Aliases for MAPK8IP2 Gene
External Ids for MAPK8IP2 Gene
Previous HGNC Symbols for MAPK8IP2 Gene
Previous GeneCards Identifiers for MAPK8IP2 Gene
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
GeneCards Summary for MAPK8IP2 Gene
MAPK8IP2 (Mitogen-Activated Protein Kinase 8 Interacting Protein 2) is a Protein Coding gene. Diseases associated with MAPK8IP2 include Cervical Verrucous Carcinoma and Ameloblastic Carcinoma. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is MAPK8IP1.
UniProtKB/Swiss-Prot for MAPK8IP2 Gene
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).