Aliases for MAPK8IP3 Gene
- Mitogen-Activated Protein Kinase 8 Interacting Protein 3 2 3 5
- Homolog Of Drosophila Sunday Driver 2 2 3
- JNK MAP Kinase Scaffold Protein 3 3 4
- JNK-Interacting Protein 3 3 4
- JIP-3 3 4
- JIP3 3 4
- JNK/Stress-Activated Protein Kinase-Associated Protein 1 3
- Mitogen-Activated Protein Kinase 8-Interacting Protein 3 4
External Ids for MAPK8IP3 Gene
Previous GeneCards Identifiers for MAPK8IP3 Gene
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPK8IP3 Gene
MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3) is a Protein Coding gene. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and Signaling events mediated by focal adhesion kinase. Gene Ontology (GO) annotations related to this gene include kinesin binding and receptor signaling complex scaffold activity. An important paralog of this gene is SPAG9.
UniProtKB/Swiss-Prot for MAPK8IP3 Gene
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).