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Aliases for MARCH3 Gene

Aliases for MARCH3 Gene

  • Membrane Associated Ring-CH-Type Finger 3 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase MARCH3 3 4
  • Membrane-Associated RING-CH Protein III 3 4
  • RING Finger Protein 173 3 4
  • MARCH-III 3 4
  • RNF173 3 4
  • Membrane-Associated Ring Finger (C3HC4) 3 2
  • Membrane-Associated RING Finger Protein 3 4
  • E3 Ubiquitin-Protein Ligase MARCH3 3
  • Membrane Associated Ring Finger 3 3
  • EC 4
  • EC 6.3.2 56

External Ids for MARCH3 Gene

Previous GeneCards Identifiers for MARCH3 Gene

  • GC05M126235
  • GC05M121395

Summaries for MARCH3 Gene

Entrez Gene Summary for MARCH3 Gene

  • This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

GeneCards Summary for MARCH3 Gene

MARCH3 (Membrane Associated Ring-CH-Type Finger 3) is a Protein Coding gene. Diseases associated with MARCH3 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH3 Gene

  • E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Additional gene information for MARCH3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH3 Gene

Genomics for MARCH3 Gene

GeneHancer (GH) Regulatory Elements for MARCH3 Gene

Promoters and enhancers for MARCH3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I127028 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559.1 +2.1 2094 3.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 MARCH3 GC05P127033 LOC105379163 PIR49999 CCDC192 C5orf63 GC05M127022
GH05I127072 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 61.6 -41.0 -40960 1.4 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 GLIS2 E2F8 C5orf63 ENSG00000279446 MARCH3 PRRC1
GH05I126970 Enhancer 1.4 Ensembl ENCODE dbSUPER 66 +60.5 60496 3.8 PKNOX1 SMAD1 ARNT ZNF766 ZNF207 ZNF592 MEF2D SMARCA4 NBN HMBOX1 MARCH3 PRRC1 C5orf63 GC05M127022 GC05M126868
GH05I126998 Enhancer 1.2 Ensembl ENCODE dbSUPER 66.4 +33.9 33863 1.1 HDAC1 ARNT NFRKB TCF12 ATF7 NCOA1 ZEB2 ZNF592 MBD2 SMARCA4 MARCH3 GC05M127022 GC05M126868
GH05I127009 Enhancer 1.1 Ensembl ENCODE dbSUPER 66.4 +20.4 20376 4.1 JUN BACH1 MAX CEBPG NFATC1 ZSCAN5C ATF7 FOS IKZF2 RUNX3 MARCH3 GC05M127022 GC05M126868
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCH3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH3 gene promoter:

Genomic Locations for MARCH3 Gene

Genomic Locations for MARCH3 Gene
164,689 bases
Minus strand

Genomic View for MARCH3 Gene

Genes around MARCH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH3 Gene

Proteins for MARCH3 Gene

  • Protein details for MARCH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH3
    Protein Accession:
    Secondary Accessions:
    • A8K264
    • B9EJE7

    Protein attributes for MARCH3 Gene

    253 amino acids
    Molecular mass:
    28504 Da
    Quaternary structure:
    • Interacts with MARCH2 and STX6.

    Alternative splice isoforms for MARCH3 Gene


neXtProt entry for MARCH3 Gene

Selected DME Specific Peptides for MARCH3 Gene


Post-translational modifications for MARCH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MARCH3 Gene

Gene Families for MARCH3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCH3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH3: view

No data available for Suggested Antigen Peptide Sequences for MARCH3 Gene

Function for MARCH3 Gene

Molecular function for MARCH3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH3 Gene

Phenotypes From GWAS Catalog for MARCH3 Gene

Gene Ontology (GO) - Molecular Function for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH3: view
genes like me logo Genes that share phenotypes with MARCH3: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH3 Gene

Localization for MARCH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH3 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH3 gene
Compartment Confidence
lysosome 5
endosome 5
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005768 endosome IEA,IDA 14722266
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with MARCH3: view

Pathways & Interactions for MARCH3 Gene

SuperPathways for MARCH3 Gene

No Data Available

UniProtKB/Swiss-Prot Q86UD3-MARH3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH3: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH3 Gene

Drugs & Compounds for MARCH3 Gene

(3) Drugs for MARCH3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MARCH3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with MARCH3: view

Transcripts for MARCH3 Gene

Unigene Clusters for MARCH3 Gene

Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH3 Gene

No ASD Table

Relevant External Links for MARCH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH3 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH3 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

SOURCE GeneReport for Unigene cluster for MARCH3 Gene:


Evidence on tissue expression from TISSUES for MARCH3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MARCH3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH3 Gene

Orthologs for MARCH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH3 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia MARCH3 33 34
  • 95.65 (n)
(Rattus norvegicus)
Mammalia March3 33
  • 94.73 (n)
(Bos Taurus)
Mammalia MARCH3 33 34
  • 94.33 (n)
(Mus musculus)
Mammalia March3 33 16 34
  • 91.55 (n)
(Gallus gallus)
Aves MARCH3 34 33
  • 85.24 (n)
(Anolis carolinensis)
Reptilia MARCH3 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march3 33
  • 82.2 (n)
(Danio rerio)
Actinopterygii zgc:158785 34
  • 48 (a)
(Caenorhabditis elegans)
Secernentea marc-3 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 34
  • 3 (a)
Species where no ortholog for MARCH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH3 Gene

Gene Tree for MARCH3 (if available)
Gene Tree for MARCH3 (if available)

Paralogs for MARCH3 Gene

Paralogs for MARCH3 Gene

(4) SIMAP similar genes for MARCH3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH3: view

Variants for MARCH3 Gene

Sequence variations from dbSNP and Humsavar for MARCH3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000016749 -- 126,887,998(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000040125 -- 126,894,362(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000067227 -- 126,937,359(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000070993 -- 126,980,880(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000109485 -- 127,000,113(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH3 Gene

Variant ID Type Subtype PubMed ID
esv3304150 CNV mobile element insertion 20981092
esv3330842 CNV duplication 20981092
esv3358268 CNV insertion 20981092
esv3570411 CNV loss 25503493
esv3606694 CNV loss 21293372
esv3606695 CNV gain 21293372
esv3606698 CNV loss 21293372
nsv1124923 CNV duplication 24896259
nsv1146007 CNV duplication 26484159

Variation tolerance for MARCH3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH3 Gene

Disorders for MARCH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCH3 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCH3

genes like me logo Genes that share disorders with MARCH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH3 Gene

Publications for MARCH3 Gene

  1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H … Hirose S (Journal of biochemistry 2006) 3 4 58
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination. (PMID: 26694610) Fatehchand K … Butchar JP (The Journal of biological chemistry 2016) 3 58

Products for MARCH3 Gene

Sources for MARCH3 Gene

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