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Aliases for MAS1L Gene

Aliases for MAS1L Gene

  • MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor 2 3 5
  • MAS1 Oncogene-Like 2 3
  • MAS1-Like 3 4
  • MAS-R 3 4
  • MRG 3 4
  • Mas-Related G-Protein Coupled Receptor MRG 3
  • Mas-Related G Protein-Coupled MRG 3
  • DJ994E9.2 3
  • MAS-L 3

External Ids for MAS1L Gene

Previous GeneCards Identifiers for MAS1L Gene

  • GC06M029511
  • GC06M029225
  • GC06M029562
  • GC06M029454
  • GC06M029261
  • GC06M029487

Summaries for MAS1L Gene

GeneCards Summary for MAS1L Gene

MAS1L (MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRD.

Gene Wiki entry for MAS1L Gene

Additional gene information for MAS1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1L Gene

Genomics for MAS1L Gene

GeneHancer (GH) Regulatory Elements for MAS1L Gene

Promoters and enhancers for MAS1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I029477 Enhancer 0.5 FANTOM5 17.1 +9.9 9858 0.6 MITF VEZF1 E2F5 USF2 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1 LOC105375008
GH06I029467 Enhancer 0.2 FANTOM5 12.1 +20.3 20257 0.3 GC06M029436 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAS1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAS1L gene promoter:

Genomic Locations for MAS1L Gene

Genomic Locations for MAS1L Gene
1,260 bases
Minus strand

Genomic View for MAS1L Gene

Genes around MAS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MAS1L Gene

  • Protein details for MAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor MRG
    Protein Accession:
    Secondary Accessions:
    • Q5SUN5

    Protein attributes for MAS1L Gene

    378 amino acids
    Molecular mass:
    42411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAS1L Gene

Post-translational modifications for MAS1L Gene

  • Glycosylation at posLast=5454 and posLast=5757

Other Protein References for MAS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1L Gene

Domains & Families for MAS1L Gene

Gene Families for MAS1L Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MAS1L Gene

Suggested Antigen Peptide Sequences for MAS1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MAS1L: view

Function for MAS1L Gene

Phenotypes From GWAS Catalog for MAS1L Gene

Gene Ontology (GO) - Molecular Function for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view
genes like me logo Genes that share phenotypes with MAS1L: view

Animal Model Products

miRNA for MAS1L Gene

miRTarBase miRNAs that target MAS1L

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAS1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAS1L Gene

Localization for MAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1L Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAS1L gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAS1L: view

Pathways & Interactions for MAS1L Gene

genes like me logo Genes that share pathways with MAS1L: view

Pathways by source for MAS1L Gene

1 BioSystems pathway for MAS1L Gene

Interacting Proteins for MAS1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000366331 for MAS1L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

No data available for SIGNOR curated interactions for MAS1L Gene

Drugs & Compounds for MAS1L Gene

No Compound Related Data Available

Transcripts for MAS1L Gene

mRNA/cDNA for MAS1L Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1L Gene

MAS1 oncogene-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAS1L

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1L Gene

No ASD Table

Relevant External Links for MAS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAS1L Gene

mRNA differential expression in normal tissues according to GTEx for MAS1L Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x6.3) and Esophagus - Muscularis (x5.5).

Protein differential expression in normal tissues from HIPED for MAS1L Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAS1L Gene

Protein tissue co-expression partners for MAS1L Gene

NURSA nuclear receptor signaling pathways regulating expression of MAS1L Gene:


SOURCE GeneReport for Unigene cluster for MAS1L Gene:

genes like me logo Genes that share expression patterns with MAS1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAS1L Gene

Orthologs for MAS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAS1L 33
  • 98.67 (n)
(Mus musculus)
Mammalia Mrgpra9 34
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 26 (a)
(Gallus gallus)
Aves -- 34
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 27 (a)
-- 34
  • 26 (a)
-- 34
  • 26 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
-- 34
  • 24 (a)
-- 34
  • 24 (a)
-- 34
  • 19 (a)
Species where no ortholog for MAS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1L Gene

Gene Tree for MAS1L (if available)
Gene Tree for MAS1L (if available)

Paralogs for MAS1L Gene

Variants for MAS1L Gene

Sequence variations from dbSNP and Humsavar for MAS1L Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000009425 -- 29,488,356(-) CACTG/ upstream_transcript_variant
rs1001537013 -- 29,489,527(-) G/A upstream_transcript_variant
rs1001651577 -- 29,489,379(-) A/G upstream_transcript_variant
rs1002408193 -- 29,486,623(-) A/C downstream_transcript_variant
rs1004890390 -- 29,489,047(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAS1L Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259

Variation tolerance for MAS1L Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAS1L Gene

Disorders for MAS1L Gene

Additional Disease Information for MAS1L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAS1L Gene

Publications for MAS1L Gene

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PMID: 1723144) Monnot C … Clauser E (Molecular endocrinology (Baltimore, Md.) 1991) 3 4 22 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F … Walther T (Molecular and cellular biochemistry 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for MAS1L Gene

  • Addgene plasmids for MAS1L

Sources for MAS1L Gene

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