MAPT Gene (Protein Coding)

Microtubule Associated Protein Tau

GC17P045894
GIFtS:
50
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders s... See more...

Aliases for MAPT Gene

Aliases for MAPT Gene

  • Microtubule Associated Protein Tau 2 3 5
  • MTBT1 2 3 4
  • TAU 2 3 4
  • G Protein Beta1/Gamma2 Subunit-Interacting Factor 1 2 3
  • Protein Phosphatase 1, Regulatory Subunit 103 2 3
  • Microtubule-Associated Protein Tau 3 4
  • Neurofibrillary Tangle Protein 3 4
  • Paired Helical Filament-Tau 3 4
  • PPP1R103 2 3
  • FTDP-17 2 3
  • PHF-Tau 3 4
  • MAPTL 3 4
  • MTBT2 2 3
  • MSTD 2 3
  • PPND 2 3
  • Microtubule-Associated Protein Tau, Isoform 4 2
  • MGC138549 2
  • FLJ31424 2
  • DDPAC 3
  • MAPT 5
  • Tau 2

External Ids for MAPT Gene

Previous HGNC Symbols for MAPT Gene

  • DDPAC
  • MAPTL

Previous GeneCards Identifiers for MAPT Gene

  • GC17P043566
  • GC17P046217
  • GC17P043982
  • GC17P044447
  • GC17P041327
  • GC17P039635
  • GC17P043971

Summaries for MAPT Gene

Entrez Gene Summary for MAPT Gene

  • This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPT Gene

MAPT (Microtubule Associated Protein Tau) is a Protein Coding gene. Diseases associated with MAPT include Frontotemporal Dementia and Supranuclear Palsy, Progressive, 1. Among its related pathways are Neuroscience and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is MAP2.

UniProtKB/Swiss-Prot Summary for MAPT Gene

  • Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Gene Wiki entry for MAPT Gene

Additional gene information for MAPT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPT Gene

Genomics for MAPT Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPT Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J045893 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.1 1136 3.8 RNF2 GATAD2A CTCF PRDM10 TFE3 ZNF692 JUND LARP7 MTA2 ZNF143 MAPT MAPT-AS1 MAPT-IT1 LINC02210 MAPK8IP1P1 ENSG00000262372 KANSL1 ARL17A ARL17B RPS7P11
GH17J045951 Promoter/Enhancer 1.1 EPDnew Ensembl 600.2 +57.3 57319 1 TCF12 EP300 EGR1 ZBTB11 TRIM24 NCOR1 NFIC STAT5A FOXM1 NR2F1 MAPT LINC02210 lnc-STH-3 lnc-STH-4 STH
GH17J045962 Promoter 0.3 EPDnew 600.2 +67.8 67845 0.1 MAPT lnc-STH-3 NONHSAG022015.2 STH
GH17J045941 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +48.3 48326 1.8 PKNOX1 SP1 FOXA2 ATF3 YY1 ZBTB33 JUND NR2F2 SPI1 ZNF366 lnc-KANSL1-5 lnc-STH-5 LINC02210 MAPT STH ENSG00000262539 CRHR1 lnc-STH-4
GH17J045948 Enhancer 1.1 ENCODE dbSUPER 39.3 +54.5 54491 1.5 GATAD2A CTCF SOX13 NFKBIZ KDM1A BACH1 JUND ZNF143 PHF21A ZIC2 LINC02210 MAPT lnc-STH-4 lnc-STH-3 STH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPT

Top Transcription factor binding sites by QIAGEN in the MAPT gene promoter:
  • ATF-2
  • CREB

Genomic Locations for MAPT Gene

Genomic Locations for MAPT Gene
chr17:45,894,382-46,028,334
(GRCh38/hg38)
Size:
133,953 bases
Orientation:
Plus strand
chr17:43,971,748-44,105,700
(GRCh37/hg19)
Size:
133,953 bases
Orientation:
Plus strand

Genomic View for MAPT Gene

Genes around MAPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPT Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPT Gene

Proteins for MAPT Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10636-TAU_HUMAN
    Recommended name:
    Microtubule-associated protein tau
    Protein Accession:
    P10636
    Secondary Accessions:
    • P18518
    • Q14799
    • Q15549
    • Q15550
    • Q15551
    • Q1RMF6
    • Q53YB1
    • Q5CZI7
    • Q5XWF0
    • Q6QT54
    • Q9UDJ3
    • Q9UMH0
    • Q9UQ96

    Protein attributes for MAPT Gene

    Size:
    758 amino acids
    Molecular mass:
    78928 Da
    Quaternary structure:
    • Interacts with MARK1, MARK2, MARK3 AND MARK4 (PubMed:23666762). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated (PubMed:15953362). Interacts with FKBP4 (By similarity). Binds to CSNK1D (PubMed:14761950). Interacts with SGK1 (PubMed:16982696). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-396 (PubMed:19542233). Interacts with PIN1 (PubMed:11313338). Interacts with LRRK2 (PubMed:26014385).

    Three dimensional structures from OCA and Proteopedia for MAPT Gene

    Alternative splice isoforms for MAPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPT Gene

Protein Expression for MAPT Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAPT Gene

  • Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly (PubMed:7706316, PubMed:23666762). Phosphorylation decreases with age. Phosphorylation within tau/MAP's repeat domain or in flanking regions seems to reduce tau/MAP's interaction with, respectively, microtubules or plasma membrane components (PubMed:7706316). Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Phosphorylation at Ser-548 by GSK3B reduces ability to bind and stabilize microtubules. Phosphorylation at Ser-579 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively. Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717. Dephosphorylated at several serine and threonine residues by the serine/threonine phosphatase PPP5C.
  • Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity). PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur.
  • O-glycosylated. O-GlcNAcylation content is around 8.2%. There is reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively. O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%.
  • Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.
  • Glycosylation at Lys383, Lys467, Lys480, Lys491, Lys87, Ser525, Lys542, Lys551, Ser555, Lys576, Lys597, Lys664, Lys598, Lys670, Lys686, and Ser717
  • Ubiquitination at Lys44, Lys584, and Lys692
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAPT Gene

Domains & Families for MAPT Gene

Gene Families for MAPT Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAPT Gene

InterPro:
Blocks:
  • Tubulin-binding Tau protein
  • Tau protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPT Gene

GenScript: Design optimal peptide antigens:
  • Paired helical filament-tau (TAU_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10636

UniProtKB/Swiss-Prot:

TAU_HUMAN :
  • The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
Domain:
  • The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
genes like me logo Genes that share domains with MAPT: view

Function for MAPT Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAPT Gene

UniProtKB/Swiss-Prot Function:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
GENATLAS Biochemistry:
microtubule (beta) associated protein tau 1,primary component of paired helical filaments with six alternatively spliced forms in normal adult brain,regulating the transport of vesicles or organelles along microtubules,phosphorylated by CDK5 and other kinases with decrease of affinity for microtubules,forming tangles of paired helical filaments (PHF) consisting of hyperphosphorylated tau protein observed in Alzheimer disease (triplet PHF-tau),overexpressed in extraskeletal myxoid chondrosarcoma and chordoma

Phenotypes From GWAS Catalog for MAPT Gene

Gene Ontology (GO) - Molecular Function for MAPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 28386764
GO:0003680 AT DNA binding TAS 28386764
GO:0003690 double-stranded DNA binding TAS 28386764
GO:0003697 single-stranded DNA binding TAS 28386764
GO:0003723 RNA binding TAS 28386764
genes like me logo Genes that share ontologies with MAPT: view
genes like me logo Genes that share phenotypes with MAPT: view

Human Phenotype Ontology for MAPT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPT Gene

MGI Knock Outs for MAPT:
  • Mapt Mapt<tm1Aha>
  • Mapt Mapt<tm1(EGFP)Klt>
  • Mapt Mapt<tm1Hnd>
  • Mapt Mapt<tm1(MAPT)Vln>
  • Mapt Mapt<tm1(Mecp2)Jae>
  • Mapt Mapt<tm1Noh>
  • Mapt Mapt<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPT

Clone Products

  • Addgene plasmids for MAPT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MAPT Gene

Localization for MAPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPT Gene

Cytoplasm, cytosol. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. {ECO:0000269 PubMed:10747907}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPT gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 28386764
GO:0005623 cell TAS --
GO:0005634 nucleus ISS,TAS 28386764
GO:0005737 cytoplasm IMP,ISS --
GO:0005739 mitochondrion TAS 28386764
genes like me logo Genes that share ontologies with MAPT: view

Pathways & Interactions for MAPT Gene

genes like me logo Genes that share pathways with MAPT: view

Pathways by source for MAPT Gene

2 Sino Biological pathways for MAPT Gene
1 PharmGKB pathway for MAPT Gene
3 GeneGo (Thomson Reuters) pathways for MAPT Gene
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Development Slit-Robo signaling
  • Neurophysiological process Receptor-mediated axon growth repulsion
5 Qiagen pathways for MAPT Gene
  • 14-3-3 Induced Intracellular Signaling
  • Alzheimers Disease Pathway
  • CDK5 Pathway
  • DHA Signaling
  • Reelin Pathway (Cajal-Retzius cells)
2 Cell Signaling Technology pathways for MAPT Gene

SIGNOR curated interactions for MAPT Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IDA,NAS 28377597
GO:0001774 microglial cell activation TAS 26363795
GO:0006475 internal protein amino acid acetylation TAS 28386764
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS 26363795
GO:0007267 cell-cell signaling NAS 28386764
genes like me logo Genes that share ontologies with MAPT: view

Drugs & Compounds for MAPT Gene

Products:

  1. Drug

(67) Drugs for MAPT Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2330
Paclitaxel Approved, Vet_approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 3701
Astemizole Approved, Withdrawn Pharma Pore Blocker, Inhibitor, Target 0
Flortaucipir F-18 Approved, Investigational Pharma Target, binder 0
Lansoprazole Approved, Investigational Pharma Target H+,K+-ATPase inhibitor 255

(40) Additional Compounds for MAPT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPT: view

Transcripts for MAPT Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPT Gene

12 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPT

Clone Products

  • Addgene plasmids for MAPT

Alternative Splicing Database (ASD) splice patterns (SP) for MAPT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for MAPT Gene

GeneLoc Exon Structure for
MAPT

Expression for MAPT Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPT Gene

mRNA expression in normal human tissues for MAPT Gene
mRNA expression by GTEx for MAPT GenemRNA expression by BioGPS for MAPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPT Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for MAPT Gene

This gene is overexpressed in Frontal cortex (25.6), Fetal Brain (19.3), and Brain (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPT Gene



Protein tissue co-expression partners for MAPT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPT

SOURCE GeneReport for Unigene cluster for MAPT Gene:

Hs.101174

mRNA Expression by UniProt/SwissProt for MAPT Gene:

P10636-TAU_HUMAN
Tissue specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Evidence on tissue expression from TISSUES for MAPT Gene

  • Nervous system(5)
  • Liver(4.5)
  • Lung(3.9)
  • Eye(3.7)
  • Muscle(3.4)
  • Kidney(3.2)
  • Skin(3.2)
  • Heart(3)
  • Blood(2.8)
  • Intestine(2.6)
  • Adrenal gland(2.6)
  • Pancreas(2.5)
  • Bone(2.1)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPT Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
Thorax:
  • chest wall
  • esophagus
  • lung
  • rib
  • rib cage
Abdomen:
  • abdominal wall
  • stomach
Pelvis:
  • pelvis
  • prostate
  • urinary bladder
Limb:
  • foot
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with MAPT: view

Orthologs for MAPT Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPT 30 31
  • 99.48 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPT 31
  • 92 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPT 30 31
  • 90.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPT 30 31
  • 87.35 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mapt 30 17 31
  • 84.92 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapt 30
  • 83.87 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MAPT 31
  • 58 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAPT 30 31
  • 78.37 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPT 31
  • 72 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapt 30
  • 72.99 (n)
Zebrafish
(Danio rerio)
 Actinopterygii mapta 31
  • 44 (a)
 OneToMany
maptb 31
  • 27 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta tau 31
  • 27 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea ptl-1 31
  • 16 (a)
 OneToMany
Species where no ortholog for MAPT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPT Gene

ENSEMBL:
Gene Tree for MAPT (if available)
TreeFam:
Gene Tree for MAPT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPT: view image

Paralogs for MAPT Gene

Paralogs for MAPT Gene

(3) SIMAP similar genes for MAPT Gene using alignment to 4 proteins:

  • TAU_HUMAN
  • I3L170_HUMAN
  • I3L2Z2_HUMAN
  • T1SGS4_HUMAN
genes like me logo Genes that share paralogs with MAPT: view

Variants for MAPT Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPT Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
323695 Uncertain Significance: MAPT-Related Spectrum Disorders 46,026,459(+) TG/CA THREE_PRIME_UTR_VARIANT
638372 Uncertain Significance: Frontotemporal dementia; Multiple system atrophy; Pick's disease; Progressive supranuclear ophthalmoplegia 45,983,468(+) C/A MISSENSE_VARIANT,INTRON_VARIANT
640803 Uncertain Significance: Frontotemporal dementia 45,996,497(+) C/T MISSENSE_VARIANT
648859 Conflicting Interpretations: Frontotemporal dementia; MAPT-Related Spectrum Disorders 45,974,448(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
662109 Uncertain Significance: Frontotemporal dementia 45,974,435(+) G/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MAPT Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPT Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv128e55 CNV gain 17911159
dgv3178n100 CNV gain 25217958
dgv935e212 CNV loss 25503493
esv2676042 CNV deletion 23128226
esv2715976 CNV deletion 23290073
esv2751686 CNV gain 17911159
esv2758692 CNV gain+loss 17122850
esv2762433 CNV gain+loss 21179565
esv3554475 CNV deletion 23714750
esv3582707 CNV loss 25503493
esv6819 CNV gain 19470904
nsv1071390 CNV deletion 25765185
nsv1072740 CNV deletion 25765185
nsv1138547 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv2068 CNV insertion 18451855
nsv469537 CNV gain+loss 16826518
nsv469705 CNV loss 16826518
nsv471698 CNV gain+loss 15918152
nsv478992 CNV novel sequence insertion 20440878
nsv510714 CNV deletion 20534489
nsv575142 CNV loss 21841781

Variation tolerance for MAPT Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.06; 95.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPT Gene

Human Gene Mutation Database (HGMD)
MAPT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPT Gene

Disorders for MAPT Gene

MalaCards: The human disease database

(124) MalaCards diseases for MAPT Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAPT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAU_HUMAN
  • Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations. {ECO:0000269 PubMed:14517953, ECO:0000269 PubMed:26086902}.
  • Frontotemporal dementia (FTD) [MIM:600274]: A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons. {ECO:0000269 PubMed:10208578, ECO:0000269 PubMed:10214944, ECO:0000269 PubMed:10374757, ECO:0000269 PubMed:10489057, ECO:0000269 PubMed:10553987, ECO:0000269 PubMed:10802785, ECO:0000269 PubMed:11071507, ECO:0000269 PubMed:11117541, ECO:0000269 PubMed:11278002, ECO:0000269 PubMed:11585254, ECO:0000269 PubMed:11889249, ECO:0000269 PubMed:11906000, ECO:0000269 PubMed:11921059, ECO:0000269 PubMed:12473774, ECO:0000269 PubMed:12509859, ECO:0000269 PubMed:14517953, ECO:0000269 PubMed:15883319, ECO:0000269 PubMed:16240366, ECO:0000269 PubMed:26086902, ECO:0000269 PubMed:9629852, ECO:0000269 PubMed:9641683, ECO:0000269 PubMed:9736786, ECO:0000269 PubMed:9789048, ECO:0000269 PubMed:9973279}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Pick disease of the brain (PIDB) [MIM:172700]: A rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration. {ECO:0000269 PubMed:10604746, ECO:0000269 PubMed:11089577, ECO:0000269 PubMed:11117542, ECO:0000269 PubMed:11601501, ECO:0000269 PubMed:11891833}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.
  • Progressive supranuclear palsy 1 (PSNP1) [MIM:601104]: Characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613. {ECO:0000269 PubMed:10534245, ECO:0000269 PubMed:11220749, ECO:0000269 PubMed:12325083, ECO:0000269 PubMed:14991828, ECO:0000269 PubMed:14991829, ECO:0000269 PubMed:16157753}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Parkinson-dementia syndrome (PARDE) [MIM:260540]: A syndrome characterized by parkinsonism, tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MAPT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPT: view

No data available for Genatlas for MAPT Gene

Publications for MAPT Gene

  1. Assessment of Alzheimer's disease case-control associations using family-based methods. (PMID: 18830724) Schjeide BM … Bertram L (Neurogenetics 2009) 3 23 41
  2. Cluster analysis of risk factor genetic polymorphisms in Alzheimer's disease. (PMID: 18307033) Randall CN … Poduslo SE (Neurochemical research 2009) 3 23 41
  3. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PMID: 19224617) Sutherland GT … Mellick GD (Movement disorders : official journal of the Movement Disorder Society 2009) 3 23 41
  4. A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. (PMID: 18234697) Beck J … Mead S (Brain : a journal of neurology 2008) 3 23 41
  5. Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. (PMID: 18991351) Kwok JB … Schofield PR (Annals of neurology 2008) 3 23 41