MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010] See more...

Aliases for MARCHF10 Gene

Aliases for MARCHF10 Gene

  • Membrane Associated Ring-CH-Type Finger 10 2 3 5
  • MARCH-X 2 3 4
  • Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase 2 3
  • Probable E3 Ubiquitin-Protein Ligase MARCHF10 3 4
  • RING-Type E3 Ubiquitin Transferase MARCHF10 3 4
  • Membrane-Associated RING Finger Protein 10 3 4
  • Membrane-Associated RING-CH Protein X 3 4
  • Ring Finger Protein 190 2 3
  • MARCH10 3 4
  • RNF190 3 4
  • Testis Secretory Sperm-Binding Protein Li 228n 3
  • Probable E3 Ubiquitin-Protein Ligase MARCH10 3
  • Membrane-Associated Ring Finger (C3HC4) 10 2
  • RING-Type E3 Ubiquitin Transferase MARCH10 3
  • Membrane Associated Ring Finger 10 3
  • RING Finger Protein 190 4
  • EC 2.3.2.27 4
  • MARCHF10 5
  • FLJ35757 2

External Ids for MARCHF10 Gene

Previous HGNC Symbols for MARCHF10 Gene

  • RNF190
  • MARCH10

Summaries for MARCHF10 Gene

Entrez Gene Summary for MARCHF10 Gene

  • MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCHF10 Gene

MARCHF10 (Membrane Associated Ring-CH-Type Finger 10) is a Protein Coding gene. Diseases associated with MARCHF10 include Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly. An important paralog of this gene is MARCHF7.

UniProtKB/Swiss-Prot Summary for MARCHF10 Gene

  • E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MARCHF10 Gene

Genomics for MARCHF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MARCHF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCHF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MARCHF10

Genomic Locations for MARCHF10 Gene

Latest Assembly
chr17:62,701,314-62,808,346
(GRCh38/hg38)
Size:
107,033 bases
Orientation:
Minus strand

Previous Assembly
chr17:60,778,675-60,885,675
(GRCh37/hg19 by Entrez Gene)
Size:
107,001 bases
Orientation:
Minus strand

chr17:60,778,675-60,885,705
(GRCh37/hg19 by Ensembl)
Size:
107,031 bases
Orientation:
Minus strand

Genomic View for MARCHF10 Gene

Genes around MARCHF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCHF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCHF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCHF10 Gene

Proteins for MARCHF10 Gene

  • Protein details for MARCHF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA82-MARHA_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase MARCHF10
    Protein Accession:
    Q8NA82
    Secondary Accessions:
    • D3DU09
    • Q8IYS7
    • Q8N7Z7

    Protein attributes for MARCHF10 Gene

    Size:
    808 amino acids
    Molecular mass:
    90511 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35021.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAC05079.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for MARCHF10 Gene

Post-translational modifications for MARCHF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MARCHF10 Gene

Domains & Families for MARCHF10 Gene

Gene Families for MARCHF10 Gene

Protein Domains for MARCHF10 Gene

InterPro:
Blocks:
  • Zn-finger, RING

Graphical View of Domain Structure for InterPro Entry

Q8NA82

UniProtKB/Swiss-Prot:

MARHA_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCHF10: view

No data available for Suggested Antigen Peptide Sequences for MARCHF10 Gene

Function for MARCHF10 Gene

Molecular function for MARCHF10 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for MARCHF10 Gene

Phenotypes From GWAS Catalog for MARCHF10 Gene

Gene Ontology (GO) - Molecular Function for MARCHF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCHF10: view
genes like me logo Genes that share phenotypes with MARCHF10: view

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MARCHF10 Gene

Localization for MARCHF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCHF10 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCHF10 Gene

Pathways & Interactions for MARCHF10 Gene

PathCards logo

SuperPathways for MARCHF10 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NA82-MARHA_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCHF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCHF10: view

No data available for Pathways by source and SIGNOR curated interactions for MARCHF10 Gene

Drugs & Compounds for MARCHF10 Gene

(3) Drugs for MARCHF10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for MARCHF10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with MARCHF10: view

Transcripts for MARCHF10 Gene

mRNA/cDNA for MARCHF10 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MARCHF10 Gene

No ASD Table

Relevant External Links for MARCHF10 Gene

GeneLoc Exon Structure for
MARCHF10

Expression for MARCHF10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MARCHF10

SOURCE GeneReport for Unigene cluster for MARCHF10 Gene:

Hs.665663

Evidence on tissue expression from TISSUES for MARCHF10 Gene

  • Kidney(2.3)
  • Adrenal gland(2.2)
  • Lung(2.2)
  • Pancreas(2.2)
  • Nervous system(2.2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCHF10 Gene

Orthologs for MARCHF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCHF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MARCH10 29 30
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MARCH10 29 30
  • 84.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MARCH10 29 30
  • 79.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia March10 29 30
  • 74.21 (n)
OneToOne
Marchf10 16
Rat
(Rattus norvegicus)
Mammalia March10 29
  • 73.85 (n)
Oppossum
(Monodelphis domestica)
Mammalia MARCH10 30
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MARCH10 30
  • 24 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MARCH10 30
  • 36 (a)
OneToOne
Species where no ortholog for MARCHF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MARCHF10 Gene

ENSEMBL:
Gene Tree for MARCHF10 (if available)
TreeFam:
Gene Tree for MARCHF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCHF10: view image
Alliance of Genome Resources:
Additional Orthologs for MARCHF10

Paralogs for MARCHF10 Gene

Paralogs for MARCHF10 Gene

genes like me logo Genes that share paralogs with MARCHF10: view

Variants for MARCHF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MARCHF10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
916237 Likely Benign: not provided 62,705,543(-) A/G
NM_152598.4(MARCHF10):c.2367T>C (p.Asn789=)
SYNONYMOUS
916238 Likely Benign: not provided 62,744,505(-) A/G
NM_152598.4(MARCHF10):c.406T>C (p.Leu136=)
SYNONYMOUS
rs16946335 -- p.Glu742Lys
rs17853369 -- p.Gly241Glu
rs9891498 -- p.Phe319Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MARCHF10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MARCHF10 Gene

Variant ID Type Subtype PubMed ID
esv2658945 CNV deletion 23128226
esv2666912 CNV deletion 23128226
esv26867 CNV loss 19812545
nsv1133236 CNV tandem duplication 24896259
nsv2115 CNV insertion 18451855
nsv509665 CNV insertion 20534489
nsv516921 CNV gain+loss 19592680

Variation tolerance for MARCHF10 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCHF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCHF10
Leiden Open Variation Database (LOVD)
MARCHF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCHF10 Gene

Disorders for MARCHF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCHF10 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCHF10

genes like me logo Genes that share disorders with MARCHF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCHF10 Gene

Publications for MARCHF10 Gene

  1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PMID: 17604280) Morokuma Y … Hirose S (The Journal of biological chemistry 2007) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for MARCHF10 Gene

Sources for MARCHF10 Gene