Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
MARK2 (Microtubule Affinity Regulating Kinase 2) is a Protein Coding gene. Diseases associated with MARK2 include Spinocerebellar Ataxia 11 and Asthenopia. Among its related pathways are Cytoskeletal Signaling and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is MARK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IDA | 14976552 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | 24522549 |
GO:0005515 | protein binding | IPI | 14676191 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 23666762 |
GO:0005739 | mitochondrion | NAS | 24522549 |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005884 | actin filament | IDA | 23902687 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytoskeletal Signaling | ||
2 | Glucose / Energy Metabolism | ||
3 | Neuroscience | ||
4 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
|
5 | LKB1 signaling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0000422 | autophagy of mitochondrion | NAS | 24522549 |
GO:0001764 | neuron migration | ISS | -- |
GO:0006468 | protein phosphorylation | IEA,NAS | 8274451 |
GO:0007275 | multicellular organism development | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | ||||||||||||
SP3: | - | - | - | ||||||||||
SP4: | - | - | |||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | - | - | - | ||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MARK2 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MARK2 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MARK2 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MARK2 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mark2 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Mark2 32 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MARK2 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mark2 32 |
|
||
Str.11090 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | mark2a 33 |
|
OneToMany | |
mark2b 33 32 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | par-1 33 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | par-1 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1554985733 | uncertain-significance, not provided | 63,902,216(+) | A/ | coding_sequence_variant, frameshift, non_coding_transcript_variant | |
rs1000025447 | -- | 63,869,725(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
rs1000033263 | -- | 63,875,808(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
rs1000079057 | -- | 63,869,932(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000166145 | -- | 63,851,813(+) | C/G | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660413 | CNV | deletion | 23128226 |
esv2671472 | CNV | deletion | 23128226 |
esv3626654 | CNV | loss | 21293372 |
nsv1127197 | CNV | deletion | 24896259 |
nsv1134138 | CNV | deletion | 24896259 |
nsv1145540 | CNV | deletion | 24896259 |
nsv555180 | CNV | loss | 21841781 |
nsv555181 | CNV | loss | 21841781 |
nsv951009 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 11 |
|
|
asthenopia |
|
|