MAPK8 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 8

GC10P048306
GIFtS:
50
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, an... See more...

Aliases for MAPK8 Gene

Aliases for MAPK8 Gene

  • Mitogen-Activated Protein Kinase 8 2 3 4 5
  • SAPK1 2 3 4
  • JNK1 2 3 4
  • Stress-Activated Protein Kinase 1c 3 4
  • C-Jun N-Terminal Kinase 1 3 4
  • JUN N-Terminal Kinase 2 3
  • MAP Kinase 8 3 4
  • EC 2.7.11.24 4 51
  • JNK-46 3 4
  • SAPK1c 3 4
  • PRKM8 3 4
  • JNK 2 3
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha1 3
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta2 3
  • Stress-Activated Protein Kinase JNK1 4
  • Stress-Activated Protein Kinase 1 3
  • JNK21B1/2 3
  • EC 2.7.11 51
  • JNK1A2 3
  • SAPK1C 4
  • MAPK 8 4
  • MAPK8 5

External Ids for MAPK8 Gene

Previous HGNC Symbols for MAPK8 Gene

  • PRKM8

Previous GeneCards Identifiers for MAPK8 Gene

  • GC10P048468
  • GC10P049407
  • GC10P048954
  • GC10P049279
  • GC10P049514
  • GC10P043874

Summaries for MAPK8 Gene

Entrez Gene Summary for MAPK8 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

GeneCards Summary for MAPK8 Gene

MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include Fatty Liver Disease and Hepatitis C. Among its related pathways are ATM Pathway and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.

UniProtKB/Swiss-Prot Summary for MAPK8 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity).
  • JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Tocris Summary for MAPK8 Gene

  • JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Gene Wiki entry for MAPK8 Gene

Additional gene information for MAPK8 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK8 Gene

Genomics for MAPK8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J048305 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 606.4 +0.6 578 2.8 RNF2 SP1 TFE3 IKZF1 ZNF692 POLR2A JUND LARP7 ZNF143 RBFOX2 MAPK8 lnc-FRMPD2-2 ARHGAP22
GH10J048386 Enhancer 0.9 Ensembl ENCODE 20 +77.7 77662 2.6 CTCF ZNF174 ZNF300 DPF2 ZNF37A ZBTB44 NFE2 HDGF NCOA2 ZNF491 BMS1P2 MAPK8 AGAP9 piR-57965-004 lnc-MAPK8-1 ARHGAP22
GH10J048476 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.5 +171.2 171161 8 HNRNPL PRDM10 ZNF512 IKZF1 ZNF692 MTA2 ZIC2 PKNOX1 MTA1 REST MAPK8 PTPN20CP ENSG00000279822 ARHGAP22-IT1 lnc-FRMPD2-5 ARHGAP22
GH10J047401 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 12.7 -901.4 -901401 8.5 CREB1 ZNF629 LEF1 IKZF1 KDM1A TARDBP ZHX2 JUND PRDM1 ZIC2 LOC107001062 AGAP9 BMS1P2 ENSG00000229227 BMS1P1 MAPK8 PTPN20 piR-37895-022 ZNF488 FAM25G
GH10J048333 Enhancer 0.7 Ensembl ENCODE 24.3 +27.1 27091 1.1 ZNF600 RFX5 FOS JUND NR3C1 GLIS2 FOSL2 MAPK8 lnc-FRMPD2-2 ARHGAP22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK8

Top Transcription factor binding sites by QIAGEN in the MAPK8 gene promoter:
  • AP-1
  • ATF-2
  • STAT3

Genomic Locations for MAPK8 Gene

Genomic Locations for MAPK8 Gene
chr10:48,306,639-48,439,360
(GRCh38/hg38)
Size:
132,722 bases
Orientation:
Plus strand
chr10:49,514,698-49,647,403
(GRCh37/hg19)
Size:
132,706 bases
Orientation:
Plus strand

Genomic View for MAPK8 Gene

Genes around MAPK8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK8 Gene

Proteins for MAPK8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45983-MK08_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 8
    Protein Accession:
    P45983
    Secondary Accessions:
    • B5BTZ5
    • B7ZLV4
    • D3DX88
    • D3DX92
    • Q15709
    • Q15712
    • Q15713
    • Q308M2

    Protein attributes for MAPK8 Gene

    Size:
    427 amino acids
    Molecular mass:
    48296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4 (PubMed:15693750). These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX (PubMed:12514174). Interacts with JAMP (By similarity). Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs under both normal growth conditions and immediately upon heat shock (PubMed:10747973). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with MECOM; regulates JNK signaling (PubMed:10856240). Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates (PubMed:21660049). Interacts with GRIPAP1 (PubMed:17761173). Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-355'. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8IP1/JIP1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK9/JNK2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK8 Gene

    Alternative splice isoforms for MAPK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8 Gene

Protein Expression for MAPK8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK8 Gene

P45983:
  • PIGSGAQGIVC
  • YVENRPKY
  • MTPYVVTRYYRAPEVI
  • IDQWNKV
  • DKQLDEREH
  • VNHKNII
  • KELIYKE
  • ILDFGLA
  • HSAGIIHRDLKPSN
  • LLNVFTPQK
  • KKLSRPFQ
  • LLSKMLVID
  • EFMKKLQPTVR
  • AKRAYRE
  • DSTFTVLKRYQ
  • LEEFQDVY
  • RDLLSKML
  • LLSKMLV
  • QARDLLS
  • VGCIMGE
  • SYLLYQMLCG
  • LDFGLAR
  • RISVDEAL
  • VMELMDANLC
  • YINVWYD
  • KNGVIRGQP
  • LKILDFGLAR

Post-translational modifications for MAPK8 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11062067). Phosphorylated by TAOK2 (PubMed:17158878). May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173). Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MAPK8 Gene

Gene Families for MAPK8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAPK8 Gene

InterPro:
Blocks:
  • MAP kinase
  • JNK MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77387, highly similar to Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant 4, mRNA (A1L4K2_HUMAN)
  • Mitogen-activated protein kinase 8 isoform JNK1 alpha1 (B5BUB8_HUMAN)
  • c-Jun N-terminal kinase 1 (MK08_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P45983

UniProtKB/Swiss-Prot:

MK08_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK8: view

Function for MAPK8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAPK8 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity).
UniProtKB/Swiss-Prot Function:
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11062067, ECO:0000269|PubMed:15141161, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:19166818, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21660049, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:8654373};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11062067, ECO:0000269|PubMed:15141161, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:19166818, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21660049, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:8654373};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
GENATLAS Biochemistry:
mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by UV irradiation and H-RAS,phosphorylating JUN

Enzyme Numbers (IUBMB) for MAPK8 Gene

Phenotypes From GWAS Catalog for MAPK8 Gene

Gene Ontology (GO) - Molecular Function for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 14967141
GO:0004705 JUN kinase activity TAS --
GO:0004707 MAP kinase activity IBA 21873635
genes like me logo Genes that share ontologies with MAPK8: view

Phenotypes for MAPK8 Gene

MGI mutant phenotypes for MAPK8:
inferred from 5 alleles
GenomeRNAi human phenotypes for MAPK8:
genes like me logo Genes that share phenotypes with MAPK8: view

Animal Models for MAPK8 Gene

MGI Knock Outs for MAPK8:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK8

CRISPR Products

miRNA for MAPK8 Gene

miRTarBase miRNAs that target MAPK8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK8

Clone Products

  • Addgene plasmids for MAPK8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8 Gene

Localization for MAPK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8 Gene

Cytoplasm. Nucleus. Cell junction, synapse. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. {ECO:0000250 UniProtKB:P49185, ECO:0000250 UniProtKB:Q91Y86}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK8 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 3
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
endosome 3
lysosome 3
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20027304
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK8 Gene

Pathways & Interactions for MAPK8 Gene

PathCards logo

SuperPathways for MAPK8 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
3 TNFR1 Pathway
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
HIV-1 Nef- Negative effector of Fas and TNF-alpha
.46
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
Fas Signaling
.35
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
.34
TNF alpha Signaling Pathway
.30
4 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
5 Development HGF signaling pathway
Development HGF signaling pathway
.44
Development Neurotrophin family signaling
.44
Neurotrophin signaling pathway
.36
Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
.35
Signaling of Hepatocyte Growth Factor Receptor
.33
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
.31
genes like me logo Genes that share pathways with MAPK8: view

Pathways by source for MAPK8 Gene

38 GeneGo (Thomson Reuters) pathways for MAPK8 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
114 Qiagen pathways for MAPK8 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Agrin Interactions at Neuromuscular Junction
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for MAPK8 Gene

SIGNOR curated interactions for MAPK8 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IDA,IMP 22441692
GO:0007254 JNK cascade IBA,TAS --
GO:0007258 JUN phosphorylation IDA 14967141
GO:0009411 response to UV IDA 14967141
genes like me logo Genes that share ontologies with MAPK8: view

Drugs & Compounds for MAPK8 Gene

Products:

  1. Drug

(98) Drugs for MAPK8 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Tamoxifen Approved Pharma Agonist, Antagonist, Target, modulator TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
Magnesium Approved, Experimental, Investigational Pharma 0
Anisomycin Experimental Pharma JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE Experimental Pharma Target 0

(67) Additional Compounds for MAPK8 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
c-JUN peptide
610273-01-3

(3) Tocris Compounds for MAPK8 Gene

Compound Action Cas Number
Anisomycin JNK, SAPK and p38 activator 22862-76-6
CEP 1347 Inhibitor of JNK signaling 156177-65-0
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3

(20) ApexBio Compounds for MAPK8 Gene

Compound Action Cas Number
AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis 63735-71-7
Anisomycin JNK agonist, potent and specific 22862-76-6
AS 602801 Jun Kinase Inhibitor 848344-36-5
AS601245 c-Jun NH2-terminal protein kinase inhibitor 345987-15-7
BI 78D3 Competitive JNK inhibitor 883065-90-5
CC-401 JNK inhibitor,ATP-competitive 395104-30-0
CC-401 hydrochloride JNK inhibitor 1438391-30-0
CC-930 JNK inhibitor,potent and selective 899805-25-5
CEP 1347 JNK inhibitor 156177-65-0
DB07268 JNK1 inhibitor 929007-72-7
DTP3 inhibitor of GADD45β/MKK7 complex
IQ 3 312538-03-7
JIP-1 (153-163) 438567-88-5
JNK-IN-7 Selective JNK inhibitor 1408064-71-0
JNK-IN-8 JNK inhibitor, selective and irreversible 1410880-22-6
PF-03394197(Oclacitinib) Novel Janus kinase inhibitor 1208319-26-9
Piperine MAPK inhibitor 94-62-2
SP 600125 JNK1/2/3 inhibitor 129-56-6
SU 3327 40045-50-9
TCS JNK 6o JNK inhibitor 894804-07-0
genes like me logo Genes that share compounds with MAPK8: view

Drug Products

Transcripts for MAPK8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK8 Gene

18 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK8

Clone Products

  • Addgene plasmids for MAPK8

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for MAPK8 Gene

GeneLoc Exon Structure for
MAPK8

Expression for MAPK8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK8 Gene

mRNA expression in normal human tissues for MAPK8 Gene
mRNA expression by BioGPS for MAPK8 GenemRNA expression by GTEx for MAPK8 Gene

Protein differential expression in normal tissues from HIPED for MAPK8 Gene

This gene is overexpressed in Lung (47.9) and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK8

SOURCE GeneReport for Unigene cluster for MAPK8 Gene:

Hs.138211

Evidence on tissue expression from TISSUES for MAPK8 Gene

  • Nervous system(4.9)
  • Liver(3.8)
  • Heart(3.7)
  • Blood(3.7)
  • Muscle(3.7)
  • Intestine(3.6)
  • Kidney(3.6)
  • Lung(3.5)
  • Skin(3.4)
  • Spleen(3.4)
  • Lymph node(3.3)
  • Pancreas(3.3)
  • Bone marrow(3.3)
  • Adrenal gland(3.1)
  • Stomach(3.1)
  • Thyroid gland(3)
  • Eye(3)
  • Bone(3)
  • Gall bladder(2.5)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with MAPK8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK8 Gene

Orthologs for MAPK8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK8 30 31
  • 99.61 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPK8 30 31
  • 96.1 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-7255 31
  • 96 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK8 30 31
  • 95.7 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 95 (a)
 OneToMany
-- 31
  • 89 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Mapk8 30 17 31
  • 91.67 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk8 30
  • 91.18 (n)
Chicken
(Gallus gallus)
 Aves MAPK8 30 31
  • 89.15 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPK8 31
  • 93 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapk8 30
  • 80.13 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398499 30
Zebrafish
(Danio rerio)
 Actinopterygii mapk8b 31
  • 84 (a)
 OneToMany
mapk8a 30 31
  • 76.89 (n)
 OneToMany
mapk8 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6867 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009461 30
  • 68.76 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta bsk 30 31 32
  • 68.6 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea jnk-1 30 31 32
  • 64.59 (n)
 OneToMany
F09C12.2 32
  • 35 (a)
C49C3.10b 32
  • 33 (a)
Y51B9A.9 32
  • 33 (a)
C49C3.10a 32
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HOG1 31
  • 34 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 59 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8900 30
Species where no ortholog for MAPK8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPK8 Gene

ENSEMBL:
Gene Tree for MAPK8 (if available)
TreeFam:
Gene Tree for MAPK8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK8: view image

Paralogs for MAPK8 Gene

Paralogs for MAPK8 Gene

(98) SIMAP similar genes for MAPK8 Gene using alignment to 7 proteins:

  • MK08_HUMAN
  • A1L4K2_HUMAN
  • A6NF29_HUMAN
  • B5BUB8_HUMAN
  • C9J762_HUMAN
  • C9JWQ4_HUMAN
  • Q308M2_HUMAN
genes like me logo Genes that share paralogs with MAPK8: view

Variants for MAPK8 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK8 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
725202 Benign: not provided 48,409,917(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
759314 Likely Benign: not provided 48,401,765(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
778386 Benign: not provided 48,434,924(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
VAR_042258 A renal clear cell carcinoma sample p.Gly171Ser
VAR_042259 A glioblastoma multiforme sample p.Gly177Arg

Additional dbSNP identifiers (rs#s) for MAPK8 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK8 Gene

Variant ID Type Subtype PubMed ID
esv2666099 CNV deletion 23128226
esv3623153 CNV loss 21293372
esv3623154 CNV loss 21293372
nsv1039508 CNV gain 25217958
nsv1042677 CNV loss 25217958
nsv467190 CNV gain 19166990
nsv518744 CNV loss 19592680
nsv519701 CNV loss 19592680
nsv550811 CNV gain 21841781
nsv550812 CNV gain 21841781
nsv6587 CNV deletion 18451855
nsv825373 CNV loss 20364138

Variation tolerance for MAPK8 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK8 Gene

Human Gene Mutation Database (HGMD)
MAPK8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8 Gene

Disorders for MAPK8 Gene

MalaCards: The human disease database

(72) MalaCards diseases for MAPK8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • steatosis of liver
hepatitis c
  • chronic hepatitis c
hepatitis
  • hepatitis a
renal fibrosis
non-alcoholic fatty liver disease
  • nafld
- elite association - COSMIC cancer census association via MalaCards
Search MAPK8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAPK8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPK8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK8 Gene

Publications for MAPK8 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S … Davis RJ (The EMBO journal 1996) 2 3 4 23
  2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Dérijard B … Davis RJ (Science (New York, N.Y.) 1995) 3 4 23
  3. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PMID: 8137421) Dérijard B … Davis RJ (Cell 1994) 2 3 4
  4. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. (PMID: 22327296) Huang J … Lei M (Nature 2012) 3 4
  5. JNK regulates the photic response of the mammalian circadian clock. (PMID: 22441692) Yoshitane H … Fukada Y (EMBO reports 2012) 3 4

ExternalLinks

View latest publications for MAPK8 gene in Mastermind

Products for MAPK8 Gene