for filament assembly (PubMed:24569476, PubMed:25018021). Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP (PubMed:16125763, PubMed:16127453, PubMed:17600090). May interact with FADD, RIPK1, CHUK and IKBKB (PubMed:16153868, PubMed:16177806, PubMed:16127453). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (PubMed:25636800, PubMed:27302953). Interacts with NLRX1 (PubMed:18200010). Interaction with NLRX1 requires the CARD domain (PubMed:18200010). Interacts with PSMA7 (PubMed:19734229). Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH (PubMed:19881509). Interacts with CYLD (PubMed:18636086). Interacts with SRC (PubMed:19419966). Interacts with DHX58/LGP2 and IKBKE (PubMed:16177806, PubMed:17020950, PubMed:28011935). Interacts with STING1 (PubMed:19416887). Interacts with IFIT3 (via N-terminus) (PubMed:21813773). Interacts with TBK1 only in the presence of IFIT3 (PubMed:21813773, PubMed:28011935). Interacts with TTLL12; the interaction prevents MAVS binding to TBK1 and IKBKE (PubMed:28011935). Interacts with MUL1 (PubMed:23399697). Interacts with ANKRD17 (PubMed:23711367). Interacts with NDFIP1 (PubMed:23087404). Interacts with SMURF1; the interaction is mediated by NDFIP1 and leads to MAVS ubiquitination and degradation (PubMed:23087404). Interacts with UBXN1; this interaction inhibits MAVS-mediated antiviral pathway (PubMed:23545497). Interacts (via C-terminus) with GPATCH3; the interaction is markedly increased upon viral infection (PubMed:28414768). Directly interacts (via CARD domain) with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates (PubMed:17709747). Interacts with DHX33 (via the helicase C-terminal domain) (By similarity). Interacts with DDX3X (via C-terminus); this interaction occurs rapidly, but transiently after Sendai virus infection (PubMed:20127681, PubMed:21170385, PubMed:27980081). The interaction with DDX3X potentiates MAVS-mediated IFNB induction (PubMed:20127681). Conversely inhibition of this interaction, for instance by HCV core protein, prevents MAVS-mediated IFNB induction (PubMed:21170385). Transiently interacts with TRAF3 early during Sendai virus infection (PubMed:27980081).
    • (Microbial infection) Interacts with hepatitis C/HCV NS3/4A protease; this interaction leads to MAVS cleavage.
    • (Microbial infection) Interacts with hepatitis GB virus B NS3/4A protease; this interaction leads to MAVS cleavage.
    • (Microbial infection) Interacts with human respiratory syncytial virus/HRSV protein NS1; this interaction disrupts MAVS binding to DDX58/RIG-I.
    • (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction allows the cleavage of MAVS and subsequent suppression of host innate immunity.
    SequenceCaution:
    • Sequence=BAA86585.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14684.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Cleavage by HCV protease complex leads to inactivation.
    • [Isoform 5]: Selectively activates an IFNbeta but not an IL8 promoter. Interacts with RIP1 and FADD and exhibits anti-viral activity against VSV infection.

    Three dimensional structures from OCA and Proteopedia for MAVS Gene

    Alternative splice isoforms for MAVS Gene

neXtProt entry for MAVS Gene

Post-translational modifications for MAVS Gene

  • Following activation, phosphorylated by TBK1 at Ser-442 in the pLxIS motif (PubMed:25636800, PubMed:27302953). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800).
  • (Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3ABC allowing the virus to disrupt the activation of host IRF3 through the MDA5 pathway.
  • (Microbial infection) Cleaved by the protease 2A of coxsackievirus B3, poliovirus and enterovirus 71 allowing the virus to disrupt the host type I interferon production.
  • Ubiquitinated (PubMed:19881509, PubMed:23087404, PubMed:25636800). Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation (PubMed:19881509). Ubiquitinated by RNF125, leading to its degradation by the proteasome (PubMed:17460044). Undergoes 'Lys-48'-linked ubiquitination catalyzed by SMURF1 (PubMed:23087404).
  • (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I production.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAVS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAVS Gene

Domains & Families for MAVS Gene

Gene Families for MAVS Gene

Protein Domains for MAVS Gene

Suggested Antigen Peptide Sequences for MAVS Gene

GenScript: Design optimal peptide antigens:
  • Virus-induced signaling adaptor variant 1a (B2BD33_HUMAN)
  • cDNA FLJ58074, highly similar to Mitochondrial antiviral signaling protein (B2BD34_HUMAN)
  • Virus-induced-signaling adapter (MAVS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z434

UniProtKB/Swiss-Prot:

MAVS_HUMAN :
  • The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of MAVS recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines (PubMed:25636800).
Domain:
  • The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of MAVS recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines (PubMed:25636800).
  • Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.
  • The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.
genes like me logo Genes that share domains with MAVS: view

Function for MAVS Gene

Molecular function for MAVS Gene

UniProtKB/Swiss-Prot Function:
Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763).

Phenotypes From GWAS Catalog for MAVS Gene

Gene Ontology (GO) - Molecular Function for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16127453
GO:0019901 protein kinase binding IPI 16127453
GO:0035591 signaling adaptor activity IMP 20451243
GO:0050700 CARD domain binding IPI 16127453
genes like me logo Genes that share ontologies with MAVS: view
genes like me logo Genes that share phenotypes with MAVS: view

Animal Models for MAVS Gene

MGI Knock Outs for MAVS:

Animal Model Products

CRISPR Products

miRNA for MAVS Gene

miRTarBase miRNAs that target MAVS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAVS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAVS Gene

Localization for MAVS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAVS Gene

Mitochondrion outer membrane. Mitochondrion. Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAVS gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 3
endosome 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IDA,TAS --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IDA 20451243
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAVS: view

Pathways & Interactions for MAVS Gene

genes like me logo Genes that share pathways with MAVS: view

SIGNOR curated interactions for MAVS Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 16127453
GO:0002218 activation of innate immune response IMP 18818105
GO:0002230 positive regulation of defense response to virus by host IDA,IMP 19609254
GO:0002376 immune system process IEA --
GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS --
genes like me logo Genes that share ontologies with MAVS: view

Drugs & Compounds for MAVS Gene

No Compound Related Data Available

Transcripts for MAVS Gene

mRNA/cDNA for MAVS Gene

2 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAVS

Alternative Splicing Database (ASD) splice patterns (SP) for MAVS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7:

Relevant External Links for MAVS Gene

GeneLoc Exon Structure for
MAVS

Expression for MAVS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAVS Gene

Protein differential expression in normal tissues from HIPED for MAVS Gene

This gene is overexpressed in Nasal epithelium (12.8), Bone (10.2), and Lavage (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAVS Gene



Protein tissue co-expression partners for MAVS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAVS

SOURCE GeneReport for Unigene cluster for MAVS Gene:

Hs.570362

mRNA Expression by UniProt/SwissProt for MAVS Gene:

Q7Z434-MAVS_HUMAN
Tissue specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for MAVS Gene

  • Nervous system(4.9)
  • Blood(4.6)
  • Liver(4.6)
  • Lung(4.6)
  • Intestine(3.5)
  • Spleen(3.2)
  • Kidney(3.1)
  • Muscle(3)
  • Lymph node(3)
  • Skin(2.9)
  • Heart(2.9)
  • Bone marrow(2.5)
  • Pancreas(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MAVS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAVS Gene

Orthologs for MAVS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAVS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAVS 30 31
  • 99.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAVS 30 31
  • 75.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAVS 30 31
  • 72.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mavs 30
  • 69.94 (n)
Mouse
(Mus musculus)
Mammalia Mavs 30 17 31
  • 69.74 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAVS 31
  • 23 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAVS 31
  • 17 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii mavs 31
  • 16 (a)
OneToOne
Species where no ortholog for MAVS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MAVS Gene

ENSEMBL:
Gene Tree for MAVS (if available)
TreeFam:
Gene Tree for MAVS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAVS: view image

Paralogs for MAVS Gene

No data available for Paralogs for MAVS Gene

Variants for MAVS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAVS Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
718324 Benign: not provided 3,857,812(+) G/A INTRON_VARIANT
725329 Likely Benign: not provided 3,864,707(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769074 Benign: not provided 3,865,761(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
771779 Benign: not provided 3,866,015(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
780585 Benign: not provided 3,857,815(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MAVS Gene

Structural Variations from Database of Genomic Variants (DGV) for MAVS Gene

Variant ID Type Subtype PubMed ID
esv2763216 CNV loss 21179565
esv3645053 CNV loss 21293372
esv3645054 CNV gain 21293372
esv3645055 CNV loss 21293372
esv3645056 CNV loss 21293372
nsv520430 CNV loss 19592680
nsv521026 CNV loss 19592680
nsv522507 CNV loss 19592680
nsv527710 CNV loss 19592680
nsv585302 CNV gain 21841781
nsv828673 CNV gain 20364138
nsv833899 CNV loss 17160897

Variation tolerance for MAVS Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.32; 97.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAVS Gene

Human Gene Mutation Database (HGMD)
MAVS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAVS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAVS Gene

Disorders for MAVS Gene

MalaCards: The human disease database

(18) MalaCards diseases for MAVS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
hepatitis
  • hepatitis a
ichthyosis, congenital, autosomal recessive 6
  • arci6
viral infectious disease
  • viral disease
chikungunya
  • chikungunya fever
- elite association - COSMIC cancer census association via MalaCards
Search MAVS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAVS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAVS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAVS Gene

Publications for MAVS Gene

  1. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. (PMID: 16125763) Seth RB … Chen ZJ (Cell 2005) 2 3 4 23
  2. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H … Seya T (European journal of immunology 2010) 3 4 23
  3. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. (PMID: 18207245) Lad SP … Li E (Molecular immunology 2008) 3 4 23
  4. VISA is an adapter protein required for virus-triggered IFN-beta signaling. (PMID: 16153868) Xu LG … Shu HB (Molecular cell 2005) 2 3 4
  5. DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS. (PMID: 27980081) Gu L … Schröder M (The Biochemical journal 2017) 3 4

Products for MAVS Gene

Sources for MAVS Gene