Aliases for MAST3 Gene

Aliases for MAST3 Gene

  • Microtubule Associated Serine/Threonine Kinase 3 2 3 5
  • Microtubule-Associated Serine/Threonine-Protein Kinase 3 3 4
  • EC 4 54
  • EC 2.7.11 54
  • KIAA0561 4

External Ids for MAST3 Gene

Previous GeneCards Identifiers for MAST3 Gene

  • GC19P018069
  • GC19P018208
  • GC19P017772
  • GC19P018137
  • GC19P018196
  • GC19P020495
  • GC19P020636
  • GC19P018364
  • GC19P018384
  • GC19P018716
  • GC19P019027
  • GC19P019342
  • GC19P019676
  • GC19P020041
  • GC19P020354

Summaries for MAST3 Gene

GeneCards Summary for MAST3 Gene

MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with MAST3 include Inflammatory Bowel Disease 6. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST2.

Additional gene information for MAST3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAST3 Gene

Genomics for MAST3 Gene

GeneHancer (GH) Regulatory Elements for MAST3 Gene

Promoters and enhancers for MAST3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018097 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 750.6 +1.0 1003 2.9 SP1 SMARCE1 POLR2A USF2 HDAC2 CC2D1A RELA DACH1 ZNF280D ZC3H8 IL12RB1 MAST3 UPF1 ENSG00000268030 ENSG00000268938 IQCN ELL PLVAP COLGALT1 PDE4C
GH19J018095 Enhancer 0.4 dbSUPER 756.2 -2.0 -1996 1.2 ZBTB40 HLF ZNF146 ZBTB33 MAST3 IL12RB1 lnc-RAB3A-1 RF00017-2890
GH19J018086 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.5 -8.5 -8520 6.1 SP1 SMARCE1 HDAC2 MYC ETV6 ELF1 HLF L3MBTL2 CEBPB MAX IL12RB1 GTPBP3 UPF1 ENSG00000268030 IQCN FKBP8 ELL ENSG00000268938 SUGP2 FCHO1
GH19J017845 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.5 -249.0 -248987 6.4 GTF3C2 SP1 RBPJ POLR2A CREB1 HCFC1 ETV6 RELA ZNF121 ZNF148 JAK3 lnc-JAK3-1 UPF1 ENSG00000268030 FCHO1 B3GNT3 INSL3 MVB12A GTPBP3 UNC13A
GH19J017841 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 -255.1 -255063 3.4 ZBTB40 POLR2A CC2D1A L3MBTL2 SP1 GTF2F1 ZFX EGR1 KLF14 GMEB1 MVB12A ENSG00000268030 PLVAP RPL18A COLGALT1 INSL3 ENSG00000268938 HAUS8 PGLS F2RL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAST3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAST3 gene promoter:
  • ATF
  • Bach1
  • HEN1
  • HSF2
  • STAT1
  • STAT3
  • STAT5A
  • XBP-1

Genomic Locations for MAST3 Gene

Genomic Locations for MAST3 Gene
53,929 bases
Plus strand
53,900 bases
Plus strand

Genomic View for MAST3 Gene

Genes around MAST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST3 Gene

Proteins for MAST3 Gene

  • Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q7LDZ8
    • Q9UPI0

    Protein attributes for MAST3 Gene

    1309 amino acids
    Molecular mass:
    143137 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PTEN.
    • Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST3 Gene

neXtProt entry for MAST3 Gene

Selected DME Specific Peptides for MAST3 Gene


Post-translational modifications for MAST3 Gene

  • Ubiquitination at Lys652
  • Modification sites at PhosphoSitePlus

Domains & Families for MAST3 Gene

Gene Families for MAST3 Gene

Suggested Antigen Peptide Sequences for MAST3 Gene

GenScript: Design optimal peptide antigens:
  • Microtubule-associated serine/threonine-protein kinase 3 (MAST3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST3: view

Function for MAST3 Gene

Molecular function for MAST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;.

Enzyme Numbers (IUBMB) for MAST3 Gene

Phenotypes From GWAS Catalog for MAST3 Gene

Gene Ontology (GO) - Molecular Function for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 15951562
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAST3: view
genes like me logo Genes that share phenotypes with MAST3: view

Animal Models for MAST3 Gene

MGI Knock Outs for MAST3:
  • Mast3 Mast3<tm1.1(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for MAST3

CRISPR Products

miRNA for MAST3 Gene

miRTarBase miRNAs that target MAST3

Clone Products

  • Addgene plasmids for MAST3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAST3 Gene

Localization for MAST3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAST3 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
extracellular 0
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAST3 Gene

Pathways & Interactions for MAST3 Gene

PathCards logo

SuperPathways for MAST3 Gene

No Data Available

SIGNOR curated interactions for MAST3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007010 cytoskeleton organization IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with MAST3: view

No data available for Pathways by source for MAST3 Gene

Drugs & Compounds for MAST3 Gene

(2) Drugs for MAST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for MAST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAST3: view

Transcripts for MAST3 Gene

mRNA/cDNA for MAST3 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for MAST3

Alternative Splicing Database (ASD) splice patterns (SP) for MAST3 Gene

No ASD Table

Relevant External Links for MAST3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAST3 Gene

This gene is overexpressed in Whole Blood (x6.4) and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAST3 Gene

This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAST3 Gene

Protein tissue co-expression partners for MAST3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAST3 Gene:


SOURCE GeneReport for Unigene cluster for MAST3 Gene:


Evidence on tissue expression from TISSUES for MAST3 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with MAST3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAST3 Gene

Orthologs for MAST3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAST3 33 32
  • 97.35 (n)
(Canis familiaris)
Mammalia MAST3 33 32
  • 88.26 (n)
(Bos Taurus)
Mammalia MAST3 33 32
  • 86.64 (n)
(Rattus norvegicus)
Mammalia Mast3 32
  • 82.42 (n)
(Mus musculus)
Mammalia Mast3 17 33 32
  • 82.41 (n)
(Ornithorhynchus anatinus)
Mammalia MAST3 33
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 68 (a)
-- 33
  • 67 (a)
(Gallus gallus)
Aves MAST3 33 32
  • 75.18 (n)
(Anolis carolinensis)
Reptilia MAST3 33
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mast3 32
  • 69 (n)
(Danio rerio)
Actinopterygii LOC100535762 32
  • 66.48 (n)
MAST3 (1 of 2) 33
  • 61 (a)
BX004890.2 33
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6498 33
  • 28 (a)
(Caenorhabditis elegans)
Secernentea kin-4 33
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 33
  • 26 (a)
FPK1 33
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 41 (a)
Species where no ortholog for MAST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST3 Gene

Gene Tree for MAST3 (if available)
Gene Tree for MAST3 (if available)
Evolutionary constrained regions (ECRs) for MAST3: view image

Paralogs for MAST3 Gene

(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAST3: view

Variants for MAST3 Gene

Sequence variations from dbSNP and Humsavar for MAST3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000005947 -- 18,145,477(+) A/G intron_variant
rs1000093999 -- 18,096,425(+) C/A/T upstream_transcript_variant
rs1000108044 -- 18,097,237(+) G/A upstream_transcript_variant
rs1000191428 -- 18,122,404(+) A/G intron_variant
rs1000204935 -- 18,120,325(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAST3 Gene

Variant ID Type Subtype PubMed ID
esv2658066 CNV deletion 23128226
esv2718285 CNV deletion 23290073
esv3556132 CNV deletion 23714750
nsv1130730 CNV deletion 24896259
nsv1138675 CNV deletion 24896259
nsv1151018 CNV deletion 26484159
nsv1160591 CNV deletion 26073780
nsv1160592 CNV deletion 26073780
nsv2429 CNV deletion 18451855
nsv470130 CNV loss 18288195
nsv833773 CNV loss 17160897
nsv833774 CNV loss 17160897
nsv833775 CNV loss 17160897
nsv952420 CNV deletion 24416366

Variation tolerance for MAST3 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAST3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST3 Gene

Disorders for MAST3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAST3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 6
  • ibd6
- elite association - COSMIC cancer census association via MalaCards
Search MAST3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAST3

genes like me logo Genes that share disorders with MAST3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAST3 Gene

Publications for MAST3 Gene

  1. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M … Pulido R (The Journal of biological chemistry 2005) 3 4 56
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 56
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 56
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  5. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. (PMID: 28613156) Musante V … Nairn AC (eLife 2017) 3 56

Products for MAST3 Gene

Sources for MAST3 Gene