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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
MAPK9 (Mitogen-Activated Protein Kinase 9) is a Protein Coding gene. Diseases associated with MAPK9 include Breast Cancer and Pheochromocytoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and NGF Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.
JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004705 | JUN kinase activity | IBA,IDA | 8654373 |
GO:0004707 | MAP kinase activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
|
3 | 4-1BB Pathway |
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
|
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
|
4 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IEA | -- |
GO:0006468 | protein phosphorylation | IEA,IMP | 22441692 |
GO:0007254 | JNK cascade | IBA,TAS | -- |
GO:0007258 | JUN phosphorylation | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Anisomycin | Experimental | Pharma | JNK agonist, potent and specific, JNK, SAPK and p38 activator | 0 | ||
Halicin | Experimental | Pharma | Target, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
c-JUN peptide |
|
610273-01-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
Anisomycin | JNK, SAPK and p38 activator | 22862-76-6 |
CEP 1347 | Inhibitor of JNK signaling | 156177-65-0 |
c-JUN peptide | Peptide inhibitor of JNK/c-Jun interaction | 610273-01-3 |
Compound | Action | Cas Number |
---|---|---|
AEG 3482 | inhibitor of Jun kinase (JNK)-dependent apoptosis | 63735-71-7 |
Anisomycin | JNK agonist, potent and specific | 22862-76-6 |
AS 602801 | Jun Kinase Inhibitor | 848344-36-5 |
AS601245 | c-Jun NH2-terminal protein kinase inhibitor | 345987-15-7 |
BI 78D3 | Competitive JNK inhibitor | 883065-90-5 |
CC-401 | JNK inhibitor,ATP-competitive | 395104-30-0 |
CC-401 hydrochloride | JNK inhibitor | 1438391-30-0 |
CC-930 | JNK inhibitor,potent and selective | 899805-25-5 |
CEP 1347 | JNK inhibitor | 156177-65-0 |
DTP3 | inhibitor of GADD45β/MKK7 complex | |
IQ 3 | 312538-03-7 | |
JIP-1 (153-163) | 438567-88-5 | |
JNK-IN-7 | Selective JNK inhibitor | 1408064-71-0 |
JNK-IN-8 | JNK inhibitor, selective and irreversible | 1410880-22-6 |
PF-03394197(Oclacitinib) | Novel Janus kinase inhibitor | 1208319-26-9 |
SP 600125 | JNK1/2/3 inhibitor | 129-56-6 |
SU 3327 | 40045-50-9 | |
TCS JNK 5a | JNK2 and JNK3 inhibitor | 312917-14-9 |
TCS JNK 6o | JNK inhibitor | 894804-07-0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAPK9 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK9 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAPK9 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAPK9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mapk9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mapk9 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAPK9 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAPK9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAPK9 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | mapk9 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | bsk 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | jnk-1 31 32 |
|
OneToMany | |
F09C12.2 32 |
|
|
|||
C49C3.10b 32 |
|
|
|||
Y51B9A.9 32 |
|
|
|||
C49C3.10a 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HOG1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_042260 | A colorectal adenocarcinoma sample | p.Val13Met | |||
VAR_042261 | A head & Neck squamous cell carcinoma sample | p.Lys56Asn | |||
rs35421153 | - | p.Ala246Thr | |||
rs35693958 | - | p.Gly268Ala | |||
rs55736180 | - | p.Arg366Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1683e212 | CNV | gain | 25503493 |
esv2678619 | CNV | deletion | 23128226 |
esv2731323 | CNV | deletion | 23290073 |
esv2759398 | CNV | gain | 17122850 |
esv3607768 | CNV | loss | 21293372 |
esv3607769 | CNV | loss | 21293372 |
nsv1033706 | CNV | gain | 25217958 |
nsv10787 | CNV | gain | 18304495 |
nsv1125864 | CNV | tandem duplication | 24896259 |
nsv1145742 | CNV | deletion | 26484159 |
nsv823363 | CNV | loss | 20364138 |
nsv830563 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
pheochromocytoma |
|
|
colorectal cancer |
|
|
alzheimer disease |
|
|
cardiomyopathy, familial hypertrophic, 25 |
|
|