MAT2B Gene (Protein Coding)

Methionine Adenosyltransferase 2B

GC05P163523
GIFtS:
40
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] See more...

Aliases for MAT2B Gene

Aliases for MAT2B Gene

  • Methionine Adenosyltransferase 2B 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 23E, Member 1 2 3
  • Putative DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3 4
  • Methionine Adenosyltransferase 2 Subunit Beta 3 4
  • Methionine Adenosyltransferase II, Beta 2 3
  • MAT II Beta 3 4
  • MATIIbeta 2 3
  • SDR23E1 2 3
  • TGR 3 4
  • Beta Regulatory Subunit Of Methionine Adenosyltransferase 3
  • DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3
  • Methionine Adenosyltransferase II Beta 4
  • Putative Protein Product Of Nbla02999 3
  • Testicular Tissue Protein Li 118 3
  • Nbla02999 3
  • MAT-II 3
  • MAT2B 5

External Ids for MAT2B Gene

Previous GeneCards Identifiers for MAT2B Gene

  • GC05P163135
  • GC05P162865
  • GC05P162911
  • GC05P162862
  • GC05P162930
  • GC05P158029

Summaries for MAT2B Gene

Entrez Gene Summary for MAT2B Gene

  • The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for MAT2B Gene

MAT2B (Methionine Adenosyltransferase 2B) is a Protein Coding gene. Diseases associated with MAT2B include Hypermethioninemia. Among its related pathways are One carbon pool by folate and superpathway of methionine degradation. Gene Ontology (GO) annotations related to this gene include enzyme binding and coenzyme binding.

UniProtKB/Swiss-Prot Summary for MAT2B Gene

  • Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Additional gene information for MAT2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAT2B Gene

Genomics for MAT2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAT2B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J163502 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 607.4 +3.4 3431 8.7 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 MAT2B HMMR CCNG1 NUDCD2 MN298678-071
GH05J163457 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.2 -42.4 -42439 6 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 RFX1 LEF1 NUDCD2 HMMR lnc-GABRB2-6 CCNG1 MAT2B HMMR-AS1
GH05J163467 Enhancer 0.4 Ensembl 12 -35.3 -35263 1.2 PRDM10 GATA3 TCF7L2 GATA2 MAT2B HMMR-AS1 CCNG1 NUDCD2 HMMR
GH05J163477 Enhancer 0.3 Ensembl 12.2 -24.6 -24563 1.4 JUND MAT2B CCNG1 NUDCD2 HMMR HMMR-AS1
GH05J163475 Enhancer 0.2 Ensembl 12.2 -27.4 -27364 1 MAT2B NUDCD2 HMMR HMMR-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAT2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAT2B

Top Transcription factor binding sites by QIAGEN in the MAT2B gene promoter:
  • c-Myb
  • E47
  • Evi-1
  • FOXO4
  • RP58
  • Tal-1

Genomic Locations for MAT2B Gene

Genomic Locations for MAT2B Gene
chr5:163,503,064-163,519,354
(GRCh38/hg38)
Size:
16,291 bases
Orientation:
Plus strand
chr5:162,930,120-162,946,342
(GRCh37/hg19)
Size:
16,223 bases
Orientation:
Plus strand

Genomic View for MAT2B Gene

Genes around MAT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAT2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAT2B Gene

Proteins for MAT2B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL9-MAT2B_HUMAN
    Recommended name:
    Methionine adenosyltransferase 2 subunit beta
    Protein Accession:
    Q9NZL9
    Secondary Accessions:
    • B2R5Y6
    • Q1WAI7
    • Q27J92
    • Q3LIE8
    • Q567T7
    • Q6NYC7
    • Q9BS89
    • Q9H3E1
    • Q9UJ54

    Protein attributes for MAT2B Gene

    Size:
    334 amino acids
    Molecular mass:
    37552 Da
    Quaternary structure:
    • Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345). NADP binding increases the affinity for MAT2A (PubMed:23189196).
    SequenceCaution:
    • Sequence=AAG39296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.

    Three dimensional structures from OCA and Proteopedia for MAT2B Gene

    Alternative splice isoforms for MAT2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAT2B Gene

Protein Expression for MAT2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAT2B Gene

  • Ubiquitination at Lys209, Lys245, Lys316, and Lys326
  • Modification sites at PhosphoSitePlus

Other Protein References for MAT2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAT2B
  • Boster Bio Antibodies for MAT2B

No data available for DME Specific Peptides for MAT2B Gene

Domains & Families for MAT2B Gene

Gene Families for MAT2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAT2B Gene

InterPro:
Blocks:
  • dTDP-4-dehydrorhamnose reductase
ProtoNet:

Suggested Antigen Peptide Sequences for MAT2B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55836, highly similar to Homo sapiens methionine adenosyltransferase II, beta (MAT2B), transcript variant 2, mRNA (B7Z1X8_HUMAN)
  • Methionine adenosyltransferase II beta (MAT2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZL9

UniProtKB/Swiss-Prot:

MAT2B_HUMAN :
  • Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Family:
  • Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
genes like me logo Genes that share domains with MAT2B: view

Function for MAT2B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAT2B Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Phenotypes From GWAS Catalog for MAT2B Gene

Gene Ontology (GO) - Molecular Function for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25075345
GO:0019899 enzyme binding IPI 10644686
GO:0048270 methionine adenosyltransferase regulator activity IBA,IDA 10644686
genes like me logo Genes that share ontologies with MAT2B: view
genes like me logo Genes that share phenotypes with MAT2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAT2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAT2B Gene

Localization for MAT2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAT2B gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol TAS --
GO:0048269 methionine adenosyltransferase complex IBA,IDA 10644686
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MAT2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAT2B Gene

Pathways & Interactions for MAT2B Gene

genes like me logo Genes that share pathways with MAT2B: view

UniProtKB/Swiss-Prot Q9NZL9-MAT2B_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

SIGNOR curated interactions for MAT2B Gene

Activates:

Gene Ontology (GO) - Biological Process for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006556 S-adenosylmethionine biosynthetic process IEA --
GO:0006730 one-carbon metabolic process IEA --
GO:0032259 methylation TAS --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with MAT2B: view

Drugs & Compounds for MAT2B Gene

Products:

  1. Drug

(5) Drugs for MAT2B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methionine Approved Nutra Enzyme, substrate 118
Phosphoric acid Approved Pharma 0
Selenomethionine Approved, Investigational Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(4) Additional Compounds for MAT2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
 14066-19-4, 14265-44-2
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
 14000-31-8
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
Se-Adenosylselenomethionine
genes like me logo Genes that share compounds with MAT2B: view

Transcripts for MAT2B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAT2B Gene

2 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAT2B

Alternative Splicing Database (ASD) splice patterns (SP) for MAT2B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for MAT2B Gene

GeneLoc Exon Structure for
MAT2B

Expression for MAT2B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAT2B Gene

mRNA expression in normal human tissues for MAT2B Gene
mRNA expression by GTEx for MAT2B GenemRNA expression by BioGPS for MAT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAT2B Gene

This gene is overexpressed in Lavage (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAT2B Gene



Protein tissue co-expression partners for MAT2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAT2B

SOURCE GeneReport for Unigene cluster for MAT2B Gene:

Hs.54642

mRNA Expression by UniProt/SwissProt for MAT2B Gene:

Q9NZL9-MAT2B_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MAT2B Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Heart(4.4)
  • Pancreas(4.4)
  • Liver(2.7)
  • Blood(2.6)
  • Kidney(2.5)
  • Intestine(2.4)
  • Thyroid gland(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with MAT2B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAT2B Gene

Orthologs for MAT2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAT2B 30 31
  • 99.36 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAT2B 30 31
  • 93.11 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAT2B 30 31
  • 92.81 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAT2B 31
  • 90 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAT2B 31
  • 89 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mat2b 30 17 31
  • 88.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mat2b 30
  • 88.62 (n)
Chicken
(Gallus gallus)
 Aves MAT2B 30 31
  • 79.83 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAT2B 31
  • 81 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mat2b 30
  • 72.85 (n)
Str.19105 30
Zebrafish
(Danio rerio)
 Actinopterygii mat2b 30 31
  • 63.68 (n)
 OneToOne
wufb48h02 30
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT4G00560 30
  • 42.25 (n)
Rice
(Oryza sativa)
 Liliopsida Os02g0826200 30
  • 42.82 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU01177 30
  • 50.76 (n)
Species where no ortholog for MAT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MAT2B Gene

ENSEMBL:
Gene Tree for MAT2B (if available)
TreeFam:
Gene Tree for MAT2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAT2B: view image

Paralogs for MAT2B Gene

No data available for Paralogs for MAT2B Gene

Variants for MAT2B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAT2B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
717327 Benign: not provided 163,518,263(+) C/T MISSENSE_VARIANT
rs17849948 - p.Ala293Thr

Additional dbSNP identifiers (rs#s) for MAT2B Gene

Structural Variations from Database of Genomic Variants (DGV) for MAT2B Gene

Variant ID Type Subtype PubMed ID
nsv1017056 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv830538 CNV gain+loss 17160897

Variation tolerance for MAT2B Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAT2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2B Gene

Disorders for MAT2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAT2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypermethioninemia
  • mat deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MAT2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAT2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAT2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAT2B Gene

Publications for MAT2B Gene

  1. Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. (PMID: 11337507) LeGros L … Kotb M (The Journal of biological chemistry 2001) 3 4 23 26
  2. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PMID: 12671891) Martínez-Chantar ML … Mato JM (Gastroenterology 2003) 3 4 23
  3. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PMID: 10644686) LeGros HL … Kotb M (The Journal of biological chemistry 2000) 2 3 4
  4. Structure and function study of the complex that synthesizes S-adenosylmethionine. (PMID: 25075345) Murray B … Rojas AL (IUCrJ 2014) 3 4
  5. Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits. (PMID: 23425511) Shafqat N … Yue WW (The Biochemical journal 2013) 3 4

ExternalLinks

View latest publications for MAT2B gene in Mastermind

Products for MAT2B Gene

  • Addgene plasmids for MAT2B
  • Signalway ELISA kits for MAT2B
  • Signalway Proteins for MAT2B

Sources for MAT2B Gene