This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on t... See more...

Aliases for MARCKSL1 Gene

Aliases for MARCKSL1 Gene

  • MARCKS Like 1 2 3 5
  • Macrophage Myristoylated Alanine-Rich C Kinase Substrate 3 4
  • MARCKS-Related Protein 3 4
  • MARCKS-Like Protein 1 3 4
  • Mac-MARCKS 3 4
  • MLP 3 4
  • MRP 3 4
  • MARCKS-Like Protein 2
  • MACMARCKS 3
  • MacMARCKS 4
  • MLP1 3
  • F52 3

External Ids for MARCKSL1 Gene

Previous HGNC Symbols for MARCKSL1 Gene

  • MLP

Previous GeneCards Identifiers for MARCKSL1 Gene

  • GC01M032470
  • GC01M032573
  • GC01M032799
  • GC01M030914

Summaries for MARCKSL1 Gene

Entrez Gene Summary for MARCKSL1 Gene

  • This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

GeneCards Summary for MARCKSL1 Gene

MARCKSL1 (MARCKS Like 1) is a Protein Coding gene. Diseases associated with MARCKSL1 include Neural Tube Defects and Anencephaly. Among its related pathways are Toxoplasmosis and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is MARCKS.

UniProtKB/Swiss-Prot Summary for MARCKSL1 Gene

  • Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Gene Wiki entry for MARCKSL1 Gene

Additional gene information for MARCKSL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARCKSL1 Gene

Genomics for MARCKSL1 Gene

GeneHancer (GH) Regulatory Elements for MARCKSL1 Gene

Promoters and enhancers for MARCKSL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCKSL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARCKSL1

Top Transcription factor binding sites by QIAGEN in the MARCKSL1 gene promoter:
  • AP-1
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • ATF-2
  • c-Jun
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MARCKSL1 Gene

Genomic Locations for MARCKSL1 Gene
chr1:32,333,829-32,336,239
(GRCh38/hg38)
Size:
2,411 bases
Orientation:
Minus strand
chr1:32,799,433-32,801,980
(GRCh37/hg19)
Size:
2,548 bases
Orientation:
Minus strand

Genomic View for MARCKSL1 Gene

Genes around MARCKSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCKSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCKSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKSL1 Gene

Proteins for MARCKSL1 Gene

  • Protein details for MARCKSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49006-MRP_HUMAN
    Recommended name:
    MARCKS-related protein
    Protein Accession:
    P49006
    Secondary Accessions:
    • D3DPQ0
    • Q5TEE6
    • Q6NXS5

    Protein attributes for MARCKSL1 Gene

    Size:
    195 amino acids
    Molecular mass:
    19529 Da
    Quaternary structure:
    • Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.

neXtProt entry for MARCKSL1 Gene

Post-translational modifications for MARCKSL1 Gene

  • Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.
  • Ubiquitination at Lys99, Lys106, and Lys110
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCKSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCKSL1 Gene

Domains & Families for MARCKSL1 Gene

Gene Families for MARCKSL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MARCKSL1 Gene

Blocks:
  • Myristoylated alanine-rich C-kinase substrate MARCKS
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MARCKSL1 Gene

GenScript: Design optimal peptide antigens:
  • Macrophage myristoylated alanine-rich C kinase substrate (MRP_HUMAN)
  • Mucin-like protein (Q9UMI9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49006

UniProtKB/Swiss-Prot:

MRP_HUMAN :
  • Belongs to the MARCKS family.
Family:
  • Belongs to the MARCKS family.
genes like me logo Genes that share domains with MARCKSL1: view

Function for MARCKSL1 Gene

Molecular function for MARCKSL1 Gene

UniProtKB/Swiss-Prot Function:
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Phenotypes From GWAS Catalog for MARCKSL1 Gene

Gene Ontology (GO) - Molecular Function for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 24863880
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view
genes like me logo Genes that share phenotypes with MARCKSL1: view

Animal Models for MARCKSL1 Gene

MGI Knock Outs for MARCKSL1:

Animal Model Products

CRISPR Products

miRNA for MARCKSL1 Gene

miRTarBase miRNAs that target MARCKSL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARCKSL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCKSL1 Gene

Localization for MARCKSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity). In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924). {ECO:0000250 UniProtKB:P28667, ECO:0000269 PubMed:22751924}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCKSL1 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 4
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with MARCKSL1: view

Pathways & Interactions for MARCKSL1 Gene

genes like me logo Genes that share pathways with MARCKSL1: view

Pathways by source for MARCKSL1 Gene

2 KEGG pathways for MARCKSL1 Gene
1 Cell Signaling Technology pathway for MARCKSL1 Gene

Gene Ontology (GO) - Biological Process for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view

No data available for SIGNOR curated interactions for MARCKSL1 Gene

Drugs & Compounds for MARCKSL1 Gene

(4) Drugs for MARCKSL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MARCKSL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCKSL1: view

Transcripts for MARCKSL1 Gene

mRNA/cDNA for MARCKSL1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MARCKSL1

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKSL1 Gene

No ASD Table

Relevant External Links for MARCKSL1 Gene

GeneLoc Exon Structure for
MARCKSL1

Expression for MARCKSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARCKSL1 Gene

mRNA differential expression in normal tissues according to GTEx for MARCKSL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.5) and Brain - Substantia nigra (x4.1).

Protein differential expression in normal tissues from HIPED for MARCKSL1 Gene

This gene is overexpressed in Testis (14.9) and Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARCKSL1 Gene



Protein tissue co-expression partners for MARCKSL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARCKSL1

SOURCE GeneReport for Unigene cluster for MARCKSL1 Gene:

Hs.75061

Evidence on tissue expression from TISSUES for MARCKSL1 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(4.2)
  • Intestine(3.5)
  • Skin(3.5)
  • Lung(3.1)
  • Eye(3)
  • Pancreas(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MARCKSL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCKSL1 Gene

Orthologs for MARCKSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCKSL1 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MARCKSL1 31 30
  • 95.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MARCKSL1 31 30
  • 93.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Marcksl1 17 31 30
  • 93.16 (n)
rat
(Rattus norvegicus)
Mammalia Marcksl1 30
  • 92.53 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCKSL1 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCKSL1 31
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCKSL1 31
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii marcksl1b 31
  • 43 (a)
OneToMany
marcksl1a 31
  • 34 (a)
OneToMany
Species where no ortholog for MARCKSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCKSL1 Gene

ENSEMBL:
Gene Tree for MARCKSL1 (if available)
TreeFam:
Gene Tree for MARCKSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCKSL1: view image

Paralogs for MARCKSL1 Gene

Paralogs for MARCKSL1 Gene

Pseudogenes.org Pseudogenes for MARCKSL1 Gene

genes like me logo Genes that share paralogs with MARCKSL1: view

Variants for MARCKSL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARCKSL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711823 Benign: not provided 32,334,639(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
731485 Benign: not provided 32,335,105(-) G/A INTRON_VARIANT
759273 Likely Benign: not provided 32,335,089(-) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MARCKSL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MARCKSL1 Gene

Variant ID Type Subtype PubMed ID
nsv1077308 CNV deletion 25765185
nsv1112529 CNV deletion 24896259

Variation tolerance for MARCKSL1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCKSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCKSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Disorders for MARCKSL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARCKSL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • neural tube defects, susceptibility to
anencephaly
  • anph
akinetic mutism
  • coma vigilans
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCKSL1

genes like me logo Genes that share disorders with MARCKSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCKSL1 Gene

Publications for MARCKSL1 Gene

  1. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. (PMID: 9598313) Stumpo DJ … Blackshear PJ (Genomics 1998) 2 3 23 54
  2. c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells. (PMID: 22751924) Björkblom B … Coffey ET (Molecular and cellular biology 2012) 3 4 54
  3. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. (PMID: 19924305) Finlayson AE … Freeman KW (PloS one 2009) 3 23 54
  4. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells. (PMID: 19246034) Chun KR … Lee WH (Cellular immunology 2009) 3 23 54
  5. Investigation into the mechanism regulating MRP localization. (PMID: 17897642) van den Bout I … Sonnenberg A (Experimental cell research 2008) 3 23 54

Products for MARCKSL1 Gene

Sources for MARCKSL1 Gene