The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008] See more...

Aliases for MAPRE3 Gene

Aliases for MAPRE3 Gene

  • Microtubule Associated Protein RP/EB Family Member 3 2 3 5
  • EB3 2 3 4
  • RP3 2 3 4
  • Microtubule-Associated Protein RP/EB Family Member 3 3 4
  • EB1 Protein Family Member 3 3 4
  • End-Binding Protein 3 3 4
  • EBF3 3 4
  • APC Binding Protein 3
  • EBF3-S 3
  • MAPRE3 5

External Ids for MAPRE3 Gene

Previous GeneCards Identifiers for MAPRE3 Gene

  • GC02P027114
  • GC02P027286
  • GC02P027168
  • GC02P027105
  • GC02P027193

Summaries for MAPRE3 Gene

Entrez Gene Summary for MAPRE3 Gene

  • The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE3 Gene

MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3) is a Protein Coding gene. Diseases associated with MAPRE3 include Neuronopathy, Distal Hereditary Motor, Type Viib and Distal Hereditary Motor Neuronopathy Type 7. Among its related pathways are Remodeling of Adherens Junctions and PAK Pathway. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE1.

UniProtKB/Swiss-Prot Summary for MAPRE3 Gene

  • Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPRE3 Gene

Genomics for MAPRE3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAPRE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026968 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 0.0 -25 5 ZNF207 ZNF600 MYC IKZF1 ATF2 ZNF10 NFIC NONO KLF11 SMAD5 MAPRE3 KHK MAPRE3-AS1 ENSG00000230286 AGBL5 AGBL5-AS1 DPYSL5 EMILIN1 ATRAID SLC5A6
GH02J027014 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.3 +44.1 44098 0.1 MAPRE3-AS1 MAPRE3 KHK HSALNG0013757 TMEM214
GH02J027085 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 +116.8 116775 5 BCLAF1 SP1 ZNF654 ZNF207 IKZF1 ZNF600 MYC SSRP1 ZNF592 ZMYM3 KHK lnc-CGREF1-1 CENPA SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN
GH02J026784 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.9 -184.2 -184236 3.2 BCLAF1 SP1 ZNF207 MYC SSRP1 ZNF592 ZMYM3 KLF9 JUND POLR2A CENPA NONHSAG027291.2 ATRAID EIF2B4 ASXL2 NRBP1 GTF3C2 GPN1 ENSG00000234072 PPM1G
GH02J026763 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.3 -205.8 -205818 2.9 BCLAF1 NCOR1 MYC ZNF600 KLF9 POLR2A ZBTB10 MXD4 NONO REST CENPA hsa-miR-5095-288 SLC35F6 EIF2B4 ATRAID CAD ENSG00000234072 ASXL2 NRBP1 GTF3C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPRE3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPRE3

Top Transcription factor binding sites by QIAGEN in the MAPRE3 gene promoter:
  • aMEF-2
  • AML1a
  • FOXO1
  • FOXO1a
  • Ik-3
  • LCR-F1
  • MEF-2A
  • NF-kappaB1
  • Pax-5
  • Sox5

Genomic Locations for MAPRE3 Gene

Latest Assembly
chr2:26,970,637-27,027,219
(GRCh38/hg38)
Size:
56,583 bases
Orientation:
Plus strand

Previous Assembly
chr2:27,193,505-27,250,087
(GRCh37/hg19 by Entrez Gene)
Size:
56,583 bases
Orientation:
Plus strand

chr2:27,193,480-27,250,064
(GRCh37/hg19 by Ensembl)
Size:
56,585 bases
Orientation:
Plus strand

Genomic View for MAPRE3 Gene

Genes around MAPRE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE3 Gene

Proteins for MAPRE3 Gene

  • Protein details for MAPRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY8-MARE3_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 3
    Protein Accession:
    Q9UPY8
    Secondary Accessions:
    • B7WPK5
    • O00265
    • Q6FHB0
    • Q6FI15
    • Q9BZP7
    • Q9BZP8

    Protein attributes for MAPRE3 Gene

    Size:
    281 amino acids
    Molecular mass:
    31982 Da
    Quaternary structure:
    • Interacts with APC2 (PubMed:10644998). Homodimer (PubMed:19255245). Heterodimer with MAPRE1 (PubMed:19255245). Interacts with DCTN1 and SRCIN1 (PubMed:14514668, PubMed:19146815). Binds to the C-terminal domain of APC (PubMed:14514668). Binds monomeric and polymerized tubulin (PubMed:10188731). Interacts (via C-terminus) with CLIP1 (PubMed:17563362). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with AKAP9 (PubMed:28814570). Interacts with PDE4DIP (PubMed:28814570). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (PubMed:25217626).
    SequenceCaution:
    • Sequence=AAK07556.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07557.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA72060.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPRE3 Gene

    Alternative splice isoforms for MAPRE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE3 Gene

Post-translational modifications for MAPRE3 Gene

  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAPRE3 Gene

Domains & Families for MAPRE3 Gene

Gene Families for MAPRE3 Gene

Protein Domains for MAPRE3 Gene

InterPro:
Blocks:
  • Calponin-like actin-binding
  • EB1 protein

Suggested Antigen Peptide Sequences for MAPRE3 Gene

GenScript: Design optimal peptide antigens:
  • RP3 (MARE3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPY8

UniProtKB/Swiss-Prot:

MARE3_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE3: view

Function for MAPRE3 Gene

Molecular function for MAPRE3 Gene

UniProtKB/Swiss-Prot Function:
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).

Phenotypes From GWAS Catalog for MAPRE3 Gene

Gene Ontology (GO) - Molecular Function for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10644998
GO:0008017 microtubule binding ISS 17310996
GO:0008022 protein C-terminus binding IPI 26323690
GO:0019901 protein kinase binding IPI 26323690
GO:0042802 identical protein binding IPI 27107012
genes like me logo Genes that share ontologies with MAPRE3: view
genes like me logo Genes that share phenotypes with MAPRE3: view

Animal Models for MAPRE3 Gene

MGI Knock Outs for MAPRE3:
  • Mapre3 Mapre3<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPRE3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPRE3 Gene

Localization for MAPRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE3 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules. {ECO:0000269 PubMed:10644998, ECO:0000269 PubMed:19255245, ECO:0000269 PubMed:28814570}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPRE3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 3
nucleus 3
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS 17310996
GO:0005815 microtubule organizing center IBA 21873635
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005881 cytoplasmic microtubule IDA --
genes like me logo Genes that share ontologies with MAPRE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPRE3 Gene

Pathways & Interactions for MAPRE3 Gene

PathCards logo

SuperPathways for MAPRE3 Gene

SuperPathway Contained pathways
1 PAK Pathway
.36
2 Remodeling of Adherens Junctions
-
genes like me logo Genes that share pathways with MAPRE3: view

Pathways by source for MAPRE3 Gene

2 Qiagen pathways for MAPRE3 Gene
  • Epithelial Adherens Junctions
  • Remodeling of Adherens Junctions

SIGNOR curated interactions for MAPRE3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008104 protein localization TAS 26323690
GO:0031110 regulation of microtubule polymerization or depolymerization IBA 21873635
GO:0031113 regulation of microtubule polymerization IMP 23159740
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS 17310996
genes like me logo Genes that share ontologies with MAPRE3: view

Drugs & Compounds for MAPRE3 Gene

No Compound Related Data Available

Transcripts for MAPRE3 Gene

mRNA/cDNA for MAPRE3 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPRE3

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - -

Relevant External Links for MAPRE3 Gene

GeneLoc Exon Structure for
MAPRE3

Expression for MAPRE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPRE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPRE3 Gene

This gene is overexpressed in Frontal cortex (19.4), Brain (13.8), Fetal Brain (11.9), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPRE3 Gene



Protein tissue co-expression partners for MAPRE3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPRE3

SOURCE GeneReport for Unigene cluster for MAPRE3 Gene:

Hs.515860

mRNA Expression by UniProt/SwissProt for MAPRE3 Gene:

Q9UPY8-MARE3_HUMAN
Tissue specificity: Predominantly expressed in brain and muscle.

Evidence on tissue expression from TISSUES for MAPRE3 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Pancreas(3.3)
  • Muscle(2.8)
  • Skin(2.6)
  • Eye(2.6)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MAPRE3: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPRE3 Gene

Orthologs for MAPRE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAPRE3 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MAPRE3 29 30
  • 94.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAPRE3 29 30
  • 94.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mapre3 29
  • 92.88 (n)
Mouse
(Mus musculus)
Mammalia Mapre3 29 16 30
  • 91.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MAPRE3 30
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE3 30
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100857732 29
  • 79.37 (n)
MAPRE3 30
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAPRE3 30
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68667 29
Zebrafish
(Danio rerio)
Actinopterygii mapre3a 30
  • 83 (a)
OneToMany
mapre3b 30 30
  • 81 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Eb1 30 31
  • 52 (a)
OneToMany
CG18190 31
  • 34 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y59A8B.7 31
  • 51 (a)
ebp-1 30
  • 40 (a)
ManyToMany
VW02B12L.3 31
  • 34 (a)
ebp-2 30
  • 31 (a)
ManyToMany
ebp-3 30
  • 28 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 30
  • 27 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EB1A 29
  • 49.42 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4467 29
Species where no ortholog for MAPRE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MAPRE3 Gene

ENSEMBL:
Gene Tree for MAPRE3 (if available)
TreeFam:
Gene Tree for MAPRE3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPRE3: view image
Alliance of Genome Resources:
Additional Orthologs for MAPRE3

Paralogs for MAPRE3 Gene

Paralogs for MAPRE3 Gene

(2) SIMAP similar genes for MAPRE3 Gene using alignment to 2 proteins:

  • MARE3_HUMAN
  • C9JB30_HUMAN
genes like me logo Genes that share paralogs with MAPRE3: view

Variants for MAPRE3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAPRE3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAPRE3 Gene

Variant ID Type Subtype PubMed ID
dgv6744n54 CNV loss 21841781
esv3590131 CNV loss 21293372
nsv455974 CNV loss 19166990

Variation tolerance for MAPRE3 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPRE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPRE3
Leiden Open Variation Database (LOVD)
MAPRE3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPRE3 Gene

Disorders for MAPRE3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MAPRE3 Gene - From: COP

Disorder Aliases PubMed IDs
neuronopathy, distal hereditary motor, type viib
  • hmn7b
distal hereditary motor neuronopathy type 7
  • dhmn7
ebola hemorrhagic fever
  • ebola virus disease
perry syndrome
  • parkinsonism with alveolar hypoventilation and mental depression
diffuse idiopathic skeletal hyperostosis
  • ankylosing vertebral hyperostosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPRE3

genes like me logo Genes that share disorders with MAPRE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE3 Gene

Publications for MAPRE3 Gene

  1. Mammalian end binding proteins control persistent microtubule growth. (PMID: 19255245) Komarova Y … Akhmanova A (The Journal of cell biology 2009) 3 4 22
  2. Characterization of human MAPRE genes and their proteins. (PMID: 11161807) Su LK … Qi Y (Genomics 2001) 3 4 22
  3. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C … Pfreundschuh M (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4
  4. EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. (PMID: 28814570) Yang C … Akhmanova A (The Journal of cell biology 2017) 3 4
  5. Molecular insights into mammalian end-binding protein heterodimerization. (PMID: 20008324) De Groot CO … Steinmetz MO (The Journal of biological chemistry 2010) 3 22

Products for MAPRE3 Gene

Sources for MAPRE3 Gene