This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017] See more...

Aliases for MAPK8IP2 Gene

Aliases for MAPK8IP2 Gene

  • Mitogen-Activated Protein Kinase 8 Interacting Protein 2 2 3 5
  • JNK-Interacting Protein 2 2 3 4
  • C-Jun-Amino-Terminal Kinase-Interacting Protein 2 3 4
  • JNK MAP Kinase Scaffold Protein 2 3 4
  • Islet-Brain 2 2 3
  • PRKM8IPL 3 4
  • IB-2 3 4
  • JIP2 3 4
  • IB2 3 4
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 2 4
  • JNK MAP Kinase Scaffold Protein JIP2 3
  • PRKM8 Interacting Protein-Like 2
  • Homologous To Mouse JIP-1 3
  • Islet-Brain-2 4
  • JIP-2 4

External Ids for MAPK8IP2 Gene

Previous HGNC Symbols for MAPK8IP2 Gene

  • PRKM8IPL

Previous GeneCards Identifiers for MAPK8IP2 Gene

  • GC22P047543
  • GC22P049171
  • GC22P049329
  • GC22P049385
  • GC22P051039
  • GC22P033930

Summaries for MAPK8IP2 Gene

Entrez Gene Summary for MAPK8IP2 Gene

  • This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]

GeneCards Summary for MAPK8IP2 Gene

MAPK8IP2 (Mitogen-Activated Protein Kinase 8 Interacting Protein 2) is a Protein Coding gene. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Isthmus Cancer. Among its related pathways are Akt Signaling and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is MAPK8IP1.

UniProtKB/Swiss-Prot Summary for MAPK8IP2 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Wiki entry for MAPK8IP2 Gene

Additional gene information for MAPK8IP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK8IP2 Gene

Genomics for MAPK8IP2 Gene

GeneHancer (GH) Regulatory Elements for MAPK8IP2 Gene

Promoters and enhancers for MAPK8IP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J050601 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 511.1 +0.1 116 1.6 ZBTB40 SIN3A REST ZBTB11 GABPA AFF1 ZBTB26 TARDBP SAP30 ZBTB25 CHKB MAPK8IP2 CPT1B LMF2
GH22J050603 Promoter 0.4 EPDnew 511 +2.4 2444 0.1 EZH2 MAPK8IP2 CHKB NONHSAG034262.2
GH22J050626 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.8 +27.4 27428 2.6 ZBTB40 CTCF SIN3A NRF1 USF1 POLR2G SP1 BCLAF1 PHB2 ZBTB5 ARSA lnc-MAPK8IP2-2 BRD1 RABL2B TUBGCP6 ENSG00000272836 ENSG00000260613 ZBED4 PLXNB2 ALG12
GH22J049957 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -635.3 -635271 16.4 EP300 ZBTB40 SIN3A NRF1 TCF12 POLR2G USF1 SP1 NCOR1 GTF2E2 PIM3 ALG12 PLXNB2 LMF2 ENSG00000273192 RABL2B CHKB ZBED4 ENSG00000273137 BRD1
GH22J050269 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -330.0 -329984 3 ZBTB40 CTCF SIN3A NRF1 ZIC2 REST POLR2A ZBTB10 ZNF423 GABPA MAPK11 HSALNG0136275 lnc-MAPK11-1 DENND6B ENSG00000273253 MAPK8IP2 MAPK12 PPP6R2 SELENOO SHANK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK8IP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK8IP2

Top Transcription factor binding sites by QIAGEN in the MAPK8IP2 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MAPK8IP2 Gene

Genomic Locations for MAPK8IP2 Gene
chr22:50,600,685-50,613,981
(GRCh38/hg38)
Size:
13,297 bases
Orientation:
Plus strand
chr22:51,039,114-51,052,409
(GRCh37/hg19)
Size:
13,296 bases
Orientation:
Plus strand

Genomic View for MAPK8IP2 Gene

Genes around MAPK8IP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8IP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8IP2 Gene

Proteins for MAPK8IP2 Gene

  • Protein details for MAPK8IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13387-JIP2_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 2
    Protein Accession:
    Q13387
    Secondary Accessions:
    • Q96G62
    • Q99771
    • Q9NZ59
    • Q9UKQ4

    Protein attributes for MAPK8IP2 Gene

    Size:
    824 amino acids
    Molecular mass:
    87975 Da
    Quaternary structure:
    • Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with the cytoplasmic domain of APP (By similarity). Interacts with DCLK2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity. Interacts with SH3RF2 (By similarity).
    Miscellaneous:
    • [Isoform 3]: Might be artifactual as it is only predicted from a genomic sequence.
    SequenceCaution:
    • Sequence=CAA16714.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPK8IP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8IP2 Gene

Post-translational modifications for MAPK8IP2 Gene

  • Ubiquitination at Lys668
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK8IP2 Gene

Antibody Products

  • Boster Bio Antibodies for MAPK8IP2

No data available for DME Specific Peptides for MAPK8IP2 Gene

Domains & Families for MAPK8IP2 Gene

Gene Families for MAPK8IP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAPK8IP2 Gene

Blocks:
  • SH3 domain signature
  • Phosphotyrosine interaction domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK8IP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54593, highly similar to C-jun-amino-terminal kinase-interactingprotein 2 (B4DED9_HUMAN)
  • Mitogen-activated protein kinase 8-interacting protein 2 (JIP2_HUMAN)
  • Mitogen-activated protein kinase 8 interacting protein 2 (Q86VW5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13387

UniProtKB/Swiss-Prot:

JIP2_HUMAN :
  • Belongs to the JIP scaffold family.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with MAPK8IP2: view

Function for MAPK8IP2 Gene

Molecular function for MAPK8IP2 Gene

UniProtKB/Swiss-Prot Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
GENATLAS Biochemistry:
mitogen-activated protein kinase 8 interacting protein 2,,homolog to mus musculus JIR1 gene

Phenotypes From GWAS Catalog for MAPK8IP2 Gene

Gene Ontology (GO) - Molecular Function for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding NAS 12023290
GO:0005078 MAP-kinase scaffold activity NAS 10490659
GO:0005198 structural molecule activity TAS 10490659
GO:0005515 protein binding IPI,IEA 16273093
GO:0019894 kinesin binding ISS,IEA --
genes like me logo Genes that share ontologies with MAPK8IP2: view
genes like me logo Genes that share phenotypes with MAPK8IP2: view

Animal Models for MAPK8IP2 Gene

MGI Knock Outs for MAPK8IP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK8IP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8IP2 Gene

Localization for MAPK8IP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8IP2 Gene

Cytoplasm. Note=Accumulates in cell surface projections. {ECO:0000269 PubMed:10490659}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK8IP2 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 10490659
GO:0005886 plasma membrane IBA 21873635
GO:0014069 postsynaptic density IEA,ISS --
GO:0032991 protein-containing complex IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with MAPK8IP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK8IP2 Gene

Pathways & Interactions for MAPK8IP2 Gene

PathCards logo

SuperPathways for MAPK8IP2 Gene

SuperPathway Contained pathways
1 MAPK signaling pathway
2 Guidance Cues and Growth Cone Motility
-
3 TGF-Beta Pathway
.51
4 ERK Signaling
.58
5 Akt Signaling
.60
genes like me logo Genes that share pathways with MAPK8IP2: view

Pathways by source for MAPK8IP2 Gene

1 KEGG pathway for MAPK8IP2 Gene
5 Qiagen pathways for MAPK8IP2 Gene
  • Guidance Cues and Growth Cone Motility
  • JNK Pathway
  • MAPK Signaling
  • p38 Signaling
  • Reelin Pathway (Cajal-Retzius cells)

SIGNOR curated interactions for MAPK8IP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA,ISS --
GO:0006898 receptor-mediated endocytosis IBA 21873635
GO:0007172 signal complex assembly TAS 10490659
GO:0007254 JNK cascade IEA --
GO:0007617 mating behavior IEA --
genes like me logo Genes that share ontologies with MAPK8IP2: view

Drugs & Compounds for MAPK8IP2 Gene

No Compound Related Data Available

Transcripts for MAPK8IP2 Gene

mRNA/cDNA for MAPK8IP2 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK8IP2

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP2 Gene

No ASD Table

Relevant External Links for MAPK8IP2 Gene

GeneLoc Exon Structure for
MAPK8IP2

Expression for MAPK8IP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK8IP2 Gene

mRNA differential expression in normal tissues according to GTEx for MAPK8IP2 Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Cerebellum (x5.5), Brain - Amygdala (x5.1), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cerebellar Hemisphere (x4.8), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Hippocampus (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK8IP2

SOURCE GeneReport for Unigene cluster for MAPK8IP2 Gene:

Hs.558180

mRNA Expression by UniProt/SwissProt for MAPK8IP2 Gene:

Q13387-JIP2_HUMAN
Tissue specificity: Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.

Evidence on tissue expression from TISSUES for MAPK8IP2 Gene

  • Nervous system(4.8)
  • Lymph node(2.8)
genes like me logo Genes that share expression patterns with MAPK8IP2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK8IP2 Gene

Orthologs for MAPK8IP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK8IP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8IP2 31 30
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK8IP2 31 30
  • 87.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK8IP2 31 30
  • 86.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8ip2 17 31 30
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia Mapk8ip2 30
  • 82.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK8IP2 31
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK8IP2 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK8IP2 31
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8ip2 30
  • 61.13 (n)
zebrafish
(Danio rerio)
Actinopterygii mapk8ip2 31 30
  • 62.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Aplip1 31 32
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jip-1 31
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for MAPK8IP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8IP2 Gene

ENSEMBL:
Gene Tree for MAPK8IP2 (if available)
TreeFam:
Gene Tree for MAPK8IP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK8IP2: view image

Paralogs for MAPK8IP2 Gene

Paralogs for MAPK8IP2 Gene

(1) SIMAP similar genes for MAPK8IP2 Gene using alignment to 6 proteins:

  • JIP2_HUMAN
  • A8MTJ1_HUMAN
  • C9JXW5_HUMAN
  • F6SWM5_HUMAN
  • J3KNN6_HUMAN
  • Q86VW5_HUMAN
genes like me logo Genes that share paralogs with MAPK8IP2: view

Variants for MAPK8IP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK8IP2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
780679 Benign: not provided 50,604,457(+) G/C SYNONYMOUS_VARIANT
rs1140555 - p.Pro743Leu

Additional dbSNP identifiers (rs#s) for MAPK8IP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK8IP2 Gene

Variant ID Type Subtype PubMed ID
nsv1059234 CNV gain 25217958
nsv1067172 CNV gain 25217958
nsv1073193 CNV deletion 25765185
nsv589223 CNV loss 21841781
nsv589224 CNV loss 21841781
nsv829340 CNV gain 20364138
nsv829342 CNV loss 20364138
nsv829343 CNV gain 20364138
nsv834239 CNV loss 17160897
nsv955203 CNV deletion 24416366

Variation tolerance for MAPK8IP2 Gene

Gene Damage Index Score: 3.26; 52.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK8IP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK8IP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8IP2 Gene

Disorders for MAPK8IP2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MAPK8IP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical verrucous carcinoma
isthmus cancer
cervix small cell carcinoma
  • small cell carcinoma of the cervix
papillary squamous carcinoma
  • papillary epidermoid carcinoma
vaginal cancer
  • malignant neoplasm of vagina
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPK8IP2

genes like me logo Genes that share disorders with MAPK8IP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK8IP2 Gene

Publications for MAPK8IP2 Gene

  1. The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J … Davis RJ (Molecular and cellular biology 1999) 2 3 4 23 54
  2. Fibroblast growth factor homologous factors are intracellular signaling proteins. (PMID: 11378392) Schoorlemmer J … Goldfarb M (Current biology : CB 2001) 3 4 23 54
  3. cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. (PMID: 10756100) Negri S … Bonny C (Genomics 2000) 3 4 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4 54

Products for MAPK8IP2 Gene

  • Boster Bio Antibodies for MAPK8IP2
  • Boster Bio ELISA Kits for MAPK8IP2

Sources for MAPK8IP2 Gene