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Aliases for MARVELD1 Gene

Aliases for MARVELD1 Gene

  • MARVEL Domain Containing 1 2 3 5
  • MARVEL (Membrane-Associating) Domain Containing 1 2 3
  • MRVLDC1 3 4
  • Putative MARVEL Domain-Containing Protein 1 3
  • MARVEL Domain-Containing Protein 1 3
  • BA548K23.8 3
  • MARVD1 3
  • GB14 3

External Ids for MARVELD1 Gene

Previous HGNC Symbols for MARVELD1 Gene

  • MRVLDC1

Previous GeneCards Identifiers for MARVELD1 Gene

  • GC10P099464
  • GC10P093098

Summaries for MARVELD1 Gene

GeneCards Summary for MARVELD1 Gene

MARVELD1 (MARVEL Domain Containing 1) is a Protein Coding gene. Diseases associated with MARVELD1 include Facial Paralysis and Facial Nerve Disease.

UniProtKB/Swiss-Prot for MARVELD1 Gene

  • Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.

Additional gene information for MARVELD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARVELD1 Gene

Genomics for MARVELD1 Gene

GeneHancer (GH) Regulatory Elements for MARVELD1 Gene

Promoters and enhancers for MARVELD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I097712 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 572.7 +1.0 1001 4.2 HDGF CLOCK SIN3A ZNF2 YY1 GLIS2 ZNF213 ZNF143 KLF7 RUNX3 MARVELD1 GC10M097562 MMS19 ZFYVE27 HOGA1
GH10I097681 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.9 -26.6 -26555 9.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC AVPI1 MORN4 MARVELD1 ZFYVE27 MMS19 RRP12 R3HCC1L PI4K2A PIR31130 PIR48246
GH10I098132 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.3 +421.3 421290 3.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 POLR2B R3HCC1L HPS1 LOXL4 EXOSC1 MMS19 MARVELD1 ENSG00000278752
GH10I097331 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15 -379.5 -379523 4.9 HDGF CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FRAT2 LOC105378448 EXOSC1 RPL13AP5 NPM1P26 R3HCC1L LOXL4 ENSG00000230928 TM9SF3 SLIT1
GH10I097736 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.7 +24.4 24396 2.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 ZFYVE27 MARVELD1 R3HCC1L HPS1 EXOSC1 MMS19 HOGA1 SFRP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARVELD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARVELD1 gene promoter:

Genomic Locations for MARVELD1 Gene

Genomic Locations for MARVELD1 Gene
chr10:97,713,173-97,718,152
(GRCh38/hg38)
Size:
4,980 bases
Orientation:
Plus strand
chr10:99,472,930-99,477,909
(GRCh37/hg19)

Genomic View for MARVELD1 Gene

Genes around MARVELD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARVELD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARVELD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARVELD1 Gene

Proteins for MARVELD1 Gene

  • Protein details for MARVELD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK0-MALD1_HUMAN
    Recommended name:
    MARVEL domain-containing protein 1
    Protein Accession:
    Q9BSK0

    Protein attributes for MARVELD1 Gene

    Size:
    173 amino acids
    Molecular mass:
    18914 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney bladder and liver. The reduced expression is owing to DNA methylation and could be reversed by pharmacologic demethylation (PubMed:19364627).

neXtProt entry for MARVELD1 Gene

Post-translational modifications for MARVELD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARVELD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARVELD1 Gene

Domains & Families for MARVELD1 Gene

Gene Families for MARVELD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MARVELD1 Gene

Suggested Antigen Peptide Sequences for MARVELD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MARVELD1: view

No data available for UniProtKB/Swiss-Prot for MARVELD1 Gene

Function for MARVELD1 Gene

Molecular function for MARVELD1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.

Phenotypes From GWAS Catalog for MARVELD1 Gene

Gene Ontology (GO) - Molecular Function for MARVELD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019911 structural constituent of myelin sheath IBA --
genes like me logo Genes that share ontologies with MARVELD1: view

Phenotypes for MARVELD1 Gene

GenomeRNAi human phenotypes for MARVELD1:
genes like me logo Genes that share phenotypes with MARVELD1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARVELD1 Gene

Localization for MARVELD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARVELD1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARVELD1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MARVELD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MARVELD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MARVELD1 Gene

Pathways & Interactions for MARVELD1 Gene

SuperPathways for MARVELD1 Gene

No Data Available

Interacting Proteins for MARVELD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000441365%0d%0a9606.ENSP00000224337%0d%0a
Selected Interacting proteins: ENSP00000441365 for MARVELD1 Gene via STRING

Symbol External ID(s) Details
BLNK

Gene Ontology (GO) - Biological Process for MARVELD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization IBA --
GO:0007049 cell cycle IEA --
GO:0008104 protein localization IBA --
GO:0042552 myelination IBA --
genes like me logo Genes that share ontologies with MARVELD1: view

No data available for Pathways by source and SIGNOR curated interactions for MARVELD1 Gene

Drugs & Compounds for MARVELD1 Gene

No Compound Related Data Available

Transcripts for MARVELD1 Gene

mRNA/cDNA for MARVELD1 Gene

Unigene Clusters for MARVELD1 Gene

MARVEL domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARVELD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for MARVELD1 Gene

GeneLoc Exon Structure for
MARVELD1
ECgene alternative splicing isoforms for
MARVELD1

Expression for MARVELD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARVELD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARVELD1 Gene

This gene is overexpressed in Bone (24.2), Colon (6.7), and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARVELD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MARVELD1 Gene:

MARVELD1

SOURCE GeneReport for Unigene cluster for MARVELD1 Gene:

Hs.744073

mRNA Expression by UniProt/SwissProt for MARVELD1 Gene:

Q9BSK0-MALD1_HUMAN
Tissue specificity: Widely expressed in normal tissues. Down-regulated in multiple primary tumors.

Evidence on tissue expression from TISSUES for MARVELD1 Gene

  • Nervous system(4.2)
  • Kidney(4)
genes like me logo Genes that share expression patterns with MARVELD1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARVELD1 Gene

Orthologs for MARVELD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARVELD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARVELD1 33 34
  • 99.61 (n)
mouse
(Mus musculus)
Mammalia Marveld1 33 16 34
  • 90.89 (n)
dog
(Canis familiaris)
Mammalia MARVELD1 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARVELD1 34 33
  • 89.21 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARVELD1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARVELD1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARVELD1 33
  • 66.41 (n)
lizard
(Anolis carolinensis)
Reptilia MARVELD1 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia marveld1 33
  • 56.99 (n)
zebrafish
(Danio rerio)
Actinopterygii marveld1 33 34
  • 60.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5523 33
Species where no ortholog for MARVELD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARVELD1 Gene

ENSEMBL:
Gene Tree for MARVELD1 (if available)
TreeFam:
Gene Tree for MARVELD1 (if available)

Paralogs for MARVELD1 Gene

No data available for Paralogs for MARVELD1 Gene

Variants for MARVELD1 Gene

Sequence variations from dbSNP and Humsavar for MARVELD1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000022448 -- 97,714,616(+) G/A 3_prime_UTR_variant
rs1000133608 -- 97,712,210(+) T/C upstream_transcript_variant
rs1001011036 -- 97,718,651(+) C/A downstream_transcript_variant
rs1001300637 -- 97,711,903(+) A/T upstream_transcript_variant
rs1001960775 -- 97,717,632(+) T/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MARVELD1 Gene

Variant ID Type Subtype PubMed ID
esv3579087 CNV loss 25503493
nsv552026 CNV loss 21841781

Variation tolerance for MARVELD1 Gene

Gene Damage Index Score: 0.16; 3.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARVELD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARVELD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARVELD1 Gene

Disorders for MARVELD1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARVELD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facial paralysis
  • bell palsy
facial nerve disease
  • facial nerve diseases
cranial nerve disease
  • cranial nerve disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARVELD1

genes like me logo Genes that share disorders with MARVELD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARVELD1 Gene

Publications for MARVELD1 Gene

  1. Identification and characterization of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. (PMID: 19364627) Wang S … Wu H (Cancer letters 2009) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer. (PMID: 26509557) Yao Y … Li Y (Molecular carcinogenesis 2016) 3 58

Products for MARVELD1 Gene

Sources for MARVELD1 Gene

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