Aliases for MATK Gene
Aliases for MATK Gene
- Megakaryocyte-Associated Tyrosine Kinase 2 3 5
- Hematopoietic Consensus Tyrosine-Lacking Kinase 2 3 4
- Tyrosine-Protein Kinase CTK 2 3 4
- Protein Kinase HYL 2 3 4
- Leukocyte Carboxyl-Terminal Src Kinase Related 2 3
- Csk-Type Protein Tyrosine Kinase 2 3
- Hydroxyaryl-Protein Kinase 2 3
- Csk-Homologous Kinase 2 3
- Tyrosylprotein Kinase 2 3
- CSK Homologous Kinase 3 4
- Tyrosine Kinase MATK 2 3
External Ids for MATK Gene
- HGNC: 6906
- Entrez Gene: 4145
- Ensembl: ENSG00000007264
- OMIM: 600038
- UniProtKB: P42679
Previous GeneCards Identifiers for MATK Gene
- GC19M003870
- GC19M003717
- GC19M003728
- GC19M003542
Summaries for MATK Gene
-
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MATK Gene
MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include Regular Astigmatism. Among its related pathways are Kit receptor signaling pathway and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSK.
UniProtKB/Swiss-Prot for MATK Gene
-
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATK Gene
Genomics for MATK Gene
GeneHancer (GH) Regulatory Elements for MATK Gene
Promoters and enhancers for MATK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MATK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MATK gene promoter:
-
- TBP
Regulatory Element Products
Genomic Locations for MATK Gene
Genomic Locations for MATK Gene
- chr19:3,777,969-3,802,129
- (GRCh38/hg38)
- Size:
- 24,161 bases
- Orientation:
- Minus strand
- chr19:3,777,967-3,802,127
- (GRCh37/hg19)
- Size:
- 24,161 bases
- Orientation:
- Minus strand
Genomic View for MATK Gene
Genes around MATK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
- 19p13.3 by Ensembl
MATK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MATK Gene
Proteins for MATK Gene
-
Protein details for MATK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42679-MATK_HUMAN
- Recommended name:
- Megakaryocyte-associated tyrosine-protein kinase
- Protein Accession:
- P42679
- B3KNZ9
- Q9NST8
Protein attributes for MATK Gene
- Size:
- 507 amino acids
- Molecular mass:
- 56469 Da
- Quaternary structure:
-
- Interacts with KIT.
Protein Expression for MATK Gene
Post-translational modifications for MATK Gene
Other Protein References for MATK Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MATK
- Novus Biologicals Antibodies for MATK
-
Abcam antibodies for MATK
- Invitrogen Antibodies for MATK (AFLGC-MATK)
- GeneTex MATK Antibody for MATK
-
Boster Bio Antibodies for MATK
-
Santa Cruz Biotechnology (SCBT) Antibodies for MATK
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MATK
- Origene Custom Protein Services for MATK
- Search GeneTex for Proteins for MATK
-
Abcam proteins for MATK
Assay Products
- antibodies-online: Search results for available MATK related products ranked by validation data
No data available for DME Specific Peptides for MATK Gene
Domains & Families for MATK Gene
Gene Families for MATK Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for MATK Gene
Suggested Antigen Peptide Sequences for MATK Gene
Graphical View of Domain Structure for InterPro Entry
P42679UniProtKB/Swiss-Prot:
MATK_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Function for MATK Gene
Molecular function for MATK Gene
- UniProtKB/Swiss-Prot Function:
- Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- GENATLAS Biochemistry:
- megakaryocyte-associated tyrosine kinase
Enzyme Numbers (IUBMB) for MATK Gene
Phenotypes From GWAS Catalog for MATK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | 7530249 |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IBA | -- |
| GO:0005102 | signaling receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 12122014 |
Phenotypes for MATK Gene
- MGI mutant phenotypes for MATK:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MATK:
-
- Decreased substrate adherent cell growth
- Decreased cell proliferation
- Decreased Salmonella enterica Typhimurium invasion
- Increased cell migration
- Decreased cell migration
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for MATK Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MATK
- Cyagen custom Knockout/knockin (KOKI) mouse models for MATK
-
CRISPR Products
-
OriGene CRISPR knockouts for MATK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MATK
- genomics-online: gRNA clones - Search results for available MATK gene related products
- Applied Biological Materials CRISPR for MATK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MATK
- GenScript: Design CRISPR guide RNA sequences for MATK
miRNA for MATK Gene
- miRTarBase miRNAs that target MATK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MATK
- Browse OriGene Inhibitory RNA Products For MATK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MATK
- genomics-online: shRNA clones - Search results for available MATK gene related products
Clone Products
-
OriGene ORF clones in human for MATK
- RC200454
- RC200454L1
- RC200454L2
- RC200454L3
- RC200454L4
- RC223161
- RC223161L1
- RC223161L2
- RC223161L3
- RC223161L4
- RC224657
- RC224657L1
- RC224657L2
- RC224657L3
- RC224657L4
- RG200454
- RG223161
- RG224657
- RC200454L1V
- RC200454L2V
- RC200454L3V
- RC200454L4V
- RC223161L1V
- RC223161L2V
- RC223161L3V
- RC223161L4V
- RC224657L1V
- RC224657L2V
- RC224657L3V
- RC224657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MATK
- Addgene plasmids for MATK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MATK
- genomics-online: cdna clones - Search results for available MATK gene related products
- orf clones - Search results for available MATK gene related products
- Applied Biological Materials Clones for MATK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MATK
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MATK Gene
Localization for MATK Gene
Subcellular locations from UniProtKB/Swiss-Prot for MATK Gene
- Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MATK Gene
Pathways & Interactions for MATK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by ERBB2 | ||
| 2 | Kit receptor signaling pathway | ||
| 3 | Development HGF signaling pathway | ||
| 4 | Tyrosine Kinases / Adaptors | ||
| 5 | Signaling by GPCR | ||
Pathways by source for MATK Gene
3 BioSystems pathways for MATK Gene
3 Reactome pathways for MATK Gene
1 KEGG pathway for MATK Gene
1 Cell Signaling Technology pathway for MATK Gene
Interacting Proteins for MATK Gene
Selected Interacting proteins:
P42679-MATK_HUMAN
ENSP00000378485
for MATK Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for MATK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | TAS | 7530249 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | -- |
| GO:0007498 | mesoderm development | TAS | 8288563 |
| GO:0008283 | cell proliferation | TAS | 8288563 |
| GO:0008284 | positive regulation of cell proliferation | TAS | 8999872 |
No data available for SIGNOR curated interactions for MATK Gene
Drugs & Compounds for MATK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for MATK Gene
mRNA/cDNA for MATK Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (113) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000395040 1907 bps (uc002lyu.4)
- ENST00000310132 2133 bps (uc002lyt.4)
- ENST00000585778 1994 bps (uc010dtq.4)
- ENST00000395045 2073 bps (uc002lyv.4)
- ENST00000590493 801 bps (uc060rsi.1)
Unigene Clusters for MATK Gene
- Megakaryocyte-associated tyrosine kinase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MATK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MATK
- genomics-online: gRNA clones - Search results for available MATK gene related products
- Applied Biological Materials CRISPR for MATK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MATK
- GenScript: Design CRISPR guide RNA sequences for MATK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MATK
- Browse OriGene Inhibitory RNA Products For MATK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MATK
- genomics-online: shRNA clones - Search results for available MATK gene related products
Clone Products
-
OriGene ORF clones in human for MATK
- RC200454
- RC200454L1
- RC200454L2
- RC200454L3
- RC200454L4
- RC223161
- RC223161L1
- RC223161L2
- RC223161L3
- RC223161L4
- RC224657
- RC224657L1
- RC224657L2
- RC224657L3
- RC224657L4
- RG200454
- RG223161
- RG224657
- RC200454L1V
- RC200454L2V
- RC200454L3V
- RC200454L4V
- RC223161L1V
- RC223161L2V
- RC223161L3V
- RC223161L4V
- RC224657L1V
- RC224657L2V
- RC224657L3V
- RC224657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MATK
- Addgene plasmids for MATK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MATK
- genomics-online: cdna clones - Search results for available MATK gene related products
- orf clones - Search results for available MATK gene related products
- Applied Biological Materials Clones for MATK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: |
Expression for MATK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for MATK Gene
This gene is overexpressed in Whole Blood (x8.0), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Hippocampus (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.6).
This gene is overexpressed in NK cells (39.0), Peripheral blood mononuclear cells (16.0), and CD8 Tcells (14.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MATK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MATK Gene:
MATKSOURCE GeneReport for Unigene cluster for MATK Gene:
Hs.631845mRNA Expression by UniProt/SwissProt for MATK Gene:
P42679-MATK_HUMAN
Tissue specificity:
Expressed in various myeloid cell lines, detected in brain and lung.
Evidence on tissue expression from TISSUES for MATK Gene
- Nervous system(4.7)
- Eye(4.6)
- Blood(4.5)
- Bone marrow(2.7)
Primer Products
-
OriGene qPCR primer pairs for MATK
-
OriGene qPCR primer pairs and template standards for MATK
- genomics-online: primer clones - Search results for available MATK gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MATK Gene
Orthologs for MATK Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MATK 34 |
|
OneToOne | |
| LOC455592 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | MATK 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MATK 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Matk 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Matk 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MATK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MATK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MATK 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | matk 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | matk 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Csk 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | csk-1 34 |
|
OneToMany | |
| T25B9.5 35 |
|
|
|||
| Y69E1A.3 35 |
|
|
|||
| Y52D5A.2 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC15 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5205 34 |
|
OneToMany |
- Species where no ortholog for MATK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MATK Gene
- ENSEMBL:
- Gene Tree for MATK (if available)
- TreeFam:
- Gene Tree for MATK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MATK: view image
Paralogs for MATK Gene
(42) SIMAP similar genes for MATK Gene using alignment to 10 proteins:
- MATK_HUMAN
- F1T0G6_HUMAN
- K7EKC4_HUMAN
- K7EKS5_HUMAN
- K7ENL8_HUMAN
- K7EPP2_HUMAN
- K7EQV3_HUMAN
- K7EQY5_HUMAN
- K7ERY4_HUMAN
- K7ES68_HUMAN
- lsk
- CSK
- EGFR
- BTK kinase deficient isoform 6
- ABL1
- MARK2
- BTK kinase deficient isoform 2
- tec
- EPHA2
- BTK kinase deficient isoform 4
- TIE1
- DKFZp564L2416
- DKFZp686M05208
- BMX
- FGFR2
- FES
- GRB2
- BTK
- BRSK2
- FGR
- PTK6
- HCK
- FGFR1
- FRK
- DKFZp434L0319
- TXK
- FGFR4
- YES1
- FGFR3
- FYN
- BCR/ABL fusion
- SRMS
- FER
- SRC
- LYN
- LCK
- ABL2
- BLK
- EPHB1
- PTPN11
- GRAP
- GRAPL
Pseudogenes.org Pseudogenes for MATK Gene
Variants for MATK Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs778726488 | A colorectal adenocarcinoma sample | 3,778,199(-) | C/T | coding_sequence_variant, missense_variant | |
| VAR_041679 | An ovarian mucinous carcinoma sample | p.Ala354Thr | |||
| rs1000125410 | -- | 3,802,932(-) | T/C | upstream_transcript_variant | |
| rs1000224708 | -- | 3,803,330(-) | C/T | upstream_transcript_variant | |
| rs1000378758 | -- | 3,782,452(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1011184 | CNV | deletion | 20482838 |
| esv2662849 | CNV | deletion | 23128226 |
| esv3643472 | CNV | loss | 21293372 |
| esv3643473 | CNV | gain | 21293372 |
| esv3643474 | CNV | loss | 21293372 |
| nsv470114 | CNV | loss | 18288195 |
| nsv509718 | CNV | insertion | 20534489 |
| nsv833715 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
5.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.79;
58.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MATK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MATK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MATK Gene
Disorders for MATK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| regular astigmatism |
|
|
Search MATK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MATK
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MATK Gene
Publications for MATK Gene
- Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PMID: 7530249) Avraham S … Avraham H (The Journal of biological chemistry 1995) 2 3 4 22 58
- Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PMID: 8288563) Bennett BD … Avraham H (The Journal of biological chemistry 1994) 2 3 4 22 58
- Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PMID: 9171348) Hirao A … Yamaguchi N (The EMBO journal 1997) 3 4 22 58
- Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PMID: 9038210) Price DJ … Avraham H (The Journal of biological chemistry 1997) 3 4 22 58
- Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). (PMID: 8134117) Sakano S … Suda T (Oncogene 1994) 3 4 22 58
Products for MATK Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MATK
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MATK
- Origene Custom Protein Services for MATK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MATK
- Browse OriGene Inhibitory RNA Products For MATK
- OriGene qPCR primer pairs for MATK
- OriGene qPCR primer pairs and template standards for MATK
- OriGene CRISPR knockouts for MATK
- OriGene ORF clones in human for MATK
- RC200454
- RC200454L1
- RC200454L2
- RC200454L3
- RC200454L4
- RC223161
- RC223161L1
- RC223161L2
- RC223161L3
- RC223161L4
- RC224657
- RC224657L1
- RC224657L2
- RC224657L3
- RC224657L4
- RG200454
- RG223161
- RG224657
- RC200454L1V
- RC200454L2V
- RC200454L3V
- RC200454L4V
- RC223161L1V
- RC223161L2V
- RC223161L3V
- RC223161L4V
- RC224657L1V
- RC224657L2V
- RC224657L3V
- RC224657L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MATK
- GenScript: Next-day shipping of latest version cDNA ORF clones for MATK in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MATK
- GenScript Custom Assay Services for MATK
- GenScript Custom overexpressing Cell Line Services for MATK
- GenScript: Design CRISPR guide RNA sequences for MATK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MATK
- Sino Biological Human cDNA Clone for MATK
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MATK
- Novus Biologicals lysates and proteins for MATK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MATK
- Abcam proteins for MATK
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for MATK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MATK (AFLGC-MATK)
- Cyagen custom Knockout/knockin (KOKI) mouse models for MATK
- Addgene plasmids for MATK
- antibodies-online: Search results for 124 available MATK Antibodies ranked by validation data
- Compare Top MATK Antibodies
- Quality Products:
- antibodies-online: Search results for available MATK related products ranked by validation data
- antibodies-online: Search results for 10 available MATK Proteins ranked by validation data
- Compare Top MATK Proteins
- Quality Products:
- GeneTex MATK Antibody for MATK
- Search GeneTex for Proteins for MATK
- Santa Cruz Biotechnology (SCBT) Antibodies for MATK
- Search Santa Cruz Biotechnology (SCBT) for MATK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MATK
- Horizon Cell Lines for MATK
- genomics-online: cdna clones - Search results for available MATK gene related products
- orf clones - Search results for available MATK gene related products
- genomics-online: gRNA clones - Search results for available MATK gene related products
- genomics-online: primer clones - Search results for available MATK gene related products
- genomics-online: shRNA clones - Search results for available MATK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MATK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MATK
- GeneCopoeia miRNA 3'UTR Target clone products for MATK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MATK
- Boster Bio Antibodies for MATK
- Browse Boster Bio ELISA Kits
Sources for MATK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt