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This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
MARK2 (Microtubule Affinity Regulating Kinase 2) is a Protein Coding gene. Diseases associated with MARK2 include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Neuroscience and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is MARK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 14976552 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | 24522549 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 23666762 |
GO:0005739 | mitochondrion | NAS | 24522549 |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005884 | actin filament | IDA | 23902687 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytoskeletal Signaling | ||
2 | Glucose / Energy Metabolism | ||
3 | Neuroscience | ||
4 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
|
5 | LKB1 signaling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0000422 | autophagy of mitochondrion | NAS | 24522549 |
GO:0001764 | neuron migration | ISS | -- |
GO:0006468 | protein phosphorylation | IEA,NAS | 8274451 |
GO:0007275 | multicellular organism development | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | ||||||||||||
SP3: | - | - | - | ||||||||||
SP4: | - | - | |||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | - | - | - | ||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MARK2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MARK2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MARK2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MARK2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mark2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mark2 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | MARK2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mark2 30 |
|
||
Str.11090 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | mark2a 31 |
|
OneToMany | |
mark2b 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | par-1 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | par-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
691445 | Uncertain Significance: Pyloric stenosis; Esophageal atresia | 63,904,997(+) | G/C | MISSENSE_VARIANT | |
711552 | Benign: not provided | 63,902,743(+) | C/A | SYNONYMOUS_VARIANT | |
717350 | Benign: not provided | 63,900,815(+) | C/T | SYNONYMOUS_VARIANT | |
734662 | Likely Benign: not provided | 63,895,154(+) | C/T | INTRON_VARIANT | |
758696 | Likely Benign: not provided | 63,900,573(+) | G/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660413 | CNV | deletion | 23128226 |
esv2671472 | CNV | deletion | 23128226 |
esv3626654 | CNV | loss | 21293372 |
nsv1127197 | CNV | deletion | 24896259 |
nsv1134138 | CNV | deletion | 24896259 |
nsv1145540 | CNV | deletion | 24896259 |
nsv555180 | CNV | loss | 21841781 |
nsv555181 | CNV | loss | 21841781 |
nsv951009 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
attention deficit-hyperactivity disorder |
|
|