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Aliases for MARCH6 Gene

Aliases for MARCH6 Gene

  • Membrane Associated Ring-CH-Type Finger 6 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 6 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH6 3 4
  • Membrane-Associated RING-CH Protein VI 3 4
  • RING Finger Protein 176 3 4
  • Doa10 Homolog 3 4
  • MARCH-VI 3 4
  • RNF176 3 4
  • TEB4 3 4
  • Membrane-Associated RING-CH Finger Protein 6 3
  • Membrane-Associated Ring Finger (C3HC4) 6 2
  • E3 Ubiquitin-Protein Ligase MARCH6 3
  • Membrane Associated Ring Finger 6 3
  • Protein TEB-4 4
  • EC 4
  • KIAA0597 4
  • DOA10 3

External Ids for MARCH6 Gene

Previous GeneCards Identifiers for MARCH6 Gene

  • GC05P010408

Summaries for MARCH6 Gene

Entrez Gene Summary for MARCH6 Gene

  • This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MARCH6 Gene

MARCH6 (Membrane Associated Ring-CH-Type Finger 6) is a Protein Coding gene. Diseases associated with MARCH6 include Intrahepatic Cholestasis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH6 Gene

  • E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Gene Wiki entry for MARCH6 Gene

Additional gene information for MARCH6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH6 Gene

Genomics for MARCH6 Gene

GeneHancer (GH) Regulatory Elements for MARCH6 Gene

Promoters and enhancers for MARCH6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I010351 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.8 +0.3 264 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 MARCH6 GC05M010353 LOC101929977 CMBL ROPN1L ROPN1L-AS1
GH05I010304 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.3 -45.4 -45439 6.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CMBL MARCH6 ROPN1L ROPN1L-AS1 FAM173B CCT5 ENSG00000271980 LOC105374651 GC05M010284
GH05I010248 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 -103.3 -103278 4.1 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CCT5 FAM173B MARCH6 CMBL ENSG00000271980 ROPN1L ROPN1L-AS1 ENSG00000248968 GC05M010252
GH05I010759 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +407.7 407655 4.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 DAP LOC105374652 MARCH6 CMBL ROPN1L CTD-2154B17.1
GH05I010562 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 10.3 +211.8 211792 6.3 HDGF PKNOX1 SIN3A IRF4 ZNF121 GLIS2 ELK1 ZNF207 ATF7 KLF7 ANKRD33B ANKRD33B-AS1 ROPN1L ROPN1L-AS1 MARCH6 GC05M010581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCH6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH6 gene promoter:

Genomic Locations for MARCH6 Gene

Genomic Locations for MARCH6 Gene
86,750 bases
Plus strand

Genomic View for MARCH6 Gene

Genes around MARCH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH6 Gene

Proteins for MARCH6 Gene

  • Protein details for MARCH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH6
    Protein Accession:
    Secondary Accessions:
    • A5PKZ4
    • B4DKJ2
    • B4DT33
    • D3DTC8
    • O14670
    • Q86X77

    Protein attributes for MARCH6 Gene

    910 amino acids
    Molecular mass:
    102545 Da
    Quaternary structure:
    • Interacts with DIO2.
    • Sequence=AAB66840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB66840.1; Type=Frameshift; Positions=381, 382, 383, 385, 391, 396, 418; Evidence={ECO:0000305}; Sequence=BAA25523.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH6 Gene


neXtProt entry for MARCH6 Gene

Post-translational modifications for MARCH6 Gene

  • Auto-ubiquitinated, which results in proteasomal degradation.
  • Ubiquitination at isoforms=520, posLast=3333, posLast=4545, isoforms=549, isoforms=556, isoforms=5, 6550, isoforms=5, 6881, isoforms=5, 6894, and isoforms=5, 6897
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MARCH6 Gene

Domains & Families for MARCH6 Gene

Gene Families for MARCH6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCH6 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH6: view

No data available for Suggested Antigen Peptide Sequences for MARCH6 Gene

Function for MARCH6 Gene

Molecular function for MARCH6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Enzyme Numbers (IUBMB) for MARCH6 Gene

Phenotypes From GWAS Catalog for MARCH6 Gene

Gene Ontology (GO) - Molecular Function for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 19651899
GO:0005515 protein binding IPI 25766235
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding IPI 19651899
genes like me logo Genes that share ontologies with MARCH6: view
genes like me logo Genes that share phenotypes with MARCH6: view

miRNA for MARCH6 Gene

miRTarBase miRNAs that target MARCH6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH6 Gene

Localization for MARCH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000835 ER ubiquitin ligase complex IC 15673284
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IDA,IEA 16373356
genes like me logo Genes that share ontologies with MARCH6: view

Pathways & Interactions for MARCH6 Gene

genes like me logo Genes that share pathways with MARCH6: view

UniProtKB/Swiss-Prot O60337-MARH6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010498 proteasomal protein catabolic process IDA 15673284
GO:0016567 protein ubiquitination IEA --
GO:0030433 ubiquitin-dependent ERAD pathway IEA --
GO:0036503 ERAD pathway TAS 25088257
GO:0070936 protein K48-linked ubiquitination IDA 15673284
genes like me logo Genes that share ontologies with MARCH6: view

No data available for SIGNOR curated interactions for MARCH6 Gene

Drugs & Compounds for MARCH6 Gene

(3) Drugs for MARCH6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MARCH6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with MARCH6: view

Transcripts for MARCH6 Gene

Unigene Clusters for MARCH6 Gene

Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - -
SP4: -
SP6: - -

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP5: -

Relevant External Links for MARCH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH6 Gene

Protein differential expression in normal tissues from HIPED for MARCH6 Gene

This gene is overexpressed in Adrenal (56.7) and Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARCH6 Gene

Protein tissue co-expression partners for MARCH6 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for MARCH6 Gene:


mRNA Expression by UniProt/SwissProt for MARCH6 Gene:

Tissue specificity: Present in brain (at protein level).

Evidence on tissue expression from TISSUES for MARCH6 Gene

  • Nervous system(4.9)
  • Pancreas(4.6)
  • Lung(2.6)
  • Thyroid gland(2.3)
  • Kidney(2.1)
  • Liver(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MARCH6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH6 Gene

Orthologs for MARCH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARCH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH6 33 34
  • 99.89 (n)
(Monodelphis domestica)
Mammalia MARCH6 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia MARCH6 34
  • 94 (a)
(Canis familiaris)
Mammalia MARCH6 33 34
  • 93.73 (n)
(Bos Taurus)
Mammalia MARCH6 33 34
  • 92.56 (n)
(Mus musculus)
Mammalia March6 33 16 34
  • 90.68 (n)
(Rattus norvegicus)
Mammalia March6 33
  • 90.31 (n)
(Gallus gallus)
Aves MARCH6 33 34
  • 83.39 (n)
(Anolis carolinensis)
Reptilia MARCH6 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march6 33
  • 80.01 (n)
Str.11781 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14661 33
(Danio rerio)
Actinopterygii march6 33 34
  • 76.19 (n)
Dr.26548 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7694 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007204 33
  • 56.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1317 33 34
  • 55.63 (n)
(Caenorhabditis elegans)
Secernentea marc-6 33 34
  • 53.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 34 36
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34100 33
  • 46.05 (n)
(Oryza sativa)
Liliopsida Os06g0639000 33
  • 45.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2510 33
Species where no ortholog for MARCH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH6 Gene

Gene Tree for MARCH6 (if available)
Gene Tree for MARCH6 (if available)

Paralogs for MARCH6 Gene

Paralogs for MARCH6 Gene

(4) SIMAP similar genes for MARCH6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH6: view

Variants for MARCH6 Gene

Sequence variations from dbSNP and Humsavar for MARCH6 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000012748 -- 10,405,999(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000029495 -- 10,380,216(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000031936 -- 10,423,553(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000032448 -- 10,380,361(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000054202 -- 10,368,124(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH6 Gene

Variant ID Type Subtype PubMed ID
esv3307696 CNV mobile element insertion 20981092
esv3309619 CNV mobile element insertion 20981092
esv3389264 CNV insertion 20981092
esv3420488 CNV insertion 20981092
nsv4713 CNV deletion 18451855

Variation tolerance for MARCH6 Gene

Residual Variation Intolerance Score: 4.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH6 Gene

Disorders for MARCH6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCH6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCH6

genes like me logo Genes that share disorders with MARCH6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH6 Gene

Publications for MARCH6 Gene

  1. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PMID: 22446040) Wang KS … Callahan K (Gene 2012) 3 44 58
  2. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. (PMID: 19651899) Zavacki AM … Bianco AC (Molecular and cellular biology 2009) 3 4 58
  3. Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). (PMID: 16373356) Kreft SG … Hochstrasser M (The Journal of biological chemistry 2006) 3 4 58
  4. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. (PMID: 15673284) Hassink G … Wiertz E (The Biochemical journal 2005) 3 4 58
  5. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 58

Products for MARCH6 Gene

Sources for MARCH6 Gene

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