Aliases for MAPRE2 Gene
External Ids for MAPRE2 Gene
Previous GeneCards Identifiers for MAPRE2 Gene
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for MAPRE2 Gene
MAPRE2 (Microtubule Associated Protein RP/EB Family Member 2) is a Protein Coding gene. Diseases associated with MAPRE2 include Skin Creases, Congenital Symmetric Circumferential, 2 and Multiple Benign Circumferential Skin Creases On Limbs. Among its related pathways are PAK Pathway and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE3.
UniProtKB/Swiss-Prot Summary for MAPRE2 Gene
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).