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The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include Bruck Syndrome and Endocardium Disease. Among its related pathways are Signaling by GPCR and Signaling by ERBB2. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | TAS | 7530249 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 12122014 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by ERBB2 | ||
2 | Kit receptor signaling pathway | ||
3 | Tyrosine Kinases / Adaptors | ||
4 | Development HGF signaling pathway | ||
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | TAS | 7530249 |
GO:0008284 | positive regulation of cell proliferation | TAS | 8999872 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
GO:0038128 | ERBB2 signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 17 | ^ | 18 | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MATK 31 |
|
OneToOne | |
LOC455592 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | MATK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MATK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Matk 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Matk 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MATK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MATK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MATK 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | matk 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | matk 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Csk 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | csk-1 31 |
|
OneToMany | |
T25B9.5 32 |
|
|
|||
Y69E1A.3 32 |
|
|
|||
Y52D5A.2 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC15 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5205 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
746469 | Likely Benign: not provided | 3,784,855(-) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
747662 | Likely Benign: not provided | 3,783,937(-) | G/A | SYNONYMOUS_VARIANT | |
768956 | Benign: not provided | 3,789,323(-) | G/A | NONSENSE | |
785911 | Benign: not provided | 3,778,312(-) | G/A | SYNONYMOUS_VARIANT | |
rs778726488 | A colorectal adenocarcinoma sample | p.Arg503Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1011184 | CNV | deletion | 20482838 |
esv2662849 | CNV | deletion | 23128226 |
esv3643472 | CNV | loss | 21293372 |
esv3643473 | CNV | gain | 21293372 |
esv3643474 | CNV | loss | 21293372 |
nsv470114 | CNV | loss | 18288195 |
nsv509718 | CNV | insertion | 20534489 |
nsv833715 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bruck syndrome |
|
|
endocardium disease |
|
|
breast cancer |
|
|
pancytopenia |
|
|
autoimmune lymphoproliferative syndrome |
|
|