This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013] See more...

Aliases for MARCHF3 Gene

Aliases for MARCHF3 Gene

  • Membrane Associated Ring-CH-Type Finger 3 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase MARCH3 3 4
  • Membrane-Associated RING-CH Protein III 3 4
  • E3 Ubiquitin-Protein Ligase MARCH3 3 4
  • RING Finger Protein 173 3 4
  • MARCH-III 3 4
  • MARCH3 3 5
  • RNF173 3 4
  • Membrane-Associated RING Finger Protein 3 4
  • Membrane-Associated Ring Finger (C3HC4) 3 2
  • Membrane Associated Ring Finger 3 3
  • EC 2.3.2.27 4
  • EC 6.3.2 52

External Ids for MARCHF3 Gene

Previous HGNC Symbols for MARCHF3 Gene

  • MARCH3

Summaries for MARCHF3 Gene

Entrez Gene Summary for MARCHF3 Gene

  • This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

GeneCards Summary for MARCHF3 Gene

MARCHF3 (Membrane Associated Ring-CH-Type Finger 3) is a Protein Coding gene. Diseases associated with MARCHF3 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Bardet-Biedl Syndrome 7. An important paralog of this gene is MARCHF2.

UniProtKB/Swiss-Prot Summary for MARCHF3 Gene

  • E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Additional gene information for MARCHF3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARCHF3 Gene

Genomics for MARCHF3 Gene

GeneHancer (GH) Regulatory Elements for MARCHF3 Gene

Promoters and enhancers for MARCHF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J127028 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509 +2.2 2211 3.6 EP300 CTCF SIN3A NRF1 POLR2G SP1 NCOR1 GTF2E2 PHF8 FOS MARCHF3 LOC105379163 lnc-LMNB1-3 piR-56000 CCDC192 C5orf63 piR-57133-492
GH05J127072 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 561.6 -41.1 -41098 2.2 ZBTB40 POLR2G PHF8 ZIC2 POLR2A ZBTB11 GABPA ZBTB26 MYC CTBP1 MARCHF3 C5orf63 ENSG00000279446 lnc-MARCH3-3 lnc-MEGF10-6 PRRC1
GH05J126998 Enhancer 1.2 Ensembl ENCODE dbSUPER 66.4 +33.8 33801 2.4 MYC CTBP1 NCOR1 NFRKB RELA MBD2 ZNF316 NFIC ARNT MAFF MARCHF3 piR-57133-492 lnc-LMNB1-3
GH05J126970 Enhancer 1.2 ENCODE dbSUPER 66 +60.5 60496 3.8 GTF2E2 JUND EP300 REST AFF1 HES1 TOE1 MYC CTBP1 JUN MARCHF3 MEGF10 PHAX C5orf63 piR-57133-492 RF00017-4854
GH05J127009 Enhancer 1.2 Ensembl ENCODE dbSUPER 54.4 +19.5 19501 6.6 ZBTB40 ZSCAN5C JUND FOS EP300 TRIM22 BCL11A ZNF384 CEBPG ARNT MARCHF3 lnc-LMNB1-3 piR-57133-492
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCHF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARCHF3

Genomic Locations for MARCHF3 Gene

Genomic Locations for MARCHF3 Gene
chr5:126,867,714-127,032,402
(GRCh38/hg38)
Size:
164,689 bases
Orientation:
Minus strand
chr5:126,203,406-126,366,500
(GRCh37/hg19)
Size:
163,095 bases
Orientation:
Minus strand

Genomic View for MARCHF3 Gene

Genes around MARCHF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCHF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCHF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCHF3 Gene

Proteins for MARCHF3 Gene

  • Protein details for MARCHF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD3-MARH3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH3
    Protein Accession:
    Q86UD3
    Secondary Accessions:
    • A8K264
    • B9EJE7

    Protein attributes for MARCHF3 Gene

    Size:
    253 amino acids
    Molecular mass:
    28504 Da
    Quaternary structure:
    • Interacts with MARCH2 and STX6.

    Alternative splice isoforms for MARCHF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCHF3 Gene

Selected DME Specific Peptides for MARCHF3 Gene

Q86UD3:
  • WTLVSFRYHC
  • HEKRTLF
  • AKDGQLLSTV
  • WLSSSNTSYCELCH
  • VCFLFITPLA
  • ISGWLCLRGA
  • EWRRTNQ
  • CRICHEG
  • LEAVGLIALT

Post-translational modifications for MARCHF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MARCHF3 Gene

Gene Families for MARCHF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCHF3 Gene

Blocks:
  • Zn-finger, RING
  • RINGv
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86UD3

UniProtKB/Swiss-Prot:

MARH3_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCHF3: view

No data available for Suggested Antigen Peptide Sequences for MARCHF3 Gene

Function for MARCHF3 Gene

Molecular function for MARCHF3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for MARCHF3 Gene

Phenotypes From GWAS Catalog for MARCHF3 Gene

Gene Ontology (GO) - Molecular Function for MARCHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCHF3: view
genes like me logo Genes that share phenotypes with MARCHF3: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCHF3 Gene

Localization for MARCHF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCHF3 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCHF3 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 3
cytosol 2
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARCHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005768 endosome IEA,IDA 14722266
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with MARCHF3: view

Pathways & Interactions for MARCHF3 Gene

PathCards logo

SuperPathways for MARCHF3 Gene

No Data Available

UniProtKB/Swiss-Prot Q86UD3-MARH3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IBA,IEA --
genes like me logo Genes that share ontologies with MARCHF3: view

No data available for Pathways by source and SIGNOR curated interactions for MARCHF3 Gene

Drugs & Compounds for MARCHF3 Gene

(3) Drugs for MARCHF3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for MARCHF3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with MARCHF3: view

Transcripts for MARCHF3 Gene

mRNA/cDNA for MARCHF3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCHF3 Gene

No ASD Table

Relevant External Links for MARCHF3 Gene

GeneLoc Exon Structure for
MARCHF3

Expression for MARCHF3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARCHF3

SOURCE GeneReport for Unigene cluster for MARCHF3 Gene:

Hs.132441

Evidence on tissue expression from TISSUES for MARCHF3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MARCHF3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCHF3 Gene

Orthologs for MARCHF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCHF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH3 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH3 31 30
  • 95.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia March3 30
  • 94.73 (n)
cow
(Bos Taurus)
Mammalia MARCH3 31 30
  • 94.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia March3 31 30
  • 91.55 (n)
OneToOne
Marchf3 17
chicken
(Gallus gallus)
Aves MARCH3 31 30
  • 85.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH3 31
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march3 30
  • 82.2 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158785 31
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 31
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 31
  • 3 (a)
OneToMany
Species where no ortholog for MARCHF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCHF3 Gene

ENSEMBL:
Gene Tree for MARCHF3 (if available)
TreeFam:
Gene Tree for MARCHF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCHF3: view image

Paralogs for MARCHF3 Gene

Paralogs for MARCHF3 Gene

genes like me logo Genes that share paralogs with MARCHF3: view

Variants for MARCHF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARCHF3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs34821177 - p.Arg68Gln

Additional dbSNP identifiers (rs#s) for MARCHF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MARCHF3 Gene

Variant ID Type Subtype PubMed ID
esv3304150 CNV mobile element insertion 20981092
esv3330842 CNV duplication 20981092
esv3358268 CNV insertion 20981092
esv3570411 CNV loss 25503493
esv3606694 CNV loss 21293372
esv3606695 CNV gain 21293372
esv3606698 CNV loss 21293372
nsv1124923 CNV duplication 24896259
nsv1146007 CNV duplication 26484159

Variation tolerance for MARCHF3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCHF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCHF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCHF3 Gene

Disorders for MARCHF3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MARCHF3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MARCHF3: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MARCHF3 Gene

Publications for MARCHF3 Gene

  1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H … Hirose S (Journal of biochemistry 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 54
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 54
  5. Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination. (PMID: 26694610) Fatehchand K … Butchar JP (The Journal of biological chemistry 2016) 3 54

Products for MARCHF3 Gene

Sources for MARCHF3 Gene