Aliases for MARS1 Gene
External Ids for MARS1 Gene
Previous HGNC Symbols for MARS1 Gene
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
GeneCards Summary for MARS1 Gene
MARS1 (Methionyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with MARS1 include Interstitial Lung And Liver Disease and Charcot-Marie-Tooth Disease, Axonal, Type 2U. Among its related pathways are tRNA Aminoacylation and One carbon pool by folate. An important paralog of this gene is VARS1.
UniProtKB/Swiss-Prot Summary for MARS1 Gene
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).