MARK2 Gene (Protein Coding)

Microtubule Affinity Regulating Kinase 2

GC11P063838
GIFtS:
45
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants enc... See more...

Aliases for MARK2 Gene

Aliases for MARK2 Gene

  • Microtubule Affinity Regulating Kinase 2 2 3 5
  • MAP/Microtubule Affinity-Regulating Kinase 2 2 3 4
  • ELKL Motif Kinase 1 2 3 4
  • Par1b 2 3 4
  • Serine/Threonine-Protein Kinase MARK2 3 4
  • Ser/Thr Protein Kinase PAR-1B 2 3
  • PAR1 Homolog B 3 4
  • EC 2.7.11.1 4 51
  • Par-1b 3 4
  • EMK-1 3 4
  • PAR-1 2 3
  • EMK1 3 4
  • Serine/Threonine Protein Kinase EMK 3
  • Testicular Tissue Protein Li 117 3
  • Protein-Serine/Threonine Kinase 2
  • Serine/Threonine Kinase 2
  • ELKL Motif Kinase 2
  • PAR1 Homolog 4
  • EC 2.7.11.26 4
  • EC 2.7.11 51
  • PAR-1B 2
  • MARK2 5

External Ids for MARK2 Gene

Previous HGNC Symbols for MARK2 Gene

  • EMK1

Previous GeneCards Identifiers for MARK2 Gene

  • GC11P066121
  • GC11P065286
  • GC11P063857
  • GC11P063382
  • GC11P063431
  • GC11P063363
  • GC11P063606
  • GC11P059934

Summaries for MARK2 Gene

Entrez Gene Summary for MARK2 Gene

  • This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for MARK2 Gene

MARK2 (Microtubule Affinity Regulating Kinase 2) is a Protein Coding gene. Diseases associated with MARK2 include Parkinson Disease, Late-Onset. Among its related pathways are Notch Signaling Pathway (WikiPathways) and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is MARK1.

UniProtKB/Swiss-Prot Summary for MARK2 Gene

  • Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

Gene Wiki entry for MARK2 Gene

Additional gene information for MARK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARK2 Gene

Genomics for MARK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MARK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARK2

Top Transcription factor binding sites by QIAGEN in the MARK2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MARK2 Gene

Latest Assembly
chr11:63,838,928-63,911,020
(GRCh38/hg38)
Size:
72,093 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,606,582-63,678,492
(GRCh37/hg19 by Entrez Gene)
Size:
71,911 bases
Orientation:
Plus strand

chr11:63,606,400-63,678,491
(GRCh37/hg19 by Ensembl)
Size:
72,092 bases
Orientation:
Plus strand

Genomic View for MARK2 Gene

Genes around MARK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MARK2 Gene

Proteins for MARK2 Gene

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  • Protein details for MARK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7KZI7-MARK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MARK2
    Protein Accession:
    Q7KZI7
    Secondary Accessions:
    • Q15449
    • Q15524
    • Q5XGA3
    • Q68A18
    • Q96HB3
    • Q96RG0

    Protein attributes for MARK2 Gene

    Size:
    788 amino acids
    Molecular mass:
    87911 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with PAK5; leading to inhibit the protein kinase activity (By similarity). Interacts with MAPT/TAU (PubMed:23666762). Interacts with MTCL1 isoform 1; the interaction is direct and increases MARK2 microtubule-binding ability (PubMed:23902687). Interacts (when phosphorylated at Thr-596) with YWHAZ (PubMed:15324659). Interacts with YWHAB, YWHAG and YWHAQ (PubMed:16959763).
    • (Microbial infection) In case of infection, interacts with H.pylori CagA, leading to inhibit kinase activity and junctional and polarity defects.
    SequenceCaution:
    • Sequence=AAK82368.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1]: Produced by alternative promoter usage.
    • [Isoform 2]: Produced by alternative splicing of isoform 6.
    • [Isoform 3]: Produced by alternative splicing of isoform 6.
    • [Isoform 4]: Produced by alternative splicing of isoform 1.
    • [Isoform 5]: Produced by alternative splicing of isoform 1.
    • [Isoform 6]: Produced by alternative promoter usage.
    • [Isoform 7]: Produced by alternative splicing of isoform 6.
    • [Isoform 8]: Produced by alternative splicing of isoform 1.
    • [Isoform 9]: Produced by alternative splicing of isoform 1.
    • [Isoform 10]: Produced by alternative splicing of isoform 6.
    • [Isoform 11]: Produced by alternative splicing of isoform 1.
    • [Isoform 12]: Produced by alternative splicing of isoform 6.
    • [Isoform 13]: Produced by alternative splicing of isoform 6.
    • [Isoform 14]: Produced by alternative splicing of isoform 6.
    • [Isoform 15]: Produced by alternative splicing of isoform 1.
    • [Isoform 16]: Produced by alternative splicing of isoform 1.

    Three dimensional structures from OCA and Proteopedia for MARK2 Gene

    Alternative splice isoforms for MARK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARK2 Gene

Protein Expression for MARK2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MARK2 Gene

Q7KZI7:
  • SLQKLFREVRIMK
  • TIGKGNFA
  • GPEVDVWS
  • VQWEMEVCKLPRLSLNGVRFKRISGTS
  • LVAHGRM
  • KIIDKTQL
  • FRQIVSA
  • EYASGGE
  • FAKVKLA
  • WSLGVILY
  • IVHRDLKAENLLLDADMNIKI
  • RQIVSAV
  • NLKELRERVLRGKYR
  • GEVFDYLV
  • DFGFSNEFT
  • WSLGVILYTLVSGSLPFDG
  • LNHPNIVKLFEVIETEKTLYL
  • GSPPYAAPE
  • HKVQRSVS
  • DEQPHIGNYRL
  • REIRKVLDAN
  • NHPNIVKL
  • IVHRDLK

Post-translational modifications for MARK2 Gene

  • Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-596 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm.
  • Ubiquitination at Lys637
  • Modification sites at PhosphoSitePlus

Other Protein References for MARK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MARK2 Gene

Gene Families for MARK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MARK2 Gene

InterPro:
Blocks:
  • Ubiquitin-associated domain
  • Kinase-associated, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for MARK2 Gene

GenScript: Design optimal peptide antigens:
  • Ser/Thr protein kinase PAR-1Balpha splicing variant (A9CP04_HUMAN)
  • PAR1 homolog (MARK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7KZI7

UniProtKB/Swiss-Prot:

MARK2_HUMAN :
  • The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain.
  • The KA1 domain mediates binding to phospholipids and targeting to membranes.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK2: view

Function for MARK2 Gene

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Molecular function for MARK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA-COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5 (By similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596. Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host substrates and binds to the kinase substrate-binding site.

Enzyme Numbers (IUBMB) for MARK2 Gene

Phenotypes From GWAS Catalog for MARK2 Gene

Gene Ontology (GO) - Molecular Function for MARK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 14976552
GO:0003723 RNA binding HDA 22658674
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS,TAS 24522549
genes like me logo Genes that share ontologies with MARK2: view
genes like me logo Genes that share phenotypes with MARK2: view

Animal Models for MARK2 Gene

MGI Knock Outs for MARK2:

Animal Models for research

miRNA for MARK2 Gene

miRTarBase miRNAs that target MARK2

Inhibitory RNAs for research

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Clone products for research

  • Addgene plasmids for MARK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARK2 Gene

Localization for MARK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK2 Gene

Cell membrane. Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite. Cytoplasm. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARK2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
mitochondrion 4
cytosol 3
extracellular 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 23666762
GO:0005739 mitochondrion NAS 24522549
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IDA 23902687
genes like me logo Genes that share ontologies with MARK2: view

Pathways & Interactions for MARK2 Gene

genes like me logo Genes that share pathways with MARK2: view

Pathways by source for MARK2 Gene

2 BioSystems pathways for MARK2 Gene
1 Qiagen pathway for MARK2 Gene
  • Epithelial Tight Junctions
3 Cell Signaling Technology pathways for MARK2 Gene

SIGNOR curated interactions for MARK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MARK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0000422 autophagy of mitochondrion NAS 24522549
GO:0001764 neuron migration ISS --
GO:0006468 protein phosphorylation NAS 8274451
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with MARK2: view

Drugs & Compounds for MARK2 Gene

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(3) Drugs for MARK2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(2) Additional Compounds for MARK2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
genes like me logo Genes that share compounds with MARK2: view

Transcripts for MARK2 Gene

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mRNA/cDNA for MARK2 Gene

5 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

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Clone products for research

  • Addgene plasmids for MARK2

Alternative Splicing Database (ASD) splice patterns (SP) for MARK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11: - -

Relevant External Links for MARK2 Gene

GeneLoc Exon Structure for
MARK2

Expression for MARK2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARK2 Gene

mRNA expression in normal human tissues for MARK2 Gene
mRNA expression by GTEx for MARK2 GenemRNA expression by BioGPS for MARK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARK2 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for MARK2 Gene

This gene is overexpressed in Lung (10.3) and CD8 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARK2 Gene



Protein tissue co-expression partners for MARK2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARK2

SOURCE GeneReport for Unigene cluster for MARK2 Gene:

Hs.567261

mRNA Expression by UniProt/SwissProt for MARK2 Gene:

Q7KZI7-MARK2_HUMAN
Tissue specificity: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.

Evidence on tissue expression from TISSUES for MARK2 Gene

  • Blood(4.4)
  • Nervous system(3.6)
  • Kidney(2.5)
  • Skin(2.5)
  • Intestine(2.3)
  • Stomach(2.3)
  • Muscle(2.3)
  • Heart(2.1)
  • Lymph node(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MARK2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MARK2 Gene

Orthologs for MARK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MARK2 30
  • 99.7 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MARK2 31
  • 95 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MARK2 30 31
  • 94.29 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MARK2 30 31
  • 93.39 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mark2 30 17 31
  • 93.08 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mark2 30
  • 91.87 (n)
Lizard
(Anolis carolinensis)
 Reptilia MARK2 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mark2 30
  • 75.51 (n)
Str.11090 30
Zebrafish
(Danio rerio)
 Actinopterygii mark2a 31
  • 71 (a)
 OneToMany
mark2b 30 31
  • 70.63 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta par-1 31
  • 35 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea par-1 31
  • 35 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 48 (a)
 OneToMany
Species where no ortholog for MARK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MARK2 Gene

ENSEMBL:
Gene Tree for MARK2 (if available)
TreeFam:
Gene Tree for MARK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARK2: view image

Paralogs for MARK2 Gene

Paralogs for MARK2 Gene

(125) SIMAP similar genes for MARK2 Gene using alignment to 7 proteins:

  • MARK2_HUMAN
  • E7ETY4_HUMAN
  • E9PC69_HUMAN
  • F5H4F6_HUMAN
  • F5H4J8_HUMAN
  • F5H6N2_HUMAN
  • Q5DNC5_HUMAN

Pseudogenes.org Pseudogenes for MARK2 Gene

genes like me logo Genes that share paralogs with MARK2: view

Variants for MARK2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARK2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
982301 Uncertain Significance: not provided 63,900,795(+) C/T
NM_001039469.3(MARK2):c.904C>T (p.Arg302Ter) 		NONSENSE
982302 Uncertain Significance: not provided 63,899,923(+) T/C
NM_001039469.3(MARK2):c.581T>C (p.Phe194Ser) 		MISSENSE
rs1554985733 Uncertain Significance: not provided 63,902,215(+) CA/C
NM_001039469.2(MARK2):c.1120del (p.Thr374fs) 		FRAMESHIFT
rs1590686402 Likely Benign: not provided 63,900,573(+) G/C
NM_001039469.2(MARK2):c.783G>C (p.Arg261=) 		SYNONYMOUS
rs184514302 Likely Benign: not provided 63,898,288(+) C/G
NM_001039469.2(MARK2):c.337+8C>G 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MARK2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MARK2 Gene

Variant ID Type Subtype PubMed ID
esv2660413 CNV deletion 23128226
esv2671472 CNV deletion 23128226
esv3626654 CNV loss 21293372
nsv1127197 CNV deletion 24896259
nsv1134138 CNV deletion 24896259
nsv1145540 CNV deletion 24896259
nsv555180 CNV loss 21841781
nsv555181 CNV loss 21841781
nsv951009 CNV deletion 24416366

Variation tolerance for MARK2 Gene

Residual Variation Intolerance Score: 5.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARK2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK2 Gene

Disorders for MARK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARK2 Gene - From: COP

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search MARK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MARK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MARK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK2 Gene

Publications for MARK2 Gene

  1. Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing. (PMID: 9730619) Espinosa L … Navarro E (Cytogenetics and cell genetics 1998) 2 3 4 23
  2. High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial. (PMID: 19530321) Motovska Z … PRAGUE-8 study investigators (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2009) 3 23 41
  3. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. (PMID: 15324659) Suzuki A … Ohno S (Current biology : CB 2004) 3 4 23
  4. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. (PMID: 12429843) Biernat J … Mandelkow EM (Molecular biology of the cell 2002) 3 4 23
  5. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. (PMID: 23666762) Gu GJ … Kamali-Moghaddam M (Neuromolecular medicine 2013) 3 4

ExternalLinks

View latest publications for MARK2 gene in Mastermind

Products for MARK2 Gene

  • Addgene plasmids for MARK2

Sources for MARK2 Gene