Aliases for MARK2 Gene
Aliases for MARK2 Gene
External Ids for MARK2 Gene
- HGNC: 3332
- Entrez Gene: 2011
- Ensembl: ENSG00000072518
- OMIM: 600526
- UniProtKB: Q7KZI7
Previous HGNC Symbols for MARK2 Gene
- EMK1
Previous GeneCards Identifiers for MARK2 Gene
- GC11P066121
- GC11P065286
- GC11P063382
- GC11P063431
- GC11P063363
- GC11P063606
- GC11P059934
Summaries for MARK2 Gene
-
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
GeneCards Summary for MARK2 Gene
MARK2 (Microtubule Affinity Regulating Kinase 2) is a Protein Coding gene. Diseases associated with MARK2 include Asthenopia. Among its related pathways are LKB1 signaling events and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is MARK1.
UniProtKB/Swiss-Prot for MARK2 Gene
-
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Additional gene information for MARK2 Gene
- Monarch Initiative
- Search for MARK2 at DataMed
- Search for MARK2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK2 Gene
Genomics for MARK2 Gene
GeneHancer (GH) Regulatory Elements for MARK2 Gene
Promoters and enhancers for MARK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MARK2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MARK2 gene promoter:
-
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- PPAR-gamma1
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for MARK2 Gene
Genomic Locations for MARK2 Gene
- chr11:63,838,928-63,911,020
- (GRCh38/hg38)
- Size:
- 72,093 bases
- Orientation:
- Plus strand
- chr11:63,606,400-63,678,492
- (GRCh37/hg19)
- Size:
- 72,093 bases
- Orientation:
- Plus strand
Genomic View for MARK2 Gene
Genes around MARK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
MARK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MARK2 Gene
Proteins for MARK2 Gene
-
Protein details for MARK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7KZI7-MARK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase MARK2
- Protein Accession:
- Q7KZI7
- Q15449
- Q15524
- Q5XGA3
- Q68A18
- Q96HB3
- Q96RG0
Protein attributes for MARK2 Gene
- Size:
- 788 amino acids
- Molecular mass:
- 87911 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer. Interacts with PAK5; leading to inhibit the protein kinase activity (By similarity). Interacts with MTCL1 isoform 1; the interaction is direct and increases MARK2 microtubule-binding ability. Interacts (when phosphorylated at Thr-596) with YWHAZ. In case of infection, interacts with H.pylori CagA, leading to inhibit kinase activity and junctional and polarity defects.
- SequenceCaution:
-
- Sequence=AAK82368.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MARK2 Gene
Protein Expression for MARK2 Gene
Post-translational modifications for MARK2 Gene
- Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-596 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm.
- Ubiquitination at posLast=637637
- Modification sites at PhosphoSitePlus
Other Protein References for MARK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MARK2
- Novus Biologicals Antibodies for MARK2
-
Abcam antibodies for MARK2
- Invitrogen Antibodies for MARK2 (AFLGC-MARK2)
- GeneTex MARK2 Antibody for MARK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MARK2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MARK2
- Origene Custom Protein Services for MARK2
- Search GeneTex for Proteins for MARK2
-
Abcam proteins for MARK2
Assay Products
No data available for DME Specific Peptides for MARK2 Gene
Domains & Families for MARK2 Gene
Gene Families for MARK2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MARK2 Gene
Suggested Antigen Peptide Sequences for MARK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7KZI7UniProtKB/Swiss-Prot:
MARK2_HUMAN :- The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
- Domain:
-
- The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain.
- The KA1 domain mediates binding to phospholipids and targeting to membranes.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Function for MARK2 Gene
Molecular function for MARK2 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [tau protein] = ADP + [tau protein] phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5 (By similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596. Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host substrates and binds to the kinase substrate-binding site.
Enzyme Numbers (IUBMB) for MARK2 Gene
Phenotypes From GWAS Catalog for MARK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 14976552 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | 24522549 |
| GO:0005515 | protein binding | IPI | 14676191 |
Phenotypes for MARK2 Gene
- MGI mutant phenotypes for MARK2:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- liver/biliary system phenotype
- reproductive system phenotype
- embryo phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MARK2:
-
- Decreased viability ratio
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased Nanog expression
- Increased cell migration
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Decreased 12E8 tau but not total tau protein expression and decreased ratio of 12E8/total tau protein expression
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for MARK2 Gene
- MGI Knock Outs for MARK2:
-
- Mark2 Mark2<tm1Hpw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MARK2
-
CRISPR Products
-
OriGene CRISPR knockouts for MARK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK2
- genomics-online: gRNA clones - Search results for available MARK2 gene related products
- Applied Biological Materials CRISPR for MARK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MARK2
- GenScript: Design CRISPR guide RNA sequences for MARK2
miRNA for MARK2 Gene
- miRTarBase miRNAs that target MARK2
-
- hsa-mir-193b-3p (MIRT041517)
- hsa-mir-320a (MIRT044813)
- hsa-mir-99a-5p (MIRT048691)
- hsa-mir-93-5p (MIRT048862)
- hsa-mir-4271 (MIRT181931)
- hsa-mir-4725-3p (MIRT181932)
- hsa-mir-6780b-5p (MIRT181935)
- hsa-mir-3150a-3p (MIRT231222)
- hsa-mir-6763-5p (MIRT231226)
- hsa-mir-190a-5p (MIRT437446)
- hsa-mir-450a-2-3p (MIRT473593)
- hsa-mir-6857-5p (MIRT473594)
- hsa-mir-6810-5p (MIRT473595)
- hsa-mir-2110 (MIRT473596)
- hsa-mir-92a-1-5p (MIRT473597)
- hsa-mir-6848-5p (MIRT473598)
- hsa-mir-6846-5p (MIRT473599)
- hsa-mir-4489 (MIRT473600)
- hsa-mir-6825-5p (MIRT473601)
- hsa-mir-939-5p (MIRT473602)
- hsa-mir-1343-5p (MIRT473603)
- hsa-mir-6722-3p (MIRT473604)
- hsa-mir-1909-3p (MIRT473605)
- hsa-mir-6836-5p (MIRT473606)
- hsa-mir-6823-5p (MIRT473607)
- hsa-mir-6132 (MIRT473608)
- hsa-mir-296-3p (MIRT473609)
- hsa-mir-6805-5p (MIRT473610)
- hsa-mir-520e (MIRT473611)
- hsa-mir-520d-3p (MIRT473612)
- hsa-mir-520c-3p (MIRT473613)
- hsa-mir-520b (MIRT473614)
- hsa-mir-520a-3p (MIRT473615)
- hsa-mir-373-3p (MIRT473616)
- hsa-mir-372-3p (MIRT473617)
- hsa-mir-302e (MIRT473618)
- hsa-mir-302d-3p (MIRT473619)
- hsa-mir-302c-3p (MIRT473620)
- hsa-mir-302b-3p (MIRT473621)
- hsa-mir-302a-3p (MIRT473622)
- hsa-mir-519c-3p (MIRT473623)
- hsa-mir-519b-3p (MIRT473624)
- hsa-mir-519a-3p (MIRT473625)
- hsa-mir-6774-5p (MIRT473626)
- hsa-mir-328-5p (MIRT473627)
- hsa-mir-6887-5p (MIRT473628)
- hsa-mir-6795-5p (MIRT473629)
- hsa-mir-6883-5p (MIRT473630)
- hsa-mir-6785-5p (MIRT473631)
- hsa-mir-4728-5p (MIRT473632)
- hsa-mir-149-3p (MIRT473633)
- hsa-mir-3202 (MIRT473634)
- hsa-mir-4722-5p (MIRT473635)
- hsa-mir-7515 (MIRT473636)
- hsa-mir-4459 (MIRT473637)
- hsa-mir-7843-5p (MIRT473638)
- hsa-mir-4761-3p (MIRT473639)
- hsa-mir-6879-5p (MIRT473640)
- hsa-mir-6735-5p (MIRT473641)
- hsa-mir-4632-5p (MIRT473642)
- hsa-mir-4436b-3p (MIRT473643)
- hsa-mir-17-3p (MIRT738000)
- hsa-mir-181a-3p (MIRT738023)
- hsa-mir-329-3p (MIRT741310)
- hsa-mir-362-3p (MIRT741782)
- hsa-mir-455-3p (MIRT746186)
- hsa-mir-639 (MIRT752712)
- hsa-mir-7151-5p (MIRT759186)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MARK2
- Browse OriGene Inhibitory RNA Products For MARK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK2
- genomics-online: shRNA clones - Search results for available MARK2 gene related products
Clone Products
-
OriGene ORF clones in human for MARK2
- RC210279
- RC210279L1
- RC210279L2
- RC210279L3
- RC210279L4
- RC213764
- RC213764L1
- RC213764L2
- RC213764L3
- RC213764L4
- RC216292
- RC216292L1
- RC216292L2
- RC216292L3
- RC216292L4
- RC228550
- RC228550L1
- RC228550L2
- RC228550L3
- RC228550L4
- RC228553
- RC228553L1
- RC228553L2
- RC228553L3
- RC228553L4
- RG210279
- RG213764
- RG216292
- RG228550
- RG228553
- RC210279L1V
- RC210279L2V
- RC210279L3V
- RC210279L4V
- RC213764L1V
- RC213764L2V
- RC213764L3V
- RC213764L4V
- RC216292L1V
- RC216292L2V
- RC216292L3V
- RC216292L4V
- RC228550L1V
- RC228550L2V
- RC228550L3V
- RC228550L4V
- RC228553L1V
- RC228553L2V
- RC228553L3V
- RC228553L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MARK2
- Addgene plasmids for MARK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK2
- genomics-online: cdna clones - Search results for available MARK2 gene related products
- orf clones - Search results for available MARK2 gene related products
- Applied Biological Materials Clones for MARK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MARK2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARK2 Gene
Localization for MARK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MARK2 Gene
- Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 3 |
| extracellular | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | NAS | 24522549 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005884 | actin filament | IDA | 23902687 |
Pathways & Interactions for MARK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytoskeletal Signaling | ||
| 2 | Glucose / Energy Metabolism | ||
| 3 | Neuroscience | ||
| 4 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 5 | LKB1 signaling events | ||
Pathways by source for MARK2 Gene
2 BioSystems pathways for MARK2 Gene
1 Qiagen pathway for MARK2 Gene
3 Cell Signaling Technology pathways for MARK2 Gene
Interacting Proteins for MARK2 Gene
Selected Interacting proteins:
Q7KZI7-MARK2_HUMAN
ENSP00000385751
for MARK2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MARK2
SIGNOR curated interactions for MARK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
| GO:0000422 | autophagy of mitochondrion | NAS | 24522549 |
| GO:0001764 | neuron migration | ISS | -- |
| GO:0006468 | protein phosphorylation | NAS,IEA | 8274451 |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for MARK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MARK2 Gene
mRNA/cDNA for MARK2 Gene
- (17) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (204) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000508192 2924 bps (uc001nxv.5)
- ENST00000361128 3004 bps (uc001nxx.4)
- ENST00000350490 2903 bps (uc001nxy.4)
- ENST00000502399 2885 bps (uc058cry.1)
- ENST00000543220 595 bps (uc058crz.1)
Unigene Clusters for MARK2 Gene
- MAP/microtubule affinity-regulating kinase 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MARK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK2
- genomics-online: gRNA clones - Search results for available MARK2 gene related products
- Applied Biological Materials CRISPR for MARK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MARK2
- GenScript: Design CRISPR guide RNA sequences for MARK2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MARK2
- Browse OriGene Inhibitory RNA Products For MARK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK2
- genomics-online: shRNA clones - Search results for available MARK2 gene related products
Clone Products
-
OriGene ORF clones in human for MARK2
- RC210279
- RC210279L1
- RC210279L2
- RC210279L3
- RC210279L4
- RC213764
- RC213764L1
- RC213764L2
- RC213764L3
- RC213764L4
- RC216292
- RC216292L1
- RC216292L2
- RC216292L3
- RC216292L4
- RC228550
- RC228550L1
- RC228550L2
- RC228550L3
- RC228550L4
- RC228553
- RC228553L1
- RC228553L2
- RC228553L3
- RC228553L4
- RG210279
- RG213764
- RG216292
- RG228550
- RG228553
- RC210279L1V
- RC210279L2V
- RC210279L3V
- RC210279L4V
- RC213764L1V
- RC213764L2V
- RC213764L3V
- RC213764L4V
- RC216292L1V
- RC216292L2V
- RC216292L3V
- RC216292L4V
- RC228550L1V
- RC228550L2V
- RC228550L3V
- RC228550L4V
- RC228553L1V
- RC228553L2V
- RC228553L3V
- RC228553L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MARK2
- Addgene plasmids for MARK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK2
- genomics-online: cdna clones - Search results for available MARK2 gene related products
- orf clones - Search results for available MARK2 gene related products
- Applied Biological Materials Clones for MARK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | ||||||||||||
| SP3: | - | - | - | ||||||||||
| SP4: | - | - | |||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | - | - | - | ||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | - | - |
Expression for MARK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for MARK2 Gene
This gene is overexpressed in Whole Blood (x4.6).
This gene is overexpressed in Lung (10.3) and CD8 Tcells (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARK2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MARK2 Gene:
MARK2SOURCE GeneReport for Unigene cluster for MARK2 Gene:
Hs.567261mRNA Expression by UniProt/SwissProt for MARK2 Gene:
Q7KZI7-MARK2_HUMAN
Tissue specificity:
High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
Evidence on tissue expression from TISSUES for MARK2 Gene
- Blood(4.3)
- Nervous system(3.3)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for MARK2
-
OriGene qPCR primer pairs and template standards for MARK2
- genomics-online: primer clones - Search results for available MARK2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MARK2 Gene
Orthologs for MARK2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MARK2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MARK2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MARK2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MARK2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mark2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mark2 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MARK2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mark2 33 |
|
||
| Str.11090 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mark2a 34 |
|
OneToMany | |
| mark2b 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | par-1 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | par-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MARK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MARK2 Gene
- ENSEMBL:
- Gene Tree for MARK2 (if available)
- TreeFam:
- Gene Tree for MARK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MARK2: view image
Paralogs for MARK2 Gene
(125) SIMAP similar genes for MARK2 Gene using alignment to 7 proteins:
- MARK2_HUMAN
- E7ETY4_HUMAN
- E9PC69_HUMAN
- F5H4F6_HUMAN
- F5H4J8_HUMAN
- F5H6N2_HUMAN
- Q5DNC5_HUMAN
- Par1b
- DKFZp547M202
- MARK4
- BRSK1
- MARK1
- BRSK2
- MARK3
- KIAA0999
- HUNK
- BRAF
- PDPK1
- PRKAA1
- STK32A
- NIM1K
- CDK3
- NUAK1
- NEK8
- CAMK2A
- KIN27
- AURKB
- PKN2
- TSSK3
- PRKACB
- DAPK3
- PRKACA
- SIK3
- MATK
- PKN1
- MYLK4
- TSSK2
- TSSK1B
- TSSK1
- AURKA
- CAMK1G
- STK17A
- PRKCZ
- STK36
- AURKC
- TSSK4
- PRKCG
- PHKG2
- CAMK2B
- TSSK6
- PRKY
- PRKX
- PRKCH
- STK38L
- STK33
- RPS6KA5
- DKFZp564L2416
- PRKAA2
- PNCK
- SGK2
- ULK3
- SGK3
- RPS6KA2
- MAPK7
- CHEK1
- CDK7
- CAMK1D
- CAMK1
- PHKG1
- STK25
- RPS6KA3
- NEK9
- PRKACG
- STK11
- SIK1
- RPS6KA1
- NEK3
- PTK2
- DAPK1
- CDK4
- CAMK2D
- CHEK2
- MAST4
- CDK1
- PkB-like 1
- PSKH1
- MKNK1
- PSKH2
- PRKG2
- PAK2
- MYO3A
- TAOK3
- CSNK2A3
- CCRK
- PIM2
- CDC42BPA
- TRIB2
- TNIK
- MAST1
- FGFR1
- CDK12
- AKT2
- CDK2
- CAMK4
- PRKG1
- MAPK8
- MAPK9
- MAPK14
- TRIB1
- PIM3
- PAK4
- STRADA
- PASK
- MYO3B
- FPGT-TNNI3K
- CDC2
- JAK2
- ZAK
- TLK2
- OBSCN
- MAP3K3
- NEK6
- TBK1
- MAP4K4
- MAP4K1
- MAP3K4
- DAPK2
- NUAK2
- MAP4K5
- AKT1
- MELK
- WNK4
Pseudogenes.org Pseudogenes for MARK2 Gene
- PGOHUM00000290858
- PGOHUM00000291448
- PGOHUM00000291999
- PGOHUM00000295173
- PGOHUM00000296810
- PGOHUM00000299161
- PGOHUM00000299166
- PGOHUM00000299337
- PGOHUM00000299340
- PGOHUM00000299344
- PGOHUM00000299345
- PGOHUM00000299583
- PGOHUM00000299584
- PGOHUM00000299895
- PGOHUM00000300080
- PGOHUM00000300804
- PGOHUM00000300872
- PGOHUM00000301230
- PGOHUM00000302102
- PGOHUM00000302584
- PGOHUM00000302861
- PGOHUM00000305822
- PGOHUM00000305823
- PGOHUM00000289934
- PGOHUM00000289947
- PGOHUM00000290252
Variants for MARK2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025447 | -- | 63,869,725(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000033263 | -- | 63,875,808(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000079057 | -- | 63,869,932(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000166145 | -- | 63,851,813(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000187336 | -- | 63,869,275(+) | C/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660413 | CNV | deletion | 23128226 |
| esv2671472 | CNV | deletion | 23128226 |
| esv3626654 | CNV | loss | 21293372 |
| nsv1127197 | CNV | deletion | 24896259 |
| nsv1134138 | CNV | deletion | 24896259 |
| nsv1145540 | CNV | deletion | 24896259 |
| nsv555180 | CNV | loss | 21841781 |
| nsv555181 | CNV | loss | 21841781 |
| nsv951009 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
5.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.56;
12.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MARK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MARK2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK2 Gene
Disorders for MARK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthenopia |
|
|
Search MARK2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MARK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MARK2 Gene
Publications for MARK2 Gene
- Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing. (PMID: 9730619) Espinosa L … Navarro E (Cytogenetics and cell genetics 1998) 2 3 4 22 58
- High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial. (PMID: 19530321) Motovska Z … PRAGUE-8 study investigators (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2009) 3 22 44 58
- aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. (PMID: 15324659) Suzuki A … Ohno S (Current biology : CB 2004) 3 4 22 58
- Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. (PMID: 12429843) Biernat J … Mandelkow EM (Molecular biology of the cell 2002) 3 4 22 58
- The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. (PMID: 23902687) Sato Y … Suzuki A (Journal of cell science 2013) 3 4 58
Products for MARK2 Gene
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- Custom Antibody ServicesOriGene Antibodies for MARK2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MARK2
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- OriGene qPCR primer pairs for MARK2
- OriGene qPCR primer pairs and template standards for MARK2
- OriGene CRISPR knockouts for MARK2
- OriGene ORF clones in human for MARK2
- RC210279
- RC210279L1
- RC210279L2
- RC210279L3
- RC210279L4
- RC213764
- RC213764L1
- RC213764L2
- RC213764L3
- RC213764L4
- RC216292
- RC216292L1
- RC216292L2
- RC216292L3
- RC216292L4
- RC228550
- RC228550L1
- RC228550L2
- RC228550L3
- RC228550L4
- RC228553
- RC228553L1
- RC228553L2
- RC228553L3
- RC228553L4
- RG210279
- RG213764
- RG216292
- RG228550
- RG228553
- RC210279L1V
- RC210279L2V
- RC210279L3V
- RC210279L4V
- RC213764L1V
- RC213764L2V
- RC213764L3V
- RC213764L4V
- RC216292L1V
- RC216292L2V
- RC216292L3V
- RC216292L4V
- RC228550L1V
- RC228550L2V
- RC228550L3V
- RC228550L4V
- RC228553L1V
- RC228553L2V
- RC228553L3V
- RC228553L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MARK2
- GenScript: Next-day shipping of latest version cDNA ORF clones for MARK2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MARK2
- GenScript Custom Assay Services for MARK2
- GenScript Custom overexpressing Cell Line Services for MARK2
- GenScript: Design CRISPR guide RNA sequences for MARK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for MARK2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MARK2
- Novus Biologicals proteins and lysates for MARK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MARK2
- Abcam proteins for MARK2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MARK2 (AFLGC-MARK2)
- Cyagen custom Knockout/knockin (KOKI) mouse models for MARK2
- Addgene plasmids for MARK2
- antibodies-online: Search results for 97 available MARK2 Antibodies ranked by validation data
- Compare Top MARK2 Antibodies
- Quality Products:
- antibodies-online: Search results for available MARK2 related products ranked by validation data
- antibodies-online: Search results for 10 available MARK2 Proteins ranked by validation data
- Compare Top MARK2 Proteins
- Quality Products:
- GeneTex MARK2 Antibody for MARK2
- Search GeneTex for Proteins for MARK2
- Santa Cruz Biotechnology (SCBT) Antibodies for MARK2
- Search Santa Cruz Biotechnology (SCBT) for MARK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MARK2
- Horizon Cell Lines for MARK2
- genomics-online: cdna clones - Search results for available MARK2 gene related products
- orf clones - Search results for available MARK2 gene related products
- genomics-online: gRNA clones - Search results for available MARK2 gene related products
- genomics-online: primer clones - Search results for available MARK2 gene related products
- genomics-online: shRNA clones - Search results for available MARK2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK2
- GeneCopoeia miRNA 3'UTR Target clone products for MARK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK2
Sources for MARK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt