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Aliases for MARC1 Gene

Aliases for MARC1 Gene

  • Mitochondrial Amidoxime Reducing Component 1 2 3 5
  • Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 1 3 4
  • Moco Sulfurase C-Terminal Domain-Containing Protein 1 3 4
  • MOCO Sulphurase C-Terminal Domain Containing 1 2 3
  • MOSC1 3 4
  • MOSC Domain-Containing Protein 1, Mitochondrial 3
  • Mitochondrial Amidoxime-Reducing Component 1 3
  • MOSC Domain-Containing Protein 1 4
  • EC 1.-.-.- 4
  • MARC1 4

External Ids for MARC1 Gene

Previous HGNC Symbols for MARC1 Gene

  • MOSC1

Previous GeneCards Identifiers for MARC1 Gene

  • GC01P220961

Summaries for MARC1 Gene

GeneCards Summary for MARC1 Gene

MARC1 (Mitochondrial Amidoxime Reducing Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and molybdenum ion binding. An important paralog of this gene is MARC2.

UniProtKB/Swiss-Prot for MARC1 Gene

  • As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Additional gene information for MARC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARC1 Gene

Genomics for MARC1 Gene

GeneHancer (GH) Regulatory Elements for MARC1 Gene

Promoters and enhancers for MARC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I220785 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566.7 +0.8 773 3.9 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MARC1 C1orf115 RNU6ATAC35P GC01M220652
GH01I220746 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.3 -37.3 -37326 5.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 MARC2 C1orf115 MARC1 GC01M220652
GH01I220689 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 6.5 -95.6 -95554 2.8 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 YY1 GLIS2 C1orf115 MARC1 MARC2 GC01M220652
GH01I220766 Enhancer 1.1 Ensembl ENCODE 12.8 -18.6 -18637 3.5 FOXA2 SMAD1 ARID4B DMAP1 ETS1 YY1 RXRA REST PPARG NFIL3 C1orf115 MARC1 MARC2 GC01M220652
GH01I220789 Enhancer 0.7 Ensembl 16.1 +3.4 3404 1 ZNF146 FOXA2 MAX ZMYM3 CEBPG YY1 SCRT2 GATAD2A ZNF280D RXRA MARC1 MARC2 RNU6ATAC35P GC01M220652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MARC1 Gene

Genomic Locations for MARC1 Gene
32,961 bases
Plus strand

Genomic View for MARC1 Gene

Genes around MARC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARC1 Gene

Proteins for MARC1 Gene

  • Protein details for MARC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial amidoxime-reducing component 1
    Protein Accession:
    Secondary Accessions:
    • A8K447
    • B2D078
    • Q5VVS9
    • Q5VVT0
    • Q5VVT1
    • Q8N9P5
    • Q96FN8
    • Q9H6C7

    Protein attributes for MARC1 Gene

    337 amino acids
    Molecular mass:
    37499 Da
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MARC1.
    • Sequence=BAB15333.1; Type=Frameshift; Positions=139; Evidence={ECO:0000305}; Sequence=CAH72118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MARC1 Gene


neXtProt entry for MARC1 Gene

Post-translational modifications for MARC1 Gene

No data available for DME Specific Peptides for MARC1 Gene

Domains & Families for MARC1 Gene

Gene Families for MARC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MARC1 Gene

Suggested Antigen Peptide Sequences for MARC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MARC1: view

No data available for UniProtKB/Swiss-Prot for MARC1 Gene

Function for MARC1 Gene

Molecular function for MARC1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=180 uM for benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=86 uM for NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=272 uM for NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=34 nmol/min/mg enzyme toward benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=105 nmol/min/mg enzyme toward benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=55 nmol/min/mg enzyme toward NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=43 nmol/min/mg enzyme toward NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752};
UniProtKB/Swiss-Prot Function:
As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Enzyme Numbers (IUBMB) for MARC1 Gene

Phenotypes From GWAS Catalog for MARC1 Gene

Gene Ontology (GO) - Molecular Function for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008940 nitrate reductase activity IDA 20861021
GO:0016491 oxidoreductase activity IEA --
GO:0030151 molybdenum ion binding IDA,IEA 20861021
GO:0030170 pyridoxal phosphate binding IEA --
GO:0043546 molybdopterin cofactor binding IDA 20861021
genes like me logo Genes that share ontologies with MARC1: view

Phenotypes for MARC1 Gene

GenomeRNAi human phenotypes for MARC1:
genes like me logo Genes that share phenotypes with MARC1: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARC1 Gene

Localization for MARC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARC1 Gene

Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARC1 gene
Compartment Confidence
mitochondrion 5
golgi apparatus 2
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,ISS 20861021
GO:0005741 mitochondrial outer membrane TAS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARC1: view

Pathways & Interactions for MARC1 Gene

genes like me logo Genes that share pathways with MARC1: view

Pathways by source for MARC1 Gene

Gene Ontology (GO) - Biological Process for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0042126 nitrate metabolic process IDA 20861021
GO:0051410 detoxification of nitrogen compound NAS 20861021
GO:0055114 oxidation-reduction process IDA,IEA 20861021
genes like me logo Genes that share ontologies with MARC1: view

No data available for SIGNOR curated interactions for MARC1 Gene

Drugs & Compounds for MARC1 Gene

(1) Drugs for MARC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Molybdenum Approved Pharma 31
genes like me logo Genes that share compounds with MARC1: view

Transcripts for MARC1 Gene

Unigene Clusters for MARC1 Gene

Mitochondrial amidoxime reducing component 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for MARC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARC1 Gene

This gene is overexpressed in Whole Blood (x8.1), Adipose - Visceral (Omentum) (x7.6), and Adipose - Subcutaneous (x6.3).

Protein differential expression in normal tissues from HIPED for MARC1 Gene

This gene is overexpressed in Testis (19.5), Nasopharynx (19.3), and Monocytes (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARC1 Gene

SOURCE GeneReport for Unigene cluster for MARC1 Gene:


Evidence on tissue expression from TISSUES for MARC1 Gene

  • Kidney(4.3)
  • Adrenal gland(4.2)
  • Eye(4.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with MARC1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARC1 Gene

Orthologs for MARC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOSC1 33
  • 99.31 (n)
MARC1 34
  • 99 (a)
(Canis familiaris)
Mammalia MARC1 33 34
  • 86.45 (n)
(Bos Taurus)
Mammalia MARC1 33 34
  • 86.21 (n)
(Rattus norvegicus)
Mammalia Marc1 33
  • 80.17 (n)
(Mus musculus)
Mammalia Marc1 33 16 34
  • 79.34 (n)
(Ornithorhynchus anatinus)
Mammalia MARC1 34
  • 75 (a)
(Gallus gallus)
Aves MARC2 33
  • 67.59 (n)
-- 34
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
-- 34
  • 55 (a)
-- 34
  • 48 (a)
-- 34
  • 6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487963 33
  • 58.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25253 33
(Danio rerio)
Actinopterygii zgc:110783 33
  • 58.36 (n)
MARC2 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1665 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F56A11.5 33 34
  • 48.63 (n)
F22B8.7 34
  • 29 (a)
F53E10.1 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for MARC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARC1 Gene

Gene Tree for MARC1 (if available)
Gene Tree for MARC1 (if available)

Paralogs for MARC1 Gene

Paralogs for MARC1 Gene

(1) SIMAP similar genes for MARC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MARC1: view

Variants for MARC1 Gene

Sequence variations from dbSNP and Humsavar for MARC1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000216514 -- 220,802,024(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000241338 -- 220,806,466(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000242670 -- 220,800,699(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000363843 -- 220,790,425(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000465612 -- 220,796,949(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARC1 Gene

Variant ID Type Subtype PubMed ID
esv1008867 CNV deletion 20482838

Variation tolerance for MARC1 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARC1 Gene

Disorders for MARC1 Gene

Additional Disease Information for MARC1

No disorders were found for MARC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARC1 Gene

Publications for MARC1 Gene

  1. Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians. (PMID: 24423752) Ott G … Havemeyer A (Drug metabolism and disposition: the biological fate of chemicals 2014) 3 4 58
  2. The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane. (PMID: 23086957) Klein JM … Schwarz G (The Journal of biological chemistry 2012) 3 4 58
  3. Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC). (PMID: 21029045) Kotthaus J … Clement B (The Biochemical journal 2011) 3 4 58
  4. The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs. (PMID: 19053771) Gruenewald S … Clement B (Journal of medicinal chemistry 2008) 3 4 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for MARC1 Gene

Sources for MARC1 Gene

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