The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell m... See more...

Aliases for MARCKS Gene

Aliases for MARCKS Gene

  • Myristoylated Alanine Rich Protein Kinase C Substrate 2 3 5
  • Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L) 2 3
  • Protein Kinase C Substrate, 80 KDa Protein, Light Chain 3 4
  • Myristoylated Alanine-Rich C-Kinase Substrate 3 4
  • PRKCSL 3 4
  • PKCSL 3 4
  • MACS 3 4
  • Phosphomyristin 3
  • 80K-L Protein 4
  • 80K-L 3

External Ids for MARCKS Gene

Previous HGNC Symbols for MARCKS Gene

  • MACS

Previous GeneCards Identifiers for MARCKS Gene

  • GC06P114013
  • GC06P114201
  • GC06P114224
  • GC06P114285
  • GC06P111756
  • GC06P114179
  • GC06P114189

Summaries for MARCKS Gene

Entrez Gene Summary for MARCKS Gene

  • The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCKS Gene

MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) is a Protein Coding gene. Diseases associated with MARCKS include Spinocerebellar Ataxia 14 and Anencephaly. Among its related pathways are Integration of energy metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include calmodulin binding and protein kinase C binding. An important paralog of this gene is MARCKSL1.

UniProtKB/Swiss-Prot Summary for MARCKS Gene

  • MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Gene Wiki entry for MARCKS Gene

Additional gene information for MARCKS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARCKS Gene

Genomics for MARCKS Gene

GeneHancer (GH) Regulatory Elements for MARCKS Gene

Promoters and enhancers for MARCKS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J113854 Promoter/Enhancer 2.8 UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.1 +0.9 889 8.4 RXRA EP300 ZBTB40 CTCF ZSCAN5C SIN3A NRF1 TCF12 MYC POLR2G MARCKS NONHSAG044655.2 LINC02880 RPS27AP11 HDAC2 MROCKI
GH06J113641 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 15.5 -213.3 -213345 5.4 EP300 FOXK2 ZNF217 SIN3A TCF12 POLR2G SP1 NCOR1 JUND FOS MARCKS LINC02541 lnc-HDAC2-10 lnc-MARCKS-11
GH06J113629 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -224.7 -224654 6.6 SIN3A POLR2G SP1 FOS EP300 POLR2A TRIM28 RELA MEF2C RCOR1 LINC02541 MARCKS lnc-MARCKS-11 lnc-MARCKS-12 lnc-MARCKS-14
GH06J113762 Enhancer 1.1 FANTOM5 Ensembl ENCODE 14.7 -93.4 -93434 5.8 POLR2A RELA EP300 ESRRA FOS CEBPB BATF STAT3 IRF4 POU2F2 MARCKS LINC02880 lnc-HDAC2-8 HSALNG0052915 LINC02541
GH06J113653 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.8 -202.8 -202811 1.7 TCF12 REST EP300 FOXA2 FOS FOSL2 CEBPB JUND SIN3A STAT3 lnc-HDAC2-14 piR-31199-315 MARCKS LINC02541 HSALNG0052906
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCKS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARCKS

Top Transcription factor binding sites by QIAGEN in the MARCKS gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • MyoD
  • YY1

Genomic Locations for MARCKS Gene

Genomic Locations for MARCKS Gene
chr6:113,857,335-113,863,475
(GRCh38/hg38)
Size:
6,141 bases
Orientation:
Plus strand
chr6:114,178,527-114,184,652
(GRCh37/hg19)
Size:
6,126 bases
Orientation:
Plus strand

Genomic View for MARCKS Gene

Genes around MARCKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKS Gene

Proteins for MARCKS Gene

  • Protein details for MARCKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29966-MARCS_HUMAN
    Recommended name:
    Myristoylated alanine-rich C-kinase substrate
    Protein Accession:
    P29966
    Secondary Accessions:
    • E1P560
    • Q2LA83
    • Q5TDB7

    Protein attributes for MARCKS Gene

    Size:
    332 amino acids
    Molecular mass:
    31555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MARCKS Gene

Post-translational modifications for MARCKS Gene

  • Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
  • Ubiquitination at Lys165
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCKS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCKS Gene

Domains & Families for MARCKS Gene

Gene Families for MARCKS Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MARCKS Gene

Blocks:
  • Myristoylated alanine-rich C-kinase substrate MARCKS
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MARCKS Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C substrate, 80 kDa protein, light chain (MARCS_HUMAN)
  • MARCKS protein (Q05C82_HUMAN)
  • MARCKS protein (Q6NVI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P29966

UniProtKB/Swiss-Prot:

MARCS_HUMAN :
  • Belongs to the MARCKS family.
Family:
  • Belongs to the MARCKS family.
genes like me logo Genes that share domains with MARCKS: view

Function for MARCKS Gene

Molecular function for MARCKS Gene

UniProtKB/Swiss-Prot Function:
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Phenotypes From GWAS Catalog for MARCKS Gene

Gene Ontology (GO) - Molecular Function for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005516 calmodulin binding IEA,TAS --
GO:0042802 identical protein binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with MARCKS: view
genes like me logo Genes that share phenotypes with MARCKS: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCKS Gene

Localization for MARCKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKS Gene

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCKS gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 4
cytosol 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with MARCKS: view

Pathways & Interactions for MARCKS Gene

genes like me logo Genes that share pathways with MARCKS: view

Pathways by source for MARCKS Gene

SIGNOR curated interactions for MARCKS Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051017 actin filament bundle assembly IEA --
GO:0051260 protein homooligomerization IEA --
GO:0051764 actin crosslink formation IEA --
genes like me logo Genes that share ontologies with MARCKS: view

Drugs & Compounds for MARCKS Gene

(25) Drugs for MARCKS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for MARCKS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCKS: view

Transcripts for MARCKS Gene

mRNA/cDNA for MARCKS Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKS Gene

No ASD Table

Relevant External Links for MARCKS Gene

GeneLoc Exon Structure for
MARCKS

Expression for MARCKS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARCKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARCKS Gene

This gene is overexpressed in Cerebral cortex (11.3), Lavage (10.1), Frontal cortex (7.5), Fetal Brain (7.2), and Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARCKS Gene



Protein tissue co-expression partners for MARCKS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARCKS

SOURCE GeneReport for Unigene cluster for MARCKS Gene:

Hs.519909

Evidence on tissue expression from TISSUES for MARCKS Gene

  • Nervous system(5)
  • Liver(4.5)
  • Lung(4.2)
  • Skin(3.2)
  • Heart(3.1)
  • Pancreas(3.1)
  • Stomach(3.1)
  • Intestine(3)
  • Muscle(3)
  • Eye(2.9)
  • Kidney(2.7)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with MARCKS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCKS Gene

Orthologs for MARCKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCKS 30
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia MARCKS 30
  • 83.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia marcks-prov 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8766 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10160 30
Species where no ortholog for MARCKS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MARCKS Gene

ENSEMBL:
Gene Tree for MARCKS (if available)
TreeFam:
Gene Tree for MARCKS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCKS: view image

Paralogs for MARCKS Gene

Paralogs for MARCKS Gene

genes like me logo Genes that share paralogs with MARCKS: view

Variants for MARCKS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARCKS Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
724957 Likely Benign: not provided 113,860,030(+) C/T SYNONYMOUS_VARIANT
770556 Benign: not provided 113,860,261(+) G/T MISSENSE_VARIANT
774449 Benign: not provided 113,860,125(+) G/GTGAGGC INFRAME_INSERTION
776147 Benign: not provided 113,860,329(+) C/T MISSENSE_VARIANT
rs1554191995 Uncertain Significance: Inborn genetic diseases 113,860,194(+) CCGAGGCGGGCGCGGC FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for MARCKS Gene

Structural Variations from Database of Genomic Variants (DGV) for MARCKS Gene

Variant ID Type Subtype PubMed ID
nsv1126755 CNV deletion 24896259
nsv482098 CNV loss 20164927
nsv965756 CNV duplication 23825009

Variation tolerance for MARCKS Gene

Gene Damage Index Score: 2.40; 42.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCKS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCKS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKS Gene

Disorders for MARCKS Gene

MalaCards: The human disease database

(7) MalaCards diseases for MARCKS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 14
  • sca14
anencephaly
  • anph
barbiturate dependence
neural tube defects
  • neural tube defects, susceptibility to
small intestine adenocarcinoma
  • adenocarcinoma of small intestine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCKS

genes like me logo Genes that share disorders with MARCKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCKS Gene

Publications for MARCKS Gene

  1. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PMID: 8557118) Palmer RH … Parker PJ (FEBS letters 1996) 3 4 23 54
  2. Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. (PMID: 1396720) Herget T … Rozengurt E (European journal of biochemistry 1992) 3 4 23 54
  3. Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. (PMID: 1427823) Sakai K … Shimizu N (Genomics 1992) 3 4 23 54
  4. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. (PMID: 1860846) Harlan DM … Blackshear PJ (The Journal of biological chemistry 1991) 3 4 23 54
  5. Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway. (PMID: 20047593) Techasen A … Yongvanit P (Cancer science 2010) 3 23 54

Products for MARCKS Gene

Sources for MARCKS Gene