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Aliases for MARCH7 Gene

Aliases for MARCH7 Gene

  • Membrane Associated Ring-CH-Type Finger 7 2 3 5
  • Axotrophin 2 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 7 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH7 3 4
  • Membrane-Associated RING-CH Protein VII 3 4
  • RING Finger Protein 177 3 4
  • MARCH-VII 3 4
  • RNF177 3 4
  • AXOT 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7 2
  • E3 Ubiquitin-Protein Ligase MARCH7 3
  • Membrane Associated Ring Finger 7 3
  • EC 4
  • AXO 3

External Ids for MARCH7 Gene

Previous HGNC Symbols for MARCH7 Gene

  • AXOT

Previous GeneCards Identifiers for MARCH7 Gene

  • GC02P160395
  • GC02P160277
  • GC02P160569
  • GC02P152452

Summaries for MARCH7 Gene

Entrez Gene Summary for MARCH7 Gene

  • MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH7 Gene

MARCH7 (Membrane Associated Ring-CH-Type Finger 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH10.

UniProtKB/Swiss-Prot for MARCH7 Gene

  • E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Gene Wiki entry for MARCH7 Gene

Additional gene information for MARCH7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH7 Gene

Genomics for MARCH7 Gene

GeneHancer (GH) Regulatory Elements for MARCH7 Gene

Promoters and enhancers for MARCH7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J159710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 682.5 +0.5 544 5 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 BAZ2B ENSG00000226266 MARCH7 LOC643072 LY75 CD302 WDSUB1 PLA2R1 GC02P159769
GH02J158966 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650 -743.4 -743391 5.5 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF48 YY1 GLIS2 SP5 TANC1 MARCH7 OR7E28P GC02P158993
GH02J159612 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 26 -97.2 -97210 6.2 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B BAZ2B LOC643072 MARCH7 PLA2R1 TANC1 LY75 ENSG00000226266 ENSG00000207117
GH02J158972 Enhancer 1.3 Ensembl ENCODE dbSUPER 22 -738.9 -738944 1.8 FEZF1 ZNF2 ZNF213 FOS ATF7 SP3 TSHZ1 ZNF491 ZNF623 SREBF1 MARCH7 BAZ2B ENSG00000226266 TANC1 OR7E28P GC02P158993
GH02J159285 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.2 -425.9 -425861 2.3 HDGF CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 WDSUB1 BAZ2B PLA2R1 MARCH7 CD302 LY75 LOC105373716
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCH7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH7 gene promoter:
  • FOXJ2 (long isoform)
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for MARCH7 Gene

Genomic Locations for MARCH7 Gene
58,571 bases
Plus strand
58,539 bases
Plus strand

Genomic View for MARCH7 Gene

Genes around MARCH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH7 Gene

Proteins for MARCH7 Gene

  • Protein details for MARCH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH7
    Protein Accession:
    Secondary Accessions:
    • A8K9X1
    • B7Z7P5
    • D3DPB0
    • Q53GQ1
    • Q9BTR9

    Protein attributes for MARCH7 Gene

    704 amino acids
    Molecular mass:
    78051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH7 Gene


neXtProt entry for MARCH7 Gene

Post-translational modifications for MARCH7 Gene

  • Ubiquitination at posLast=608608, posLast=571571, and isoforms=2536
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MARCH7 Gene

Domains & Families for MARCH7 Gene

Gene Families for MARCH7 Gene

Protein Domains for MARCH7 Gene


Graphical View of Domain Structure for InterPro Entry



  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH7: view

No data available for Suggested Antigen Peptide Sequences for MARCH7 Gene

Function for MARCH7 Gene

Molecular function for MARCH7 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for MARCH7 Gene

Phenotypes From GWAS Catalog for MARCH7 Gene

Gene Ontology (GO) - Molecular Function for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH7: view
genes like me logo Genes that share phenotypes with MARCH7: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH7 Gene

Localization for MARCH7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH7 gene
Compartment Confidence
plasma membrane 4
cytosol 4
cytoskeleton 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH7 Gene

Pathways & Interactions for MARCH7 Gene

SuperPathways for MARCH7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H992-MARH7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002643 regulation of tolerance induction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
genes like me logo Genes that share ontologies with MARCH7: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH7 Gene

Drugs & Compounds for MARCH7 Gene

(3) Drugs for MARCH7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for MARCH7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with MARCH7: view

Transcripts for MARCH7 Gene

Unigene Clusters for MARCH7 Gene

Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP2: -
SP3: -
SP5: - - -
SP6: - -

Relevant External Links for MARCH7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH7 Gene

Protein differential expression in normal tissues from HIPED for MARCH7 Gene

This gene is overexpressed in Placenta (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MARCH7 Gene

Protein tissue co-expression partners for MARCH7 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for MARCH7 Gene:


Evidence on tissue expression from TISSUES for MARCH7 Gene

  • Nervous system(4.5)
  • Skin(4.4)
  • Liver(4.3)
  • Muscle(2.6)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with MARCH7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH7 Gene

Orthologs for MARCH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH7 34 33
  • 99.81 (n)
(Canis familiaris)
Mammalia MARCH7 34 33
  • 92.76 (n)
(Bos Taurus)
Mammalia MARCH7 34 33
  • 91.3 (n)
(Rattus norvegicus)
Mammalia March7 33
  • 87.87 (n)
(Mus musculus)
Mammalia March7 16 34 33
  • 87.43 (n)
(Monodelphis domestica)
Mammalia MARCH7 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MARCH7 34
  • 69 (a)
(Gallus gallus)
Aves MARCH7 34 33
  • 72.19 (n)
(Anolis carolinensis)
Reptilia MARCH7 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march7 33
  • 60.45 (n)
Str.2990 33
(Danio rerio)
Actinopterygii march7 34 34 33
  • 51.52 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12853 33
Species where no ortholog for MARCH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH7 Gene

Gene Tree for MARCH7 (if available)
Gene Tree for MARCH7 (if available)
Evolutionary constrained regions (ECRs) for MARCH7: view image

Paralogs for MARCH7 Gene

Paralogs for MARCH7 Gene

(2) SIMAP similar genes for MARCH7 Gene using alignment to 5 proteins:

  • B7Z7P5_HUMAN
  • C9J159_HUMAN
  • F5H6W4_HUMAN
genes like me logo Genes that share paralogs with MARCH7: view

Variants for MARCH7 Gene

Sequence variations from dbSNP and Humsavar for MARCH7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000098893 -- 159,731,092(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000185884 -- 159,734,488(+) A/G intron_variant
rs1000249244 -- 159,765,820(+) A/C intron_variant
rs1000279255 -- 159,725,411(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000476570 -- 159,729,492(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH7 Gene

Variant ID Type Subtype PubMed ID
esv2443442 CNV deletion 19546169
nsv1010774 CNV gain 25217958
nsv470497 CNV loss 18288195
nsv834436 CNV loss 17160897

Variation tolerance for MARCH7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH7 Gene

Disorders for MARCH7 Gene

Additional Disease Information for MARCH7

No disorders were found for MARCH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH7 Gene

Publications for MARCH7 Gene

  1. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D … Chau V (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  2. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. (PMID: 19901269) Szigyarto CA … Metcalfe SM (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010) 3 22 58
  3. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. (PMID: 17161353) Muthukumarana PA … Metcalfe SM (International immunopharmacology 2006) 3 22 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. (PMID: 15670816) Metcalfe SM … Lyons GE (FEBS letters 2005) 3 4 58

Products for MARCH7 Gene

Sources for MARCH7 Gene

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