Aliases for MAT2B Gene
Aliases for MAT2B Gene
- Methionine Adenosyltransferase 2B 2 3 5
- Short Chain Dehydrogenase/Reductase Family 23E, Member 1 2 3
- Putative DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3 4
- Methionine Adenosyltransferase II, Beta 2 3
- MAT II Beta 3 4
- TGR 3 4
- Beta Regulatory Subunit Of Methionine Adenosyltransferase 3
- Methionine Adenosyltransferase 2 Subunit Beta 3
- DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3
External Ids for MAT2B Gene
- HGNC: 6905
- Entrez Gene: 27430
- Ensembl: ENSG00000038274
- OMIM: 605527
- UniProtKB: Q9NZL9
Previous GeneCards Identifiers for MAT2B Gene
- GC05P163135
- GC05P162865
- GC05P162911
- GC05P162862
- GC05P162930
- GC05P158029
Summaries for MAT2B Gene
-
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
GeneCards Summary for MAT2B Gene
MAT2B (Methionine Adenosyltransferase 2B) is a Protein Coding gene. Among its related pathways are Metabolism and Methylation Pathways. Gene Ontology (GO) annotations related to this gene include enzyme binding and coenzyme binding.
UniProtKB/Swiss-Prot for MAT2B Gene
-
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT2B Gene
Genomics for MAT2B Gene
GeneHancer (GH) Regulatory Elements for MAT2B Gene
Promoters and enhancers for MAT2B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J163502 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 657.5 | +3.4 | 3431 | 8.7 | DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN NR2C1 | MAT2B HMMR CCNG1 NUDCD2 GC05P163619 GC05P163387 | |
| GH05J163457 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 17.2 | -42.4 | -42412 | 6 | DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D GLIS1 NBN NR2C1 | NUDCD2 HMMR CCNG1 MAT2B HMMR-AS1 GC05P163387 | |
| GH05J163773 | Enhancer | 0.2 | dbSUPER | 5.7 | +271.9 | 271916 | 2.1 | MAT2B RNU6-168P GC05M163722 GC05M163721 | ||
| GH05J163533 | Enhancer | 0.8 | Ensembl ENCODE | 0.3 | +31.4 | 31443 | 2.3 | USF1 MAX USF2 FEZF1 SP1 ZNF316 POU5F1 ZNF143 MAFK EMSY | MAT2B GC05P163619 GC05P163387 | |
| GH05J163565 | Enhancer | 1 | Ensembl ENCODE | 0.2 | +63.2 | 63169 | 1.3 | ELF3 FOXA2 ARID4B SIN3A BATF ZNF48 RARA CREM IKZF2 MIXL1 | GC05P163619 MAT2B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAT2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MAT2B Gene
Genomic Locations for MAT2B Gene
- chr5:163,503,064-163,519,353
- (GRCh38/hg38)
- Size:
- 16,290 bases
- Orientation:
- Plus strand
- chr5:162,930,120-162,946,342
- (GRCh37/hg19)
Genomic View for MAT2B Gene
Genes around MAT2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q34 by Entrez Gene
- 5q34 by HGNC
- 5q34 by Ensembl
MAT2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAT2B Gene
Proteins for MAT2B Gene
-
Protein details for MAT2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NZL9-MAT2B_HUMAN
- Recommended name:
- Methionine adenosyltransferase 2 subunit beta
- Protein Accession:
- Q9NZL9
- B2R5Y6
- Q1WAI7
- Q27J92
- Q3LIE8
- Q567T7
- Q6NYC7
- Q9BS89
- Q9H3E1
- Q9UJ54
Protein attributes for MAT2B Gene
- Size:
- 334 amino acids
- Molecular mass:
- 37552 Da
- Quaternary structure:
-
- Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345). NADP binding increases the affinity for MAT2A (PubMed:23189196).
- Miscellaneous:
-
- Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.
- SequenceCaution:
-
- Sequence=AAG39296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MAT2B Gene
Protein Expression for MAT2B Gene
Post-translational modifications for MAT2B Gene
Other Protein References for MAT2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAT2B
- Novus Biologicals Antibodies for MAT2B
- Invitrogen Antibodies for MAT2B
- GeneTex MAT2B Antibody for MAT2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAT2B
Protein Products
-
OriGene Purified Proteins for MAT2B
- Search Origene for MassSpec and Protein Over-expression Lysates for MAT2B
- Origene Custom Protein Services for MAT2B
- ProSpec Recombinant Proteins for MAT2B
- Search GeneTex for Proteins for MAT2B
Assay Products
No data available for DME Specific Peptides for MAT2B Gene
Domains & Families for MAT2B Gene
Gene Families for MAT2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MAT2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAT2B Gene
Graphical View of Domain Structure for InterPro Entry
Q9NZL9UniProtKB/Swiss-Prot:
MAT2B_HUMAN :- Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
- Family:
-
- Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Function for MAT2B Gene
Molecular function for MAT2B Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).
Phenotypes From GWAS Catalog for MAT2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25075345 |
| GO:0019899 | enzyme binding | IPI | 10644686 |
| GO:0048270 | methionine adenosyltransferase regulator activity | IDA | 10644686 |
Phenotypes for MAT2B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAT2B
-
CRISPR Products
-
OriGene CRISPR knockouts for MAT2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAT2B
- genomics-online: gRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- Applied Biological Materials CRISPR for MAT2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAT2B
- GenScript: Design CRISPR guide RNA sequences for MAT2B
miRNA for MAT2B Gene
- miRTarBase miRNAs that target MAT2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAT2B
- Browse OriGene Inhibitory RNA Products For MAT2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAT2B
- genomics-online: shRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAT2B
- VectorBuilder custom plasmid, inducible vectors for MAT2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAT2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAT2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAT2B
- Applied Biological Materials Clones for MAT2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAT2B Gene
Localization for MAT2B Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IC | 10644686 |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0048269 | methionine adenosyltransferase complex | IDA | 10644686 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MAT2B Gene
Pathways & Interactions for MAT2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sulfur amino acid metabolism | ||
| 2 | Cytochrome P450 - arranged by substrate type |
.01
|
|
| 3 | Methylation Pathways | ||
| 4 | Metabolism |
.37
|
|
| 5 | Deubiquitination |
.74
|
|
Pathways by source for MAT2B Gene
9 BioSystems pathways for MAT2B Gene
8 Reactome pathways for MAT2B Gene
3 KEGG pathways for MAT2B Gene
UniProtKB/Swiss-Prot Q9NZL9-MAT2B_HUMAN
- Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Interacting Proteins for MAT2B Gene
Selected Interacting proteins:
Q9NZL9-MAT2B_HUMAN
ENSP00000325425
for MAT2B Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for MAT2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006556 | S-adenosylmethionine biosynthetic process | IEA | -- |
| GO:0006730 | one-carbon metabolic process | IEA | -- |
| GO:0032259 | methylation | TAS | -- |
| GO:0050790 | regulation of catalytic activity | IEA | -- |
No data available for SIGNOR curated interactions for MAT2B Gene
Drugs & Compounds for MAT2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Methionine | Approved | Nutra | Enzyme, substrate | 102 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Selenomethionine | Approved, Investigational | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
|||
| pyrophosphate |
|
14000-31-8 |
|
|||
| s-adenosylmethionine |
|
485-80-3 |
|
|||
| Se-Adenosylselenomethionine |
|
|
Transcripts for MAT2B Gene
mRNA/cDNA for MAT2B Gene
- (316) Selected AceView cDNA sequences:
- (16) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000523606 3210 bps (uc063jja.1)
- ENST00000521838 1526 bps (uc063jjc.1)
- ENST00000520449 557 bps (uc063jjb.1)
- ENST00000519719 572 bps (uc063jiy.1)
- ENST00000518095 3409 bps (uc003lzl.3)
Unigene Clusters for MAT2B Gene
- Methionine adenosyltransferase II, beta:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAT2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAT2B
- genomics-online: gRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- Applied Biological Materials CRISPR for MAT2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAT2B
- GenScript: Design CRISPR guide RNA sequences for MAT2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAT2B
- Browse OriGene Inhibitory RNA Products For MAT2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAT2B
- genomics-online: shRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAT2B
- VectorBuilder custom plasmid, inducible vectors for MAT2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAT2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAT2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAT2B
- Applied Biological Materials Clones for MAT2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | - | - | - |
Expression for MAT2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lavage (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAT2B Gene
NURSA nuclear receptor signaling pathways regulating expression of MAT2B Gene:
MAT2BSOURCE GeneReport for Unigene cluster for MAT2B Gene:
Hs.54642mRNA Expression by UniProt/SwissProt for MAT2B Gene:
Q9NZL9-MAT2B_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for MAT2B Gene
- Nervous system(4.9)
- Heart(4.3)
- Skin(4.3)
- Pancreas(4.2)
- Liver(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for MAT2B
-
OriGene qPCR primer pairs for MAT2B
- genomics-online: primer clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAT2B Gene
Orthologs for MAT2B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAT2B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAT2B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAT2B 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAT2B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAT2B 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mat2b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mat2b 33 |
|
||
| chicken (Gallus gallus) |
Aves | MAT2B 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAT2B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mat2b 33 |
|
||
| Str.19105 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mat2b 34 33 |
|
OneToOne | |
| wufb48h02 33 |
|
||||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G00560 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0826200 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01177 33 |
|
- Species where no ortholog for MAT2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MAT2B Gene
- ENSEMBL:
- Gene Tree for MAT2B (if available)
- TreeFam:
- Gene Tree for MAT2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAT2B: view image
Paralogs for MAT2B Gene
No data available for Paralogs for MAT2B Gene
Variants for MAT2B Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000078228 | -- | 163,509,954(+) | C/G | intron_variant | |
| rs1000091216 | -- | 163,501,838(+) | T/C | upstream_transcript_variant | |
| rs1000183993 | -- | 163,501,092(+) | T/A | upstream_transcript_variant | |
| rs1000314529 | -- | 163,519,175(+) | T/A | 3_prime_UTR_variant | |
| rs1000324252 | -- | 163,507,773(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1017056 | CNV | gain | 25217958 |
| nsv1029437 | CNV | gain | 25217958 |
| nsv830538 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.00;
20.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAT2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAT2B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2B Gene
Disorders for MAT2B Gene
Additional Disease Information for MAT2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MAT2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAT2B Gene
Publications for MAT2B Gene
- Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. (PMID: 11337507) LeGros L … Kotb M (The Journal of biological chemistry 2001) 3 4 22 25 58
- Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PMID: 12671891) Martínez-Chantar ML … Mato JM (Gastroenterology 2003) 3 4 22 58
- Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PMID: 10644686) LeGros HL … Kotb M (The Journal of biological chemistry 2000) 2 3 4 58
- Structure and function study of the complex that synthesizes S-adenosylmethionine. (PMID: 25075345) Murray B … Rojas AL (IUCrJ 2014) 3 4 58
- Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits. (PMID: 23425511) Shafqat N … Yue WW (The Biochemical journal 2013) 3 4 58
Products for MAT2B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAT2B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAT2B
- Search Origene for MassSpec and Protein Over-expression Lysates for MAT2B
- Origene Custom Protein Services for MAT2B
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MAT2B
- Browse OriGene Inhibitory RNA Products For MAT2B
- OriGene qPCR primer pairs and template standards for MAT2B
- OriGene qPCR primer pairs for MAT2B
- OriGene CRISPR knockouts for MAT2B
- OriGene ORF clones in human for MAT2B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAT2B
- GenScript: Next-day shipping of latest version cDNA ORF clones for MAT2B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MAT2B
- GenScript Custom Assay Services for MAT2B
- GenScript Custom overexpressing Cell Line Services for MAT2B
- GenScript: Design CRISPR guide RNA sequences for MAT2B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAT2B
- Sino Biological Human cDNA Clone for MAT2B
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MAT2B
- Novus Biologicals lysates and proteins for MAT2B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for MAT2B
- VectorBuilder custom plasmid, inducible vectors for MAT2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAT2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAT2B
- antibodies-online: Search results for 64 available MAT2B Antibodies ranked by validation data
- Compare Top MAT2B Antibodies
- antibodies-online: Search results for 6 available MAT2B Elisa Kits ranked by validation data
- Compare Top MAT2B Elisa Kits
- antibodies-online: Search results for 16 available MAT2B Proteins ranked by validation data
- Compare Top MAT2B Proteins
- GeneTex MAT2B Antibody for MAT2B
- Search GeneTex for Proteins for MAT2B
- Santa Cruz Biotechnology (SCBT) Antibodies for MAT2B
- Search Santa Cruz Biotechnology (SCBT) for MAT2B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAT2B
- Horizon Cell Lines for MAT2B
- genomics-online: cdna clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- orf clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- genomics-online: gRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- genomics-online: primer clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- genomics-online: shRNA clones - Search results for 115 available MAT2B gene related products
- Overview of 115 available MAT2B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAT2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAT2B
- GeneCopoeia miRNA 3'UTR Target clone products for MAT2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAT2B
Sources for MAT2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio