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MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
MARCHF2 (Membrane Associated Ring-CH-Type Finger 2) is a Protein Coding gene. Diseases associated with MARCHF2 include Rubeosis Iridis and Cholesterol Embolism. An important paralog of this gene is MARCHF3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA,IDA | 14722266 |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0016567 | protein ubiquitination | IBA,IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MARCH2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MARCH2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MARCH2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | March2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | March2 30 31 |
|
OneToOne | |
Marchf2 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | MARCH2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MARCH2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MARCH2 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | march2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | march2 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4783 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG13442 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | marc-3 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSM4 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1133893 | - | p.Ala54Thr | |||
rs34099346 | - | p.Arg219Pro |
Disorder | Aliases | PubMed IDs |
---|---|---|
rubeosis iridis |
|
|
cholesterol embolism |
|
|