Aliases for MAS1L Gene

Aliases for MAS1L Gene

  • MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor 2 3 5
  • MRG 2 3 4
  • Mas-Related G-Protein Coupled Receptor MRG 3 4
  • MAS1 Oncogene-Like 2 3
  • DJ994E9.2 2 3
  • MAS1-Like 3 4
  • MAS-L 2 3
  • MAS-R 3 4
  • Mas-Related G Protein-Coupled MRG 3
  • MAS1L 5

External Ids for MAS1L Gene

Previous GeneCards Identifiers for MAS1L Gene

  • GC06M029511
  • GC06M029225
  • GC06M029562
  • GC06M029454
  • GC06M029261
  • GC06M029487
  • GC06M029509
  • GC06M029517
  • GC06M029499
  • GC06M029519
  • GC06M029488
  • GC06M029496

Summaries for MAS1L Gene

GeneCards Summary for MAS1L Gene

MAS1L (MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor) is a Protein Coding gene. Diseases associated with MAS1L include Cataract 23, Multiple Types and Diabetes Mellitus, Insulin-Dependent, 20. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MRGPRX1.

Gene Wiki entry for MAS1L Gene

Additional gene information for MAS1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAS1L Gene

Genomics for MAS1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAS1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029477 Enhancer 0.5 FANTOM5 17.1 +9.9 9858 0.6 FOXJ2 E2F5 VEZF1 USF2 lnc-MAS1L-1 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1 OR2H1
GH06J029467 Enhancer 0.2 FANTOM5 12.1 +20.3 20257 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J029490 Enhancer 0.9 Ensembl ENCODE 0.7 -2.8 -2803 0.5 IKZF1 JUND MTA1 HDAC1 SOX6 TCF12 EP300 ZNF766 CTBP1 HES1 RPS17P1 lnc-MAS1L-2 OR5V1 LINC01015 OR2H2 MAS1L LINC02829 UBD
GH06J029516 Enhancer 0.8 Ensembl 0.3 -28.5 -28496 0.7 PRDM10 ZNF629 ZNF692 ZIC2 ZNF600 ZNF561 SCRT2 ZBTB44 KLF9 ARID3A ZFP57 OR11A1 OR2H1 OR5V1 OR2H2 HLA-W piR-37170-058 LINC02829 MAS1L UBD
GH06J029510 Enhancer 0.6 Ensembl 0.4 -22.3 -22345 0.2 PRDM10 ZIC2 ZNF561 RAD21 CTCF ZBTB48 HIC1 BHLHE40 ZNF366 GLIS1 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 HLA-W MAS1LP1 piR-37170-058 LINC02829 MAS1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAS1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAS1L

Top Transcription factor binding sites by QIAGEN in the MAS1L gene promoter:
  • c-Myb
  • C/EBPalpha
  • E47
  • Evi-1
  • GATA-1
  • GATA-3
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • Tal-1

Genomic Locations for MAS1L Gene

Genomic Locations for MAS1L Gene
chr6:29,486,697-29,487,956
(GRCh38/hg38)
Size:
1,260 bases
Orientation:
Minus strand
chr6:29,454,474-29,455,738
(GRCh37/hg19)
Size:
1,265 bases
Orientation:
Minus strand

Genomic View for MAS1L Gene

Genes around MAS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MAS1L Gene

  • Protein details for MAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35410-MAS1L_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor MRG
    Protein Accession:
    P35410
    Secondary Accessions:
    • Q5SUN5

    Protein attributes for MAS1L Gene

    Size:
    378 amino acids
    Molecular mass:
    42411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAS1L Gene

Post-translational modifications for MAS1L Gene

  • Glycosylation at Asn54 and Asn57

Other Protein References for MAS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1L Gene

Domains & Families for MAS1L Gene

Gene Families for MAS1L Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MAS1L Gene

Suggested Antigen Peptide Sequences for MAS1L Gene

GenScript: Design optimal peptide antigens:
  • MAS1-like (MAS1L_HUMAN)
  • MAS1 oncogene-like (Q502V9_HUMAN)
  • MAS1 oncogene-like (Q5SUN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35410

UniProtKB/Swiss-Prot:

MAS1L_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MAS1L: view

Function for MAS1L Gene

Phenotypes From GWAS Catalog for MAS1L Gene

Gene Ontology (GO) - Molecular Function for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view
genes like me logo Genes that share phenotypes with MAS1L: view

Animal Model Products

CRISPR Products

miRNA for MAS1L Gene

miRTarBase miRNAs that target MAS1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAS1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAS1L Gene

Localization for MAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1L Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAS1L gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
mitochondrion 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

Pathways & Interactions for MAS1L Gene

PathCards logo

SuperPathways for MAS1L Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with MAS1L: view

Pathways by source for MAS1L Gene

1 BioSystems pathway for MAS1L Gene

Interacting Proteins for MAS1L Gene

Gene Ontology (GO) - Biological Process for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

No data available for SIGNOR curated interactions for MAS1L Gene

Drugs & Compounds for MAS1L Gene

No Compound Related Data Available

Transcripts for MAS1L Gene

mRNA/cDNA for MAS1L Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAS1L

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1L Gene

No ASD Table

Relevant External Links for MAS1L Gene

GeneLoc Exon Structure for
MAS1L

Expression for MAS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAS1L Gene

mRNA differential expression in normal tissues according to GTEx for MAS1L Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x6.3) and Esophagus - Muscularis (x5.5).

Protein differential expression in normal tissues from HIPED for MAS1L Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAS1L Gene



Protein tissue co-expression partners for MAS1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAS1L

SOURCE GeneReport for Unigene cluster for MAS1L Gene:

Hs.533297

Evidence on tissue expression from TISSUES for MAS1L Gene

  • Skin(2.5)
genes like me logo Genes that share expression patterns with MAS1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAS1L Gene

Orthologs for MAS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAS1L 30
  • 98.67 (n)
Mouse
(Mus musculus)
Mammalia Mrgpra9 31
  • 31 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 30 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 20 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
Species where no ortholog for MAS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MAS1L Gene

ENSEMBL:
Gene Tree for MAS1L (if available)
TreeFam:
Gene Tree for MAS1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAS1L: view image

Paralogs for MAS1L Gene

Variants for MAS1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAS1L Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17184100 - p.Asp288Glu

Additional dbSNP identifiers (rs#s) for MAS1L Gene

Structural Variations from Database of Genomic Variants (DGV) for MAS1L Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259

Variation tolerance for MAS1L Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAS1L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAS1L Gene

Disorders for MAS1L Gene

MalaCards: The human disease database

(17) MalaCards diseases for MAS1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 23, multiple types
  • ctrct23
diabetes mellitus, insulin-dependent, 20
  • iddm20
podoconiosis
  • podoconiosis, susceptibility to
hypersensitivity reaction type iv disease
  • immunoproliferative disease
diabetes mellitus, insulin-dependent, 24
  • iddm24
- elite association - COSMIC cancer census association via MalaCards
Search MAS1L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAS1L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAS1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAS1L Gene

Publications for MAS1L Gene

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PMID: 1723144) Monnot C … Clauser E (Molecular endocrinology (Baltimore, Md.) 1991) 3 4 23
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  3. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F … Walther T (Molecular and cellular biochemistry 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for MAS1L Gene

Sources for MAS1L Gene