Aliases for MAPK8IP1 Gene
External Ids for MAPK8IP1 Gene
Previous HGNC Symbols for MAPK8IP1 Gene
Previous GeneCards Identifiers for MAPK8IP1 Gene
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
GeneCards Summary for MAPK8IP1 Gene
MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) is a Protein Coding gene. Diseases associated with MAPK8IP1 include Diabetes Mellitus, Noninsulin-Dependent and Sarcomatoid Squamous Cell Skin Carcinoma. Among its related pathways are Akt Signaling and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include identical protein binding and kinesin binding. An important paralog of this gene is MAPK8IP2.
UniProtKB/Swiss-Prot for MAPK8IP1 Gene
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.