Aliases for MARCKS Gene
External Ids for MARCKS Gene
Previous HGNC Symbols for MARCKS Gene
Previous GeneCards Identifiers for MARCKS Gene
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for MARCKS Gene
MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) is a Protein Coding gene. Diseases associated with MARCKS include Spinocerebellar Ataxia 14 and Anencephaly. Among its related pathways are Integration of energy metabolism and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include calmodulin binding and protein kinase C binding. An important paralog of this gene is MARCKSL1.
UniProtKB/Swiss-Prot Summary for MARCKS Gene
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.