The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon ph... See more...

Aliases for MAPKAPK5 Gene

Aliases for MAPKAPK5 Gene

  • MAPK Activated Protein Kinase 5 2 3
  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 2 3 5
  • P38-Regulated/Activated Protein Kinase 3 4
  • MAP Kinase-Activated Protein Kinase 5 3 4
  • MAPKAP Kinase 5 3 4
  • EC 2.7.11.1 4 54
  • MAPKAP-K5 3 4
  • MAPKAPK-5 3 4
  • MK-5 3 4
  • PRAK 3 4
  • MK5 3 4
  • MAPK-Activated Protein Kinase 5 4
  • EC 2.7.11 54

External Ids for MAPKAPK5 Gene

Previous GeneCards Identifiers for MAPKAPK5 Gene

  • GC12P111177
  • GC12P111802
  • GC12P112062
  • GC12P110692
  • GC12P110691
  • GC12P110742
  • GC12P112282
  • GC12P109293

Summaries for MAPKAPK5 Gene

Entrez Gene Summary for MAPKAPK5 Gene

  • The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

GeneCards Summary for MAPKAPK5 Gene

MAPKAPK5 (MAPK Activated Protein Kinase 5) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK3.

UniProtKB/Swiss-Prot Summary for MAPKAPK5 Gene

  • Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Gene Wiki entry for MAPKAPK5 Gene

Additional gene information for MAPKAPK5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPKAPK5 Gene

Genomics for MAPKAPK5 Gene

GeneHancer (GH) Regulatory Elements for MAPKAPK5 Gene

Promoters and enhancers for MAPKAPK5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPKAPK5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAPKAPK5 gene promoter:
  • AP-2beta
  • AP-2gamma
  • p53

Genomic Locations for MAPKAPK5 Gene

Genomic Locations for MAPKAPK5 Gene
chr12:111,842,228-111,902,222
(GRCh38/hg38)
Size:
59,995 bases
Orientation:
Plus strand
chr12:112,279,782-112,334,343
(GRCh37/hg19)
Size:
54,562 bases
Orientation:
Plus strand

Genomic View for MAPKAPK5 Gene

Genes around MAPKAPK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAPK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAPK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK5 Gene

Proteins for MAPKAPK5 Gene

  • Protein details for MAPKAPK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW41-MAPK5_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 5
    Protein Accession:
    Q8IW41
    Secondary Accessions:
    • B3KVA5
    • O60491
    • Q86X46
    • Q9BVX9
    • Q9UG86

    Protein attributes for MAPKAPK5 Gene

    Size:
    473 amino acids
    Molecular mass:
    54220 Da
    Quaternary structure:
    • Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity). Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1.

    Alternative splice isoforms for MAPKAPK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAPK5 Gene

Selected DME Specific Peptides for MAPKAPK5 Gene

Q8IW41:
  • DLWSLGV
  • LKPENLL
  • RDLKPEN
  • TPYYVAP

Post-translational modifications for MAPKAPK5 Gene

  • Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Protein Products

  • Abcam proteins for MAPKAPK5

Domains & Families for MAPKAPK5 Gene

Gene Families for MAPKAPK5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAPKAPK5 Gene

Suggested Antigen Peptide Sequences for MAPKAPK5 Gene

GenScript: Design optimal peptide antigens:
  • p38-regulated/activated protein kinase (MAPK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IW41

UniProtKB/Swiss-Prot:

MAPK5_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK5: view

Function for MAPKAPK5 Gene

Molecular function for MAPKAPK5 Gene

UniProtKB/Swiss-Prot Function:
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine.
UniProtKB/Swiss-Prot Induction:
Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback regulatory loop.

Enzyme Numbers (IUBMB) for MAPKAPK5 Gene

Phenotypes From GWAS Catalog for MAPKAPK5 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0002039 p53 binding IDA 17254968
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,EXP --
GO:0004683 calmodulin-dependent protein kinase activity IBA 21873635
genes like me logo Genes that share ontologies with MAPKAPK5: view
genes like me logo Genes that share phenotypes with MAPKAPK5: view

Animal Models for MAPKAPK5 Gene

MGI Knock Outs for MAPKAPK5:

Animal Model Products

CRISPR Products

miRNA for MAPKAPK5 Gene

miRTarBase miRNAs that target MAPKAPK5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKAPK5 Gene

Localization for MAPKAPK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAPK5 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with MAPKAPK5: view

Pathways & Interactions for MAPKAPK5 Gene

genes like me logo Genes that share pathways with MAPKAPK5: view

Pathways by source for MAPKAPK5 Gene

1 R&D Systems pathway for MAPKAPK5 Gene
2 Qiagen pathways for MAPKAPK5 Gene
  • MAPK Family Pathway
  • p38 Signaling
1 Cell Signaling Technology pathway for MAPKAPK5 Gene

SIGNOR curated interactions for MAPKAPK5 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0006417 regulation of translation IDA 21329882
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 9628874
genes like me logo Genes that share ontologies with MAPKAPK5: view

Drugs & Compounds for MAPKAPK5 Gene

(4) Drugs for MAPKAPK5 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Calcium Approved Nutra 7773
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
GLPG0259 Pharma 0

(1) Additional Compounds for MAPKAPK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAPKAPK5: view

Transcripts for MAPKAPK5 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for MAPKAPK5 Gene

GeneLoc Exon Structure for
MAPKAPK5
ECgene alternative splicing isoforms for
MAPKAPK5

Expression for MAPKAPK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPKAPK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPKAPK5 Gene

This gene is overexpressed in Lung (43.0) and Monocytes (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPKAPK5 Gene



Protein tissue co-expression partners for MAPKAPK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPKAPK5 Gene:

MAPKAPK5

SOURCE GeneReport for Unigene cluster for MAPKAPK5 Gene:

Hs.413901

mRNA Expression by UniProt/SwissProt for MAPKAPK5 Gene:

Q8IW41-MAPK5_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for MAPKAPK5 Gene

  • Nervous system(4.6)
  • Pancreas(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with MAPKAPK5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAPK5 Gene

Orthologs for MAPKAPK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK5 33 32
  • 99.65 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 98 (a)
OneToMany
-- 33
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK5 33
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK5 33 32
  • 94.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK5 33 32
  • 93.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkapk5 17 33 32
  • 90.7 (n)
rat
(Rattus norvegicus)
Mammalia Mapkapk5 32
  • 90.63 (n)
chicken
(Gallus gallus)
Aves MAPKAPK5 33 32
  • 85.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAPK5 33
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk5 32
  • 80.24 (n)
Str.17845 32
zebrafish
(Danio rerio)
Actinopterygii mapkapk5 33 32
  • 77.38 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 33
  • 22 (a)
ManyToMany
RCK2 33
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 50 (a)
OneToOne
Cin.14027 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14027 32
Species where no ortholog for MAPKAPK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAPKAPK5 Gene

ENSEMBL:
Gene Tree for MAPKAPK5 (if available)
TreeFam:
Gene Tree for MAPKAPK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPKAPK5: view image

Paralogs for MAPKAPK5 Gene

Paralogs for MAPKAPK5 Gene

(14) SIMAP similar genes for MAPKAPK5 Gene using alignment to 4 proteins:

  • MAPK5_HUMAN
  • F8VRP2_HUMAN
  • R4GN33_HUMAN
  • R4GN93_HUMAN

Pseudogenes.org Pseudogenes for MAPKAPK5 Gene

genes like me logo Genes that share paralogs with MAPKAPK5: view

Variants for MAPKAPK5 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000102324 -- 111,846,556(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000122251 -- 111,865,630(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000219735 -- 111,884,697(+) G/A intron_variant
rs1000278909 -- 111,885,942(+) G/T coding_sequence_variant, missense_variant
rs1000306834 -- 111,841,570(+) C/A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK5 Gene

Variant ID Type Subtype PubMed ID
dgv1556n100 CNV gain 25217958
dgv2874n54 CNV gain 21841781
dgv304e214 CNV gain 21293372
dgv514e212 CNV gain 25503493
esv1010936 CNV deletion 20482838
esv2665280 CNV deletion 23128226
esv2746359 CNV deletion 23290073
esv2760710 CNV gain 21179565
esv3549773 CNV deletion 23714750
esv3630769 CNV loss 21293372
esv3630770 CNV gain 21293372
esv3630771 CNV loss 21293372
esv6864 CNV loss 19470904
nsv1044606 CNV gain 25217958
nsv1045488 CNV gain 25217958
nsv455715 CNV gain 19166990
nsv470317 CNV gain 18288195
nsv515716 CNV gain 19592680

Variation tolerance for MAPKAPK5 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPKAPK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAPK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Disorders for MAPKAPK5 Gene

Additional Disease Information for MAPKAPK5

No disorders were found for MAPKAPK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPKAPK5 Gene

Publications for MAPKAPK5 Gene

  1. PRAK, a novel protein kinase regulated by the p38 MAP kinase. (PMID: 9628874) New L … Han J (The EMBO journal 1998) 2 3 4 23 56
  2. Regulation of PRAK subcellular location by p38 MAP kinases. (PMID: 12808055) New L … Han J (Molecular biology of the cell 2003) 3 4 23 56
  3. The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. (PMID: 21329882) Kress TR … Eilers M (Molecular cell 2011) 3 4 56
  4. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. (PMID: 19166925) Kostenko S … Moens U (Cellular signalling 2009) 3 4 56
  5. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PMID: 18720373) Déléris P … Meloche S (Journal of cellular physiology 2008) 3 23 56

Products for MAPKAPK5 Gene