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MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]
MARCHF9 (Membrane Associated Ring-CH-Type Finger 9) is a Protein Coding gene. Diseases associated with MARCHF9 include Pelizaeus-Merzbacher Disease. An important paralog of this gene is MARCHF4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005795 | Golgi stack | IDA | 14722266 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MARCH9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MARCH9 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MARCH9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | March9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | March9 30 31 |
|
OneToOne | |
Marchf9 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | MARCH9 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MARCH9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | march9 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | march9 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17850517 | - | p.Thr307Pro | |||
rs17856312 | - | p.Gln257His |
Disorder | Aliases | PubMed IDs |
---|---|---|
pelizaeus-merzbacher disease |
|
|