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Aliases for MARK1 Gene
Aliases for MARK1 Gene
External Ids for MARK1 Gene
- HGNC: 6896
- Entrez Gene: 4139
- Ensembl: ENSG00000116141
- OMIM: 606511
- UniProtKB: Q9P0L2
Previous GeneCards Identifiers for MARK1 Gene
- GC01P219297
- GC01P216545
- GC01P217248
- GC01P217758
- GC01P217757
- GC01P217089
- GC01P218768
- GC01P220701
- GC01P191375
Summaries for MARK1 Gene
GeneCards Summary for MARK1 Gene
MARK1 (Microtubule Affinity Regulating Kinase 1) is a Protein Coding gene. Diseases associated with MARK1 include Peutz-Jeghers Syndrome and Autism. Among its related pathways are Glucose / Energy Metabolism and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.
UniProtKB/Swiss-Prot Summary for MARK1 Gene
-
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Additional gene information for MARK1 Gene
- HGNC(6896)
- Entrez Gene(4139)
- Ensembl(ENSG00000116141)
- OMIM(606511)
- UniProtKB(Q9P0L2)
- Open Targets Platform(ENSG00000116141)
- Search for MARK1 at DataMed
- Search for MARK1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARK1 Gene
Genomics for MARK1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MARK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MARK1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARK1
- Top Transcription factor binding sites by QIAGEN in the MARK1 gene promoter:
-
- aMEF-2
- AP-1
- ARP-1
- ATF-2
- c-Jun
- IRF-1
- MEF-2A
- MyoD
- p300
Genomic Locations for MARK1 Gene
Genomic Locations for MARK1 Gene
- chr1:220,528,136-220,664,461
- (GRCh38/hg38)
- Size:
- 136,326 bases
- Orientation:
- Plus strand
- chr1:220,701,568-220,837,803
- (GRCh37/hg19)
- Size:
- 136,236 bases
- Orientation:
- Plus strand
Genomic View for MARK1 Gene
Genes around MARK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by HGNC
- 1q41 by Entrez Gene
- 1q41 by Ensembl
MARK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MARK1 Gene
Proteins for MARK1 Gene
-
Protein details for MARK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P0L2-MARK1_HUMAN
- Recommended name:
- Serine/threonine-protein kinase MARK1
- Protein Accession:
- Q9P0L2
- D3DTB0
- D3DTB1
- Q2HIY1
- Q5VTF9
- Q5VTG0
- Q96SW9
- Q9P251
Protein attributes for MARK1 Gene
- Size:
- 795 amino acids
- Molecular mass:
- 89003 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with MAPT/TAU.
- SequenceCaution:
-
- Sequence=BAA96001.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55152.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Phosphorylation of MAPT/tau by MARK1 could play a role in early steps of Alzheimer disease. Pathological aggregation of MAPT/tau to neurofibrillary tangles, filamentous structures consisting of paired helical filaments (PHFs), is one of the hallmarks of Alzheimer disease. Hyperphosphorylation by MARK1 could be the initial step for this abnormal aggregation of tau in Alzheimer disease and animal models of tauopathy (PubMed:11089574).
Protein Expression for MARK1 Gene
Selected DME Specific Peptides for MARK1 Gene
- Q9P0L2:
-
- SLQKLFREVRIMK
- LTGREVA
- TIGKGNFA
- GPEVDVWS
- VQWEMEVCKLPRLSLNGVRFKRISGTS
- LVAHGRM
- KIIDKTQL
- YNGPPASPS
- RRNTYVC
- FRQIVSA
- EYASGGE
- FAKVKLA
- RPSSDLNNST
- WSLGVILY
- RQIVSAV
- NLKELRERVLRGKYR
- GEVFDYLV
- DFGFSNEFT
- WSLGVILYTLVSGSLPFDG
- GHEEEELKP
- LNHPNIVKLFEVIETEKTLYL
- GSPPYAAPE
- LVLNPIKRG
- DEQPHIGNYRL
- REIRKVLDAN
- NHPNIVKL
- IVHRDLK
Post-translational modifications for MARK1 Gene
- Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MARK1 Gene
Antibody Products
- NSJ Bioreagents MARK1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MARK1
- Novus Biologicals Antibodies for MARK1
-
Abcam antibodies for MARK1
- Invitrogen Antibodies for MARK1 (AFLGC-MARK1)
-
Boster Bio Antibodies for MARK1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MARK1
- Origene Custom Protein Services for MARK1
- Novus Biologicals proteins for MARK1
- antibodies-online: Show 7 available MARK1 Proteins ranked by validation data
- Compare Top MARK1 Proteins
-
Quality Products:
-
Signalway Proteins for MARK1
Assay Products
- antibodies-online: Show 6 available MARK1 Elisa Kits ranked by validation data
- Compare Top MARK1 Elisa Kits
-
Quality Products:
Domains & Families for MARK1 Gene
Gene Families for MARK1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MARK1 Gene
- InterPro:
- Blocks:
-
- Ubiquitin-associated domain
- Kinase-associated, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for MARK1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58728, highly similar to Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (B4DIB3_HUMAN)
- MAP/microtubule affinity-regulating kinase 1 (MARK1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9P0L2UniProtKB/Swiss-Prot:
MARK1_HUMAN :- The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity).
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
- Domain:
-
- The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity).
- The KA1 domain mediates binding to phospholipids and targeting to membranes. Binds phosphatidic acid (PA), phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Function for MARK1 Gene
Molecular function for MARK1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA-COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by phosphorylation at Ser-219 (By similarity). Activated by phosphorylation on Thr-215.
Enzyme Numbers (IUBMB) for MARK1 Gene
Phenotypes From GWAS Catalog for MARK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IEA,IDA | 14976552 |
| GO:0001786 | phosphatidylserine binding | IDA | 21145462 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,NAS | 28386764 |
Phenotypes for MARK1 Gene
- MGI mutant phenotypes for MARK1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MARK1:
-
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in ovarian lineage
- Increased homologous recombination repair frequency
- Synthetic lethal with gemcitabine
- Decreased viability with paclitaxel
- Increased HPV16-GFP infection
Animal Model Products
-
Taconic Biosciences Mouse Models for MARK1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MARK1 - Select products 50% OFF >
- * MARK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MARK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MARK1
miRNA for MARK1 Gene
- miRTarBase miRNAs that target MARK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MARK1
- Browse OriGene Inhibitory RNA Products For MARK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK1
Clone Products
- Applied Biological Materials (abm): Clones for MARK1 - Select products 50% OFF >
- * MARK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MARK1
- Addgene plasmids for MARK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARK1 Gene
Localization for MARK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MARK1 Gene
- Cell membrane. Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite. Note=Appears to localize to an intracellular network. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 4 |
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0005856 | cytoskeleton | IEA,ISS | -- |
| GO:0005886 | plasma membrane | IEA,IDA | 21145462 |
| GO:0015630 | microtubule cytoskeleton | TAS | 9108484 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MARK1 Gene
Pathways & Interactions for MARK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytoskeletal Signaling | ||
| 2 | Glucose / Energy Metabolism | ||
Pathways by source for MARK1 Gene
2 Cell Signaling Technology pathways for MARK1 Gene
Interacting Proteins for MARK1 Gene
Selected Interacting proteins:
Q9P0L2-MARK1_HUMAN
ENSP00000483424
for MARK1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MARK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IEA,ISS | -- |
| GO:0001764 | neuron migration | IEA,ISS | -- |
| GO:0006468 | protein phosphorylation | IEA,IMP | 23666762 |
| GO:0007010 | cytoskeleton organization | IEA,ISS | -- |
| GO:0010975 | regulation of neuron projection development | IEA,ISS | -- |
Drugs & Compounds for MARK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for MARK1 Gene
mRNA/cDNA for MARK1 Gene
- 5 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366917 5370 nts (view in UCSC)
- ENST00000366918 5169 nts (view in UCSC)
- ENST00000402574 5273 nts (view in UCSC)
- ENST00000485104 270 nts (view in UCSC)
- ENST00000611084 5321 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MARK1 - Select products 50% OFF >
- * MARK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MARK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MARK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MARK1
- Browse OriGene Inhibitory RNA Products For MARK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK1
Clone Products
- Applied Biological Materials (abm): Clones for MARK1 - Select products 50% OFF >
- * MARK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MARK1
- Addgene plasmids for MARK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for MARK1 Gene
- GeneLoc Exon Structure for
- MARK1
Expression for MARK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
This gene is overexpressed in Lung (46.4) and Fetal Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARK1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARK1
SOURCE GeneReport for Unigene cluster for MARK1 Gene:
Hs.497806mRNA Expression by UniProt/SwissProt for MARK1 Gene:
Q9P0L2-MARK1_HUMAN
Tissue specificity:
Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Evidence on tissue expression from TISSUES for MARK1 Gene
- Nervous system(3.9)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for MARK1
-
OriGene qPCR primer pairs and template standards for MARK1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARK1 Gene
Orthologs for MARK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MARK1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| MARK1 30 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | MARK1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MARK1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MARK1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mark1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mark1 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MARK1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MARK1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mark1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mark1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | KP78a 32 |
|
|
|
| CG15072 32 |
|
|
|||
| KP78b 32 |
|
|
|||
| par-1 31 32 |
|
OneToMany | |||
| CG3105 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | kin-29 32 |
|
|
|
| par-1 31 |
|
OneToMany | |||
| B0511.4 32 |
|
|
|||
| R02C2.1 32 |
|
|
|||
| Y38H8A.4 32 |
|
|
|||
| F23C8.8 32 |
|
|
|||
| DC2.7a 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MARK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MARK1 Gene
- ENSEMBL:
- Gene Tree for MARK1 (if available)
- TreeFam:
- Gene Tree for MARK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MARK1: view image
Paralogs for MARK1 Gene
(55) SIMAP similar genes for MARK1 Gene using alignment to 2 proteins:
- MARK1_HUMAN
- B4DIB3_HUMAN
- DKFZp547M202
- MARK4
- MARK2
- KIAA0999
- Par1b
- SIK3
- MARK3
- PRKAA2
- NUAK1
- PRKAA1
- NUAK2
- TSSK3
- PRKACA
- PRKACB
- TSSK2
- TSSK1B
- TSSK1
- RPS6KA2
- KIN27
- CAMK2B
- CAMK1G
- AURKC
- AURKA
- TSSK6
- STK17A
- NIM1K
- DKFZp564L2416
- STK11
- PRKY
- PNCK
- CAMK1D
- TSSK4
- RPS6KA3
- PRKX
- PRKACG
- PHKG1
- SIK1
- DAPK2
- CAMK1
- AURKB
- PIM2
- NEK6
- PkB-like 1
- PSKH1
- MYO3A
- CDK4
- CAMK2D
- SGK2
- PAK4
- CDK2
- CCRK
- PSKH2
- PIM3
- TRIB1
- Nbla00650
Variants for MARK1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARK1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 738034 | Likely Benign: not provided | 220,618,363(+) | T/C | SYNONYMOUS_VARIANT | |
| 756166 | Likely Benign: not provided | 220,635,855(+) | T/C | SYNONYMOUS_VARIANT | |
| 779300 | Likely Benign: not provided | 220,618,528(+) | C/T | SYNONYMOUS_VARIANT | |
| 784970 | Benign: not provided | 220,652,035(+) | G/C | MISSENSE_VARIANT | |
| VAR_040760 | A gastric adenocarcinoma sample | p.Tyr233Cys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2470287 | CNV | insertion | 19546169 |
| nsv508061 | OTHER | sequence alteration | 20534489 |
Residual Variation Intolerance Score:
9.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.43;
71.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MARK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MARK1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK1 Gene
Disorders for MARK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| peutz-jeghers syndrome |
|
|
| autism |
|
|
| camptodactyly-tall stature-scoliosis-hearing loss syndrome |
|
|
| alzheimer disease |
|
|
Search MARK1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MARK1_HUMAN- Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
Additional Disease Information for MARK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MARK1 Gene
Publications for MARK1 Gene
- Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. (PMID: 18492799) Maussion G … Simonneau M (Human molecular genetics 2008) 3 4 23 41
- MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PMID: 9108484) Drewes G … Mandelkow E (Cell 1997) 2 3 4
- Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. (PMID: 23666762) Gu GJ … Kamali-Moghaddam M (Neuromolecular medicine 2013) 3 4
- Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. (PMID: 21145462) Moravcevic K … Lemmon MA (Cell 2010) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for MARK1 Gene
- Custom Antibody ServicesOriGene Antibodies for MARK1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- OriGene qPCR primer pairs and template standards for MARK1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MARK1
- Sino Biological Human cDNA Clone for MARK1
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- Novus Biologicals proteins for MARK1
- Browse Antibodies
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- Taconic Biosciences Mouse Models for MARK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MARK1 (AFLGC-MARK1)
- VectorBuilder Custom and pre-made DNA vectors for MARK1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MARK1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MARK1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MARK1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MARK1
- Addgene plasmids for MARK1
- antibodies-online: Show 45 available MARK1 Antibodies ranked by validation data
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- antibodies-online: Show 6 available MARK1 Elisa Kits ranked by validation data
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- Quality Products:
- Horizon Cell Lines for MARK1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MARK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MARK1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MARK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARK1
- Boster Bio Antibodies for MARK1
- Browse Boster Bio ELISA Kits
- Signalway Proteins for MARK1
Sources for MARK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
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- (64) Proteopedia
- (65) MOPED
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (90) CYP
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- (104) diseasecard
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- (115) NCBI Bookshelf
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- (156) Mastermind
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- (178) MirGeneDB