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MATK Gene(Protein Coding)

Megakaryocyte-Associated Tyrosine Kinase

GCID:
GC19M003777
GIFtS:
53
Genes Participants
UDN Logo

Aliases for MATK Gene

Aliases for MATK Gene

  • Megakaryocyte-Associated Tyrosine Kinase 2 3 5
  • Hematopoietic Consensus Tyrosine-Lacking Kinase 2 3 4
  • Tyrosine-Protein Kinase CTK 2 3 4
  • Protein Kinase HYL 2 3 4
  • Leukocyte Carboxyl-Terminal Src Kinase Related 2 3
  • Csk-Type Protein Tyrosine Kinase 2 3
  • Hydroxyaryl-Protein Kinase 2 3
  • Tyrosylprotein Kinase 2 3
  • Csk-Homologous Kinase 2 3
  • CSK Homologous Kinase 3 4
  • Tyrosine Kinase MATK 2 3
  • HYL Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 56
  • CHK 3 4
  • CTK 3 4
  • HYL 3 4
  • Megakaryocyte-Associated Tyrosine-Protein Kinase 3
  • EC 2.7.10 56
  • HHYLTK 3
  • HYLTK 3
  • LSK 3

External Ids for MATK Gene

Previous GeneCards Identifiers for MATK Gene

  • GC19M003870
  • GC19M003717
  • GC19M003728
  • GC19M003542

Summaries for MATK Gene

Entrez Gene Summary for MATK Gene

  • The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATK Gene

MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include Regular Astigmatism. Among its related pathways are Kit receptor signaling pathway and Signaling by ERBB2. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSK.

UniProtKB/Swiss-Prot for MATK Gene

  • Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Gene Wiki entry for MATK Gene

Additional gene information for MATK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATK Gene

Genomics for MATK Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MATK Gene

Promoters and enhancers for MATK Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I003784 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.8 +16.4 16406 2.3 SIN3A ZNF2 GLIS2 ZNF143 SP3 GMEB1 KDM1A ZNF785 KLF1 ZNF777 MATK ENSG00000267030 CCDC94 CACTIN-AS1 ZNF77 C19orf71 CACTIN APBA3 MRPL54 ENSG00000267769
GH19I003801 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 556.9 +0.4 440 1 CTCF MXI1 KLF17 SIN3A BMI1 ZFHX2 CTBP1 GLIS2 EGR1 PATZ1 MATK ENSG00000267148
GH19I003363 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +434.4 434392 8.1 HDGF SMAD1 ARNT YBX1 ZNF2 YY1 POLR2B ZNF213 ZNF143 ZNF263 NFIC CACTIN-AS1 CACTIN ZNF77 LMNB2 CCDC94 APBA3 PIAS4 ENSG00000267139 ZNF555
GH19I003605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +194.5 194526 4.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF766 SP3 MCM5 CACTIN-AS1 TBXA2R ZNF77 CACTIN CCDC94 ENSG00000267030 ZNF555 ENSG00000267769 APBA3 GNA11
GH19I004227 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 10.1 -427.3 -427317 4.2 HDGF PKNOX1 SMAD1 YBX1 ZNF2 ZNF48 ZNF121 GLIS2 ARID2 ZNF207 EBI3 CACTIN CACTIN-AS1 ENSG00000267030 CCDC94 ENSG00000267769 APBA3 ENSG00000267138 DPP9-AS1 HDGFL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MATK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MATK gene promoter:

Genomic Locations for MATK Gene

Genomic Locations for MATK Gene
chr19:3,777,969-3,802,129
(GRCh38/hg38)
Size:
24,161 bases
Orientation:
Minus strand
chr19:3,777,967-3,802,127
(GRCh37/hg19)

Genomic View for MATK Gene

Genes around MATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MATK Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MATK Gene

Proteins for MATK Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42679-MATK_HUMAN
    Recommended name:
    Megakaryocyte-associated tyrosine-protein kinase
    Protein Accession:
    P42679
    Secondary Accessions:
    • B3KNZ9
    • Q9NST8

    Protein attributes for MATK Gene

    Size:
    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    • Interacts with KIT.

    Three dimensional structures from OCA and Proteopedia for MATK Gene

    Alternative splice isoforms for MATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MATK Gene

Protein Expression for MATK Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MATK Gene

P42679:
  • RDLAARN
  • KWTAPEA
  • TSKSDVW
  • KLSLMPWFHGKI
  • KSDVWSFG

Post-translational modifications for MATK Gene

Other Protein References for MATK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MATK Gene

Gene Families for MATK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MATK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MATK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42679

UniProtKB/Swiss-Prot:

MATK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with MATK: view

Function for MATK Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MATK Gene

GENATLAS Biochemistry:
megakaryocyte-associated tyrosine kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Enzyme Numbers (IUBMB) for MATK Gene

Phenotypes From GWAS Catalog for MATK Gene

Gene Ontology (GO) - Molecular Function for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 7530249
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 12122014
genes like me logo Genes that share ontologies with MATK: view
genes like me logo Genes that share phenotypes with MATK: view

Animal Models for MATK Gene

MGI Knock Outs for MATK:

Animal Model Products

CRISPR Products

miRNA for MATK Gene

miRTarBase miRNAs that target MATK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MATK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MATK Gene

Localization for MATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATK Gene

Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MATK gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with MATK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MATK Gene

Pathways & Interactions for MATK Gene

genes like me logo Genes that share pathways with MATK: view

Pathways by source for MATK Gene

1 Cell Signaling Technology pathway for MATK Gene
1 KEGG pathway for MATK Gene

Gene Ontology (GO) - Biological Process for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 7530249
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007498 mesoderm development TAS 8288563
GO:0008283 cell proliferation TAS 8288563
GO:0008284 positive regulation of cell proliferation TAS 8999872
genes like me logo Genes that share ontologies with MATK: view

No data available for SIGNOR curated interactions for MATK Gene

Drugs & Compounds for MATK Gene

Products:

  1. Drug

(2) Drugs for MATK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MATK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MATK: view

Transcripts for MATK Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MATK Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MATK Gene

Megakaryocyte-associated tyrosine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MATK

Alternative Splicing Database (ASD) splice patterns (SP) for MATK Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: -
SP8: -
SP9: - -
SP10: - -
SP11:
SP12: - - - - -
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MATK Gene

GeneLoc Exon Structure for
MATK
ECgene alternative splicing isoforms for
MATK

Expression for MATK Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MATK Gene

mRNA expression in normal human tissues for MATK Gene
mRNA expression by GTEx for MATK GenemRNA expression by BioGPS for MATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MATK Gene

This gene is overexpressed in Whole Blood (x8.0), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Hippocampus (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for MATK Gene

This gene is overexpressed in NK cells (39.0), Peripheral blood mononuclear cells (16.0), and CD8 Tcells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MATK Gene



Protein tissue co-expression partners for MATK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MATK Gene:

MATK

SOURCE GeneReport for Unigene cluster for MATK Gene:

Hs.631845

mRNA Expression by UniProt/SwissProt for MATK Gene:

P42679-MATK_HUMAN
Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung.

Evidence on tissue expression from TISSUES for MATK Gene

  • Nervous system(4.7)
  • Eye(4.6)
  • Blood(4.5)
  • Bone marrow(2.7)
genes like me logo Genes that share expression patterns with MATK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MATK Gene

Orthologs for MATK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MATK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MATK 34
  • 99 (a)
 OneToOne
LOC455592 33
  • 98.34 (n)
dog
(Canis familiaris)
 Mammalia MATK 33 34
  • 88.77 (n)
cow
(Bos Taurus)
 Mammalia MATK 33 34
  • 88.64 (n)
rat
(Rattus norvegicus)
 Mammalia Matk 33
  • 83.91 (n)
mouse
(Mus musculus)
 Mammalia Matk 33 16 34
  • 83.56 (n)
oppossum
(Monodelphis domestica)
 Mammalia MATK 34
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MATK 34
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MATK 33 34
  • 76.24 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia matk 33
  • 62.12 (n)
zebrafish
(Danio rerio)
 Actinopterygii matk 33 34
  • 62.44 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Csk 35 34
  • 48 (a)
worm
(Caenorhabditis elegans)
 Secernentea csk-1 34
  • 36 (a)
 OneToMany
T25B9.5 35
  • 31 (a)
Y69E1A.3 35
  • 31 (a)
Y52D5A.2 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC15 34
  • 7 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5205 34
  • 42 (a)
 OneToMany
Species where no ortholog for MATK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MATK Gene

ENSEMBL:
Gene Tree for MATK (if available)
TreeFam:
Gene Tree for MATK (if available)

Paralogs for MATK Gene

Variants for MATK Gene

Sequence variations from dbSNP and Humsavar for MATK Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs778726488 A colorectal adenocarcinoma sample 3,778,199(-) C/T coding_sequence_variant, missense_variant
VAR_041679 An ovarian mucinous carcinoma sample p.Ala354Thr
rs1000125410 -- 3,802,932(-) T/C upstream_transcript_variant
rs1000224708 -- 3,803,330(-) C/T upstream_transcript_variant
rs1000378758 -- 3,782,452(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MATK Gene

Variant ID Type Subtype PubMed ID
nsv833715 CNV loss 17160897
nsv509718 CNV insertion 20534489
nsv470114 CNV loss 18288195
esv3643474 CNV loss 21293372
esv3643473 CNV gain 21293372
esv3643472 CNV loss 21293372
esv2662849 CNV deletion 23128226
esv1011184 CNV deletion 20482838

Variation tolerance for MATK Gene

Residual Variation Intolerance Score: 5.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MATK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MATK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MATK Gene

Disorders for MATK Gene

MalaCards: The human disease database

(1) MalaCards diseases for MATK Gene - From: DISEASES

Disorder Aliases PubMed IDs
regular astigmatism
- elite association - COSMIC cancer census association via MalaCards
Search MATK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MATK

Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MATK Gene

Publications for MATK Gene

  1. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PMID: 7530249) Avraham S … Avraham H (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PMID: 8288563) Bennett BD … Avraham H (The Journal of biological chemistry 1994) 2 3 4 22 58
  3. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PMID: 9171348) Hirao A … Yamaguchi N (The EMBO journal 1997) 3 4 22 58
  4. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PMID: 9038210) Price DJ … Avraham H (The Journal of biological chemistry 1997) 3 4 22 58
  5. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). (PMID: 8134117) Sakano S … Suda T (Oncogene 1994) 3 4 22 58

Products for MATK Gene

  • Addgene plasmids for MATK

Sources for MATK Gene

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