Aliases for MAPRE3 Gene
External Ids for MAPRE3 Gene
Previous GeneCards Identifiers for MAPRE3 Gene
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPRE3 Gene
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3) is a Protein Coding gene. Diseases associated with MAPRE3 include Neuronopathy, Distal Hereditary Motor, Type Viib and Distal Hereditary Motor Neuronopathy Type 7. Among its related pathways are Remodeling of Adherens Junctions and PAK Pathway. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE1.
UniProtKB/Swiss-Prot Summary for MAPRE3 Gene
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).