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Aliases for MARCH9 Gene

Aliases for MARCH9 Gene

  • Membrane Associated Ring-CH-Type Finger 9 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 9 2 3
  • Membrane-Associated RING Finger Protein 9 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH9 3 4
  • Membrane-Associated RING-CH Protein IX 3 4
  • RING Finger Protein 179 3 4
  • MARCH-IX 3 4
  • RNF179 3 4
  • E3 Ubiquitin-Protein Ligase MARCH9 3
  • Membrane Associated Ring Finger 9 3
  • EC 2.3.2.27 4

External Ids for MARCH9 Gene

Previous GeneCards Identifiers for MARCH9 Gene

  • GC12P056437
  • GC12P058149
  • GC12P055185

Summaries for MARCH9 Gene

Entrez Gene Summary for MARCH9 Gene

  • MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH9 Gene

MARCH9 (Membrane Associated Ring-CH-Type Finger 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH4.

UniProtKB/Swiss-Prot for MARCH9 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Additional gene information for MARCH9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH9 Gene

Genomics for MARCH9 Gene

GeneHancer (GH) Regulatory Elements for MARCH9 Gene

Promoters and enhancers for MARCH9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 236 6.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 CDK4 MARCH9 NEMP1 TSFM CTDSP2 EEF1AKMT3 MBD6 ENSG00000224713 LOC283387 TSPAN31
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.9 -642.4 -642368 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I057886 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +139.7 139673 13.7 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 ZNF143 FOS SP3 JUNB LOC101927608 ATP23 EEF1AKMT3 CTDSP2 TSFM MIR26A2 AVIL RNU6-1083P MARCH9 LOC283387
GH12I057238 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 9.9 -513.9 -513934 4.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF213 ZNF143 KLF13 NDUFA4L2 STAT6 DTX3 NXPH4 ANKRD52 ENSG00000257740 NAB2 INHBE TSPAN31 MYO1A
GH12I057863 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +111.3 111296 2.6 ATF1 SIN3A GLIS2 ATF7 DEK SP3 REST SMARCB1 ZNF184 SMARCA4 EEF1AKMT3 MIR26A2 CDK4 AVIL RNU6-1083P TSFM METTL1 CYP27B1 MARCH9 CTDSP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCH9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH9 gene promoter:

Genomic Locations for MARCH9 Gene

Genomic Locations for MARCH9 Gene
chr12:57,753,622-57,760,410
(GRCh38/hg38)
Size:
6,789 bases
Orientation:
Plus strand
chr12:58,148,881-58,154,190
(GRCh37/hg19)

Genomic View for MARCH9 Gene

Genes around MARCH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH9 Gene

Proteins for MARCH9 Gene

  • Protein details for MARCH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YJ5-MARH9_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH9
    Protein Accession:
    Q86YJ5
    Secondary Accessions:
    • B2R9U9
    • Q86VN5
    • Q96GG2

    Protein attributes for MARCH9 Gene

    Size:
    346 amino acids
    Molecular mass:
    37772 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH50397.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH9 Gene

Post-translational modifications for MARCH9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH9 Gene

Domains & Families for MARCH9 Gene

Gene Families for MARCH9 Gene

Protein Domains for MARCH9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YJ5

UniProtKB/Swiss-Prot:

MARH9_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH9: view

No data available for Suggested Antigen Peptide Sequences for MARCH9 Gene

Function for MARCH9 Gene

Molecular function for MARCH9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH9 Gene

Phenotypes From GWAS Catalog for MARCH9 Gene

Gene Ontology (GO) - Molecular Function for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH9: view
genes like me logo Genes that share phenotypes with MARCH9: view

Animal Models for MARCH9 Gene

MGI Knock Outs for MARCH9:

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCH9 Gene

Localization for MARCH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH9 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH9 gene
Compartment Confidence
golgi apparatus 5
lysosome 3
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IDA 14722266
genes like me logo Genes that share ontologies with MARCH9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MARCH9 Gene

Pathways & Interactions for MARCH9 Gene

SuperPathways for MARCH9 Gene

No Data Available

UniProtKB/Swiss-Prot Q86YJ5-MARH9_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH9: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH9 Gene

Drugs & Compounds for MARCH9 Gene

(3) Drugs for MARCH9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MARCH9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH9: view

Transcripts for MARCH9 Gene

mRNA/cDNA for MARCH9 Gene

Unigene Clusters for MARCH9 Gene

Membrane-associated ring finger (C3HC4) 9:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH9 Gene

No ASD Table

Relevant External Links for MARCH9 Gene

GeneLoc Exon Structure for
MARCH9
ECgene alternative splicing isoforms for
MARCH9

Expression for MARCH9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH9 Gene

Protein differential expression in normal tissues from HIPED for MARCH9 Gene

This gene is overexpressed in Rectum (25.7), Heart (16.5), and Adipocyte (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH9 Gene



SOURCE GeneReport for Unigene cluster for MARCH9 Gene:

Hs.632709

mRNA Expression by UniProt/SwissProt for MARCH9 Gene:

Q86YJ5-MARH9_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for MARCH9 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MARCH9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH9 Gene

Orthologs for MARCH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH9 34 33
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH9 33 34
  • 95.58 (n)
cow
(Bos Taurus)
Mammalia MARCH9 33 34
  • 94.03 (n)
rat
(Rattus norvegicus)
Mammalia March9 33
  • 92.1 (n)
mouse
(Mus musculus)
Mammalia March9 16 34 33
  • 91.81 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH9 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH9 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march9 33
  • 70.93 (n)
zebrafish
(Danio rerio)
Actinopterygii march9 33 34
  • 70.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for MARCH9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH9 Gene

ENSEMBL:
Gene Tree for MARCH9 (if available)
TreeFam:
Gene Tree for MARCH9 (if available)

Paralogs for MARCH9 Gene

Paralogs for MARCH9 Gene

(2) SIMAP similar genes for MARCH9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MARCH9: view

Variants for MARCH9 Gene

Sequence variations from dbSNP and Humsavar for MARCH9 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000017904 -- 57,756,619(+) T/C intron_variant
rs1000170434 -- 57,755,895(+) G/A intron_variant
rs1000224122 -- 57,754,933(+) G/A upstream_transcript_variant
rs1000505886 -- 57,757,618(+) G/T intron_variant
rs1002018434 -- 57,757,024(+) C/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH9 Gene

Variant ID Type Subtype PubMed ID
nsv1069673 CNV deletion 25765185
nsv1126317 CNV deletion 24896259
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for MARCH9 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH9 Gene

Disorders for MARCH9 Gene

Additional Disease Information for MARCH9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MARCH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH9 Gene

Publications for MARCH9 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. (PMID: 17174307) Hoer S … Lehner PJ (FEBS letters 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MARCH9 Gene

Sources for MARCH9 Gene

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