MAPK9 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 9

GC05M180234
GIFtS:
49
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expre... See more...

Aliases for MAPK9 Gene

Aliases for MAPK9 Gene

  • Mitogen-Activated Protein Kinase 9 2 3 4 5
  • JNK2 2 3 4
  • Stress-Activated Protein Kinase JNK2 3 4
  • Stress-Activated Protein Kinase 1a 3 4
  • C-Jun N-Terminal Kinase 2 3 4
  • MAP Kinase 9 3 4
  • EC 2.7.11.24 4 50
  • Jun Kinase 2 3
  • JNK-55 3 4
  • SAPK1a 3 4
  • MAPK 9 3 4
  • PRKM9 3 4
  • SAPK 2 3
  • P54a 2 3
  • C-Jun Kinase 2 3
  • JNK2ALPHA 3
  • EC 2.7.11 50
  • JNK2BETA 3
  • P54aSAPK 3
  • SAPK1A 4
  • JNK2A 3
  • JNK2B 3
  • MAPK9 5

External Ids for MAPK9 Gene

Previous HGNC Symbols for MAPK9 Gene

  • PRKM9

Previous GeneCards Identifiers for MAPK9 Gene

  • GC05M179777
  • GC05M180640
  • GC05M179772
  • GC05M179595
  • GC05M174385
  • GC05M179661

Summaries for MAPK9 Gene

Entrez Gene Summary for MAPK9 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

GeneCards Summary for MAPK9 Gene

MAPK9 (Mitogen-Activated Protein Kinase 9) is a Protein Coding gene. Diseases associated with MAPK9 include Pheochromocytoma and Breast Cancer. Among its related pathways are Toll-Like receptor Signaling Pathways and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.

UniProtKB/Swiss-Prot Summary for MAPK9 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).
  • MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Tocris Summary for MAPK9 Gene

  • JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Gene Wiki entry for MAPK9 Gene

Additional gene information for MAPK9 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK9 Gene

Genomics for MAPK9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J180290 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 261.3 -0.2 -202 4.2 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 ZNF580 ZNF592 ZNF223 POLR2A NFIC MAPK9 ENSG00000248367 lnc-GFPT2-1 HNRNPH1 MAML1 CTC-338M12.4 RUFY1 MRNIP ZFP62 RACK1
GH05J180329 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 17.5 -39.6 -39568 6.2 ZNF654 POLR2A ZIC2 CTCF REST CEBPB DEK ETS1 TRIM22 MAX MAPK9 ENSG00000248367 HSALNG0047158 GFPT2 RF00017-4698
GH05J180208 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 +83.0 82998 1 MYC ZNF580 ZNF223 ZIC2 ZBTB10 NONO BHLHE40 ZNF341 CTCF MAX RASGEF1C MAPK9 ENSG00000248367 piR-57567-001 RNF130
GH05J181160 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 12.6 -868.9 -868856 2.1 NCOR1 IKZF1 ZNF600 ZNF592 ZNF223 ZNF10 POLR2A ZIC2 NFIC TBP HSALNG0047227 MAPK9 ENSG00000248514 TRV-AAC1-2 OR2V2 TRIM7
GH05J180323 Enhancer 0.7 Ensembl dbSUPER 17.3 -32.3 -32302 1.2 ZNF600 POLR2A REST CEBPB MAX EP300 SMC3 TBP NFIL3 HLF MAPK9 ENSG00000248367 HSALNG0047158 RF00017-4698 GFPT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK9

Top Transcription factor binding sites by QIAGEN in the MAPK9 gene promoter:
  • TBP
  • TFIID

Genomic Locations for MAPK9 Gene

Latest Assembly
chr5:180,233,143-180,292,099
(GRCh38/hg38)
Size:
58,957 bases
Orientation:
Minus strand

Previous Assembly
chr5:179,660,143-179,719,083
(GRCh37/hg19 by Entrez Gene)
Size:
58,941 bases
Orientation:
Minus strand

chr5:179,660,143-179,719,099
(GRCh37/hg19 by Ensembl)
Size:
58,957 bases
Orientation:
Minus strand

Genomic View for MAPK9 Gene

Genes around MAPK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK9 Gene

Proteins for MAPK9 Gene

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  • Protein details for MAPK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45984-MK09_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 9
    Protein Accession:
    P45984
    Secondary Accessions:
    • A8K0S3
    • B5BU66
    • B5M0B4
    • D3DWQ8
    • D3DWQ9
    • Q15708
    • Q15710
    • Q15711
    • Q8N5C5

    Protein attributes for MAPK9 Gene

    Size:
    424 amino acids
    Molecular mass:
    48139 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MECOM (By similarity). Interacts with DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (PubMed:10376527). Interacts with BCL10 (PubMed:17189706). Interacts with CTNNB1 and GSK3B (PubMed:19675674). Interacts with MAPKBP1 (PubMed:28089251). Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-355'. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK9 Gene

    Alternative splice isoforms for MAPK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK9 Gene

Protein Expression for MAPK9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK9 Gene

P45984:
  • PIGSGAQGIVC
  • YVENRPKY
  • MTPYVVTRYYRAPEVI
  • TVRNYVENR
  • IDQWNKV
  • VNHKNII
  • KELIYKE
  • ILDFGLA
  • HSAGIIHRDLKPSN
  • LLNVFTPQK
  • KKLSRPFQ
  • LLSKMLVID
  • EFMKKLQPTVR
  • AKRAYRE
  • DSTFTVLKRYQ
  • LEEFQDVY
  • RDLLSKML
  • EAPPPQIYD
  • LLSKMLV
  • QARDLLS
  • VGCIMGE
  • DIWSVGCI
  • SYLLYQMLCG
  • LDFGLAR
  • RISVDEAL
  • VMELMDANLC
  • LKILDFGLAR

Post-translational modifications for MAPK9 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.
  • Glycosylation at Asn384
  • Ubiquitination at Lys353
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for MAPK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for MAPK9 Gene

Gene Families for MAPK9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAPK9 Gene

InterPro:
Blocks:
  • MAP kinase
  • JNK MAP kinase signature

Suggested Antigen Peptide Sequences for MAPK9 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase 9 isoform JNK2 alpha2 (B5BUJ7_HUMAN)
  • Mitogen-activated protein kinase 9 isoform JNK2 alpha 3 (D7R526_HUMAN)
  • Mitogen-activated protein kinase 9 isoform JNK2 beta 3 (D7R527_HUMAN)
  • c-Jun N-terminal kinase 2 (MK09_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P45984

UniProtKB/Swiss-Prot:

MK09_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK9: view

Function for MAPK9 Gene

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Molecular function for MAPK9 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).
UniProtKB/Swiss-Prot Function:
MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11062067, ECO:0000269|PubMed:15805466, ECO:0000269|PubMed:17189706, ECO:0000269|PubMed:17525747, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:21110917, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:7969172, ECO:0000269|PubMed:8001819, ECO:0000269|PubMed:8654373};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11062067, ECO:0000269|PubMed:15805466, ECO:0000269|PubMed:17189706, ECO:0000269|PubMed:17525747, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:21110917, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:7969172, ECO:0000269|PubMed:8001819, ECO:0000269|PubMed:8654373};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.

Enzyme Numbers (IUBMB) for MAPK9 Gene

Phenotypes From GWAS Catalog for MAPK9 Gene

Gene Ontology (GO) - Molecular Function for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA 21873635
GO:0004705 JUN kinase activity IBA,IDA 8654373
GO:0004707 MAP kinase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with MAPK9: view
genes like me logo Genes that share phenotypes with MAPK9: view

Animal Models for MAPK9 Gene

MGI Knock Outs for MAPK9:

Animal Models for research

  • Taconic Biosciences Mouse Models for MAPK9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK9

Clone products for research

  • Addgene plasmids for MAPK9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK9 Gene

Localization for MAPK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK9 Gene

Cytoplasm. Nucleus. Note=Colocalizes with POU5F1 in the nucleus. {ECO:0000250 UniProtKB:Q9WTU6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK9 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK9 Gene

Pathways & Interactions for MAPK9 Gene

PathCards logo

SuperPathways for MAPK9 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
3 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
4 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
Lipid and atherosclerosis
.32
Chagas disease
.31
5 Toll-Like receptor Signaling Pathways
NOD-like Receptor Signaling Pathways
.59
Toll-Like receptor Signaling Pathways
.59
Inflammasome Activation Pathways
.51
IL-1 Family Signaling Pathways
.43
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
genes like me logo Genes that share pathways with MAPK9: view

Pathways by source for MAPK9 Gene

1 PharmGKB pathway for MAPK9 Gene
33 GeneGo (Thomson Reuters) pathways for MAPK9 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival TNFR1 signaling pathway
108 Qiagen pathways for MAPK9 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Agrin Interactions at Neuromuscular Junction
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for MAPK9 Gene

SIGNOR curated interactions for MAPK9 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IEA,IMP 22441692
GO:0007254 JNK cascade IBA,TAS --
GO:0007258 JUN phosphorylation IEA --
GO:0010468 regulation of gene expression IBA --
genes like me logo Genes that share ontologies with MAPK9: view

Drugs & Compounds for MAPK9 Gene

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(48) Drugs for MAPK9 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Minocycline Approved, Investigational Pharma Target, inhibitor 240
Magnesium Approved, Experimental, Investigational Pharma 0
Anisomycin Experimental Pharma JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
Halicin Experimental Pharma Target, inhibitor 0

(15) Additional Compounds for MAPK9 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
c-JUN peptide
610273-01-3

(3) Tocris Compounds for MAPK9 Gene

Compound Action Cas Number
Anisomycin JNK, SAPK and p38 activator 22862-76-6
CEP 1347 Inhibitor of JNK signaling 156177-65-0
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3

(19) ApexBio Compounds for MAPK9 Gene

Compound Action Cas Number
AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis 63735-71-7
Anisomycin JNK agonist, potent and specific 22862-76-6
AS 602801 Jun Kinase Inhibitor 848344-36-5
AS601245 c-Jun NH2-terminal protein kinase inhibitor 345987-15-7
BI 78D3 Competitive JNK inhibitor 883065-90-5
CC-401 JNK inhibitor,ATP-competitive 395104-30-0
CC-401 hydrochloride JNK inhibitor 1438391-30-0
CC-930 JNK inhibitor,potent and selective 899805-25-5
CEP 1347 JNK inhibitor 156177-65-0
DTP3 inhibitor of GADD45β/MKK7 complex
IQ 3 312538-03-7
JIP-1 (153-163) 438567-88-5
JNK-IN-7 Selective JNK inhibitor 1408064-71-0
JNK-IN-8 JNK inhibitor, selective and irreversible 1410880-22-6
PF-03394197(Oclacitinib) Novel Janus kinase inhibitor 1208319-26-9
SP 600125 JNK1/2/3 inhibitor 129-56-6
SU 3327 40045-50-9
TCS JNK 5a JNK2 and JNK3 inhibitor 312917-14-9
TCS JNK 6o JNK inhibitor 894804-07-0
genes like me logo Genes that share compounds with MAPK9: view

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Transcripts for MAPK9 Gene

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mRNA/cDNA for MAPK9 Gene

13 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK9

Clone products for research

  • Addgene plasmids for MAPK9

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for MAPK9 Gene

GeneLoc Exon Structure for
MAPK9

Expression for MAPK9 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK9 Gene

mRNA expression in normal human tissues for MAPK9 Gene
mRNA expression by BioGPS for MAPK9 GenemRNA expression by GTEx for MAPK9 Gene

Protein differential expression in normal tissues from HIPED for MAPK9 Gene

This gene is overexpressed in Lung (16.1) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK9 Gene



Protein tissue co-expression partners for MAPK9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK9

SOURCE GeneReport for Unigene cluster for MAPK9 Gene:

Hs.484371

Evidence on tissue expression from TISSUES for MAPK9 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Heart(2.7)
  • Muscle(2.7)
  • Liver(2.6)
  • Kidney(2.6)
  • Lung(2.5)
  • Intestine(2.5)
  • Blood(2.5)
  • Pancreas(2.4)
  • Adrenal gland(2.3)
  • Spleen(2.3)
  • Lymph node(2.3)
  • Bone marrow(2.2)
  • Thyroid gland(2.1)
  • Stomach(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with MAPK9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK9 Gene

Orthologs for MAPK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK9 29 30
  • 99.45 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPK9 30
  • 97 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAPK9 30
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK9 29 30
  • 93.37 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk9 29
  • 91.49 (n)
Mouse
(Mus musculus)
 Mammalia Mapk9 29 16 30
  • 91.41 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPK9 29 30
  • 90.64 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAPK9 29 30
  • 84.53 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPK9 30
  • 97 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii mapk9 29 30
  • 73.33 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta bsk 30 31
  • 74 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea jnk-1 30 31
  • 55 (a)
 OneToMany
F09C12.2 31
  • 37 (a)
C49C3.10b 31
  • 35 (a)
Y51B9A.9 31
  • 34 (a)
C49C3.10a 31
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HOG1 30
  • 34 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 58 (a)
 OneToMany
Species where no ortholog for MAPK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MAPK9 Gene

ENSEMBL:
Gene Tree for MAPK9 (if available)
TreeFam:
Gene Tree for MAPK9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK9: view image
Alliance of Genome Resources:
Additional Orthologs for MAPK9

Paralogs for MAPK9 Gene

Paralogs for MAPK9 Gene

(45) SIMAP similar genes for MAPK9 Gene using alignment to 8 proteins:

  • MK09_HUMAN
  • B5BUJ7_HUMAN
  • D7R525_HUMAN
  • D7R526_HUMAN
  • D7R527_HUMAN
  • D7R528_HUMAN
  • E5RJ57_HUMAN
  • J3KNK1_HUMAN
genes like me logo Genes that share paralogs with MAPK9: view

Variants for MAPK9 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_042260 A colorectal adenocarcinoma sample p.Val13Met
VAR_042261 A head & Neck squamous cell carcinoma sample p.Lys56Asn
rs35421153 -- p.Ala246Thr
rs35693958 -- p.Gly268Ala
rs55736180 -- p.Arg366Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAPK9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAPK9 Gene

Variant ID Type Subtype PubMed ID
dgv1683e212 CNV gain 25503493
esv2678619 CNV deletion 23128226
esv2731323 CNV deletion 23290073
esv2759398 CNV gain 17122850
esv3607768 CNV loss 21293372
esv3607769 CNV loss 21293372
nsv1033706 CNV gain 25217958
nsv10787 CNV gain 18304495
nsv1125864 CNV tandem duplication 24896259
nsv1145742 CNV deletion 26484159
nsv823363 CNV loss 20364138
nsv830563 CNV loss 17160897

Variation tolerance for MAPK9 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK9
Leiden Open Variation Database (LOVD)
MAPK9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK9 Gene

Disorders for MAPK9 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MAPK9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, susceptibility to
breast cancer
  • breast cancer, familial
alzheimer disease
  • ad
cardiomyopathy, familial hypertrophic, 25
  • cmh25
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search MAPK9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAPK9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MAPK9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK9 Gene

Publications for MAPK9 Gene

  1. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (PMID: 8001819) Kallunki T … Karin M (Genes & development 1994) 2 3 4 22
  2. The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. (PMID: 18801372) Shaw D … Kuglstatter A (Journal of molecular biology 2008) 3 4 22
  3. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PMID: 17189706) Blonska M … Lin X (Immunity 2007) 3 4 22
  4. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PMID: 15693750) Jagadish N … Suri A (The Biochemical journal 2005) 3 4 22
  5. Role of the ATFa/JNK2 complex in Jun activation. (PMID: 10376527) De Graeve F … Chatton B (Oncogene 1999) 3 4 22

ExternalLinks

View latest publications for MAPK9 gene in Mastermind

Products for MAPK9 Gene

  • Addgene plasmids for MAPK9

Sources for MAPK9 Gene