This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a rol... See more...

Aliases for MASP2 Gene

Aliases for MASP2 Gene

  • Mannan Binding Lectin Serine Peptidase 2 2 3 5
  • Mannan-Binding Lectin Serine Protease 2 2 3 4
  • Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1 2 3
  • Mannan-Binding Lectin Serine Protease 1 Pseudogene 1 2 3
  • Mannose-Binding Protein-Associated Serine Protease 2 3 4
  • MBL-Associated Serine Protease 2 3 4
  • MASP-2 3 4
  • MBL-Associated Plasma Protein Of 19 KD 3
  • Small MBL-Associated Protein 3
  • EC 3.4.21.104 4
  • EC 3.4.21 51
  • MASP1P1 3
  • MAP19 3
  • MASP2 5
  • SMAP 3

External Ids for MASP2 Gene

Previous HGNC Symbols for MASP2 Gene

  • MASP1P1

Previous GeneCards Identifiers for MASP2 Gene

  • GC01M011047
  • GC01M010930
  • GC01M010695
  • GC01M010796
  • GC01M011020
  • GC01M011009
  • GC01M011086
  • GC01M010238

Summaries for MASP2 Gene

Entrez Gene Summary for MASP2 Gene

  • This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for MASP2 Gene

MASP2 (Mannan Binding Lectin Serine Peptidase 2) is a Protein Coding gene. Diseases associated with MASP2 include Masp2 Deficiency and Rheumatic Fever. Among its related pathways are Innate Immune System and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is MASP1.

UniProtKB/Swiss-Prot Summary for MASP2 Gene

  • Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.

Gene Wiki entry for MASP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MASP2 Gene

Genomics for MASP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MASP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J011047 Promoter 1 EPDnew 600.7 0.0 -20 0.1 HNRNPL GATAD2A RCOR2 RBFOX2 RXRB SP1 KMT2B SOX13 TAF1 FOXA2 MASP2 SRM
GH01J011045 Enhancer 0.9 Ensembl ENCODE 600.7 +1.1 1059 1.6 HNRNPL RBFOX2 PKNOX1 SP1 PBX2 KMT2B SP2 ATF3 YY1 JUND MASP2 ANGPTL7 ENSG00000226849 ENSG00000271895 ENSG00000277726
GH01J011011 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10 +34.2 34150 3.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 TARDBP ENSG00000277726 piR-48221-001 EXOSC10 ENSG00000226849 CLCN6 ENSG00000271895 FBXO44 DFFA MASP2
GH01J010968 Promoter/Enhancer 1.1 Ensembl ENCODE 5.9 +78.7 78710 1 ZIC2 POLR2A TCF12 IKZF2 PKNOX1 SCRT2 EED ARID3A DPF2 RELB MASP2 FJ601684-005 C1orf127 CASZ1
GH01J011280 Enhancer 1 Ensembl ENCODE 4.7 -236.7 -236661 8.6 CTCF PRDM10 ZNF629 POLR2A JUND PRDM1 RBFOX2 DPF2 RAD21 ZNF10 MTOR ANGPTL7 MTOR-AS1 EXOSC10 MASP2 UBE2V2P3 lnc-MTOR-5 piR-40706 UBIAD1 DISP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MASP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MASP2

Top Transcription factor binding sites by QIAGEN in the MASP2 gene promoter:
  • c-Myc
  • Max
  • Max1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for MASP2 Gene

Genomic Locations for MASP2 Gene
chr1:11,026,523-11,047,239
(GRCh38/hg38)
Size:
20,717 bases
Orientation:
Minus strand
chr1:11,086,580-11,107,296
(GRCh37/hg19)
Size:
20,717 bases
Orientation:
Minus strand

Genomic View for MASP2 Gene

Genes around MASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MASP2 Gene

Proteins for MASP2 Gene

  • Protein details for MASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00187-MASP2_HUMAN
    Recommended name:
    Mannan-binding lectin serine protease 2
    Protein Accession:
    O00187
    Secondary Accessions:
    • A8K458
    • A8MWJ2
    • O75754
    • Q5TEQ5
    • Q5TER0
    • Q96QG4
    • Q9BZH0
    • Q9H498
    • Q9H499
    • Q9UBP3
    • Q9UC48
    • Q9ULC7
    • Q9UMV3
    • Q9Y270

    Protein attributes for MASP2 Gene

    Size:
    686 amino acids
    Molecular mass:
    75702 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.

    Three dimensional structures from OCA and Proteopedia for MASP2 Gene

    Alternative splice isoforms for MASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MASP2 Gene

Selected DME Specific Peptides for MASP2 Gene

O00187:
  • GIVSWGS
  • WVLTAAH
  • DIALIKL

Post-translational modifications for MASP2 Gene

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MASP2 Gene

Domains & Families for MASP2 Gene

Gene Families for MASP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for MASP2 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • CUB domain
  • EGF-like calcium-binding
  • Sushi domain/SCR domain/CCP module
ProtoNet:

Suggested Antigen Peptide Sequences for MASP2 Gene

GenScript: Design optimal peptide antigens:
  • Mannose-binding protein-associated serine protease 2 (MASP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00187

UniProtKB/Swiss-Prot:

MASP2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with MASP2: view

Function for MASP2 Gene

Molecular function for MASP2 Gene

UniProtKB/Swiss-Prot Function:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).; EC=3.4.21.104;.
GENATLAS Biochemistry:
mannan-binding lectin serine protease 2,including an alternatively spliced (truncated) isoform of 19kDa (Map19),also included in the complex formed with MBL2 and MASP1 to form the antibody independent activator of the classical pathway of complement

Enzyme Numbers (IUBMB) for MASP2 Gene

Phenotypes From GWAS Catalog for MASP2 Gene

Gene Ontology (GO) - Molecular Function for MASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001855 complement component C4b binding IDA 22949645
GO:0004252 serine-type endopeptidase activity IBA,IDA 9087411
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10946292
GO:0008233 peptidase activity IEA,IDA 10946292
genes like me logo Genes that share ontologies with MASP2: view
genes like me logo Genes that share phenotypes with MASP2: view

Human Phenotype Ontology for MASP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MASP2 Gene

MGI Knock Outs for MASP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MASP2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MASP2

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for MASP2 Gene

Localization for MASP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MASP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MASP2 gene
Compartment Confidence
extracellular 5
nucleus 3
golgi apparatus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with MASP2: view

Pathways & Interactions for MASP2 Gene

genes like me logo Genes that share pathways with MASP2: view

Pathways by source for MASP2 Gene

1 GeneGo (Thomson Reuters) pathway for MASP2 Gene
  • Immune response Lectin induced complement pathway
2 Qiagen pathways for MASP2 Gene
  • Complement Pathway
  • Lectin Induced Complement Pathway

Gene Ontology (GO) - Biological Process for MASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway IEA --
genes like me logo Genes that share ontologies with MASP2: view

No data available for SIGNOR curated interactions for MASP2 Gene

Drugs & Compounds for MASP2 Gene

(5) Drugs for MASP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
beta-Hydroxyasparagine Experimental Pharma Target 0
Calcium Nutra 6556

(3) Additional Compounds for MASP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MASP2: view

Transcripts for MASP2 Gene

mRNA/cDNA for MASP2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MASP2

Alternative Splicing Database (ASD) splice patterns (SP) for MASP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for MASP2 Gene

GeneLoc Exon Structure for
MASP2

Expression for MASP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MASP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for MASP2 Gene

This gene is overexpressed in Liver (x29.7).

Protein differential expression in normal tissues from HIPED for MASP2 Gene

This gene is overexpressed in Urine (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MASP2 Gene



Protein tissue co-expression partners for MASP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MASP2

SOURCE GeneReport for Unigene cluster for MASP2 Gene:

Hs.655645

mRNA Expression by UniProt/SwissProt for MASP2 Gene:

O00187-MASP2_HUMAN
Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for MASP2 Gene

  • Liver(4.7)
  • Urine(4.3)
  • Blood(2.5)
  • Nervous system(2.3)
  • Heart(2.3)
  • Kidney(2.3)
  • Muscle(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MASP2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • mouth
Thorax:
  • esophagus
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with MASP2: view

Orthologs for MASP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MASP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MASP2 30 31
  • 99.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MASP2 30 31
  • 85.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Masp2 30 17 31
  • 82.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Masp2 30
  • 82.59 (n)
Dog
(Canis familiaris)
Mammalia MASP2 30 31
  • 81.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MASP2 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MASP2 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MASP2 30 31
  • 63.91 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia masp2 30
  • 57.78 (n)
Zebrafish
(Danio rerio)
Actinopterygii masp2 30 31
  • 56.89 (n)
OneToOne
Dr.17391 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
CSA.10613 31
  • 23 (a)
ManyToMany
Species where no ortholog for MASP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MASP2 Gene

ENSEMBL:
Gene Tree for MASP2 (if available)
TreeFam:
Gene Tree for MASP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MASP2: view image

Paralogs for MASP2 Gene

Paralogs for MASP2 Gene

(13) SIMAP similar genes for MASP2 Gene using alignment to 1 proteins:

  • MASP2_HUMAN
genes like me logo Genes that share paralogs with MASP2: view

Variants for MASP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MASP2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
708053 Benign: not provided 11,046,598(-) C/T MISSENSE_VARIANT
716795 Benign: not provided 11,047,087(-) G/A MISSENSE_VARIANT
729733 Benign: MASP2 deficiency; not provided 11,042,883(-) G/A MISSENSE_VARIANT
786449 Benign: MASP2 deficiency; not provided 11,047,092(-) A/G SYNONYMOUS_VARIANT
873851 Uncertain Significance: MASP2 deficiency; Amyotrophic lateral sclerosis type 10 11,024,777(-) T/C THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for MASP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MASP2 Gene

Variant ID Type Subtype PubMed ID
dgv106n54 CNV loss 21841781
esv25881 CNV gain+loss 19812545
esv2660954 CNV deletion 23128226
esv2743741 CNV deletion 23290073
esv3585212 CNV loss 21293372
nsv1133809 CNV deletion 24896259
nsv545407 CNV gain 21841781
nsv545408 CNV gain 21841781
nsv545411 CNV gain 21841781
nsv832425 CNV loss 17160897
nsv953456 CNV deletion 24416366
nsv956625 CNV deletion 24416366

Variation tolerance for MASP2 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MASP2 Gene

Human Gene Mutation Database (HGMD)
MASP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MASP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MASP2 Gene

Disorders for MASP2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MASP2 Gene - From: UniProtKB/Swiss-Prot, OMIM, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
masp2 deficiency
  • lectin complement activation pathway, defect in, 2; lcapd2
rheumatic fever
  • acute rheumatic fever
mannose-binding lectin deficiency
  • mbld
sporotrichosis
  • rose gardener's disease
hereditary angioedema
  • hane
- elite association - COSMIC cancer census association via MalaCards
Search MASP2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MASP2_HUMAN
  • MASP2 deficiency (MASPD) [MIM:613791]: A disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. {ECO:0000269 PubMed:12904520, ECO:0000269 PubMed:17252003}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MASP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MASP2: view

No data available for Genatlas for MASP2 Gene

Publications for MASP2 Gene

  1. Novel MASP2 variants detected among North African and Sub-Saharan individuals. (PMID: 16029433) Lozano F … Horcajada JP (Tissue antigens 2005) 3 4 23 41
  2. A second serine protease associated with mannan-binding lectin that activates complement. (PMID: 9087411) Thiel S … Jensenius JC (Nature 1997) 2 3 4 23
  3. Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome. (PMID: 20042521) Smithson A … Nicolas JM (Clinical and vaccine immunology : CVI 2010) 3 23 41
  4. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. (PMID: 19234189) Thiel S … Jensenius JC (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 23 41
  5. Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection. (PMID: 19405982) Wang Y … Cao C (BMC infectious diseases 2009) 3 23 41

Products for MASP2 Gene

Sources for MASP2 Gene