The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with comp... See more...

Aliases for MAPRE1 Gene

Aliases for MAPRE1 Gene

  • Microtubule Associated Protein RP/EB Family Member 1 2 3 5
  • EB1 2 3 4
  • Microtubule-Associated Protein RP/EB Family Member 1 3 4
  • Adenomatous Polyposis Coli-Binding Protein EB1 2 3
  • APC-Binding Protein EB1 3 4
  • End-Binding Protein 1 3 4
  • MAPRE1 5

External Ids for MAPRE1 Gene

Previous GeneCards Identifiers for MAPRE1 Gene

  • GC20P031166
  • GC20P032076
  • GC20P032123
  • GC20P030871
  • GC20P031407
  • GC20P028194

Summaries for MAPRE1 Gene

Entrez Gene Summary for MAPRE1 Gene

  • The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE1 Gene

MAPRE1 (Microtubule Associated Protein RP/EB Family Member 1) is a Protein Coding gene. Diseases associated with MAPRE1 include Familial Adenomatous Polyposis and Pediatric Ependymoma. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is MAPRE3.

UniProtKB/Swiss-Prot Summary for MAPRE1 Gene

  • Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPRE1 Gene

Genomics for MAPRE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAPRE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPRE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPRE1

Top Transcription factor binding sites by QIAGEN in the MAPRE1 gene promoter:
  • AML1a
  • E47
  • Egr-3
  • Evi-1
  • GATA-1
  • HFH-1
  • LCR-F1
  • N-Myc
  • NF-YC

Genomic Locations for MAPRE1 Gene

Latest Assembly
chr20:32,819,780-32,850,405
(GRCh38/hg38)
Size:
30,626 bases
Orientation:
Plus strand

Previous Assembly
chr20:31,407,760-31,438,211
(GRCh37/hg19 by Entrez Gene)
Size:
30,452 bases
Orientation:
Plus strand

chr20:31,407,699-31,438,211
(GRCh37/hg19 by Ensembl)
Size:
30,513 bases
Orientation:
Plus strand

Genomic View for MAPRE1 Gene

Genes around MAPRE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE1 Gene

Proteins for MAPRE1 Gene

  • Protein details for MAPRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15691-MARE1_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 1
    Protein Accession:
    Q15691
    Secondary Accessions:
    • B2R6I7
    • E1P5M8
    • Q3KQS8

    Protein attributes for MAPRE1 Gene

    Size:
    268 amino acids
    Molecular mass:
    29999 Da
    Quaternary structure:
    • Homodimer (PubMed:15616574). Heterodimer with MAPRE3 (PubMed:19255245). Interacts with DCTN1, DCTN2, TERF1 and dynein intermediate chain (PubMed:10226031, PubMed:11943150, PubMed:12388762, PubMed:14514668, PubMed:23874158, PubMed:16109370, PubMed:16949363). Interaction with DIAPH1 and DIAPH2 (By similarity). Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends (PubMed:7606712, PubMed:12388762, PubMed:14514668, PubMed:15631994, PubMed:19543227, PubMed:15616574, PubMed:19632184). Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules (PubMed:19543227). Interacts with APC2 (PubMed:10644998). Interacts with CLASP1 (PubMed:15631994). Interacts with CDK5RAP2 (PubMed:19553473). Interacts with MACF1 (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with KCNAB2 (By similarity). Interacts (via C-terminus) with CLIP1 (PubMed:17563362, PubMed:21646404). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends (PubMed:21820309). Interacts with MISP (PubMed:23509069). Interacts with KNSTRN (PubMed:23035123). Interacts with NCKAP5L (PubMed:26485573). Interacts with CAMSAP2 (PubMed:28726242). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (PubMed:25217626, PubMed:28814570). Forms a pericentrosomal complex with AKAP9, CDK5RAP2 and PDE4DIP isoform 13/MMG8/SMYLE; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (PubMed:29162697). Interacts with AKNA (By similarity). Interacts with GAS2L1, GAS2L2, and GAS2L3 (PubMed:24706950).

    Three dimensional structures from OCA and Proteopedia for MAPRE1 Gene

neXtProt entry for MAPRE1 Gene

Post-translational modifications for MAPRE1 Gene

  • Ubiquitination at Lys66, Lys76, Lys83, Lys100, Lys151, Lys174, Lys182, and Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPRE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAPRE1 Gene

Domains & Families for MAPRE1 Gene

Gene Families for MAPRE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAPRE1 Gene

InterPro:
Blocks:
  • Calponin-like actin-binding
  • EB1 protein

Suggested Antigen Peptide Sequences for MAPRE1 Gene

GenScript: Design optimal peptide antigens:
  • MAPRE1 protein (A2VCR0_HUMAN)
  • End-binding protein 1 (MARE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15691

UniProtKB/Swiss-Prot:

MARE1_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE1: view

Function for MAPRE1 Gene

Molecular function for MAPRE1 Gene

UniProtKB/Swiss-Prot Function:
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity).
GENATLAS Biochemistry:
Microtubule-associated protein, RP/EB family, member 1,component of the microtubule cytoskeleton,colocalyzing both to cytoplasmic microtubules in interphase cells and to spindle microtubules during mitosis,associating with the C terminal region of APC

Phenotypes From GWAS Catalog for MAPRE1 Gene

Gene Ontology (GO) - Molecular Function for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 10226031
GO:0008017 microtubule binding IEA --
GO:0008022 protein C-terminus binding TAS 7606712
GO:0019901 protein kinase binding IPI 26323690
genes like me logo Genes that share ontologies with MAPRE1: view
genes like me logo Genes that share phenotypes with MAPRE1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPRE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPRE1 Gene

Localization for MAPRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Note=Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). {ECO:0000269 PubMed:25217626, ECO:0000269 PubMed:28814570}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPRE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 3
nucleus 3
golgi apparatus 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (4)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IBA 21873635
GO:0005819 colocalizes_with spindle IDA 11943150
genes like me logo Genes that share ontologies with MAPRE1: view

Pathways & Interactions for MAPRE1 Gene

genes like me logo Genes that share pathways with MAPRE1: view

Pathways by source for MAPRE1 Gene

2 Qiagen pathways for MAPRE1 Gene
  • Epithelial Adherens Junctions
  • Remodeling of Adherens Junctions
2 Cell Signaling Technology pathways for MAPRE1 Gene

SIGNOR curated interactions for MAPRE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001578 microtubule bundle formation IEA --
GO:0007049 cell cycle IEA --
GO:0008104 protein localization TAS 26323690
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with MAPRE1: view

Drugs & Compounds for MAPRE1 Gene

(1) Drugs for MAPRE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MAPRE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPRE1: view

Transcripts for MAPRE1 Gene

mRNA/cDNA for MAPRE1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPRE1

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for MAPRE1 Gene

GeneLoc Exon Structure for
MAPRE1

Expression for MAPRE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPRE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPRE1 Gene



Protein tissue co-expression partners for MAPRE1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPRE1

SOURCE GeneReport for Unigene cluster for MAPRE1 Gene:

Hs.472437

mRNA Expression by UniProt/SwissProt for MAPRE1 Gene:

Q15691-MARE1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for MAPRE1 Gene

  • Nervous system(5)
  • Liver(4.6)
  • Blood(4.5)
  • Skin(3.6)
  • Kidney(3.1)
  • Lung(3)
  • Eye(3)
  • Heart(2.7)
  • Pancreas(2.5)
  • Intestine(2.5)
  • Spleen(2.4)
  • Muscle(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with MAPRE1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPRE1 Gene

Orthologs for MAPRE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAPRE1 29 30
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAPRE1 29 30
  • 93.9 (n)
OneToMany
-- 30
  • 86 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MAPRE1 29 30
  • 91.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mapre1 29 16 30
  • 91.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mapre1 29
  • 90.14 (n)
Oppossum
(Monodelphis domestica)
Mammalia MAPRE1 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE1 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAPRE1 29 30
  • 80.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAPRE1 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mapre1 29
  • 73.93 (n)
MGC75947 29
African clawed frog
(Xenopus laevis)
Amphibia mapre1-prov 29
Zebrafish
(Danio rerio)
Actinopterygii mapre1b 29 30
  • 71.62 (n)
OneToMany
mapre1a 30
  • 71 (a)
OneToMany
-- 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8649 29
Fruit Fly
(Drosophila melanogaster)
Insecta Eb1 30 31
  • 53 (a)
OneToMany
CG18190 31
  • 38 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y59A8B.7 31
  • 55 (a)
ebp-1 30
  • 43 (a)
ManyToMany
VW02B12L.3 31
  • 34 (a)
ebp-3 30
  • 31 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 29 30 32
  • 50.57 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR024W 29
  • 49.93 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11550g 29
  • 48.92 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EB1C 29
  • 50.28 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0498900 29
  • 50.88 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00243 29
  • 50.63 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mal3 29
  • 48.18 (n)
Species where no ortholog for MAPRE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPRE1 Gene

ENSEMBL:
Gene Tree for MAPRE1 (if available)
TreeFam:
Gene Tree for MAPRE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPRE1: view image
Alliance of Genome Resources:
Additional Orthologs for MAPRE1

Paralogs for MAPRE1 Gene

Paralogs for MAPRE1 Gene

(2) SIMAP similar genes for MAPRE1 Gene using alignment to 2 proteins:

  • MARE1_HUMAN
  • A2VCR0_HUMAN

Pseudogenes.org Pseudogenes for MAPRE1 Gene

genes like me logo Genes that share paralogs with MAPRE1: view

Variants for MAPRE1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAPRE1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAPRE1 Gene

Variant ID Type Subtype PubMed ID
esv2722348 CNV deletion 23290073
nsv1056411 CNV loss 25217958
nsv1143982 CNV deletion 24896259
nsv179907 CNV deletion 16902084
nsv179909 CNV deletion 16902084
nsv833957 CNV gain+loss 17160897
nsv833959 CNV loss 17160897
nsv979428 CNV duplication 23825009

Variation tolerance for MAPRE1 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPRE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPRE1
Leiden Open Variation Database (LOVD)
MAPRE1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPRE1 Gene

Disorders for MAPRE1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MAPRE1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
familial adenomatous polyposis
  • adenomatous polyposis of the colon
pediatric ependymoma
  • childhood ependymoma
neuropathy, hereditary sensory and autonomic, type vi
  • hsan6
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPRE1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAPRE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE1 Gene

Publications for MAPRE1 Gene

  1. APC binds to the novel protein EB1. (PMID: 7606712) Su LK … Kinzler KW (Cancer research 1995) 2 3 4 22
  2. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K … Yao X (EMBO reports 2009) 3 4 22
  3. Structural insights into the EB1-APC interaction. (PMID: 15616574) Honnappa S … Steinmetz MO (The EMBO journal 2005) 3 4 22
  4. Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). (PMID: 12857735) Hayashi I … Ikura M (The Journal of biological chemistry 2003) 3 4 22
  5. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. (PMID: 12388762) Askham JM … Morrison EE (Molecular biology of the cell 2002) 3 4 22

Products for MAPRE1 Gene

Sources for MAPRE1 Gene