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Aliases for MARCH2 Gene

Aliases for MARCH2 Gene

  • Membrane Associated Ring-CH-Type Finger 2 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH2 3 4
  • Membrane-Associated RING-CH Protein II 3 4
  • RING Finger Protein 172 3 4
  • MARCH-II 3 4
  • RNF172 3 4
  • Membrane-Associated Ring Finger (C3HC4) 2 2
  • E3 Ubiquitin-Protein Ligase MARCH2 3
  • Membrane Associated Ring Finger 2 3
  • EC 2.3.2.27 4
  • HSPC240 3

External Ids for MARCH2 Gene

Previous GeneCards Identifiers for MARCH2 Gene

  • GC19P008391
  • GC19P008478
  • GC19P008132

Summaries for MARCH2 Gene

Entrez Gene Summary for MARCH2 Gene

  • MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH2 Gene

MARCH2 (Membrane Associated Ring-CH-Type Finger 2) is a Protein Coding gene. Diseases associated with MARCH2 include Rubeosis Iridis. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH3.

UniProtKB/Swiss-Prot for MARCH2 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Gene Wiki entry for MARCH2 Gene

Additional gene information for MARCH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH2 Gene

Genomics for MARCH2 Gene

GeneHancer (GH) Regulatory Elements for MARCH2 Gene

Promoters and enhancers for MARCH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008417 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 678.4 +4.9 4860 1.9 HDGF PKNOX1 SMAD1 ARNT ZNF766 CBX5 E2F8 REST ZNF592 MEF2D MARCH2 XAB2 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF414 MAP2K7 ZNF559
GH19J008413 Promoter/Enhancer 1.4 Ensembl ENCODE 665.5 +0.1 131 0.8 HDGF PKNOX1 ARID4B SIN3A GLIS2 ZNF143 FOS SP3 CEBPZ SP5 MARCH2 ELAVL1 HNRNPM XAB2 ZNF558 ZNF699 PIR43177 GC19P008426
GH19J008444 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 32.3 +32.9 32900 3.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 HNRNPM ENSG00000279827 MARCH2 LINC01862 ENSG00000261866 OR7G3 LYPLA2P2 ELOCP29 OR7E25P OR7H1P
GH19J008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 18.5 -20.4 -20426 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ZNF559 ENSG00000269300
GH19J008485 Enhancer 1.1 Ensembl ENCODE dbSUPER 38.4 +74.9 74870 4.7 ZBTB6 MAX HIC1 POLR2A RBM22 RUNX3 SMAD5 MNT ZSCAN16 ZNF341 GC19P008487 MARCH2 PRAM1 HNRNPM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH2 gene promoter:
  • Nkx2-5
  • ATF
  • Pax-5
  • p300
  • CBF(2)
  • NF-Y
  • HTF
  • En-1
  • RFX1
  • CUTL1

Genomic Locations for MARCH2 Gene

Genomic Locations for MARCH2 Gene
chr19:8,413,270-8,439,017
(GRCh38/hg38)
Size:
25,748 bases
Orientation:
Plus strand
chr19:8,478,154-8,503,901
(GRCh37/hg19)
Size:
25,748 bases
Orientation:
Plus strand

Genomic View for MARCH2 Gene

Genes around MARCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH2 Gene

Proteins for MARCH2 Gene

  • Protein details for MARCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0N8-MARH2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH2
    Protein Accession:
    Q9P0N8
    Secondary Accessions:
    • A6NP10
    • Q5H785
    • Q8N5A3
    • Q96B78

    Protein attributes for MARCH2 Gene

    Size:
    246 amino acids
    Molecular mass:
    26995 Da
    Quaternary structure:
    • Interacts with STX6 (By similarity). Interacts with MARCH3.

    Alternative splice isoforms for MARCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH2 Gene

Post-translational modifications for MARCH2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MARCH2 Gene

Domains & Families for MARCH2 Gene

Gene Families for MARCH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0N8

UniProtKB/Swiss-Prot:

MARH2_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH2: view

No data available for Suggested Antigen Peptide Sequences for MARCH2 Gene

Function for MARCH2 Gene

Molecular function for MARCH2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for MARCH2 Gene

Phenotypes From GWAS Catalog for MARCH2 Gene

Gene Ontology (GO) - Molecular Function for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH2: view
genes like me logo Genes that share phenotypes with MARCH2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH2 Gene

Localization for MARCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 4
plasma membrane 3
lysosome 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 14722266
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with MARCH2: view

Pathways & Interactions for MARCH2 Gene

SuperPathways for MARCH2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0N8-MARH2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH2: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH2 Gene

Drugs & Compounds for MARCH2 Gene

(3) Drugs for MARCH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for MARCH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with MARCH2: view

Transcripts for MARCH2 Gene

Unigene Clusters for MARCH2 Gene

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for MARCH2 Gene

GeneLoc Exon Structure for
MARCH2
ECgene alternative splicing isoforms for
MARCH2

Expression for MARCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH2 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH2 Gene

This gene is overexpressed in Whole Blood (x5.1).

SOURCE GeneReport for Unigene cluster for MARCH2 Gene:

Hs.631861

mRNA Expression by UniProt/SwissProt for MARCH2 Gene:

Q9P0N8-MARH2_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for MARCH2 Gene

  • Nervous system(4.3)
  • Skin(4.2)
  • Blood(4.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MARCH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH2 Gene

Orthologs for MARCH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH2 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH2 34 33
  • 90.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH2 34 33
  • 89.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia March2 33
  • 86.04 (n)
mouse
(Mus musculus)
Mammalia March2 16 34 33
  • 84.69 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH2 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH2 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH2 34 33
  • 76.15 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march2 33
  • 69.92 (n)
zebrafish
(Danio rerio)
Actinopterygii march2 34 33
  • 74.8 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4783 33
fruit fly
(Drosophila melanogaster)
Insecta CG13442 34
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 34
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 34
  • 4 (a)
OneToMany
Species where no ortholog for MARCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH2 Gene

ENSEMBL:
Gene Tree for MARCH2 (if available)
TreeFam:
Gene Tree for MARCH2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MARCH2: view image

Paralogs for MARCH2 Gene

Paralogs for MARCH2 Gene

(1) SIMAP similar genes for MARCH2 Gene using alignment to 5 proteins:

  • MARH2_HUMAN
  • M0QXU4_HUMAN
  • M0R0S4_HUMAN
  • M0R138_HUMAN
  • M0R1P2_HUMAN
genes like me logo Genes that share paralogs with MARCH2: view

Variants for MARCH2 Gene

Sequence variations from dbSNP and Humsavar for MARCH2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000235901 -- 8,419,605(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000251345 -- 8,419,767(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000372333 -- 8,424,491(+) C/T intron_variant
rs1000529588 -- 8,427,393(+) C/T intron_variant
rs1000554807 -- 8,416,198(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH2 Gene

Variant ID Type Subtype PubMed ID
nsv513514 CNV insertion 21212237

Variation tolerance for MARCH2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH2 Gene

Disorders for MARCH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCH2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rubeosis iridis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCH2

genes like me logo Genes that share disorders with MARCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH2 Gene

Publications for MARCH2 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E … Früh K (Journal of virology 2004) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H … Hirose S (Journal of biochemistry 2006) 3 4 58
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PMID: 15689499) Nakamura N … Hirose S (Molecular biology of the cell 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MARCH2 Gene

Sources for MARCH2 Gene

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