Aliases for MAPK8IP2 Gene
External Ids for MAPK8IP2 Gene
Previous HGNC Symbols for MAPK8IP2 Gene
Previous GeneCards Identifiers for MAPK8IP2 Gene
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
GeneCards Summary for MAPK8IP2 Gene
MAPK8IP2 (Mitogen-Activated Protein Kinase 8 Interacting Protein 2) is a Protein Coding gene. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Isthmus Cancer. Among its related pathways are Akt Signaling and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is MAPK8IP1.
UniProtKB/Swiss-Prot Summary for MAPK8IP2 Gene
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).