Aliases for MARCO Gene
External Ids for MARCO Gene
Previous GeneCards Identifiers for MARCO Gene
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
GeneCards Summary for MARCO Gene
MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include Igg4-Related Disease and Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Phagocytosis of Microbes and Phagosome. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is MSR1.
UniProtKB/Swiss-Prot for MARCO Gene
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).