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MARK1 (Microtubule Affinity Regulating Kinase 1) is a Protein Coding gene. Diseases associated with MARK1 include Peutz-Jeghers Syndrome and Autism. Among its related pathways are Glucose / Energy Metabolism and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IEA,IDA | 14976552 |
GO:0001786 | phosphatidylserine binding | IDA | 21145462 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,NAS | 28386764 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,ISS | -- |
GO:0005856 | cytoskeleton | IEA,ISS | -- |
GO:0005886 | plasma membrane | IEA,IDA | 21145462 |
GO:0015630 | microtubule cytoskeleton | TAS | 9108484 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytoskeletal Signaling | ||
2 | Glucose / Energy Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IEA,ISS | -- |
GO:0001764 | neuron migration | IEA,ISS | -- |
GO:0006468 | protein phosphorylation | IEA,IMP | 23666762 |
GO:0007010 | cytoskeleton organization | IEA,ISS | -- |
GO:0010975 | regulation of neuron projection development | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MARK1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
MARK1 30 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | MARK1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MARK1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MARK1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mark1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mark1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MARK1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MARK1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mark1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mark1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | KP78a 32 |
|
|
|
CG15072 32 |
|
|
|||
KP78b 32 |
|
|
|||
par-1 31 32 |
|
OneToMany | |||
CG3105 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | kin-29 32 |
|
|
|
par-1 31 |
|
OneToMany | |||
B0511.4 32 |
|
|
|||
R02C2.1 32 |
|
|
|||
Y38H8A.4 32 |
|
|
|||
F23C8.8 32 |
|
|
|||
DC2.7a 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
738034 | Likely Benign: not provided | 220,618,363(+) | T/C | SYNONYMOUS_VARIANT | |
756166 | Likely Benign: not provided | 220,635,855(+) | T/C | SYNONYMOUS_VARIANT | |
779300 | Likely Benign: not provided | 220,618,528(+) | C/T | SYNONYMOUS_VARIANT | |
784970 | Benign: not provided | 220,652,035(+) | G/C | MISSENSE_VARIANT | |
VAR_040760 | A gastric adenocarcinoma sample | p.Tyr233Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2470287 | CNV | insertion | 19546169 |
nsv508061 | OTHER | sequence alteration | 20534489 |
Disorder | Aliases | PubMed IDs |
---|---|---|
peutz-jeghers syndrome |
|
|
autism |
|
|
camptodactyly-tall stature-scoliosis-hearing loss syndrome |
|
|
alzheimer disease |
|
|