This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulat... See more...

Aliases for MAPKAPK3 Gene

Aliases for MAPKAPK3 Gene

  • MAPK Activated Protein Kinase 3 2 3 5
  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 2 3
  • MAP Kinase-Activated Protein Kinase 3 3 4
  • Chromosome 3p Kinase 3 4
  • MAPKAP Kinase 3 3 4
  • EC 2.7.11.1 4 52
  • MAPKAP-K3 3 4
  • MAPKAPK-3 3 4
  • MK-3 3 4
  • MAPK-Activated Protein Kinase 3 4
  • EC 2.7.11 52
  • MAPKAP3 3
  • MDPT3 3
  • 3PK 3
  • MK3 3
  • 3pK 4

External Ids for MAPKAPK3 Gene

Previous GeneCards Identifiers for MAPKAPK3 Gene

  • GC03M049300
  • GC03M049470
  • GC03P050509
  • GC03P050613
  • GC03P050624

Summaries for MAPKAPK3 Gene

Entrez Gene Summary for MAPKAPK3 Gene

  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAPKAPK3 Gene

MAPKAPK3 (MAPK Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPKAPK3 include Macular Dystrophy, Patterned, 3 and Patterned Macular Dystrophy. Among its related pathways are Immune response Fc epsilon RI pathway and Signaling mediated by p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK2.

UniProtKB/Swiss-Prot Summary for MAPKAPK3 Gene

  • Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Gene Wiki entry for MAPKAPK3 Gene

Additional gene information for MAPKAPK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPKAPK3 Gene

Genomics for MAPKAPK3 Gene

GeneHancer (GH) Regulatory Elements for MAPKAPK3 Gene

Promoters and enhancers for MAPKAPK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPKAPK3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPKAPK3

Top Transcription factor binding sites by QIAGEN in the MAPKAPK3 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • NRSF form 1
  • NRSF form 2
  • STAT3
  • STAT5A
  • STAT5B

Genomic Locations for MAPKAPK3 Gene

Genomic Locations for MAPKAPK3 Gene
chr3:50,611,520-50,649,297
(GRCh38/hg38)
Size:
37,778 bases
Orientation:
Plus strand
chr3:50,648,951-50,686,720
(GRCh37/hg19)
Size:
37,770 bases
Orientation:
Plus strand

Genomic View for MAPKAPK3 Gene

Genes around MAPKAPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK3 Gene

Proteins for MAPKAPK3 Gene

  • Protein details for MAPKAPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16644-MAPK3_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 3
    Protein Accession:
    Q16644
    Secondary Accessions:
    • B5BU67

    Protein attributes for MAPKAPK3 Gene

    Size:
    382 amino acids
    Molecular mass:
    42987 Da
    Quaternary structure:
    • Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.

    Three dimensional structures from OCA and Proteopedia for MAPKAPK3 Gene

neXtProt entry for MAPKAPK3 Gene

Selected DME Specific Peptides for MAPKAPK3 Gene

Q16644:
  • AISPGMK
  • NIAHRDVKPENLLYTSK
  • YVAPEVL
  • AFTEREA
  • TDFGFAK
  • PEWSEVSE
  • TPYYVAP

Post-translational modifications for MAPKAPK3 Gene

  • Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK3 Gene

Protein Products

Domains & Families for MAPKAPK3 Gene

Gene Families for MAPKAPK3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MAPKAPK3 Gene

Suggested Antigen Peptide Sequences for MAPKAPK3 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase-activated protein kinase 3 (B5BUJ8_HUMAN)
  • Chromosome 3p kinase (MAPK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16644

UniProtKB/Swiss-Prot:

MAPK3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK3: view

Function for MAPKAPK3 Gene

Molecular function for MAPKAPK3 Gene

UniProtKB/Swiss-Prot Function:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited by ligand 5B (2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]- 4'(1'h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors.
GENATLAS Biochemistry:
mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small cell lung cancer

Enzyme Numbers (IUBMB) for MAPKAPK3 Gene

Phenotypes From GWAS Catalog for MAPKAPK3 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 8774846
GO:0004683 calmodulin-dependent protein kinase activity IBA 21873635
GO:0004708 MAP kinase kinase activity TAS 10781029
genes like me logo Genes that share ontologies with MAPKAPK3: view
genes like me logo Genes that share phenotypes with MAPKAPK3: view

Human Phenotype Ontology for MAPKAPK3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPKAPK3 Gene

MGI Knock Outs for MAPKAPK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPKAPK3

CRISPR Products

miRNA for MAPKAPK3 Gene

miRTarBase miRNAs that target MAPKAPK3

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for MAPKAPK3 Gene

Localization for MAPKAPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAPK3 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAPK3: view

Pathways & Interactions for MAPKAPK3 Gene

genes like me logo Genes that share pathways with MAPKAPK3: view

Pathways by source for MAPKAPK3 Gene

1 R&D Systems pathway for MAPKAPK3 Gene
4 Qiagen pathways for MAPKAPK3 Gene
  • MAPK Family Pathway
  • p38 Signaling
  • Signaling Involved in Cardiac Hypertrophy
  • VEGF Pathway
1 Cell Signaling Technology pathway for MAPKAPK3 Gene

SIGNOR curated interactions for MAPKAPK3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway ISS --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 8626550
genes like me logo Genes that share ontologies with MAPKAPK3: view

Drugs & Compounds for MAPKAPK3 Gene

(6) Drugs for MAPKAPK3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for MAPKAPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAPKAPK3: view

Transcripts for MAPKAPK3 Gene

mRNA/cDNA for MAPKAPK3 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: -
SP6:
SP7: - - -

Relevant External Links for MAPKAPK3 Gene

GeneLoc Exon Structure for
MAPKAPK3

Expression for MAPKAPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPKAPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKAPK3 Gene

This gene is overexpressed in Heart - Left Ventricle (x9.3), Muscle - Skeletal (x6.8), and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for MAPKAPK3 Gene

This gene is overexpressed in Heart (33.3) and Peripheral blood mononuclear cells (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPKAPK3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPKAPK3

SOURCE GeneReport for Unigene cluster for MAPKAPK3 Gene:

Hs.234521

mRNA Expression by UniProt/SwissProt for MAPKAPK3 Gene:

Q16644-MAPK3_HUMAN
Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).

Evidence on tissue expression from TISSUES for MAPKAPK3 Gene

  • Heart(4.6)
  • Intestine(4.3)
  • Skin(4.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MAPKAPK3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAPK3 Gene

Orthologs for MAPKAPK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK3 31 30
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK3 31 30
  • 91.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK3 31 30
  • 90.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk3 30
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Mapkapk3 17 31 30
  • 88.13 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK3 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAPK3 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPKAPK3 31 30
  • 79.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAPK3 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk3 30
  • 73.81 (n)
Str.11839 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19914 30
zebrafish
(Danio rerio)
Actinopterygii mapkapk3 31 30
  • 73.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MAPk-Ak2 31 32 30
  • 67.46 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011890 30
  • 65.08 (n)
worm
(Caenorhabditis elegans)
Secernentea C44C8.6a 32
  • 59 (a)
C44C8.6b 32
  • 59 (a)
mak-2 31 30
  • 57.41 (n)
ManyToMany
mak-1 31
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 31
  • 20 (a)
ManyToMany
RCK2 31
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToMany
Species where no ortholog for MAPKAPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAPK3 Gene

ENSEMBL:
Gene Tree for MAPKAPK3 (if available)
TreeFam:
Gene Tree for MAPKAPK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPKAPK3: view image

Paralogs for MAPKAPK3 Gene

Paralogs for MAPKAPK3 Gene

(46) SIMAP similar genes for MAPKAPK3 Gene using alignment to 5 proteins:

  • MAPK3_HUMAN
  • B5BUJ8_HUMAN
  • C9J8E1_HUMAN
  • C9JPW3_HUMAN
  • H7C0G6_HUMAN
genes like me logo Genes that share paralogs with MAPKAPK3: view

Variants for MAPKAPK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPKAPK3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs375412266 A glioblastoma multiforme sample p.Pro28Ser
rs414171 Affects, Risk Factor: Tuberculosis, susceptibility to; Susceptibility to malaria; Bacteremia, susceptibility to, 2 50,612,068(+) A/T FIVE_PRIME_UTR_VARIANT
rs886037913 Pathogenic: Macular dystrophy, patterned, 3. Macular dystrophy, patterned, 3 (MDPT3) [MIM:617111] 50,644,422(+) T/Cp.Leu173Pro MISSENSE_VARIANT
rs56107897 - p.Asp276Tyr
VAR_040756 - p.Glu105Ala

Additional dbSNP identifiers (rs#s) for MAPKAPK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK3 Gene

Variant ID Type Subtype PubMed ID
esv1531131 CNV insertion 17803354
esv3302726 CNV tandem duplication 20981092
esv3584502 CNV gain 24956385
esv990051 CNV insertion 20482838
nsv3815 CNV insertion 18451855
nsv460533 CNV loss 19166990
nsv508919 CNV insertion 20534489
nsv590273 CNV loss 21841781

Variation tolerance for MAPKAPK3 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPKAPK3 Gene

Human Gene Mutation Database (HGMD)
MAPKAPK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Disorders for MAPKAPK3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MAPKAPK3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
macular dystrophy, patterned, 3
  • mdpt3
patterned macular dystrophy
  • patterned dystrophy of retinal pigment epithelium
interstitial myocarditis
central corneal ulcer
immature cataract
  • incipient cataract
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MAPK3_HUMAN
  • Macular dystrophy, patterned, 3 (MDPT3) [MIM:617111]: A form of retinal patterned dystrophy, characterized by retinal pigment epithelium and Bruch's membrane changes resembling a 'dry desert land'. It begins around the age of 30 and progresses to retinitis pigmentosa. MDPT3 inheritance is autosomal dominant. {ECO:0000269 PubMed:26744326}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MAPKAPK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAPKAPK3: view

No data available for Genatlas for MAPKAPK3 Gene

Publications for MAPKAPK3 Gene

  1. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PMID: 8626550) McLaughlin MM … Young PR (The Journal of biological chemistry 1996) 2 3 4 23 54
  2. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PMID: 8622688) Sithanandam G … Shrestha S (Molecular and cellular biology 1996) 2 3 4 23 54
  3. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PMID: 19208361) Tsukada H … Chayama K (Gastroenterology 2009) 3 23 41 54
  4. Mitogen-activated 3p kinase is active in the nucleus. (PMID: 15302577) Zakowski V … Ludwig S (Experimental cell research 2004) 3 4 23 54
  5. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PMID: 10781029) Neufeld B … Rapp UR (The Journal of biological chemistry 2000) 3 4 23 54

Products for MAPKAPK3 Gene