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The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | TAS | 7530249 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12122014 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by ERBB2 | ||
2 | Kit receptor signaling pathway | ||
3 | Tyrosine Kinases / Adaptors | ||
4 | Development HGF signaling pathway | ||
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | TAS | 7530249 |
GO:0008284 | positive regulation of cell proliferation | TAS | 8999872 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
GO:0038128 | ERBB2 signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 17 | ^ | 18 | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MATK 33 |
|
OneToOne | |
LOC455592 32 |
|
||||
dog (Canis familiaris) |
Mammalia | MATK 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MATK 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Matk 32 |
|
||
mouse (Mus musculus) |
Mammalia | Matk 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MATK 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MATK 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MATK 33 32 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | matk 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | matk 33 32 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | Csk 33 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | csk-1 33 |
|
OneToMany | |
T25B9.5 34 |
|
|
|||
Y69E1A.3 34 |
|
|
|||
Y52D5A.2 34 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC15 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5205 33 |
|
OneToMany |
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs778726488 | A colorectal adenocarcinoma sample | 3,778,199(-) | C/G/T | coding_sequence_variant, missense_variant | |
VAR_041679 | An ovarian mucinous carcinoma sample | p.Ala354Thr | |||
rs1000125410 | -- | 3,802,932(-) | T/C | upstream_transcript_variant | |
rs1000224708 | -- | 3,803,330(-) | C/T | upstream_transcript_variant | |
rs1000378758 | -- | 3,782,452(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1011184 | CNV | deletion | 20482838 |
esv2662849 | CNV | deletion | 23128226 |
esv3643472 | CNV | loss | 21293372 |
esv3643473 | CNV | gain | 21293372 |
esv3643474 | CNV | loss | 21293372 |
nsv470114 | CNV | loss | 18288195 |
nsv509718 | CNV | insertion | 20534489 |
nsv833715 | CNV | loss | 17160897 |
No disorders were found for MATK Gene.