Aliases for MAPK9 Gene
Aliases for MAPK9 Gene
External Ids for MAPK9 Gene
- HGNC: 6886
- Entrez Gene: 5601
- Ensembl: ENSG00000050748
- OMIM: 602896
- UniProtKB: P45984
Previous HGNC Symbols for MAPK9 Gene
- PRKM9
Previous GeneCards Identifiers for MAPK9 Gene
- GC05M179777
- GC05M180640
- GC05M179772
- GC05M179595
- GC05M174385
- GC05M179661
Summaries for MAPK9 Gene
-
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
GeneCards Summary for MAPK9 Gene
MAPK9 (Mitogen-Activated Protein Kinase 9) is a Protein Coding gene. Diseases associated with MAPK9 include Breast Cancer and Colorectal Cancer. Among its related pathways are RANK Signaling in Osteoclasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.
UniProtKB/Swiss-Prot for MAPK9 Gene
-
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
-
MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
-
JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.
Additional gene information for MAPK9 Gene
- Monarch Initiative
- Search for MAPK9 at DataMed
- Search for MAPK9 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK9 Gene
Genomics for MAPK9 Gene
GeneHancer (GH) Regulatory Elements for MAPK9 Gene
Promoters and enhancers for MAPK9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAPK9 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK9 gene promoter:
Regulatory Element Products
Genomic Locations for MAPK9 Gene
Genomic Locations for MAPK9 Gene
- chr5:180,233,143-180,292,099
- (GRCh38/hg38)
- Size:
- 58,957 bases
- Orientation:
- Minus strand
- chr5:179,660,143-179,719,099
- (GRCh37/hg19)
Genomic View for MAPK9 Gene
Genes around MAPK9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
MAPK9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK9 Gene
Proteins for MAPK9 Gene
-
Protein details for MAPK9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P45984-MK09_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 9
- Protein Accession:
- P45984
- A8K0S3
- B5BU66
- B5M0B4
- D3DWQ8
- D3DWQ9
- Q15708
- Q15710
- Q15711
- Q8N5C5
Protein attributes for MAPK9 Gene
- Size:
- 424 amino acids
- Molecular mass:
- 48139 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with MECOM (By similarity). Interacts with DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (PubMed:10376527). Interacts with BCL10 (PubMed:17189706). Interacts with CTNNB1 and GSK3B (PubMed:19675674). Interacts with MAPKBP1 (PubMed:28089251).
Protein Expression for MAPK9 Gene
Selected DME Specific Peptides for MAPK9 Gene
- P45984:
-
- PIGSGAQGIVC
- YVENRPKY
- MTPYVVTRYYRAPEVI
- TVRNYVENR
- IDQWNKV
- VNHKNII
- KELIYKE
- ILDFGLA
- HSAGIIHRDLKPSN
- LLNVFTPQK
- KKLSRPFQ
- LLSKMLVID
- EFMKKLQPTVR
- AKRAYRE
- DSTFTVLKRYQ
- LEEFQDVY
- RDLLSKML
- EAPPPQIYD
- LLSKMLV
- QARDLLS
- VGCIMGE
- DIWSVGCI
- SYLLYQMLCG
- LDFGLAR
- RISVDEAL
- VMELMDANLC
- LKILDFGLAR
Post-translational modifications for MAPK9 Gene
- Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.
- Ubiquitination at posLast=353353
- Modification sites at PhosphoSitePlus
Other Protein References for MAPK9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK9 (JNK2)
- Novus Biologicals Antibodies for MAPK9
-
Abcam antibodies for MAPK9
-
Cloud-Clone Corp. Antibodies for MAPK9
- Invitrogen Antibodies for MAPK9
- antibodies-online: Search results for 192 available MAPK9 Antibodies ranked by validation data
- Compare Top MAPK9 Antibodies
-
Recommended
- 176 WB Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 79 WB Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- 176 WB Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 79 WB Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- GeneTex MAPK9 antibody for MAPK9
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK9
- Sino Biological Antibodies for MAPK9
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK9
- Origene Custom Protein Services for MAPK9
- Sino Biological Recombinant Proteins for MAPK9
- Sino Biological Cell Lysates for MAPK9
- ProSpec Recombinant Proteins for MAPK9
-
Cloud-Clone Corp. Proteins for MAPK9
- Search GeneTex for Proteins for MAPK9
-
Abcam proteins for MAPK9
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for MAPK9 (JNK2)
-
Cloud-Clone Corp. Assay Kits for MAPK9
-
Abcam assays for MAPK9
Domains & Families for MAPK9 Gene
Gene Families for MAPK9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAPK9 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK9 Gene
Graphical View of Domain Structure for InterPro Entry
P45984UniProtKB/Swiss-Prot:
MK09_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK9 Gene
Molecular function for MAPK9 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
- UniProtKB/Swiss-Prot Function:
- MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
Enzyme Numbers (IUBMB) for MAPK9 Gene
Phenotypes From GWAS Catalog for MAPK9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004705 | JUN kinase activity | IDA | 8654373 |
| GO:0004707 | MAP kinase activity | IEA | -- |
Phenotypes for MAPK9 Gene
- MGI mutant phenotypes for MAPK9:
-
inferred from 4 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for MAPK9:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Increased simian virus 40 (SV40) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for MAPK9
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK9
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK9 gene
- Search ViGene Biosciences for MAPK9
CRISPR Products
-
OriGene CRISPR knockouts for MAPK9
- genomics-online: gRNA clones - Search results for 172 available MAPK9 gene related products
- Overview of 172 available MAPK9 gene related products
- Applied Biological Materials CRISPR for MAPK9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK9
- GenScript: Design CRISPR guide RNA sequences for MAPK9
miRNA for MAPK9 Gene
- miRTarBase miRNAs that target MAPK9
-
- hsa-mir-93-5p (MIRT003240)
- hsa-mir-199a-3p (MIRT003982)
- hsa-mir-17-5p (MIRT004359)
- hsa-mir-20a-5p (MIRT005856)
- hsa-mir-106b-5p (MIRT005864)
- hsa-mir-141-3p (MIRT021647)
- hsa-mir-215-5p (MIRT024284)
- hsa-mir-7-5p (MIRT025800)
- hsa-mir-192-5p (MIRT026550)
- hsa-mir-27b-3p (MIRT046207)
- hsa-mir-92a-3p (MIRT049753)
- hsa-mir-20b-5p (MIRT054220)
- hsa-mir-106a-5p (MIRT054221)
- hsa-mir-1178-3p (MIRT313265)
- hsa-mir-4635 (MIRT448677)
- hsa-mir-6765-3p (MIRT448678)
- hsa-mir-3622b-3p (MIRT448679)
- hsa-mir-3622a-3p (MIRT448680)
- hsa-mir-203a-3p (MIRT448681)
miRNA Products
- Search ViGene Biosciences for MAPK9
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for MAPK9
- Browse OriGene Inhibitory RNA Products For MAPK9
- genomics-online: shRNA clones - Search results for 172 available MAPK9 gene related products
- Overview of 172 available MAPK9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK9 gene
Clone Products
-
OriGene ORF clones in human for MAPK9
- RG212273
- RC212273L2
- RC212273L1
- RC212273
- RG217862
- RC217862L2
- RC217862L1
- RC217862
- RG207608
- RC207608L2
- RC207608L1
- RC207608
- RG212814
- RC212814L2
- RC212814L1
- RC212814
- RG225304
- RC225304L2
- RC225304L1
- RC225304
- RC212273L2V
- RC212273L1V
- RC217862L2V
- RC217862L1V
- RC207608L2V
- RC207608L1V
- RC212814L2V
- RC212814L1V
- RC225304L2V
- RC225304L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAPK9
- VectorBuilder custom plasmid, inducible vectors for MAPK9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK9
- Applied Biological Materials Clones for MAPK9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK9
-
ViGene Biosciences adenoviral particle packaged cDNA for MAPK9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK9 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK9 Gene
Localization for MAPK9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK9 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK9 Gene
Pathways & Interactions for MAPK9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | IL-2 Pathway |
.59
.48
|
.43
.36
|
| 3 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 4 | GPCR Pathway |
.73
.62
|
.55
|
| 5 | Toll-like receptor signaling pathway | ||
Pathways by source for MAPK9 Gene
3 Sino Biological pathways for MAPK9 Gene
53 BioSystems pathways for MAPK9 Gene
28 Reactome pathways for MAPK9 Gene
1 PharmGKB pathway for MAPK9 Gene
58 KEGG pathways for MAPK9 Gene
33 GeneGo (Thomson Reuters) pathways for MAPK9 Gene
4 R&D Systems pathways for MAPK9 Gene
5 Tocris pathways for MAPK9 Gene
108 Qiagen pathways for MAPK9 Gene
1 Cell Signaling Technology pathway for MAPK9 Gene
Interacting Proteins for MAPK9 Gene
Selected Interacting proteins:
ENSP00000389338
P45984-MK09_HUMAN
for MAPK9 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for MAPK9 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA,IMP | 22441692 |
| GO:0006950 | response to stress | TAS | 7969172 |
| GO:0007254 | JNK cascade | TAS,IDA | -- |
| GO:0007258 | JUN phosphorylation | IEA | -- |
| GO:0009612 | response to mechanical stimulus | IBA | -- |
Drugs & Compounds for MAPK9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved | Nutra | 0 | |||
| N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide | Experimental | Pharma | Target | 0 | ||
| Anisomycin | Experimental | Pharma | JNK agonist, potent and specific | 0 | ||
| CC-401 | Investigational | Pharma | JNK inhibitor,ATP-competitive | 0 | ||
| ATP | Investigational | Nutra | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(3) Tocris Compounds for MAPK9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Anisomycin | JNK, SAPK and p38 activator | 22862-76-6 |
| CEP 1347 | Inhibitor of JNK signaling | 156177-65-0 |
| c-JUN peptide | Peptide inhibitor of JNK/c-Jun interaction | 610273-01-3 |
(20) ApexBio Compounds for MAPK9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AEG 3482 | inhibitor of Jun kinase (JNK)-dependent apoptosis | 63735-71-7 |
| Anisomycin | JNK agonist, potent and specific | 22862-76-6 |
| AS 602801 | Jun Kinase Inhibitor | 848344-36-5 |
| AS601245 | c-Jun NH2-terminal protein kinase inhibitor | 345987-15-7 |
| BI 78D3 | Competitive JNK inhibitor | 883065-90-5 |
| CC-401 | JNK inhibitor,ATP-competitive | 395104-30-0 |
| CC-401 hydrochloride | JNK inhibitor | 1438391-30-0 |
| CC-930 | JNK inhibitor,potent and selective | 899805-25-5 |
| CEP 1347 | JNK inhibitor | 156177-65-0 |
| c-JUN peptide | 610273-01-3 | |
| DTP3 | inhibitor of GADD45β/MKK7 complex | |
| IQ 3 | 312538-03-7 | |
| JIP-1 (153-163) | 438567-88-5 | |
| JNK-IN-7 | Selective JNK inhibitor | 1408064-71-0 |
| JNK-IN-8 | JNK inhibitor, selective and irreversible | 1410880-22-6 |
| PF-03394197(Oclacitinib) | Novel Janus kinase inhibitor | 1208319-26-9 |
| SP 600125 | JNK1/2/3 inhibitor | 129-56-6 |
| SU 3327 | 40045-50-9 | |
| TCS JNK 5a | JNK2 and JNK3 inhibitor | 312917-14-9 |
| TCS JNK 6o | JNK inhibitor | 894804-07-0 |
Transcripts for MAPK9 Gene
mRNA/cDNA for MAPK9 Gene
- (14) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (305) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAPK9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MAPK9
- genomics-online: gRNA clones - Search results for 172 available MAPK9 gene related products
- Overview of 172 available MAPK9 gene related products
- Applied Biological Materials CRISPR for MAPK9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK9
- GenScript: Design CRISPR guide RNA sequences for MAPK9
miRNA Products
- Search ViGene Biosciences for MAPK9
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for MAPK9
- Browse OriGene Inhibitory RNA Products For MAPK9
- genomics-online: shRNA clones - Search results for 172 available MAPK9 gene related products
- Overview of 172 available MAPK9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK9 gene
Clone Products
-
OriGene ORF clones in human for MAPK9
- RG212273
- RC212273L2
- RC212273L1
- RC212273
- RG217862
- RC217862L2
- RC217862L1
- RC217862
- RG207608
- RC207608L2
- RC207608L1
- RC207608
- RG212814
- RC212814L2
- RC212814L1
- RC212814
- RG225304
- RC225304L2
- RC225304L1
- RC225304
- RC212273L2V
- RC212273L1V
- RC217862L2V
- RC217862L1V
- RC207608L2V
- RC207608L1V
- RC212814L2V
- RC212814L1V
- RC225304L2V
- RC225304L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAPK9
- VectorBuilder custom plasmid, inducible vectors for MAPK9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK9
- Applied Biological Materials Clones for MAPK9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for MAPK9 Gene
This gene is overexpressed in Lung (16.1) and Peripheral blood mononuclear cells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK9 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK9 Gene:
MAPK9SOURCE GeneReport for Unigene cluster for MAPK9 Gene:
Hs.484371Evidence on tissue expression from TISSUES for MAPK9 Gene
- Nervous system(4.8)
- Skin(4.4)
- Muscle(2.4)
- Blood(2.3)
- Heart(2.3)
- Kidney(2.3)
- Liver(2.3)
- Lung(2.3)
- Intestine(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for MAPK9
-
OriGene qPCR primer pairs and template standards for MAPK9
- genomics-online: primer clones - Search results for 172 available MAPK9 gene related products
- Overview of 172 available MAPK9 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK9 Gene
Orthologs for MAPK9 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK9 33 34 |
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| oppossum (Monodelphis domestica) |
Mammalia | MAPK9 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK9 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAPK9 33 34 |
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| rat (Rattus norvegicus) |
Mammalia | Mapk9 33 |
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| mouse (Mus musculus) |
Mammalia | Mapk9 33 16 34 |
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| dog (Canis familiaris) |
Mammalia | MAPK9 33 34 |
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| chicken (Gallus gallus) |
Aves | MAPK9 33 34 |
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| lizard (Anolis carolinensis) |
Reptilia | MAPK9 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | mapk9 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | bsk 35 34 |
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| worm (Caenorhabditis elegans) |
Secernentea | jnk-1 35 34 |
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| F09C12.2 35 |
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| C49C3.10b 35 |
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| Y51B9A.9 35 |
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| C49C3.10a 35 |
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| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HOG1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MAPK9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for MAPK9 Gene
(45) SIMAP similar genes for MAPK9 Gene using alignment to 8 proteins:
Variants for MAPK9 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042260 | A colorectal adenocarcinoma sample | p.Val13Met | |||
| VAR_042261 | A head & Neck squamous cell carcinoma sample | p.Lys56Asn | |||
| rs1000016107 | -- | 180,240,174(-) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000065812 | -- | 180,248,897(-) | A/G | intron_variant | |
| rs1000085739 | -- | 180,280,541(-) | G/C | 5_prime_UTR_variant, coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1683e212 | CNV | gain | 25503493 |
| esv2678619 | CNV | deletion | 23128226 |
| esv2731323 | CNV | deletion | 23290073 |
| esv2759398 | CNV | gain | 17122850 |
| esv3607768 | CNV | loss | 21293372 |
| esv3607769 | CNV | loss | 21293372 |
| nsv1033706 | CNV | gain | 25217958 |
| nsv10787 | CNV | gain | 18304495 |
| nsv1125864 | CNV | tandem duplication | 24896259 |
| nsv1145742 | CNV | deletion | 26484159 |
| nsv823363 | CNV | loss | 20364138 |
| nsv830563 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.78;
16.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAPK9
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK9 Gene
Disorders for MAPK9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
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| colorectal cancer |
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| pharynx cancer |
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Search MAPK9 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAPK9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK9 Gene
Publications for MAPK9 Gene
- JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (PMID: 8001819) Kallunki T … Karin M (Genes & development 1994) 2 3 4 22 58
- The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. (PMID: 18801372) Shaw D … Kuglstatter A (Journal of molecular biology 2008) 3 4 22 58
- The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PMID: 17189706) Blonska M … Lin X (Immunity 2007) 3 4 22 58
- Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. (PMID: 28089251) Macia MS … Benmerah A (American journal of human genetics 2017) 3 4 58
- JNK regulates the photic response of the mammalian circadian clock. (PMID: 22441692) Yoshitane H … Fukada Y (EMBO reports 2012) 3 4 58
Products for MAPK9 Gene
- R&D Systems Antibodies for MAPK9 (JNK2)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MAPK9 (JNK2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAPK9
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK9
- Origene Custom Protein Services for MAPK9
- Origene shrna and RNAi products in human, mouse, rat for MAPK9
- Browse OriGene Inhibitory RNA Products For MAPK9
- OriGene qPCR primer pairs and template standards for MAPK9
- OriGene qPCR primer pairs for MAPK9
- OriGene CRISPR knockouts for MAPK9
- OriGene ORF clones in human for MAPK9