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The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
MAPK6 (Mitogen-Activated Protein Kinase 6) is a Protein Coding gene. Diseases associated with MAPK6 include Pulmonary Immaturity and Breast Mucoepidermoid Carcinoma. Among its related pathways are Signaling by GPCR and VEGF Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0004707 | MAP kinase activity | IBA,ISS | -- |
GO:0005515 | protein binding | IPI | 20936779 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,ISS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0032156 | septin cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
|
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
|
2 | GPCR Pathway |
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
|
3 | VEGF Signaling |
.38
|
|
4 | TNFR1 Pathway |
TNF Signaling
.55
|
.34
|
5 | Apoptotic Pathways in Synovial Fibroblasts |
Glioma Invasiveness
.64
eIF2 Pathway
.60
|
Rap1 Pathway
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IEA | -- |
GO:0006468 | protein phosphorylation | ISS | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007165 | signal transduction | TAS | 2032290 |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target | 1512 | ||
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
FR 180204 | Pharma | ERK inhibitor, Selective ERK inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
FR 180204 | ERK inhibitor | 865362-74-9 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAPK6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAPK6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | MAPK6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mapk6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mapk6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAPK6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAPK6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mapk6 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23931 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mapk6 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KSS1 31 |
|
ManyToMany | |
FUS3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7149 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35697691 | - | p.Leu290Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2595n100 | CNV | gain | 25217958 |
dgv303e201 | CNV | deletion | 23290073 |
esv2351837 | CNV | deletion | 18987734 |
esv2749691 | CNV | deletion | 23290073 |
nsv1039841 | CNV | gain | 25217958 |
nsv1116073 | CNV | deletion | 24896259 |
nsv1138369 | CNV | deletion | 24896259 |
nsv1536 | CNV | deletion | 18451855 |
nsv471244 | CNV | gain | 18288195 |
nsv984070 | CNV | duplication | 23825009 |
nsv984071 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pulmonary immaturity |
|
|
breast mucoepidermoid carcinoma |
|
|