Aliases for MAT2B Gene
External Ids for MAT2B Gene
Previous GeneCards Identifiers for MAT2B Gene
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
GeneCards Summary for MAT2B Gene
MAT2B (Methionine Adenosyltransferase 2B) is a Protein Coding gene. Diseases associated with MAT2B include Hypermethioninemia. Among its related pathways are Cytochrome P450 - arranged by substrate type and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and coenzyme binding.
UniProtKB/Swiss-Prot Summary for MAT2B Gene
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).