The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spac... See more...

Aliases for MARCO Gene

Aliases for MARCO Gene

  • Macrophage Receptor With Collagenous Structure 2 3 4 5
  • SCARA2 2 3 4
  • Scavenger Receptor Class A, Member 2 2 3
  • Macrophage Receptor MARCO 3 4
  • SR-A6 2 3
  • Scavenger Receptor Class A Member 2 4
  • MARCO 5

External Ids for MARCO Gene

Previous GeneCards Identifiers for MARCO Gene

  • GC02P116905
  • GC02P117620
  • GC02P119606
  • GC02P119794
  • GC02P119415
  • GC02P112024

Summaries for MARCO Gene

Entrez Gene Summary for MARCO Gene

  • The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCO Gene

MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include Igg4-Related Disease and Bacterial Pneumonia. Among its related pathways are A-beta Pathways: Uptake and Degradation and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is MSR1.

UniProtKB/Swiss-Prot Summary for MARCO Gene

  • Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Gene Wiki entry for MARCO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARCO Gene

Genomics for MARCO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MARCO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J118941 Promoter/Enhancer 0.9 FANTOM5 Ensembl dbSUPER 259.9 -1.5 -1450 0.5 SPI1 POLR2A MARCO DBI piR-45012-289 EN1
GH02J118942 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.7 0.0 -3 0.1 MARCO piR-45012-289 EN1
GH02J118940 Enhancer 0.4 FANTOM5 dbSUPER 257.2 -2.0 -1991 0.2 MARCO DBI piR-45012-289 EN1
GH02J118968 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +29.0 29021 9.6 CEBPB JUND CTCF SPI1 POLR2A ATF2 KLF1 FOS MNT SCRT2 ENSG00000259094 MARCO DBI HSALNG0018296 piR-53029-059 C1QL2
GH02J118912 Enhancer 0.8 Ensembl ENCODE dbSUPER 20 -28.2 -28179 2.8 CEBPB EP300 STAT3 JUND POLR2A MEIS2 ZNF512 MARCO piR-45012-289 EN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARCO

Top Transcription factor binding sites by QIAGEN in the MARCO gene promoter:
  • aMEF-2
  • ARP-1
  • CUTL1
  • MEF-2A
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a
  • Sox9
  • ZID

Genomic Locations for MARCO Gene

Latest Assembly
chr2:118,942,180-118,994,664
(GRCh38/hg38)
Size:
52,485 bases
Orientation:
Plus strand

Previous Assembly
chr2:119,699,770-119,752,236
(GRCh37/hg19 by Entrez Gene)
Size:
52,467 bases
Orientation:
Plus strand

chr2:119,699,742-119,752,236
(GRCh37/hg19 by Ensembl)
Size:
52,495 bases
Orientation:
Plus strand

Genomic View for MARCO Gene

Genes around MARCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCO Gene

Proteins for MARCO Gene

  • Protein details for MARCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEW3-MARCO_HUMAN
    Recommended name:
    Macrophage receptor MARCO
    Protein Accession:
    Q9UEW3
    Secondary Accessions:
    • B4DW79
    • Q9Y5S3

    Protein attributes for MARCO Gene

    Size:
    520 amino acids
    Molecular mass:
    52658 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.

    Alternative splice isoforms for MARCO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCO Gene

Post-translational modifications for MARCO Gene

  • N-glycosylated.
  • Glycosylation at Asn83 and Asn136
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • MARCO_HUMAN (1957)

Other Protein References for MARCO Gene

No data available for DME Specific Peptides for MARCO Gene

Domains & Families for MARCO Gene

Gene Families for MARCO Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCO Gene

InterPro:
Blocks:
  • Collagen triple helix repeat
  • Collagen helix repeat
  • Speract/scavenger receptor

Suggested Antigen Peptide Sequences for MARCO Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51344, highly similar to Macrophage receptor MARCO (B4DW79_HUMAN)
  • Scavenger receptor class A member 2 (MARCO_HUMAN)
  • cDNA, FLJ93629, Homo sapiens macrophage receptor with collagenous structure(MARCO), mRNA (Q4ZG40_HUMAN)
genes like me logo Genes that share domains with MARCO: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MARCO Gene

Function for MARCO Gene

Molecular function for MARCO Gene

UniProtKB/Swiss-Prot Function:
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).
GENATLAS Biochemistry:
macrophage receptor with collagenous structure,constitutively expressed in macrophages of spleen and lymph nodes and in other tissues following systemic,bacterial infection

Phenotypes From GWAS Catalog for MARCO Gene

Gene Ontology (GO) - Molecular Function for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IEA,ISS --
GO:0001664 G protein-coupled receptor binding ISS --
GO:0004888 transmembrane signaling receptor activity TAS 10331948
GO:0005044 scavenger receptor activity IEA --
GO:0038024 cargo receptor activity IEA,ISS --
genes like me logo Genes that share ontologies with MARCO: view
genes like me logo Genes that share phenotypes with MARCO: view

Animal Models for MARCO Gene

MGI Knock Outs for MARCO:

Animal Models for research

  • Taconic Biosciences Mouse Models for MARCO

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARCO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MARCO Gene

Localization for MARCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCO Gene

Cell membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCO gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005622 intracellular IBA 21873635
GO:0005737 cytoplasm IEA,ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9468508
genes like me logo Genes that share ontologies with MARCO: view

Pathways & Interactions for MARCO Gene

genes like me logo Genes that share pathways with MARCO: view

Pathways by source for MARCO Gene

1 R&D Systems pathway for MARCO Gene
1 Qiagen pathway for MARCO Gene
  • Phagocytosis of Microbes

SIGNOR curated interactions for MARCO Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA,IBA 21873635
GO:0006898 receptor-mediated endocytosis IEA,TAS --
GO:0006911 phagocytosis, engulfment IEA,ISS --
genes like me logo Genes that share ontologies with MARCO: view

Drugs & Compounds for MARCO Gene

(2) Drugs for MARCO Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Silica Approved Pharma Target 0
Titanium dioxide Approved Pharma Target 69

(2) Additional Compounds for MARCO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCO: view

Transcripts for MARCO Gene

mRNA/cDNA for MARCO Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARCO

Alternative Splicing Database (ASD) splice patterns (SP) for MARCO Gene

No ASD Table

Relevant External Links for MARCO Gene

GeneLoc Exon Structure for
MARCO

Expression for MARCO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCO Gene

This gene is overexpressed in Lung (x9.0), Whole Blood (x6.8), Spleen (x6.6), and Liver (x4.1).

Protein differential expression in normal tissues from HIPED for MARCO Gene

This gene is overexpressed in Urine (34.9), Plasma (10.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MARCO Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARCO

SOURCE GeneReport for Unigene cluster for MARCO Gene:

Hs.67726

mRNA Expression by UniProt/SwissProt for MARCO Gene:

Q9UEW3-MARCO_HUMAN
Tissue specificity: Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).

Evidence on tissue expression from TISSUES for MARCO Gene

  • Lung(4.5)
  • Liver(4.5)
  • Bone marrow(4.3)
  • Spleen(2.5)
  • Intestine(2.4)
  • Heart(2.4)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with MARCO: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCO Gene

Orthologs for MARCO Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCO Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MARCO 29 30
  • 98.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MARCO 29 30
  • 79.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Marco 29 16 30
  • 74.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Marco 29
  • 74.32 (n)
Cow
(Bos Taurus)
Mammalia MARCO 30
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MARCO 30
  • 46 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MARCO 30
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MARCO 29 30
  • 53.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MARCO 30
  • 35 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492872 29
  • 58.38 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571584 29
  • 46.57 (n)
marco 30
  • 41 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
OneToMany
Species where no ortholog for MARCO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MARCO Gene

ENSEMBL:
Gene Tree for MARCO (if available)
TreeFam:
Gene Tree for MARCO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCO: view image
Alliance of Genome Resources:
Additional Orthologs for MARCO

Paralogs for MARCO Gene

Paralogs for MARCO Gene

(18) SIMAP similar genes for MARCO Gene using alignment to 4 proteins:

  • MARCO_HUMAN
  • B4DW79_HUMAN
  • C9JKT8_HUMAN
  • Q4ZG40_HUMAN
genes like me logo Genes that share paralogs with MARCO: view

Variants for MARCO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARCO Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs147872741 Benign: not provided 118,982,178(+) T/C
NM_006770.3(MARCO):c.924T>C (p.Val308=)
SYNONYMOUS
rs757193219 Likely Benign: not provided 118,970,331(+) G/A
NM_006770.3(MARCO):c.417G>A (p.Gln139=)
SYNONYMOUS
rs80217020 Likely Benign: not provided 118,942,330(+) C/T
NM_006770.3(MARCO):c.30C>T (p.Asp10=)
SYNONYMOUS
rs6761637 -- p.Phe282Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MARCO Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MARCO Gene

Variant ID Type Subtype PubMed ID
esv2380956 CNV deletion 18987734
esv2544799 CNV deletion 19546169
esv2660693 CNV deletion 23128226
esv2720622 CNV deletion 23290073
esv2720623 CNV deletion 23290073
esv3017674 CNV deletion 24192839
esv3560020 CNV deletion 23714750
esv3592163 CNV loss 21293372
nsv459119 CNV gain 19166990
nsv522323 CNV loss 19592680
nsv527208 CNV loss 19592680
nsv528763 CNV loss 19592680
nsv582783 CNV gain 21841781
nsv582784 CNV gain 21841781

Variation tolerance for MARCO Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCO
Leiden Open Variation Database (LOVD)
MARCO

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCO Gene

Disorders for MARCO Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARCO Gene - From: COP and GCD

Disorder Aliases PubMed IDs
igg4-related disease
  • hyper-igg4 disease
bacterial pneumonia
  • gram-negative pneumonia
waterhouse-friderichsen syndrome
  • meningococcal hemorrhagic adrenalitis
- elite association - COSMIC cancer census association via MalaCards
Search MARCO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MARCO

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MARCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCO Gene

Publications for MARCO Gene

  1. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (PMID: 10331948) Kangas M … Tryggvason K (Genomics 1999) 2 3 4 22
  2. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. (PMID: 9468508) Elomaa O … Tryggvason K (The Journal of biological chemistry 1998) 2 3 4 22
  3. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. (PMID: 20141570) Brandenburg LO … Pufe T (Journal of neurochemistry 2010) 3 22
  4. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. (PMID: 19403625) Wright AK … Ziegler-Heitbrock L (Journal of leukocyte biology 2009) 3 22
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 40

Products for MARCO Gene

Sources for MARCO Gene