Aliases for MARCH4 Gene
External Ids for MARCH4 Gene
Previous GeneCards Identifiers for MARCH4 Gene
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
GeneCards Summary for MARCH4 Gene
MARCH4 (Membrane Associated Ring-CH-Type Finger 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH9.
UniProtKB/Swiss-Prot for MARCH4 Gene
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.