MAPKAP1 Gene (Protein Coding)

MAPK Associated Protein 1

GC09M125437
GIFtS:
44
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for MAPKAP1 Gene

Aliases for MAPKAP1 Gene

  • MAPK Associated Protein 1 2 3 5
  • MIP1 2 3 4
  • SIN1 2 3 4
  • Mitogen-Activated Protein Kinase 2-Associated Protein 1 3 4
  • Mitogen-Activated Protein Kinase Associated Protein 1 2 3
  • Stress-Activated Protein Kinase-Interacting 1 2 3
  • Target Of Rapamycin Complex 2 Subunit MAPKAP1 3 4
  • SAPK-Interacting Protein 1 3 4
  • TORC2 Subunit MAPKAP1 3 4
  • MSIN1 3 4
  • Stress-Activated Map Kinase Interacting Protein 1 3
  • Stress-Activated Map Kinase-Interacting Protein 1 4
  • MEKK2-Interacting Protein 1 3
  • Ras Inhibitor MGC2745 3
  • MAPKAP1 5
  • MGC2745 2
  • JC310 3
  • SIN1b 3
  • SIN1g 3

External Ids for MAPKAP1 Gene

Previous GeneCards Identifiers for MAPKAP1 Gene

  • GC09M119314
  • GC09M119846
  • GC09M121653
  • GC09M123576
  • GC09M125280
  • GC09M127239
  • GC09M128199
  • GC09M097812

Summaries for MAPKAP1 Gene

Entrez Gene Summary for MAPKAP1 Gene

  • This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPKAP1 Gene

MAPKAP1 (MAPK Associated Protein 1) is a Protein Coding gene. Diseases associated with MAPKAP1 include Short Syndrome and Nephrogenic Systemic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatidylinositol-3,4,5-trisphosphate binding.

UniProtKB/Swiss-Prot Summary for MAPKAP1 Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Gene Wiki entry for MAPKAP1 Gene

Additional gene information for MAPKAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPKAP1 Gene

Genomics for MAPKAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPKAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPKAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPKAP1

Top Transcription factor binding sites by QIAGEN in the MAPKAP1 gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for MAPKAP1 Gene

Latest Assembly
chr9:125,437,393-125,707,234
(GRCh38/hg38)
Size:
269,842 bases
Orientation:
Minus strand

Previous Assembly
chr9:128,199,673-128,469,487
(GRCh37/hg19 by Entrez Gene)
Size:
269,815 bases
Orientation:
Minus strand

chr9:128,199,672-128,469,513
(GRCh37/hg19 by Ensembl)
Size:
269,842 bases
Orientation:
Minus strand

Genomic View for MAPKAP1 Gene

Genes around MAPKAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPKAP1 Gene

Proteins for MAPKAP1 Gene

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  • Protein details for MAPKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ7-SIN1_HUMAN
    Recommended name:
    Target of rapamycin complex 2 subunit MAPKAP1
    Protein Accession:
    Q9BPZ7
    Secondary Accessions:
    • A8K1Z5
    • B1AMA4
    • B7Z309
    • Q00426
    • Q5JSV5
    • Q5JSV6
    • Q5JSV9
    • Q658R0
    • Q699U1
    • Q699U2
    • Q699U3
    • Q699U4
    • Q6GVJ0
    • Q6GVJ1
    • Q6GVJ2

    Protein attributes for MAPKAP1 Gene

    Size:
    522 amino acids
    Molecular mass:
    59123 Da
    Quaternary structure:
    • All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B.
    Miscellaneous:
    • [Isoform 4]: Not involved in a TORC2 complex.

    Three dimensional structures from OCA and Proteopedia for MAPKAP1 Gene

    Alternative splice isoforms for MAPKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAP1 Gene

Protein Expression for MAPKAP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAPKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAPKAP1 Gene

Domains & Families for MAPKAP1 Gene

Gene Families for MAPKAP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAPKAP1 Gene

InterPro:
Blocks:
  • Stress-activated map kinase interacting 1
ProtoNet:

Suggested Antigen Peptide Sequences for MAPKAP1 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase associated protein 1 (B1AMA7_HUMAN)
  • Mitogen-activated protein kinase associated protein 1 (B1AMA8_HUMAN)
  • Mitogen-activated protein kinase associated protein 1 (B1ANI4_HUMAN)
  • cDNA FLJ50615, highly similar to Homo sapiens mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 2, mRNA (B7Z5E5_HUMAN)
  • Stress-activated map kinase-interacting protein 1 (SIN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BPZ7

UniProtKB/Swiss-Prot:

SIN1_HUMAN :
  • Belongs to the SIN1 family.
Family:
  • Belongs to the SIN1 family.
genes like me logo Genes that share domains with MAPKAP1: view

Function for MAPKAP1 Gene

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  6. Cell Lines for research

Molecular function for MAPKAP1 Gene

UniProtKB/Swiss-Prot Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Phenotypes From GWAS Catalog for MAPKAP1 Gene

Gene Ontology (GO) - Molecular Function for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24365180
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 17303383
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 17303383
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IPI 21177249
genes like me logo Genes that share ontologies with MAPKAP1: view
genes like me logo Genes that share phenotypes with MAPKAP1: view

Animal Models for MAPKAP1 Gene

MGI Knock Outs for MAPKAP1:

Animal Models for research

  • Taconic Biosciences Mouse Models for MAPKAP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPKAP1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKAP1 Gene

Localization for MAPKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAP1 Gene

Cell membrane. Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAP1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 2
cytoskeleton 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IDA 17303383
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAP1: view

Pathways & Interactions for MAPKAP1 Gene

genes like me logo Genes that share pathways with MAPKAP1: view

Pathways by source for MAPKAP1 Gene

1 KEGG pathway for MAPKAP1 Gene
1 R&D Systems pathway for MAPKAP1 Gene
1 Cell Signaling Technology pathway for MAPKAP1 Gene
1 GeneTex pathway for MAPKAP1 Gene

Gene Ontology (GO) - Biological Process for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0021762 substantia nigra development HEP 22926577
GO:0030950 establishment or maintenance of actin cytoskeleton polarity IBA 21873635
GO:0032148 activation of protein kinase B activity TAS --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
genes like me logo Genes that share ontologies with MAPKAP1: view

No data available for SIGNOR curated interactions for MAPKAP1 Gene

Drugs & Compounds for MAPKAP1 Gene

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  1. Drug products for research

(4) Drugs for MAPKAP1 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
OSI-027 Investigational Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0

(2) Additional Compounds for MAPKAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPKAP1: view

Transcripts for MAPKAP1 Gene

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mRNA/cDNA for MAPKAP1 Gene

6 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPKAP1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for MAPKAP1 Gene

GeneLoc Exon Structure for
MAPKAP1

Expression for MAPKAP1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPKAP1 Gene

mRNA expression in normal human tissues for MAPKAP1 Gene
mRNA expression by BioGPS for MAPKAP1 GenemRNA expression by GTEx for MAPKAP1 Gene

Protein differential expression in normal tissues from HIPED for MAPKAP1 Gene

This gene is overexpressed in Heart (24.9) and Placenta (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPKAP1 Gene



Protein tissue co-expression partners for MAPKAP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPKAP1

SOURCE GeneReport for Unigene cluster for MAPKAP1 Gene:

Hs.495138

mRNA Expression by UniProt/SwissProt for MAPKAP1 Gene:

Q9BPZ7-SIN1_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for MAPKAP1 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Stomach(4.4)
  • Intestine(3.1)
  • Eye(2.8)
  • Skin(2.6)
  • Muscle(2.6)
  • Kidney(2.6)
  • Heart(2.5)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Liver(2.2)
  • Pancreas(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with MAPKAP1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAP1 Gene

Orthologs for MAPKAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPKAP1 30 31
  • 99.68 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPKAP1 30 31
  • 95.34 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPKAP1 30 31
  • 95.15 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapkap1 30
  • 92.59 (n)
Mouse
(Mus musculus)
 Mammalia Mapkap1 30 17 31
  • 92.46 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAPKAP1 31
  • 90 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPKAP1 31
  • 78 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAPKAP1 30 31
  • 82.76 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPKAP1 31
  • 83 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapkap1 30
  • 76.09 (n)
Str.16707 30
African clawed frog
(Xenopus laevis)
 Amphibia mapkap1-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii mapkap1 31
  • 81 (a)
 OneToOne
LOC100537196 30
  • 74.81 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008831 30
  • 45.92 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Sin1 30 31
  • 44.78 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea sinh-1 31
  • 19 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 45 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1005 30
Species where no ortholog for MAPKAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPKAP1 Gene

ENSEMBL:
Gene Tree for MAPKAP1 (if available)
TreeFam:
Gene Tree for MAPKAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPKAP1: view image

Paralogs for MAPKAP1 Gene

No data available for Paralogs for MAPKAP1 Gene

Variants for MAPKAP1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPKAP1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs111458512 Benign: not provided 125,438,992(-) C/T
NM_001006617.3(MAPKAP1):c.1464G>A (p.Ser488=) 		SYNONYMOUS
rs11542134 Benign: not provided 125,543,111(-) C/T
NM_001006617.3(MAPKAP1):c.906G>A (p.Lys302=) 		SYNONYMOUS
rs142713473 Likely Benign: not provided 125,672,527(-) C/T
NM_001006617.3(MAPKAP1):c.48G>A (p.Gln16=) 		SYNONYMOUS_VARIANT,INTRON
rs35549826 Benign: not provided 125,444,576(-) C/T
NM_001006617.3(MAPKAP1):c.1368G>A (p.Thr456=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAPKAP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAPKAP1 Gene

Variant ID Type Subtype PubMed ID
esv1597155 CNV insertion 17803354
esv2659060 CNV deletion 23128226
esv2662785 CNV deletion 23128226
esv2665863 CNV deletion 23128226
esv3573387 CNV loss 25503493
esv3576704 CNV gain 25503493
esv3621749 CNV loss 21293372
esv3621752 CNV loss 21293372
esv3621754 CNV loss 21293372
nsv1046626 CNV gain 25217958
nsv1052626 CNV gain 25217958
nsv466560 CNV loss 19166990
nsv472759 CNV novel sequence insertion 20440878
nsv478448 CNV novel sequence insertion 20440878
nsv515979 CNV loss 19592680
nsv615293 CNV loss 21841781
nsv6714 CNV insertion 18451855
nsv825077 CNV gain 20364138
nsv831722 CNV gain 17160897
nsv972451 CNV duplication 23825009

Variation tolerance for MAPKAP1 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPKAP1 Gene

Human Gene Mutation Database (HGMD)
MAPKAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAP1 Gene

Disorders for MAPKAP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAPKAP1 Gene - From: GCD

Disorder Aliases PubMed IDs
short syndrome
  • short stature, hyperextensibility, hernia, ocular depression, rieger anomaly, and teething delay
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
bardet-biedl syndrome
  • bbs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPKAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAPKAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPKAP1 Gene

Publications for MAPKAP1 Gene

  1. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. (PMID: 15363842) Schroder W … Sculley T (Gene 2004) 2 3 4 23
  2. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. (PMID: 17303383) Schroder WA … Bushell G (Cellular signalling 2007) 3 4 23
  3. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. (PMID: 15988011) Cheng J … Su B (Molecular and cellular biology 2005) 3 4 23
  4. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang JQ … Wu KJ (PloS one 2013) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

ExternalLinks

View latest publications for MAPKAP1 gene in Mastermind

Products for MAPKAP1 Gene

Sources for MAPKAP1 Gene