This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011] See more...

Aliases for MARS1 Gene

Aliases for MARS1 Gene

  • Methionyl-TRNA Synthetase 1 2 3
  • Methionyl-TRNA Synthetase 2 4 5
  • Methionine--TRNA Ligase, Cytoplasmic 3 4
  • EC 6.1.1.10 4 52
  • MARS 3 5
  • Methionine TRNA Ligase 1, Cytoplasmic 2
  • Cytosolic Methionyl-TRNA Synthetase 3
  • CMT2U 3
  • ILFS2 3
  • METRS 3
  • MTRNS 3
  • SPG70 3
  • MetRS 4
  • ILLD 3
  • MRS 3

External Ids for MARS1 Gene

Previous HGNC Symbols for MARS1 Gene

  • MARS

Summaries for MARS1 Gene

Entrez Gene Summary for MARS1 Gene

  • This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

GeneCards Summary for MARS1 Gene

MARS1 (Methionyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with MARS1 include Interstitial Lung And Liver Disease and Charcot-Marie-Tooth Disease, Axonal, Type 2U. Among its related pathways are Gene Expression and tRNA Aminoacylation. An important paralog of this gene is VARS1.

UniProtKB/Swiss-Prot Summary for MARS1 Gene

  • Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).

Gene Wiki entry for MARS1 Gene

Additional gene information for MARS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARS1 Gene

Genomics for MARS1 Gene

GeneHancer (GH) Regulatory Elements for MARS1 Gene

Promoters and enhancers for MARS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057475 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.4 +3.4 3391 6.9 SIN3A CTCF ZBTB5 ZBTB11 TRIM22 POLR2A MXI1 EZH2 NFRKB KDM5B ARHGAP9 DCTN2 NEMP1 MARS1 ATP23 NONHSAG011429.2 HSALNG0091627
GH12J057487 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +13.2 13203 2.9 ZBTB40 ZNF217 CTCF SIN3A MYC POLR2G GTF2E2 PHF8 SIX5 PHB2 ARHGAP9 HSALNG0091627 NEMP1 BAZ2A RN7SL809P EEF1AKMT3 CDK4 CTDSP2 MBD6 NAB2
GH12J057516 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +45.6 45644 8.8 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC DDIT3 ENSG00000285133 MIR616 MBD6 lnc-MBD6-2 DTX3 RN7SL809P NACA NEMP1 CDK4
GH12J057517 Enhancer 1 ENCODE dbSUPER 0.3 +40.9 40938 0.3 POLR2G BCLAF1 AFF1 DNMT1 CTBP1 KDM4B NCOR1 KDM5B RELA ARNT HSALNG0091630 MIR616 MARS1
GH12J057483 Enhancer 0.4 ENCODE dbSUPER 0.4 +8.2 8152 0.6 HDGF DCTN2 HSALNG0091627 ARHGAP9 MARS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARS1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARS1

Genomic Locations for MARS1 Gene

Genomic Locations for MARS1 Gene
chr12:57,475,445-57,517,569
(GRCh38/hg38)
Size:
42,125 bases
Orientation:
Plus strand
chr12:57,869,228-57,911,352
(GRCh37/hg19)
Size:
42,125 bases
Orientation:
Plus strand

Genomic View for MARS1 Gene

Genes around MARS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARS1 Gene

Proteins for MARS1 Gene

  • Protein details for MARS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56192-SYMC_HUMAN
    Recommended name:
    Methionine--tRNA ligase, cytoplasmic
    Protein Accession:
    P56192
    Secondary Accessions:
    • B3KVK7
    • Q14895
    • Q53H14
    • Q96A15
    • Q96BZ0
    • Q9NSE0

    Protein attributes for MARS1 Gene

    Size:
    900 amino acids
    Molecular mass:
    101116 Da
    Quaternary structure:
    • Monomer (PubMed:11714285). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS1), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref.24, PubMed:26472928). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).

    Three dimensional structures from OCA and Proteopedia for MARS1 Gene

    Alternative splice isoforms for MARS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARS1 Gene

Selected DME Specific Peptides for MARS1 Gene

P56192:
  • NQWLEWEA
  • ITRDLKWG
  • CGKLINA
  • ARGDQCD
  • LLEKVRIRDALR
  • ISRHGNQYIQVNEPWK
  • RPEGQDSAFSW
  • TEYLNYEDGKFSKS
  • FDIFGRTT
  • LSADVFAR
  • EICDKYH
  • KVFYVWFDA
  • ALPYVNN
  • LITSALPY
  • KDNVPFH
  • GKFSKSRGVGVFG
  • SITANYTD

Post-translational modifications for MARS1 Gene

  • Ubiquitination at Lys191, Lys375, Lys500, Lys663, and Lys726
  • Modification sites at PhosphoSitePlus

Domains & Families for MARS1 Gene

Gene Families for MARS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MARS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16674 fis, clone THYMU3008136, highly similar to Methionyl-tRNA synthetase (EC 6.1.1.10) (B3KVK7_HUMAN)
  • Methionine--tRNA ligase (SYMC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56192

UniProtKB/Swiss-Prot:

SYMC_HUMAN :
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with MARS1: view

Function for MARS1 Gene

Molecular function for MARS1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667, Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530, ChEBI:CHEBI:456215; EC=6.1.1.10; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Enzyme activity is increased by spermidine, EEF1A1, and when the Mg(2+) concentration is increased from 5 mM to 13 mM (in vitro), possibly by promoting the dissociation of the complex between the enzyme and its product.

Enzyme Numbers (IUBMB) for MARS1 Gene

Gene Ontology (GO) - Molecular Function for MARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004825 methionine-tRNA ligase activity IEA,TAS --
genes like me logo Genes that share ontologies with MARS1: view
genes like me logo Genes that share phenotypes with MARS1: view

Human Phenotype Ontology for MARS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MARS1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARS1

Clone Products

  • Addgene plasmids for MARS1

No data available for Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for MARS1 Gene

Localization for MARS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARS1 Gene

Cytoplasm, cytosol. Nucleus, nucleolus. Note=Localizes to the nucleolus in proliferative cells but disappears in quiescent cells. {ECO:0000269 PubMed:10791971}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARS1 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA 10791971
GO:0005737 cytoplasm IDA 10791971
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with MARS1: view

Pathways & Interactions for MARS1 Gene

genes like me logo Genes that share pathways with MARS1: view

Pathways by source for MARS1 Gene

1 GeneGo (Thomson Reuters) pathway for MARS1 Gene
  • Methionine metabolism

SIGNOR curated interactions for MARS1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA,TAS --
GO:0006431 methionyl-tRNA aminoacylation IEA,IDA 11714285
GO:0009267 cellular response to starvation IDA 10791971
GO:0009303 rRNA transcription IMP 10791971
genes like me logo Genes that share ontologies with MARS1: view

Drugs & Compounds for MARS1 Gene

(9) Drugs for MARS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methionine Approved Nutra Enzyme, substrate 114
Phosphoric acid Approved Pharma 0
Selenomethionine Approved, Investigational Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(9) Additional Compounds for MARS1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with MARS1: view

Transcripts for MARS1 Gene

mRNA/cDNA for MARS1 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
35 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARS1

Clone Products

  • Addgene plasmids for MARS1

Alternative Splicing Database (ASD) splice patterns (SP) for MARS1 Gene

No ASD Table

Relevant External Links for MARS1 Gene

GeneLoc Exon Structure for
MARS1

Expression for MARS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARS1

SOURCE GeneReport for Unigene cluster for MARS1 Gene:

Hs.632707

Evidence on tissue expression from TISSUES for MARS1 Gene

  • Nervous system(5)
  • Muscle(4.9)
  • Intestine(4.8)
  • Liver(4.6)
  • Lung(3.8)
  • Skin(2.9)
  • Eye(2.3)
  • Kidney(2.3)
  • Stomach(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MARS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • epiglottis
  • head
  • larynx
  • neck
Thorax:
  • lung
Abdomen:
  • liver
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • shin
  • toe
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MARS1 Gene

Orthologs for MARS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARS 31 30
  • 99.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MARS 31 30
  • 90.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MARS 31 30
  • 89.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mars 30
  • 87.26 (n)
mouse
(Mus musculus)
Mammalia Mars 31 30
  • 86.89 (n)
OneToOne
Mars1 17
platypus
(Ornithorhynchus anatinus)
Mammalia MARS 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARS 31 30
  • 66.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARS 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mars 30
  • 66.63 (n)
Str.16107 30
African clawed frog
(Xenopus laevis)
Amphibia MGC69150 30
zebrafish
(Danio rerio)
Actinopterygii mars 31 30 30
  • 63.66 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007891 30
  • 55.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15100 31 30
  • 54.76 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mars-1 31
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR332C 30
  • 55.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MES1 33 31 30
  • 53.97 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09647g 30
  • 52.25 (n)
rice
(Oryza sativa)
Liliopsida Os10g0400100 30
  • 58.23 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.795 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2777 31
  • 65 (a)
OneToOne
Cin.55 30
bread mold
(Neurospora crassa)
Ascomycetes NCU07451 30
  • 54.52 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rar1 30
  • 54.11 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.55 30
Species where no ortholog for MARS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARS1 Gene

ENSEMBL:
Gene Tree for MARS1 (if available)
TreeFam:
Gene Tree for MARS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARS1: view image

Paralogs for MARS1 Gene

Paralogs for MARS1 Gene

genes like me logo Genes that share paralogs with MARS1: view

Variants for MARS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARS1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
635457 Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u 57,516,518(+) G/C MISSENSE_VARIANT
641147 Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u; Interstitial lung and liver disease 57,515,024(+) C/T MISSENSE_VARIANT
646980 Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u; Interstitial lung and liver disease 57,515,225(+) G/A MISSENSE_VARIANT
648138 Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u; Interstitial lung and liver disease 57,516,556(+) C/T MISSENSE_VARIANT
654957 Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u; Interstitial lung and liver disease 57,500,507(+) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MARS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MARS1 Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv1408918 CNV insertion 17803354
esv2759901 CNV gain 17122850
esv3419248 CNV duplication 20981092
nsv1071035 CNV deletion 25765185
nsv1144629 CNV deletion 24896259
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781
nsv819781 CNV loss 19587683

Variation tolerance for MARS1 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARS1 Gene

Disorders for MARS1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for MARS1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MARS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYMC_HUMAN
  • Interstitial lung and liver disease (ILLD) [MIM:615486]: An autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition. {ECO:0000269 PubMed:24103465, ECO:0000269 PubMed:25913036}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Charcot-Marie-Tooth disease 2U (CMT2U) [MIM:616280]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset. {ECO:0000269 PubMed:23729695, ECO:0000269 PubMed:24354524}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with MARS1: view

No data available for Genatlas and External Links for MARS1 Gene

Publications for MARS1 Gene

  1. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G … Gleeson JG (Science (New York, N.Y.) 2014) 2 3 4 54
  2. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. (PMID: 19131329) Kaminska M … Mirande M (The Journal of biological chemistry 2009) 3 4 23 54
  3. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. (PMID: 11714285) Kaminska M … Mirande M (Biochemistry 2001) 3 4 23 54
  4. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. (PMID: 10791971) Ko YG … Kim S (The Journal of cell biology 2000) 3 4 23 54
  5. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. (PMID: 10448063) Ubeda M … Habener JF (Biochemical and biophysical research communications 1999) 2 3 23 54

Products for MARS1 Gene

Sources for MARS1 Gene