Aliases for MAPK8 Gene
Aliases for MAPK8 Gene
External Ids for MAPK8 Gene
- HGNC: 6881
- Entrez Gene: 5599
- Ensembl: ENSG00000107643
- OMIM: 601158
- UniProtKB: P45983
Previous HGNC Symbols for MAPK8 Gene
- PRKM8
Previous GeneCards Identifiers for MAPK8 Gene
- GC10P048468
- GC10P049407
- GC10P048954
- GC10P049279
- GC10P049514
- GC10P043874
Summaries for MAPK8 Gene
-
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
GeneCards Summary for MAPK8 Gene
MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include Fatty Liver Disease and Renal Fibrosis. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.
UniProtKB/Swiss-Prot for MAPK8 Gene
-
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973).
-
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
-
JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.
Additional gene information for MAPK8 Gene
- Monarch Initiative
- Search for MAPK8 at DataMed
- Search for MAPK8 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8 Gene
Genomics for MAPK8 Gene
GeneHancer (GH) Regulatory Elements for MAPK8 Gene
Promoters and enhancers for MAPK8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAPK8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK8 gene promoter:
Regulatory Element Products
Genomic Locations for MAPK8 Gene
Genomic Locations for MAPK8 Gene
- chr10:48,306,639-48,439,360
- (GRCh38/hg38)
- Size:
- 132,722 bases
- Orientation:
- Plus strand
- chr10:49,514,698-49,647,403
- (GRCh37/hg19)
Genomic View for MAPK8 Gene
Genes around MAPK8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.22 by Entrez Gene
- 10q11.22 by HGNC
- 10q11.22 by Ensembl
MAPK8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK8 Gene
Proteins for MAPK8 Gene
-
Protein details for MAPK8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P45983-MK08_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 8
- Protein Accession:
- P45983
- B5BTZ5
- B7ZLV4
- D3DX88
- D3DX92
- Q15709
- Q15712
- Q15713
- Q308M2
Protein attributes for MAPK8 Gene
- Size:
- 427 amino acids
- Molecular mass:
- 48296 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4 (PubMed:15693750). These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX (PubMed:12514174). Interacts with JAMP (By similarity). Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs under both normal growth conditions and immediately upon heat shock (PubMed:10747973). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with MECOM; regulates JNK signaling (PubMed:10856240). Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates (PubMed:21660049). Interacts with GRIPAP1 (PubMed:17761173).
Three dimensional structures from OCA and Proteopedia for MAPK8 Gene
Protein Expression for MAPK8 Gene
Post-translational modifications for MAPK8 Gene
- Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11062067). Phosphorylated by TAOK2 (PubMed:17158878). May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAPK8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK8 (JNK1)
-
Custom Antibody ServicesOriGene Antibodies for MAPK8
- TA327585
- TA500043
- TA500075
- TA500081
- TA500276
- AM00081BT-N
- AM00081PU-N
- AM00082PU-N
- AM06773PU-N
- AM31930PU-N
- AM31931PU-N
- AM31950PU-N
- AM31951PU-N
- AM31952PU-N
- AM31953PU-N
- AM31954PU-N
- AM31955PU-N
- AP00339PU-N
- AP09471PU-N
- AP09471PU-S
- AP12858PU-N
- AP14120PU-N
- AP20387PU-N
- AP20729PU-N
- AP20730PU-N
- AP20849PU-N
- AP52605PU-N
- TA308811
- TA312593
- TA322056
- TA324295
- TA324296
- TA324297
- TA325661
- TA325662
- TA325663
- TA325664
- TA325665
- TA327955
- TA336276
- TA347001
- CF500043
- CF500075
- CF500081
- TA500275
- CF500275
- CF500276
- TA590142
- Novus Biologicals Antibodies for MAPK8
- Invitrogen Antibodies for MAPK8
- antibodies-online: Search results for 439 available JNK Antibodies ranked by validation data
- Compare Top JNK Antibodies
-
Recommended
- 314 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 7 DB Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 153 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 2 ICS Antibodies (anti-mouse)
- 124 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- GeneTex MAPK8 Antibody for MAPK8
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK8
- Sino Biological Antibodies for MAPK8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK8
- Origene Custom Protein Services for MAPK8
- Sino Biological Cell Lysates for MAPK8
- Sino Biological Recombinant Proteins for MAPK8
- ProSpec Recombinant Proteins for MAPK8
- GeneTex Proteins for MAPK8
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MAPK8 (JNK1)
No data available for DME Specific Peptides for MAPK8 Gene
Domains & Families for MAPK8 Gene
Gene Families for MAPK8 Gene
- HGNC:
- IUPHAR :
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAPK8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK8 Gene
Graphical View of Domain Structure for InterPro Entry
P45983UniProtKB/Swiss-Prot:
MK08_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK8 Gene
Molecular function for MAPK8 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973).
- UniProtKB/Swiss-Prot Function:
- JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
- GENATLAS Biochemistry:
- mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by UV irradiation and H-RAS,phosphorylating JUN
Enzyme Numbers (IUBMB) for MAPK8 Gene
Phenotypes From GWAS Catalog for MAPK8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 14967141 |
| GO:0004705 | JUN kinase activity | TAS | -- |
| GO:0004707 | MAP kinase activity | IBA,IEA | -- |
Phenotypes for MAPK8 Gene
- MGI mutant phenotypes for MAPK8:
-
inferred from 5 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- embryo phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MAPK8:
-
- Increased mitotic index
- Decreased telomerase activity
- Increased G1 DNA content
- Increased viability after TNF/CHX stimulation
- Decreased Hepatitis C virus replication
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Increased circadian period length
- Decreased shRNA abundance
- Decreased IL-13 protein expression
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with Ras
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased simian virus 40 (SV40) infection
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for MAPK8 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MAPK8
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK8
-
CRISPR Products
-
OriGene CRISPR knockouts for MAPK8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK8
- genomics-online: gRNA clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
- Applied Biological Materials CRISPR for MAPK8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK8
- GenScript: Design CRISPR guide RNA sequences for MAPK8
miRNA for MAPK8 Gene
- miRTarBase miRNAs that target MAPK8
-
- hsa-mir-199a-3p (MIRT003985)
- hsa-mir-214-3p (MIRT005427)
- hsa-mir-421 (MIRT016104)
- hsa-mir-193b-3p (MIRT016510)
- hsa-mir-125a-5p (MIRT021289)
- hsa-mir-140-3p (MIRT021678)
- hsa-mir-10a-5p (MIRT025602)
- hsa-mir-33a-5p (MIRT028235)
- hsa-mir-877-5p (MIRT037323)
- hsa-mir-92a-3p (MIRT437964)
- hsa-mir-3163 (MIRT441783)
- hsa-mir-4480 (MIRT441784)
- hsa-mir-1277-5p (MIRT441785)
- hsa-mir-3662 (MIRT441786)
- hsa-mir-374b-3p (MIRT473685)
- hsa-mir-548s (MIRT473686)
- hsa-mir-4524b-5p (MIRT473687)
- hsa-mir-4524a-5p (MIRT473688)
- hsa-mir-3926 (MIRT473689)
- hsa-mir-3190-5p (MIRT473690)
- hsa-mir-4280 (MIRT473691)
- hsa-mir-892b (MIRT473692)
- hsa-mir-193a-3p (MIRT473693)
- hsa-mir-497-3p (MIRT473694)
- hsa-mir-30b-5p (MIRT473695)
- hsa-mir-30e-5p (MIRT473696)
- hsa-mir-30c-5p (MIRT473697)
- hsa-mir-30d-5p (MIRT473698)
- hsa-mir-30a-5p (MIRT473699)
- hsa-mir-3680-3p (MIRT501958)
- hsa-mir-433-3p (MIRT501959)
- hsa-mir-7154-5p (MIRT501960)
- hsa-mir-4795-3p (MIRT501961)
- hsa-mir-8060 (MIRT501962)
- hsa-mir-496 (MIRT501963)
- hsa-mir-664a-3p (MIRT501964)
- hsa-mir-126-5p (MIRT501965)
- hsa-mir-203a-3p (MIRT501966)
- hsa-mir-33b-5p (MIRT501967)
- hsa-mir-557 (MIRT536119)
- hsa-mir-507 (MIRT536120)
- hsa-mir-450b-5p (MIRT536121)
- hsa-mir-4325 (MIRT536122)
- hsa-mir-7703 (MIRT536123)
- hsa-mir-4775 (MIRT536124)
- hsa-mir-616-5p (MIRT536125)
- hsa-mir-373-5p (MIRT536126)
- hsa-mir-371b-5p (MIRT536127)
- hsa-mir-3613-3p (MIRT536128)
- hsa-mir-888-5p (MIRT536129)
- hsa-mir-590-3p (MIRT536130)
- hsa-mir-548aw (MIRT566815)
- hsa-mir-1468-3p (MIRT566816)
- hsa-mir-548x-5p (MIRT566817)
- hsa-mir-548g-5p (MIRT566818)
- hsa-mir-548f-5p (MIRT566819)
- hsa-mir-548aj-5p (MIRT566820)
- hsa-mir-4282 (MIRT566821)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK8
- Browse OriGene Inhibitory RNA Products For MAPK8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK8
- genomics-online: shRNA clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for MAPK8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for MAPK8 in any vector
- NM_139046.3
- NM_002750.3
- NM_139049.3
- NM_001323326.1
- NM_001323302.1
- NM_001278547.1
- NM_001323329.1
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- XM_011539954.1
- NM_001323325.1
- NM_001323330.1
- NM_001323330.1
- NM_001323320.1
- NM_001323331.1
- NM_001278548.1
- NM_001323324.1
- NM_001323323.1
- NM_001323323.1
- NM_001323324.1
- NM_001323323.1
- NM_001323324.1
- NM_001323321.1
- NM_001323328.1
- XM_011539955.1
- XM_011539953.1
- NM_001323322.1
- XM_011539958.1
- NM_001323327.1
- Sino Biological Human cDNA Clone for MAPK8
- VectorBuilder custom plasmid, inducible vectors for MAPK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK8
- genomics-online: cdna clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
- orf clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
- Applied Biological Materials Clones for MAPK8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK8
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8 Gene
Localization for MAPK8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK8 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| peroxisome | 2 |
| lysosome | 2 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 20027304 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK8 Gene
Pathways & Interactions for MAPK8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | IL-2 Pathway |
.59
.48
|
.43
.36
|
| 3 | TNFR1 Pathway |
.56
.55
|
.35
|
| 4 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 5 | Toll-like Receptor Signaling Pathway | ||
Pathways by source for MAPK8 Gene
2 Sino Biological pathways for MAPK8 Gene
5 GeneTex pathways for MAPK8 Gene
93 BioSystems pathways for MAPK8 Gene
46 Reactome pathways for MAPK8 Gene
3 PharmGKB pathways for MAPK8 Gene
59 KEGG pathways for MAPK8 Gene
38 GeneGo (Thomson Reuters) pathways for MAPK8 Gene
5 R&D Systems pathways for MAPK8 Gene
5 Tocris pathways for MAPK8 Gene
114 Qiagen pathways for MAPK8 Gene
1 Cell Signaling Technology pathway for MAPK8 Gene
Interacting Proteins for MAPK8 Gene
Selected Interacting proteins:
P45983-MK08_HUMAN
ENSP00000353483
for MAPK8 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for MAPK8
SIGNOR curated interactions for MAPK8 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IMP,IDA | 22441692 |
| GO:0007254 | JNK cascade | TAS,IDA | -- |
| GO:0007258 | JUN phosphorylation | IDA | 14967141 |
| GO:0009411 | response to UV | IDA | 14967141 |
| GO:0009612 | response to mechanical stimulus | IBA | -- |
Drugs & Compounds for MAPK8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved | Nutra | 0 | |||
| Anisomycin | Experimental | Pharma | JNK agonist, potent and specific, JNK, SAPK and p38 activator | 0 | ||
| 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE | Experimental | Pharma | Target | 0 | ||
| 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One | Experimental | Pharma | Target | 0 | ||
| 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
(3) Tocris Compounds for MAPK8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Anisomycin | JNK, SAPK and p38 activator | 22862-76-6 |
| CEP 1347 | Inhibitor of JNK signaling | 156177-65-0 |
| c-JUN peptide | Peptide inhibitor of JNK/c-Jun interaction | 610273-01-3 |
(22) ApexBio Compounds for MAPK8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AEG 3482 | inhibitor of Jun kinase (JNK)-dependent apoptosis | 63735-71-7 |
| Anisomycin | JNK agonist, potent and specific | 22862-76-6 |
| AS 602801 | Jun Kinase Inhibitor | 848344-36-5 |
| AS601245 | c-Jun NH2-terminal protein kinase inhibitor | 345987-15-7 |
| BI 78D3 | Competitive JNK inhibitor | 883065-90-5 |
| CC-401 | JNK inhibitor,ATP-competitive | 395104-30-0 |
| CC-401 hydrochloride | JNK inhibitor | 1438391-30-0 |
| CC-930 | JNK inhibitor,potent and selective | 899805-25-5 |
| CEP 1347 | JNK inhibitor | 156177-65-0 |
| c-JUN peptide | 610273-01-3 | |
| DB07268 | JNK1 inhibitor | 929007-72-7 |
| DTP3 | inhibitor of GADD45β/MKK7 complex | |
| IQ 3 | 312538-03-7 | |
| JIP-1 (153-163) | 438567-88-5 | |
| JNK-IN-7 | Selective JNK inhibitor | 1408064-71-0 |
| JNK-IN-8 | JNK inhibitor, selective and irreversible | 1410880-22-6 |
| PF-03394197(Oclacitinib) | Novel Janus kinase inhibitor | 1208319-26-9 |
| Piperine | MAPK inhibitor | 94-62-2 |
| SP 600125 | JNK1/2/3 inhibitor | 129-56-6 |
| SU 3327 | 40045-50-9 | |
| TCS JNK 6o | JNK inhibitor | 894804-07-0 |
| YS-49 | JNK/ROS inhibitor | 132836-42-1 |
Transcripts for MAPK8 Gene
mRNA/cDNA for MAPK8 Gene
- (122) Selected AceView cDNA sequences:
- (14) Additional mRNA sequences :
- (20) REFSEQ mRNAs :
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000360332 5438 bps (uc009xoa.5)
- ENST00000374174 739 bps (uc057tcv.1)
- ENST00000374176 5628 bps (uc001jgm.5)
- ENST00000374179 5637 bps (uc010qgk.4)
- ENST00000374182 5638 bps (uc001jgq.5)
Unigene Clusters for MAPK8 Gene
- Mitogen-activated protein kinase 8:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAPK8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK8
- genomics-online: gRNA clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK8
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miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
Clone Products
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-
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- NM_139046.3
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- Sino Biological Human cDNA Clone for MAPK8
- VectorBuilder custom plasmid, inducible vectors for MAPK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK8
- genomics-online: cdna clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
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- Overview of 126 available JNK gene related products
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Recommended
- Applied Biological Materials Clones for MAPK8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for MAPK8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Blood (Hematopoietic System)
- Liver (Hepatobiliary System)
- Neural Tube (Nervous System)
This gene is overexpressed in Lung (47.9) and Heart (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK8 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK8 Gene:
MAPK8SOURCE GeneReport for Unigene cluster for MAPK8 Gene:
Hs.138211Evidence on tissue expression from TISSUES for MAPK8 Gene
- Nervous system(4.8)
- Liver(3.4)
- Heart(3.3)
- Muscle(3.3)
- Blood(3.2)
- Lung(3.2)
- Intestine(3.1)
- Kidney(3.1)
- Skin(2.9)
- Adrenal gland(2.7)
- Pancreas(2.7)
- Spleen(2.7)
- Bone marrow(2.6)
- Lymph node(2.6)
- Eye(2.5)
- Bone(2.4)
- Stomach(2.4)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for MAPK8
-
OriGene qPCR primer pairs for MAPK8
- genomics-online: primer clones - Search results for 126 available JNK gene related products
- Overview of 126 available JNK gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK8 Gene
Orthologs for MAPK8 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAPK8 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-7255 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAPK8 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Mapk8 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mapk8 33 |
|
||
| chicken (Gallus gallus) |
Aves | MAPK8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAPK8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mapk8 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398499 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mapk8b 34 |
|
OneToMany | |
| mapk8a 34 33 |
|
OneToMany | |||
| mapk8 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6867 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009461 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | bsk 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | jnk-1 34 35 33 |
|
OneToMany | |
| F09C12.2 35 |
|
|
|||
| C49C3.10b 35 |
|
|
|||
| Y51B9A.9 35 |
|
|
|||
| C49C3.10a 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HOG1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.8900 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8900 33 |
|
- Species where no ortholog for MAPK8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MAPK8 Gene
- ENSEMBL:
- Gene Tree for MAPK8 (if available)
- TreeFam:
- Gene Tree for MAPK8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAPK8: view image
Paralogs for MAPK8 Gene
(98) SIMAP similar genes for MAPK8 Gene using alignment to 7 proteins:
- MK08_HUMAN
- A1L4K2_HUMAN
- A6NF29_HUMAN
- B5BUB8_HUMAN
- C9J762_HUMAN
- C9JWQ4_HUMAN
- Q308M2_HUMAN
- MAPK10
- MAPK9
- STK11
- MAPK14
- MAPK11
- MYO3B
- MAPK13
- OXSR1
- CDK14
- MAPK3
- EIF2AK3
- CDK19
- CAMKK2
- MOK
- NLK
- CDKL2
- STK38L
- MAP2K3
- MAPK12
- MAPK1
- DKFZp686O0215
- TXK
- TYK2
- PAK2
- PAK1
- GRK5
- FGFR4
- CSNK2A3
- CSNK1D
- CAMK1
- PHKG2
- MAPK7
- RPS6KA4
- ROCK2
- PRKG2
- DKFZp686M02159
- BRAF
- MAPK4
- CDK16
- STK36
- RPS6KA3
- RPS6KA1
- NEK9
- MAP3K6
- FGFR1
- CDK12
- CDK10
- CDKL3
- TNIK
- RPS6KA2
- PLK4
- NEK8
- MAST4
- CHEK1
- ERBB2
- STK35
- PRKACA
- PHKG1
- MAP4K1
- MAP3K4
- CDK7
- ULK1
- PNCK
- MAP4K4
- DAPK1
- CDK11B
- MARK2
- CDK3
- TAOK3
- STK33
- MAPKAPK3
- EPHA6
- CDKL1
- CDK11A
- CDC2L2
- CDC2L1
- CDK17
- CDK2
- CDK4
- PTK2
- PRKD2
- MAP4K5
- MAK
- EGFR
- CDK5
- CDC2
- CDK1
- MAPK15
- OBSCN
- NEK10
- MAP3K19
- FGFR2
- CDKL5
- CAMK2B
- GRK6
- FGFR3
- CAMK2D
- CDK6
Variants for MAPK8 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042258 | A renal clear cell carcinoma sample | p.Gly171Ser | |||
| VAR_042259 | A glioblastoma multiforme sample | p.Gly177Arg | |||
| rs1000001859 | -- | 48,348,954(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000005083 | -- | 48,399,675(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000010300 | -- | 48,436,574(+) | C/A | 3_prime_UTR_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2666099 | CNV | deletion | 23128226 |
| esv3623153 | CNV | loss | 21293372 |
| esv3623154 | CNV | loss | 21293372 |
| nsv1039508 | CNV | gain | 25217958 |
| nsv1042677 | CNV | loss | 25217958 |
| nsv467190 | CNV | gain | 19166990 |
| nsv518744 | CNV | loss | 19592680 |
| nsv519701 | CNV | loss | 19592680 |
| nsv550811 | CNV | gain | 21841781 |
| nsv550812 | CNV | gain | 21841781 |
| nsv6587 | CNV | deletion | 18451855 |
| nsv825373 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.32;
7.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8 Gene
Disorders for MAPK8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fatty liver disease |
|
|
| renal fibrosis |
|
|
| myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency |
|
|
| hepatitis |
|
|
| bile duct carcinoma |
|
|
Search MAPK8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAPK8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK8 Gene
Publications for MAPK8 Gene
- Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S … Davis RJ (The EMBO journal 1996) 2 3 4 58
- JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PMID: 8137421) Dérijard B … Davis RJ (Cell 1994) 2 3 4 58
- A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. (PMID: 21660049) Park JE … Cho S (Cell death and differentiation 2012) 3 4 58
- JNK regulates the photic response of the mammalian circadian clock. (PMID: 22441692) Yoshitane H … Fukada Y (EMBO reports 2012) 3 4 58
- Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis. (PMID: 21148294) Wang J … Zhang J (Molecular biology of the cell 2011) 3 4 58
Products for MAPK8 Gene
- R&D Systems Antibodies for MAPK8 (JNK1)
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- Custom Antibody ServicesOriGene Antibodies for MAPK8
- TA327585
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- TA500276
- AM00081BT-N
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- AM31930PU-N
- AM31931PU-N
- AM31950PU-N
- AM31951PU-N
- AM31952PU-N
- AM31953PU-N
- AM31954PU-N
- AM31955PU-N
- AP00339PU-N
- AP09471PU-N
- AP09471PU-S
- AP12858PU-N
- AP14120PU-N
- AP20387PU-N
- AP20729PU-N
- AP20730PU-N
- AP20849PU-N
- AP52605PU-N
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- TA312593
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- TA327955
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- TA347001
- CF500043
- CF500075
- CF500081
- TA500275
- CF500275
- CF500276
- TA590142
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- GenScript: Next-day shipping of latest version cDNA ORF clones for MAPK8 in any vector
- NM_139046.3
- NM_002750.3
- NM_139049.3
- NM_001323326.1
- NM_001323302.1
- NM_001278547.1
- NM_001323329.1
- XM_011539954.1
- XM_011539954.1
- NM_001323325.1
- NM_001323330.1
- NM_001323330.1
- NM_001323320.1
- NM_001323331.1
- NM_001278548.1
- NM_001323324.1
- NM_001323323.1
- NM_001323323.1
- NM_001323324.1
- NM_001323323.1
- NM_001323324.1
- NM_001323321.1
- NM_001323328.1
- XM_011539955.1
- XM_011539953.1
- NM_001323322.1
- XM_011539958.1
- NM_001323327.1
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- ProSpec Recombinant Proteins for MAPK8
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- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
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- VectorBuilder custom plasmid, inducible vectors for MAPK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK8