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Aliases for MARCH8 Gene

Aliases for MARCH8 Gene

  • Membrane Associated Ring-CH-Type Finger 8 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase 2 3
  • C-Mir, Cellular Modulator Of Immune Recognition 2 3
  • Membrane-Associated RING Finger Protein 8 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH8 3 4
  • Membrane-Associated RING-CH Protein VIII 3 4
  • RING Finger Protein 178 3 4
  • MARCH-VIII 3 4
  • RNF178 3 4
  • C-MIR 3 4
  • MIR 3 4
  • Cellular Modulator Of Immune Recognition (C-MIR) 3
  • Membrane-Associated Ring Finger (C3HC4) 8 2
  • Cellular Modulator Of Immune Recognition 4
  • E3 Ubiquitin-Protein Ligase MARCH8 3
  • Membrane Associated Ring Finger 8 3
  • EC 4
  • EC 6.3.2 56
  • CMIR 3

External Ids for MARCH8 Gene

Previous HGNC Symbols for MARCH8 Gene

  • MIR

Previous GeneCards Identifiers for MARCH8 Gene

  • GC10M045273
  • GC10M045950
  • GC10M042478

Summaries for MARCH8 Gene

Entrez Gene Summary for MARCH8 Gene

  • MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH8 Gene

MARCH8 (Membrane Associated Ring-CH-Type Finger 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and MHC class II protein binding. An important paralog of this gene is MARCH1.

UniProtKB/Swiss-Prot for MARCH8 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Additional gene information for MARCH8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH8 Gene

Genomics for MARCH8 Gene

GeneHancer (GH) Regulatory Elements for MARCH8 Gene

Promoters and enhancers for MARCH8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I045592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.8 +0.9 858 3 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 MARCH8 PARGP1 ZFAND4 WASHC2C ENSG00000273363 AGAP4 GC10P045511
GH10I045535 Promoter 0.5 EPDnew 561.4 +59.5 59515 0.1 MARCH8 GC10P045511
GH10I045595 Enhancer 0.3 ENCODE 550.8 -1.6 -1608 1.5 SAP130 MARCH8 ZFAND4
GH10I045468 Enhancer 1.3 Ensembl ENCODE 23.1 +124.6 124550 4.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B YY1 ZNF766 E2F8 MARCH8 PARGP1 WASHC2C ENSG00000273363 AGAP4 LOC105378286 GC10P045511
GH10I045671 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 -77.9 -77873 2.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZFAND4 MARCH8 WASHC2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCH8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH8 gene promoter:

Genomic Locations for MARCH8 Gene

Genomic Locations for MARCH8 Gene
140,322 bases
Minus strand

Genomic View for MARCH8 Gene

Genes around MARCH8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH8 Gene

Proteins for MARCH8 Gene

  • Protein details for MARCH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH8
    Protein Accession:
    Secondary Accessions:
    • B2R8E7
    • H0Y7C6
    • Q5T0S8
    • Q8TC72

    Protein attributes for MARCH8 Gene

    291 amino acids
    Molecular mass:
    32965 Da
    Quaternary structure:
    • Interacts with CD86.

    Three dimensional structures from OCA and Proteopedia for MARCH8 Gene

    Alternative splice isoforms for MARCH8 Gene


neXtProt entry for MARCH8 Gene

Selected DME Specific Peptides for MARCH8 Gene


Post-translational modifications for MARCH8 Gene

No Post-translational modifications

Domains & Families for MARCH8 Gene

Gene Families for MARCH8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCH8 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH8: view

No data available for Suggested Antigen Peptide Sequences for MARCH8 Gene

Function for MARCH8 Gene

Molecular function for MARCH8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Enzyme Numbers (IUBMB) for MARCH8 Gene

Phenotypes From GWAS Catalog for MARCH8 Gene

Gene Ontology (GO) - Molecular Function for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH8: view
genes like me logo Genes that share phenotypes with MARCH8: view

Animal Models for MARCH8 Gene

MGI Knock Outs for MARCH8:

miRNA for MARCH8 Gene

miRTarBase miRNAs that target MARCH8

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCH8 Gene

Localization for MARCH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH8 gene
Compartment Confidence
lysosome 5
endosome 5
plasma membrane 3
cytosol 3

Gene Ontology (GO) - Cellular Components for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 14722266
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA,IDA 14722266
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARCH8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MARCH8 Gene

Pathways & Interactions for MARCH8 Gene

SuperPathways for MARCH8 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T0T0-MARH8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19117940
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH8: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH8 Gene

Drugs & Compounds for MARCH8 Gene

(3) Drugs for MARCH8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MARCH8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with MARCH8: view

Transcripts for MARCH8 Gene

Unigene Clusters for MARCH8 Gene

Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP6: - -

Relevant External Links for MARCH8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH8 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH8 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for MARCH8 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH8 Gene

Protein tissue co-expression partners for MARCH8 Gene

SOURCE GeneReport for Unigene cluster for MARCH8 Gene:


mRNA Expression by UniProt/SwissProt for MARCH8 Gene:

Tissue specificity: Broadly expressed. Present in immature dendritic cells (at protein level).

Evidence on tissue expression from TISSUES for MARCH8 Gene

  • Nervous system(3.8)
  • Lung(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with MARCH8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH8 Gene

Orthologs for MARCH8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH8 33 34
  • 99.07 (n)
(Bos Taurus)
Mammalia MARCH8 33 34
  • 90.1 (n)
(Mus musculus)
Mammalia March8 33 16 34
  • 88.35 (n)
(Rattus norvegicus)
Mammalia March8 33
  • 88 (n)
(Canis familiaris)
Mammalia MARCH8 33 34
  • 87.46 (n)
(Monodelphis domestica)
Mammalia MARCH8 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia MARCH8 34
  • 33 (a)
(Gallus gallus)
Aves MARCH8 33 34
  • 76.38 (n)
(Anolis carolinensis)
Reptilia MARCH8 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march8 33
  • 74.11 (n)
Str.8463 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8458 33
(Danio rerio)
Actinopterygii march8 33 34
  • 74.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4080 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 34
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for MARCH8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH8 Gene

Gene Tree for MARCH8 (if available)
Gene Tree for MARCH8 (if available)

Paralogs for MARCH8 Gene

Paralogs for MARCH8 Gene

(2) SIMAP similar genes for MARCH8 Gene using alignment to 2 proteins: Pseudogenes for MARCH8 Gene

genes like me logo Genes that share paralogs with MARCH8: view

Variants for MARCH8 Gene

Sequence variations from dbSNP and Humsavar for MARCH8 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000021639 -- 45,563,885(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000033858 -- 45,569,496(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000039093 -- 45,576,894(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000107217 -- 45,473,765(-) C/G intron_variant
rs1000126166 -- 45,492,952(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH8 Gene

Variant ID Type Subtype PubMed ID
nsv6532 CNV insertion 18451855
nsv528750 CNV loss 19592680
nsv442178 CNV loss 18776908
nsv1161941 OTHER complex 26073780
nsv1043536 CNV gain 25217958
esv3891797 CNV gain 25118596
esv3623097 CNV loss 21293372
esv3623096 CNV loss 21293372
esv3623095 CNV loss 21293372
esv3623094 CNV loss 21293372
esv3623093 CNV loss 21293372
esv3623092 CNV loss 21293372
esv3578792 CNV loss 25503493
esv3578791 CNV loss 25503493
esv2761592 CNV loss 21179565
esv2736141 CNV deletion 23290073
dgv730n100 CNV loss 25217958
dgv211e212 CNV loss 25503493

Variation tolerance for MARCH8 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH8 Gene

Disorders for MARCH8 Gene

Additional Disease Information for MARCH8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MARCH8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH8 Gene

Publications for MARCH8 Gene

  1. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PMID: 12582153) Goto E … Hotta H (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 4 58
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh SK … Lin JP (Nature genetics 2009) 3 44 58

Products for MARCH8 Gene

Sources for MARCH8 Gene

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