Aliases for MAST3 Gene

Aliases for MAST3 Gene

  • Microtubule Associated Serine/Threonine Kinase 3 2 3 5
  • Microtubule-Associated Serine/Threonine-Protein Kinase 3 3 4
  • EC 2.7.11.1 4 51
  • KIAA0561 2 4
  • EC 2.7.11 51
  • MAST3 5

External Ids for MAST3 Gene

Previous GeneCards Identifiers for MAST3 Gene

  • GC19P018069
  • GC19P018208
  • GC19P017772
  • GC19P018137
  • GC19P018196
  • GC19P020495
  • GC19P020636
  • GC19P020742
  • GC19P022249
  • GC19P018364
  • GC19P018384
  • GC19P018716
  • GC19P019027
  • GC19P019342
  • GC19P019676
  • GC19P020041
  • GC19P020354

Summaries for MAST3 Gene

GeneCards Summary for MAST3 Gene

MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with MAST3 include Inflammatory Bowel Disease 6 and Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.

Additional gene information for MAST3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAST3 Gene

Genomics for MAST3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAST3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018097 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.0 1003 2.9 ARHGAP35 SP1 ZBTB33 KDM1A POLR2A RCOR2 ZNF143 RELA ZIC2 ZNF24 IL12RB1 MAST3 PLVAP PDE4C RF00017-2892
GH19J018095 Enhancer 0.4 dbSUPER 606.3 -2.0 -1996 1.2 ZBTB40 ZNF146 ZBTB33 HLF MAST3 IL12RB1 lnc-RAB3A-1 RF00017-2892 ARRDC2
GH19J018086 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.5 -8.5 -8520 6.1 SP1 KDM1A RCOR2 POLR2A BACH1 JUND ETV6 ZNF24 REST IKZF2 IL12RB1 ENSG00000268030 UPF1 IQCN GTPBP3 SUGP2 ELL ENSG00000268938 COLGALT1 ENSG00000269191
GH19J017845 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.5 -249.0 -248987 6.4 SP1 HNRNPL GATAD2A POLR2A BACH1 LARP7 STAT3 ZNF143 RELA RBFOX2 JAK3 lnc-JAK3-1 FCHO1 B3GNT3 INSL3 UNC13A RPL18A MAST3 NIBAN3 IL12RB1
GH19J017841 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 -255.1 -255063 3.4 RNF2 PRDM10 KDM1A MTA2 PKNOX1 PATZ1 REST SP1 BRD9 POLR2A INSL3 RAB3A MAST3 JAK3 lnc-JAK3-1 piR-50437-342 L13712-013 RF00017-2892
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAST3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAST3

Top Transcription factor binding sites by QIAGEN in the MAST3 gene promoter:
  • ATF
  • Bach1
  • HEN1
  • HSF2
  • STAT1
  • STAT3
  • STAT5A
  • XBP-1

Genomic Locations for MAST3 Gene

Genomic Locations for MAST3 Gene
chr19:18,097,764-18,151,692
(GRCh38/hg38)
Size:
53,929 bases
Orientation:
Plus strand
chr19:18,208,603-18,262,502
(GRCh37/hg19)
Size:
53,900 bases
Orientation:
Plus strand

Genomic View for MAST3 Gene

Genes around MAST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST3 Gene

Proteins for MAST3 Gene

  • Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60307-MAST3_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 3
    Protein Accession:
    O60307
    Secondary Accessions:
    • Q7LDZ8
    • Q9UPI0

    Protein attributes for MAST3 Gene

    Size:
    1309 amino acids
    Molecular mass:
    143137 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PTEN.
    SequenceCaution:
    • Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST3 Gene

neXtProt entry for MAST3 Gene

Selected DME Specific Peptides for MAST3 Gene

O60307:
  • RFSKVYSS
  • MFCSFET
  • AETVLALEYLH
  • LYEFLVGCVPFFGDTPEELFGQV
  • LTDFGLSK
  • RPRSRSL
  • CSFETRRHLCMVMEYVEGGDCATL
  • CGTPEYIAPE
  • KLTDFGL
  • TIKLISNGAYGAVYLVRHRDTRQRFA
  • ELARDCL
  • SSTLSSSSS
  • ESDFETIKLISNGAYGAVY
  • DNEIVMMNHVY
  • DELHFLSKHF
  • RSLSPGR
  • GHIKLTD
  • GKPVDWWA
  • RPARLLECLEF
  • GHIKLTDFGLSK
  • KELSLPRRG
  • IKLTDFG
  • WPEGDEALP
  • GIVHRDLKPDN
  • FVERDILTFAENPFVV
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for MAST3 Gene

  • Ubiquitination at Lys652
  • Modification sites at PhosphoSitePlus

Domains & Families for MAST3 Gene

Gene Families for MAST3 Gene

Protein Domains for MAST3 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
  • Protein kinase C-terminal domain
ProtoNet:

Suggested Antigen Peptide Sequences for MAST3 Gene

GenScript: Design optimal peptide antigens:
  • Microtubule-associated serine/threonine-protein kinase 3 (MAST3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60307

UniProtKB/Swiss-Prot:

MAST3_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST3: view

Function for MAST3 Gene

Molecular function for MAST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for MAST3 Gene

Phenotypes From GWAS Catalog for MAST3 Gene

Gene Ontology (GO) - Molecular Function for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 15951562
genes like me logo Genes that share ontologies with MAST3: view
genes like me logo Genes that share phenotypes with MAST3: view

Animal Models for MAST3 Gene

MGI Knock Outs for MAST3:
  • Mast3 Mast3<tm1.1(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for MAST3

CRISPR Products

miRNA for MAST3 Gene

miRTarBase miRNAs that target MAST3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAST3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAST3 Gene

Localization for MAST3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAST3 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAST3 Gene

Pathways & Interactions for MAST3 Gene

PathCards logo

SuperPathways for MAST3 Gene

No Data Available

SIGNOR curated interactions for MAST3 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007010 cytoskeleton organization IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with MAST3: view

No data available for Pathways by source for MAST3 Gene

Drugs & Compounds for MAST3 Gene

(2) Drugs for MAST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for MAST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with MAST3: view

Transcripts for MAST3 Gene

mRNA/cDNA for MAST3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAST3

Alternative Splicing Database (ASD) splice patterns (SP) for MAST3 Gene

No ASD Table

Relevant External Links for MAST3 Gene

GeneLoc Exon Structure for
MAST3

Expression for MAST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAST3 Gene

This gene is overexpressed in Whole Blood (x6.4) and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAST3 Gene

This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAST3 Gene



Protein tissue co-expression partners for MAST3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAST3

SOURCE GeneReport for Unigene cluster for MAST3 Gene:

Hs.466184

Evidence on tissue expression from TISSUES for MAST3 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Kidney(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MAST3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAST3 Gene

Orthologs for MAST3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAST3 30 31
  • 97.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAST3 30 31
  • 88.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAST3 30 31
  • 86.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mast3 30
  • 82.42 (n)
Mouse
(Mus musculus)
Mammalia Mast3 30 17 31
  • 82.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAST3 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
Chicken
(Gallus gallus)
Aves MAST3 30 31
  • 75.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAST3 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mast3 30
  • 69 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100535762 30
  • 66.48 (n)
MAST3 (1 of 2) 31
  • 61 (a)
OneToMany
BX004890.2 31
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6498 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea kin-4 31
  • 29 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 31
  • 26 (a)
ManyToMany
FPK1 31
  • 23 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for MAST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAST3 Gene

ENSEMBL:
Gene Tree for MAST3 (if available)
TreeFam:
Gene Tree for MAST3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAST3: view image

Paralogs for MAST3 Gene

(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:

  • MAST3_HUMAN
  • V9GYV0_HUMAN
genes like me logo Genes that share paralogs with MAST3: view

Variants for MAST3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAST3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769963 Benign: not provided 18,135,783(+) C/T SYNONYMOUS_VARIANT
781463 Benign: not provided 18,134,696(+) G/A SYNONYMOUS_VARIANT
rs35945810 - p.Arg203Gln
rs369960905 - p.Gly883Ser
rs8108738 - p.Gly861Ser

Additional dbSNP identifiers (rs#s) for MAST3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAST3 Gene

Variant ID Type Subtype PubMed ID
esv2658066 CNV deletion 23128226
esv2718285 CNV deletion 23290073
esv3556132 CNV deletion 23714750
nsv1130730 CNV deletion 24896259
nsv1138675 CNV deletion 24896259
nsv1151018 CNV deletion 26484159
nsv1160591 CNV deletion 26073780
nsv1160592 CNV deletion 26073780
nsv2429 CNV deletion 18451855
nsv470130 CNV loss 18288195
nsv833773 CNV loss 17160897
nsv833774 CNV loss 17160897
nsv833775 CNV loss 17160897
nsv952420 CNV deletion 24416366

Variation tolerance for MAST3 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAST3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAST3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST3 Gene

Disorders for MAST3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAST3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search MAST3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MAST3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAST3 Gene

Publications for MAST3 Gene

  1. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M … Pulido R (The Journal of biological chemistry 2005) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4
  4. Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. (PMID: 30344098) Weith M … Meyer H (Molecular cell 2018) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for MAST3 Gene

  • Boster Bio Antibodies for MAST3
  • Boster Bio ELISA Kits for MAST3
  • Signalway ELISA kits for MAST3

Sources for MAST3 Gene