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MAPK9 Gene(Protein Coding)

Mitogen-Activated Protein Kinase 9

GCID:
GC05M180234
GIFtS:
55
Genes Participants
UDN Logo

Aliases for MAPK9 Gene

Aliases for MAPK9 Gene

  • Mitogen-Activated Protein Kinase 9 2 3 3 5
  • Stress-Activated Protein Kinase JNK2 3 4
  • Stress-Activated Protein Kinase 1a 3 4
  • C-Jun N-Terminal Kinase 2 3 4
  • MAP Kinase 9 3 4
  • Jun Kinase 2 3
  • JNK-55 3 4
  • MAPK 9 3 4
  • SAPK1a 3 4
  • PRKM9 3 4
  • JNK2 3 4
  • C-Jun Kinase 2 3
  • EC 2.7.11.24 4
  • JNK2ALPHA 3
  • JNK2BETA 3
  • P54aSAPK 3
  • SAPK1A 4
  • JNK2A 3
  • JNK2B 3
  • SAPK 3
  • P54a 3

External Ids for MAPK9 Gene

Previous HGNC Symbols for MAPK9 Gene

  • PRKM9

Previous GeneCards Identifiers for MAPK9 Gene

  • GC05M179777
  • GC05M180640
  • GC05M179772
  • GC05M179595
  • GC05M174385
  • GC05M179661

Summaries for MAPK9 Gene

Entrez Gene Summary for MAPK9 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

GeneCards Summary for MAPK9 Gene

MAPK9 (Mitogen-Activated Protein Kinase 9) is a Protein Coding gene. Diseases associated with MAPK9 include Breast Cancer and Pharynx Cancer. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.

UniProtKB/Swiss-Prot for MAPK9 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).

  • MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Tocris Summary for MAPK9 Gene

  • JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Gene Wiki entry for MAPK9 Gene

Additional gene information for MAPK9 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK9 Gene

Genomics for MAPK9 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MAPK9 Gene

Promoters and enhancers for MAPK9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J180290 Promoter/Enhancer 1.5 Ensembl ENCODE 661.4 -0.5 -519 3.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS DEK MAPK9 ENSG00000248367 GC05P180311 HNRNPH1 MAML1 ENSG00000233937 RUFY1 ZFP62 MRNIP RACK1
GH05J181221 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.6 -931.2 -931153 4.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIR33457 TRK-CTT2-3 TRV-CAC1-5 TRIM41 PIR62653 MIR4638 ENSG00000233937 TRIM52 RACK1 CNOT6
GH05J181240 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -953.1 -953100 9 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 ZNF610 GLIS1 NBN ENSG00000233937 RACK1 GC05M181247 GC05M181248 SNORD95 GC05M181250 GC05M181249 CTC-338M12.4 TRIM52-AS1 TRIM52
GH05J180493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 -203.3 -203267 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 CNOT6 HNRNPH1 MAML1 MRNIP ENSG00000233937 TRIM52 ZFP62 RUFY1 RACK1 LOC100420514
GH05J180328 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.5 -39.8 -39790 5.8 ZNF133 SIN3A RAD21 RFX5 ETS1 ZNF766 ELK1 EGR1 ZNF143 SMARCC2 MAPK9 ENSG00000248367 PIR49031 GFPT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAPK9 gene promoter:
  • TBP
  • TFIID

Genomic Locations for MAPK9 Gene

Genomic Locations for MAPK9 Gene
chr5:180,233,143-180,292,099
(GRCh38/hg38)
Size:
58,957 bases
Orientation:
Minus strand
chr5:179,660,143-179,719,099
(GRCh37/hg19)
Size:
58,957 bases
Orientation:
Minus strand

Genomic View for MAPK9 Gene

Genes around MAPK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK9 Gene

Proteins for MAPK9 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45984-MK09_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 9
    Protein Accession:
    P45984
    Secondary Accessions:
    • A8K0S3
    • B5BU66
    • B5M0B4
    • D3DWQ8
    • D3DWQ9
    • Q15708
    • Q15710
    • Q15711
    • Q8N5C5

    Protein attributes for MAPK9 Gene

    Size:
    424 amino acids
    Molecular mass:
    48139 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MECOM (By similarity). Interacts with DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (PubMed:10376527). Interacts with BCL10 (PubMed:17189706). Interacts with CTNNB1 and GSK3B (PubMed:19675674). Interacts with MAPKBP1 (PubMed:28089251).

    Three dimensional structures from OCA and Proteopedia for MAPK9 Gene

    Alternative splice isoforms for MAPK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK9 Gene

Protein Expression for MAPK9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAPK9 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.
  • Ubiquitination at posLast=353353
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAPK9 Gene

Domains & Families for MAPK9 Gene

Gene Families for MAPK9 Gene

HGNC:
IUPHAR :
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAPK9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P45984

UniProtKB/Swiss-Prot:

MK09_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK9: view

Function for MAPK9 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAPK9 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
UniProtKB/Swiss-Prot Function:
MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.

Enzyme Numbers (IUBMB) for MAPK9 Gene

Phenotypes From GWAS Catalog for MAPK9 Gene

Gene Ontology (GO) - Molecular Function for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004705 JUN kinase activity IDA 8654373
GO:0004707 MAP kinase activity IBA,IEA --
genes like me logo Genes that share ontologies with MAPK9: view
genes like me logo Genes that share phenotypes with MAPK9: view

Animal Models for MAPK9 Gene

MGI Knock Outs for MAPK9:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK9

Clone Products

  • Addgene plasmids for MAPK9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK9 Gene

Localization for MAPK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK9 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MAPK9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK9 Gene

Pathways & Interactions for MAPK9 Gene

SuperPathways for MAPK9 Gene

PathCards logo More details on SuperPathways for MAPK9
SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
3 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
4 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
NOD-like Receptor Signaling Pathways
.39
Chagas disease (American trypanosomiasis)
.31
NOD-like receptor signaling pathway
.31
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with MAPK9: view

Pathways by source for MAPK9 Gene

1 PharmGKB pathway for MAPK9 Gene
1 Cell Signaling Technology pathway for MAPK9 Gene

SIGNOR curated interactions for MAPK9 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IMP,IEA 22441692
GO:0007254 JNK cascade IDA,TAS --
GO:0007258 JUN phosphorylation IEA --
GO:0009612 response to mechanical stimulus IBA --
GO:0010468 regulation of gene expression IBA --
genes like me logo Genes that share ontologies with MAPK9: view

Drugs & Compounds for MAPK9 Gene

Products:

  1. Drug

(46) Drugs for MAPK9 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
Anisomycin Experimental Pharma JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Experimental Pharma Target 0
CC-401 Investigational Pharma JNK inhibitor,ATP-competitive 0

(15) Additional Compounds for MAPK9 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(3) Tocris Compounds for MAPK9 Gene

Compound Action Cas Number
Anisomycin JNK, SAPK and p38 activator 22862-76-6
CEP 1347 Inhibitor of JNK signaling 156177-65-0
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3
genes like me logo Genes that share compounds with MAPK9: view

Transcripts for MAPK9 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK9 Gene

(14) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(305) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAPK9 Gene

Mitogen-activated protein kinase 9:
Representative Sequences:

Clone Products

  • Addgene plasmids for MAPK9

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for MAPK9 Gene

GeneLoc Exon Structure for
MAPK9
ECgene alternative splicing isoforms for
MAPK9

Expression for MAPK9 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK9 Gene

mRNA expression in normal human tissues for MAPK9 Gene
mRNA expression by GTEx for MAPK9 GenemRNA expression by BioGPS for MAPK9 Gene

Protein differential expression in normal tissues from HIPED for MAPK9 Gene

This gene is overexpressed in Lung (16.1) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK9 Gene



Protein tissue co-expression partners for MAPK9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPK9 Gene:

MAPK9

SOURCE GeneReport for Unigene cluster for MAPK9 Gene:

Hs.484371

Evidence on tissue expression from TISSUES for MAPK9 Gene

  • Nervous system(4.8)
  • Skin(4.4)
  • Muscle(2.5)
  • Heart(2.4)
  • Blood(2.3)
  • Kidney(2.3)
  • Liver(2.3)
  • Lung(2.3)
  • Intestine(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MAPK9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK9 Gene

Orthologs for MAPK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAPK9 34 33
  • 99.45 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MAPK9 34
  • 97 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MAPK9 34
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MAPK9 34 33
  • 93.37 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mapk9 33
  • 91.49 (n)
mouse
(Mus musculus)
 Mammalia Mapk9 16 34 33
  • 91.41 (n)
dog
(Canis familiaris)
 Mammalia MAPK9 34 33
  • 90.64 (n)
 OneToOne
chicken
(Gallus gallus)
 Aves MAPK9 34 33
  • 84.53 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MAPK9 34
  • 97 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii mapk9 34 33
  • 73.33 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta bsk 34 35
  • 74 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea jnk-1 34 35
  • 55 (a)
 OneToMany
F09C12.2 35
  • 37 (a)
C49C3.10b 35
  • 35 (a)
Y51B9A.9 35
  • 34 (a)
C49C3.10a 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HOG1 34
  • 34 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 58 (a)
 OneToMany
Species where no ortholog for MAPK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPK9 Gene

ENSEMBL:
Gene Tree for MAPK9 (if available)
TreeFam:
Gene Tree for MAPK9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK9: view image

Paralogs for MAPK9 Gene

Paralogs for MAPK9 Gene

(45) SIMAP similar genes for MAPK9 Gene using alignment to 8 proteins:

  • MK09_HUMAN
  • B5BUJ7_HUMAN
  • D7R525_HUMAN
  • D7R526_HUMAN
  • D7R527_HUMAN
  • D7R528_HUMAN
  • E5RJ57_HUMAN
  • J3KNK1_HUMAN
genes like me logo Genes that share paralogs with MAPK9: view

Variants for MAPK9 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MAPK9 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_042260 A colorectal adenocarcinoma sample p.Val13Met
VAR_042261 A head & Neck squamous cell carcinoma sample p.Lys56Asn
rs1000016107 -- 180,240,174(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000065812 -- 180,248,897(-) A/G intron_variant
rs1000085739 -- 180,280,541(-) G/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK9 Gene

Variant ID Type Subtype PubMed ID
dgv1683e212 CNV gain 25503493
esv2678619 CNV deletion 23128226
esv2731323 CNV deletion 23290073
esv2759398 CNV gain 17122850
esv3607768 CNV loss 21293372
esv3607769 CNV loss 21293372
nsv1033706 CNV gain 25217958
nsv10787 CNV gain 18304495
nsv1125864 CNV tandem duplication 24896259
nsv1145742 CNV deletion 26484159
nsv823363 CNV loss 20364138
nsv830563 CNV loss 17160897

Variation tolerance for MAPK9 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK9 Gene

Disorders for MAPK9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPK9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards
Search MAPK9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAPK9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAPK9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK9 Gene

Publications for MAPK9 Gene

  1. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (PMID: 8001819) Kallunki T … Karin M (Genes & development 1994) 2 3 4 22 58
  2. The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. (PMID: 18801372) Shaw D … Kuglstatter A (Journal of molecular biology 2008) 3 4 22 58
  3. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PMID: 17189706) Blonska M … Lin X (Immunity 2007) 3 4 22 58
  4. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. (PMID: 28089251) Macia MS … Benmerah A (American journal of human genetics 2017) 3 4 58
  5. JNK regulates the photic response of the mammalian circadian clock. (PMID: 22441692) Yoshitane H … Fukada Y (EMBO reports 2012) 3 4 58

Products for MAPK9 Gene