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Aliases for MARCO Gene

Aliases for MARCO Gene

  • Macrophage Receptor With Collagenous Structure 2 3 4 5
  • Scavenger Receptor Class A, Member 2 2 3
  • SCARA2 3 4
  • Scavenger Receptor Class A Member 2 4
  • Macrophage Receptor MARCO 3
  • SR-A6 3

External Ids for MARCO Gene

Previous GeneCards Identifiers for MARCO Gene

  • GC02P116905
  • GC02P117620
  • GC02P119606
  • GC02P119794
  • GC02P119415
  • GC02P112024

Summaries for MARCO Gene

Entrez Gene Summary for MARCO Gene

  • The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCO Gene

MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include Igg4-Related Disease and Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Phagocytosis of Microbes and Phagosome. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is MSR1.

UniProtKB/Swiss-Prot for MARCO Gene

  • Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Gene Wiki entry for MARCO Gene

Additional gene information for MARCO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCO Gene

Genomics for MARCO Gene

GeneHancer (GH) Regulatory Elements for MARCO Gene

Promoters and enhancers for MARCO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I118940 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 560 -1.6 -1565 1.2 POLR2A SPI1 MARCO DBI EN1
GH02I118942 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.0 11 0.1 MARCO LOC105373580
GH02I118970 Enhancer 0.8 Ensembl ENCODE dbSUPER 20.4 +29.1 29114 1.7 KLF1 JUND POLR2A MARCO LOC105373580 C1QL2
GH02I118912 Enhancer 0.8 ENCODE dbSUPER 20 -28.3 -28317 1.8 MEIS2 JUND POLR2A ZNF512 STAT3 CEBPB CEBPG EP300 MARCO EN1
GH02I118954 Enhancer 0.8 Ensembl ENCODE dbSUPER 19.4 +12.6 12557 0.9 NFE2 FOS LOC105373580 MARCO C1QL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCO gene promoter:

Genomic Locations for MARCO Gene

Genomic Locations for MARCO Gene
52,499 bases
Plus strand

Genomic View for MARCO Gene

Genes around MARCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCO Gene

Proteins for MARCO Gene

  • Protein details for MARCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Macrophage receptor MARCO
    Protein Accession:
    Secondary Accessions:
    • B4DW79
    • Q9Y5S3

    Protein attributes for MARCO Gene

    520 amino acids
    Molecular mass:
    52658 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.

    Alternative splice isoforms for MARCO Gene


neXtProt entry for MARCO Gene

Post-translational modifications for MARCO Gene

Other Protein References for MARCO Gene

No data available for DME Specific Peptides for MARCO Gene

Domains & Families for MARCO Gene

Gene Families for MARCO Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MARCO: view

No data available for UniProtKB/Swiss-Prot for MARCO Gene

Function for MARCO Gene

Molecular function for MARCO Gene

GENATLAS Biochemistry:
macrophage receptor with collagenous structure,constitutively expressed in macrophages of spleen and lymph nodes and in other tissues following systemic,bacterial infection
UniProtKB/Swiss-Prot Function:
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Phenotypes From GWAS Catalog for MARCO Gene

Gene Ontology (GO) - Molecular Function for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding ISS --
GO:0001664 G-protein coupled receptor binding ISS --
GO:0004888 transmembrane signaling receptor activity TAS 10331948
GO:0005044 scavenger receptor activity IEA --
GO:0008329 signaling pattern recognition receptor activity TAS 10331948
genes like me logo Genes that share ontologies with MARCO: view
genes like me logo Genes that share phenotypes with MARCO: view

Animal Models for MARCO Gene

MGI Knock Outs for MARCO:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MARCO Gene

Localization for MARCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCO Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCO gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005622 intracellular ISS --
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS 9468508
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MARCO: view

Pathways & Interactions for MARCO Gene

genes like me logo Genes that share pathways with MARCO: view

Pathways by source for MARCO Gene

1 R&D Systems pathway for MARCO Gene
1 Qiagen pathway for MARCO Gene

SIGNOR curated interactions for MARCO Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with MARCO: view

Drugs & Compounds for MARCO Gene

(2) Drugs for MARCO Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Silica Approved Pharma Target 0
Titanium dioxide Approved Pharma Target 39

(2) Additional Compounds for MARCO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCO: view

Transcripts for MARCO Gene

Unigene Clusters for MARCO Gene

Macrophage receptor with collagenous structure:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCO Gene

No ASD Table

Relevant External Links for MARCO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCO Gene

This gene is overexpressed in Lung (x9.0), Whole Blood (x6.8), Spleen (x6.6), and Liver (x4.1).

Protein differential expression in normal tissues from HIPED for MARCO Gene

This gene is overexpressed in Urine (34.9), Plasma (10.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCO Gene

NURSA nuclear receptor signaling pathways regulating expression of MARCO Gene:


SOURCE GeneReport for Unigene cluster for MARCO Gene:


mRNA Expression by UniProt/SwissProt for MARCO Gene:

Tissue specificity: Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).

Evidence on tissue expression from TISSUES for MARCO Gene

  • Lung(4.5)
  • Liver(4.3)
  • Bone marrow(4.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with MARCO: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCO Gene

Orthologs for MARCO Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCO 33 34
  • 98.46 (n)
(Canis familiaris)
Mammalia MARCO 33 34
  • 79.87 (n)
(Mus musculus)
Mammalia Marco 33 16 34
  • 74.64 (n)
(Rattus norvegicus)
Mammalia Marco 33
  • 74.32 (n)
(Bos Taurus)
Mammalia MARCO 34
  • 54 (a)
(Monodelphis domestica)
Mammalia MARCO 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia MARCO 34
  • 46 (a)
(Gallus gallus)
Aves MARCO 33 34
  • 53.87 (n)
(Anolis carolinensis)
Reptilia MARCO 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492872 33
  • 58.38 (n)
(Danio rerio)
Actinopterygii LOC571584 33
  • 46.57 (n)
marco 34
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for MARCO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCO Gene

Gene Tree for MARCO (if available)
Gene Tree for MARCO (if available)

Paralogs for MARCO Gene

Paralogs for MARCO Gene

genes like me logo Genes that share paralogs with MARCO: view

Variants for MARCO Gene

Sequence variations from dbSNP and Humsavar for MARCO Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000014732 -- 118,956,381(+) G/T intron_variant
rs1000076074 -- 118,962,262(+) G/T intron_variant
rs1000128176 -- 118,962,032(+) C/T intron_variant
rs1000152272 -- 118,951,189(+) C/T intron_variant
rs1000153657 -- 118,990,139(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCO Gene

Variant ID Type Subtype PubMed ID
nsv582784 CNV gain 21841781
nsv582783 CNV gain 21841781
nsv528763 CNV loss 19592680
nsv527208 CNV loss 19592680
nsv522323 CNV loss 19592680
nsv459119 CNV gain 19166990
esv3592163 CNV loss 21293372
esv3560020 CNV deletion 23714750
esv3017674 CNV deletion 24192839
esv2720623 CNV deletion 23290073
esv2720622 CNV deletion 23290073
esv2660693 CNV deletion 23128226
esv2544799 CNV deletion 19546169
esv2380956 CNV deletion 18987734

Variation tolerance for MARCO Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCO Gene

Disorders for MARCO Gene

MalaCards: The human disease database

(2) MalaCards diseases for MARCO Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
igg4-related disease
  • hyper-igg4 disease
syndromic x-linked intellectual disability snyder type
  • mental retardation, x-linked, snyder-robinson type
- elite association - COSMIC cancer census association via MalaCards
Search MARCO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MARCO

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MARCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCO Gene

Publications for MARCO Gene

  1. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (PMID: 10331948) Kangas M … Tryggvason K (Genomics 1999) 2 3 4 22 58
  2. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. (PMID: 9468508) Elomaa O … Tryggvason K (The Journal of biological chemistry 1998) 2 3 4 22 58
  3. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. (PMID: 20141570) Brandenburg LO … Pufe T (Journal of neurochemistry 2010) 3 22 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. (PMID: 19403625) Wright AK … Ziegler-Heitbrock L (Journal of leukocyte biology 2009) 3 22 58

Products for MARCO Gene

Sources for MARCO Gene

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