The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a si... See more...

Aliases for MATK Gene

Aliases for MATK Gene

  • Megakaryocyte-Associated Tyrosine Kinase 2 3 5
  • Hematopoietic Consensus Tyrosine-Lacking Kinase 2 3 4
  • Tyrosine-Protein Kinase CTK 2 3 4
  • Protein Kinase HYL 2 3 4
  • CHK 2 3 4
  • CTK 2 3 4
  • HYL 2 3 4
  • Megakaryocyte-Associated Tyrosine-Protein Kinase 3 4
  • Leukocyte Carboxyl-Terminal Src Kinase Related 2 3
  • Csk-Type Protein Tyrosine Kinase 2 3
  • Hydroxyaryl-Protein Kinase 2 3
  • Csk-Homologous Kinase 2 3
  • Tyrosylprotein Kinase 2 3
  • CSK Homologous Kinase 3 4
  • Tyrosine Kinase MATK 2 3
  • HYL Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 51
  • HHYLTK 2 3
  • HYLTK 2 3
  • Lsk 2 3
  • DKFZp434N1212 2
  • EC 2.7.10 51
  • MGC1708 2
  • MGC2101 2
  • MATK 5

External Ids for MATK Gene

Previous GeneCards Identifiers for MATK Gene

  • GC19M003870
  • GC19M003717
  • GC19M003728
  • GC19M003542

Summaries for MATK Gene

Entrez Gene Summary for MATK Gene

  • The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATK Gene

MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include Bruck Syndrome and Endocardium Disease. Among its related pathways are Signaling by GPCR and Signaling by ERBB2. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSK.

UniProtKB/Swiss-Prot Summary for MATK Gene

  • Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Gene Wiki entry for MATK Gene

Additional gene information for MATK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MATK Gene

Genomics for MATK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MATK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MATK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MATK

Top Transcription factor binding sites by QIAGEN in the MATK gene promoter:
  • TBP

Genomic Locations for MATK Gene

Genomic Locations for MATK Gene
chr19:3,777,970-3,802,129
(GRCh38/hg38)
Size:
24,160 bases
Orientation:
Minus strand
chr19:3,777,967-3,802,127
(GRCh37/hg19)
Size:
24,161 bases
Orientation:
Minus strand

Genomic View for MATK Gene

Genes around MATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MATK Gene

Proteins for MATK Gene

  • Protein details for MATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42679-MATK_HUMAN
    Recommended name:
    Megakaryocyte-associated tyrosine-protein kinase
    Protein Accession:
    P42679
    Secondary Accessions:
    • B3KNZ9
    • Q9NST8

    Protein attributes for MATK Gene

    Size:
    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    • Interacts with KIT.

    Three dimensional structures from OCA and Proteopedia for MATK Gene

    Alternative splice isoforms for MATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MATK Gene

Selected DME Specific Peptides for MATK Gene

P42679:
  • RDLAARN
  • KWTAPEA
  • TSKSDVW
  • KLSLMPWFHGKI
  • KSDVWSFG

Post-translational modifications for MATK Gene

  • Ubiquitination at Lys116
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MATK
  • Santa Cruz Biotechnology (SCBT) Antibodies for MATK

Domains & Families for MATK Gene

Gene Families for MATK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MATK Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tyrosine protein kinase, active site
  • SH3 domain signature
  • Variant SH3
ProtoNet:

Suggested Antigen Peptide Sequences for MATK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ30833 fis, clone FEBRA2002027, highly similar to Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (B3KNZ9_HUMAN)
  • Megakaryocyte-associated tyrosine-protein kinase (F1T0G6_HUMAN)
  • Tyrosine-protein kinase CTK (MATK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42679

UniProtKB/Swiss-Prot:

MATK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with MATK: view

Function for MATK Gene

Molecular function for MATK Gene

UniProtKB/Swiss-Prot Function:
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
GENATLAS Biochemistry:
megakaryocyte-associated tyrosine kinase

Enzyme Numbers (IUBMB) for MATK Gene

Phenotypes From GWAS Catalog for MATK Gene

Gene Ontology (GO) - Molecular Function for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 7530249
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 12122014
genes like me logo Genes that share ontologies with MATK: view
genes like me logo Genes that share phenotypes with MATK: view

Animal Models for MATK Gene

MGI Knock Outs for MATK:

Animal Model Products

  • Taconic Biosciences Mouse Models for MATK

CRISPR Products

miRNA for MATK Gene

miRTarBase miRNAs that target MATK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MATK

Clone Products

  • Addgene plasmids for MATK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MATK Gene

Localization for MATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATK Gene

Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MATK gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Centriolar satellite (2)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Mitotic spindle (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MATK: view

Pathways & Interactions for MATK Gene

genes like me logo Genes that share pathways with MATK: view

Pathways by source for MATK Gene

SIGNOR curated interactions for MATK Gene

Inactivates:

Gene Ontology (GO) - Biological Process for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 7530249
GO:0008284 positive regulation of cell proliferation TAS 8999872
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0038128 ERBB2 signaling pathway TAS --
genes like me logo Genes that share ontologies with MATK: view

Drugs & Compounds for MATK Gene

(3) Drugs for MATK Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0

(1) Additional Compounds for MATK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MATK: view

Transcripts for MATK Gene

mRNA/cDNA for MATK Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MATK

Clone Products

  • Addgene plasmids for MATK

Alternative Splicing Database (ASD) splice patterns (SP) for MATK Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: -
SP8: -
SP9: - -
SP10: - -
SP11:
SP12: - - - - -
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MATK Gene

GeneLoc Exon Structure for
MATK

Expression for MATK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MATK Gene

This gene is overexpressed in Whole Blood (x8.0), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Hippocampus (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for MATK Gene

This gene is overexpressed in NK cells (39.0), Peripheral blood mononuclear cells (16.0), and CD8 Tcells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MATK Gene



Protein tissue co-expression partners for MATK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MATK

SOURCE GeneReport for Unigene cluster for MATK Gene:

Hs.631845

mRNA Expression by UniProt/SwissProt for MATK Gene:

P42679-MATK_HUMAN
Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung.

Evidence on tissue expression from TISSUES for MATK Gene

  • Nervous system(4.8)
  • Blood(4.6)
  • Eye(4.6)
  • Bone marrow(3.3)
  • Spleen(3.1)
  • Bone(2.6)
  • Lymph node(2.6)
  • Liver(2.5)
  • Intestine(2.4)
  • Skin(2.4)
  • Heart(2.3)
  • Kidney(2.2)
  • Lung(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MATK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MATK Gene

Orthologs for MATK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MATK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MATK 31
  • 99 (a)
OneToOne
LOC455592 30
  • 98.34 (n)
Dog
(Canis familiaris)
Mammalia MATK 30 31
  • 88.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MATK 30 31
  • 88.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Matk 30
  • 83.91 (n)
Mouse
(Mus musculus)
Mammalia Matk 30 17 31
  • 83.56 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MATK 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MATK 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MATK 30 31
  • 76.24 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia matk 30
  • 62.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii matk 30 31
  • 62.44 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Csk 31 32
  • 19 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea csk-1 31
  • 36 (a)
OneToMany
T25B9.5 32
  • 31 (a)
Y69E1A.3 32
  • 31 (a)
Y52D5A.2 32
  • 30 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 31
  • 7 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5205 31
  • 42 (a)
OneToMany
Species where no ortholog for MATK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MATK Gene

ENSEMBL:
Gene Tree for MATK (if available)
TreeFam:
Gene Tree for MATK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MATK: view image

Paralogs for MATK Gene

(42) SIMAP similar genes for MATK Gene using alignment to 10 proteins:

  • MATK_HUMAN
  • F1T0G6_HUMAN
  • K7EKC4_HUMAN
  • K7EKS5_HUMAN
  • K7ENL8_HUMAN
  • K7EPP2_HUMAN
  • K7EQV3_HUMAN
  • K7EQY5_HUMAN
  • K7ERY4_HUMAN
  • K7ES68_HUMAN

Pseudogenes.org Pseudogenes for MATK Gene

genes like me logo Genes that share paralogs with MATK: view

Variants for MATK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MATK Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
746469 Likely Benign: not provided 3,784,855(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
747662 Likely Benign: not provided 3,783,937(-) G/A SYNONYMOUS_VARIANT
768956 Benign: not provided 3,789,323(-) G/A NONSENSE
785911 Benign: not provided 3,778,312(-) G/A SYNONYMOUS_VARIANT
rs778726488 A colorectal adenocarcinoma sample p.Arg503Gln

Additional dbSNP identifiers (rs#s) for MATK Gene

Structural Variations from Database of Genomic Variants (DGV) for MATK Gene

Variant ID Type Subtype PubMed ID
esv1011184 CNV deletion 20482838
esv2662849 CNV deletion 23128226
esv3643472 CNV loss 21293372
esv3643473 CNV gain 21293372
esv3643474 CNV loss 21293372
nsv470114 CNV loss 18288195
nsv509718 CNV insertion 20534489
nsv833715 CNV loss 17160897

Variation tolerance for MATK Gene

Residual Variation Intolerance Score: 5.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MATK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MATK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MATK Gene

Disorders for MATK Gene

MalaCards: The human disease database

(6) MalaCards diseases for MATK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bruck syndrome
  • osteogenesis imperfecta with congenital joint contractures
endocardium disease
  • abnormality of the endocardium
breast cancer
  • breast lobular carcinoma
pancytopenia
autoimmune lymphoproliferative syndrome
  • css
- elite association - COSMIC cancer census association via MalaCards
Search MATK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MATK

genes like me logo Genes that share disorders with MATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MATK Gene

Publications for MATK Gene

  1. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PMID: 7530249) Avraham S … Avraham H (The Journal of biological chemistry 1995) 2 3 4 23
  2. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PMID: 8288563) Bennett BD … Avraham H (The Journal of biological chemistry 1994) 2 3 4 23
  3. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PMID: 9038210) Price DJ … Avraham H (The Journal of biological chemistry 1997) 3 4 23
  4. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PMID: 9171348) Hirao A … Yamaguchi N (The EMBO journal 1997) 3 4 23
  5. Characterization of mouse non-receptor tyrosine kinase gene, HYL. (PMID: 7936664) Hamaguchi I … Suda T (Oncogene 1994) 3 4 23

Products for MATK Gene

  • Signalway ELISA kits for MATK

Sources for MATK Gene