Aliases for MAPK6 Gene
Aliases for MAPK6 Gene
External Ids for MAPK6 Gene
- HGNC: 6879
- Entrez Gene: 5597
- Ensembl: ENSG00000069956
- OMIM: 602904
- UniProtKB: Q16659
Previous HGNC Symbols for MAPK6 Gene
- PRKM6
Previous GeneCards Identifiers for MAPK6 Gene
- GC15P047869
- GC15P045358
- GC15P049890
- GC15P050027
- GC15P050098
- GC15P052311
- GC15P029169
Summaries for MAPK6 Gene
-
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPK6 Gene
MAPK6 (Mitogen-Activated Protein Kinase 6) is a Protein Coding gene. Diseases associated with MAPK6 include Pulmonary Immaturity. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK4.
UniProtKB/Swiss-Prot for MAPK6 Gene
-
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Additional gene information for MAPK6 Gene
- Monarch Initiative
- Search for MAPK6 at DataMed
- Search for MAPK6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK6 Gene
Genomics for MAPK6 Gene
GeneHancer (GH) Regulatory Elements for MAPK6 Gene
Promoters and enhancers for MAPK6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAPK6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK6 gene promoter:
-
- Sox9
- NF-AT4
- NF-AT3
- NF-AT2
- NF-AT1
- NF-AT
- ER-alpha
- ARP-1
- Egr-3
- CREB
Regulatory Element Products
Genomic Locations for MAPK6 Gene
Genomic Locations for MAPK6 Gene
- chr15:51,952,106-52,067,372
- (GRCh38/hg38)
- Size:
- 115,267 bases
- Orientation:
- Plus strand
- chr15:52,244,303-52,358,462
- (GRCh37/hg19)
- Size:
- 114,160 bases
- Orientation:
- Plus strand
Genomic View for MAPK6 Gene
Genes around MAPK6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q21.2 by Entrez Gene
- 15q21.2 by HGNC
- 15q21.2 by Ensembl
MAPK6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK6 Gene
Proteins for MAPK6 Gene
-
Protein details for MAPK6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16659-MK06_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 6
- Protein Accession:
- Q16659
- B2R945
- B5BU65
- Q68DH4
- Q8IYN8
Protein attributes for MAPK6 Gene
- Size:
- 721 amino acids
- Molecular mass:
- 82681 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4.
Protein Expression for MAPK6 Gene
Post-translational modifications for MAPK6 Gene
- Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
- Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
- Ubiquitination at posLast=703703, isoforms=691, isoforms=1672, isoforms=631, posLast=563563, isoforms=517, posLast=480480, isoforms=471, and isoforms=447
- Modification sites at PhosphoSitePlus
Other Protein References for MAPK6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK6 (ERK3)
-
Custom Antibody ServicesOriGene Antibodies for MAPK6
- Novus Biologicals Antibodies for MAPK6
- Invitrogen Antibodies for MAPK6 (AFLGC-MAPK6)
- GeneTex MAPK6 Antibody for MAPK6
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK6
- Sino Biological Antibodies for MAPK6
Protein Products
-
OriGene Purified Proteins for MAPK6
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK6
- Origene Custom Protein Services for MAPK6
- Search GeneTex for Proteins for MAPK6
-
Abcam proteins for MAPK6
Assay Products
No data available for DME Specific Peptides for MAPK6 Gene
Domains & Families for MAPK6 Gene
Gene Families for MAPK6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAPK6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16659UniProtKB/Swiss-Prot:
MK06_HUMAN :- In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK6 Gene
Molecular function for MAPK6 Gene
- UniProtKB/Swiss-Prot Function:
- Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation at Ser-189.
Enzyme Numbers (IUBMB) for MAPK6 Gene
Phenotypes From GWAS Catalog for MAPK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004707 | MAP kinase activity | IBA,ISS | -- |
| GO:0005515 | protein binding | IPI | 20936779 |
Phenotypes for MAPK6 Gene
- MGI mutant phenotypes for MAPK6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAPK6:
-
- Increased mitotic index
- Decreased substrate adherent cell growth
- Decreased viability
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased cell migration
- Decreased cell migration
- Increased cell viability after pRB stimulation
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for MAPK6 Gene
- MGI Knock Outs for MAPK6:
-
- Mapk6 Mapk6<tm1Melo>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK6
-
CRISPR Products
-
OriGene CRISPR knockouts for MAPK6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK6
- genomics-online: gRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- Applied Biological Materials CRISPR for MAPK6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK6
- GenScript: Design CRISPR guide RNA sequences for MAPK6
miRNA for MAPK6 Gene
- miRTarBase miRNAs that target MAPK6
-
- hsa-mir-128-3p (MIRT021894)
- hsa-mir-100-5p (MIRT048392)
- hsa-mir-99a-5p (MIRT048608)
- hsa-mir-15a-5p (MIRT051334)
- hsa-mir-577 (MIRT193058)
- hsa-mir-26a-5p (MIRT193070)
- hsa-mir-26b-5p (MIRT193071)
- hsa-mir-1297 (MIRT193073)
- hsa-mir-3662 (MIRT193075)
- hsa-mir-4465 (MIRT193076)
- hsa-mir-511-3p (MIRT193093)
- hsa-mir-3177-5p (MIRT193094)
- hsa-let-7a-5p (MIRT193097)
- hsa-let-7b-5p (MIRT193098)
- hsa-let-7c-5p (MIRT193099)
- hsa-let-7d-5p (MIRT193100)
- hsa-let-7e-5p (MIRT193101)
- hsa-let-7f-5p (MIRT193102)
- hsa-mir-98-5p (MIRT193103)
- hsa-let-7g-5p (MIRT193104)
- hsa-let-7i-5p (MIRT193105)
- hsa-mir-3935 (MIRT193110)
- hsa-mir-4458 (MIRT193112)
- hsa-mir-4500 (MIRT193113)
- hsa-mir-4643 (MIRT193114)
- hsa-mir-10a-3p (MIRT281381)
- hsa-mir-363-5p (MIRT281386)
- hsa-mir-1293 (MIRT281393)
- hsa-mir-3115 (MIRT281394)
- hsa-mir-4307 (MIRT281397)
- hsa-mir-4483 (MIRT281400)
- hsa-mir-6745 (MIRT281402)
- hsa-mir-6756-5p (MIRT281403)
- hsa-mir-6766-5p (MIRT281404)
- hsa-mir-4304 (MIRT385976)
- hsa-mir-302a-5p (MIRT448682)
- hsa-mir-3920 (MIRT448683)
- hsa-mir-29a-5p (MIRT448684)
- hsa-mir-5697 (MIRT448685)
- hsa-mir-4776-3p (MIRT501968)
- hsa-mir-4715-3p (MIRT501969)
- hsa-mir-3064-3p (MIRT501970)
- hsa-mir-19b-2-5p (MIRT501971)
- hsa-mir-19b-1-5p (MIRT501972)
- hsa-mir-19a-5p (MIRT501973)
- hsa-mir-2052 (MIRT501974)
- hsa-mir-190a-3p (MIRT542883)
- hsa-mir-8076 (MIRT542884)
- hsa-mir-5011-5p (MIRT542885)
- hsa-mir-8485 (MIRT542886)
- hsa-mir-664b-3p (MIRT556260)
- hsa-mir-579-3p (MIRT556261)
- hsa-mir-5696 (MIRT556262)
- hsa-mir-4724-3p (MIRT556263)
- hsa-mir-202-3p (MIRT556264)
- hsa-mir-153-5p (MIRT556265)
- hsa-mir-1250-3p (MIRT556266)
- hsa-mir-664a-3p (MIRT556267)
- hsa-mir-6813-3p (MIRT556268)
- hsa-mir-3200-3p (MIRT556269)
- hsa-mir-4789-5p (MIRT611992)
- hsa-mir-3941 (MIRT611993)
- hsa-mir-603 (MIRT611994)
- hsa-mir-362-3p (MIRT611995)
- hsa-mir-329-3p (MIRT611996)
- hsa-mir-6787-3p (MIRT656449)
- hsa-mir-3942-3p (MIRT656450)
- hsa-mir-499b-5p (MIRT656451)
- hsa-mir-4494 (MIRT656452)
- hsa-mir-8087 (MIRT656453)
- hsa-mir-7161-5p (MIRT656454)
- hsa-mir-548u (MIRT656455)
- hsa-mir-1277-5p (MIRT708054)
- hsa-mir-1252-3p (MIRT708055)
- hsa-mir-3646 (MIRT708056)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK6
- Browse OriGene Inhibitory RNA Products For MAPK6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK6
- genomics-online: shRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAPK6
- Addgene plasmids for MAPK6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK6
- Applied Biological Materials Clones for MAPK6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK6
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK6 Gene
Localization for MAPK6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK6 Gene
- Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS,IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS,IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0032156 | septin cytoskeleton | IEA | -- |
Pathways & Interactions for MAPK6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
.59
|
.48
.36
|
| 2 | GPCR Pathway |
.73
.62
|
|
| 3 | VEGF Signaling Pathway | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
.60
|
.57
|
| 5 | TNF Signaling (sino) | ||
Pathways by source for MAPK6 Gene
13 Sino Biological pathways for MAPK6 Gene
7 BioSystems pathways for MAPK6 Gene
3 Reactome pathways for MAPK6 Gene
1 PharmGKB pathway for MAPK6 Gene
1 KEGG pathway for MAPK6 Gene
2 Tocris pathways for MAPK6 Gene
55 Qiagen pathways for MAPK6 Gene
1 Cell Signaling Technology pathway for MAPK6 Gene
Interacting Proteins for MAPK6 Gene
Selected Interacting proteins:
Q16659-MK06_HUMAN
ENSP00000261845
for MAPK6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAPK6
SIGNOR curated interactions for MAPK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0006468 | protein phosphorylation | ISS | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | TAS | 2032290 |
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
Drugs & Compounds for MAPK6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MAPK6 Gene
mRNA/cDNA for MAPK6 Gene
- (4) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (264) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000560802 552 bps (uc059jhm.1)
- ENST00000558063 583 bps (uc059jho.1)
- ENST00000560254 574 bps (uc059jhp.1)
- ENST00000261845 5345 bps (uc002abp.4)
- ENST00000558100 514 bps (uc059jhs.1)
Unigene Clusters for MAPK6 Gene
- Mitogen-activated protein kinase 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAPK6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK6
- genomics-online: gRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- Applied Biological Materials CRISPR for MAPK6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK6
- GenScript: Design CRISPR guide RNA sequences for MAPK6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK6
- Browse OriGene Inhibitory RNA Products For MAPK6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK6
- genomics-online: shRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAPK6
- Addgene plasmids for MAPK6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK6
- Applied Biological Materials Clones for MAPK6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - |
Expression for MAPK6 Gene
This gene is overexpressed in Brain (37.6), Monocytes (18.1), and Heart (13.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK6 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK6 Gene:
MAPK6SOURCE GeneReport for Unigene cluster for MAPK6 Gene:
Hs.411847mRNA Expression by UniProt/SwissProt for MAPK6 Gene:
Q16659-MK06_HUMAN
Tissue specificity:
Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
Evidence on tissue expression from TISSUES for MAPK6 Gene
- Muscle(4.4)
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for MAPK6
-
OriGene qPCR primer pairs and template standards for MAPK6
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK6 Gene
Orthologs for MAPK6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAPK6 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MAPK6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mapk6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mapk6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAPK6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAPK6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mapk6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23931 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mapk6 34 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KSS1 34 |
|
ManyToMany | |
| FUS3 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7149 34 |
|
OneToMany |
- Species where no ortholog for MAPK6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MAPK6 Gene
- ENSEMBL:
- Gene Tree for MAPK6 (if available)
- TreeFam:
- Gene Tree for MAPK6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAPK6: view image
Paralogs for MAPK6 Gene
(9) SIMAP similar genes for MAPK6 Gene using alignment to 1 proteins:
- MK06_HUMAN
Pseudogenes.org Pseudogenes for MAPK6 Gene
Variants for MAPK6 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000053982 | -- | 52,043,833(+) | A/G | intron_variant | |
| rs1000123528 | -- | 52,034,369(+) | G/A | intron_variant | |
| rs1000160156 | -- | 52,014,142(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000169703 | -- | 52,052,598(+) | A/T | intron_variant | |
| rs1000200218 | -- | 52,019,301(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2595n100 | CNV | gain | 25217958 |
| dgv303e201 | CNV | deletion | 23290073 |
| esv2351837 | CNV | deletion | 18987734 |
| esv2749691 | CNV | deletion | 23290073 |
| nsv1039841 | CNV | gain | 25217958 |
| nsv1116073 | CNV | deletion | 24896259 |
| nsv1138369 | CNV | deletion | 24896259 |
| nsv1536 | CNV | deletion | 18451855 |
| nsv471244 | CNV | gain | 18288195 |
| nsv984070 | CNV | duplication | 23825009 |
| nsv984071 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
9.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAPK6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK6 Gene
Disorders for MAPK6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pulmonary immaturity |
|
|
Search MAPK6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAPK6
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK6 Gene
Publications for MAPK6 Gene
- Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. (PMID: 8875998) Meloche S … Pellerin J (Oncogene 1996) 2 3 4 22 58
- N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. (PMID: 15226418) Coulombe P … Meloche S (Molecular and cellular biology 2004) 3 4 22 58
- Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PMID: 22645313) Martínez-Noël G … Howley PM (Molecular and cellular biology 2012) 3 4 58
- Regulation of ERK3/MAPK6 expression by BRAF. (PMID: 16964379) Hoeflich KP … Seshagiri S (International journal of oncology 2006) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for MAPK6 Gene
- R&D Systems Antibodies for MAPK6 (ERK3)
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for MAPK6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAPK6
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK6
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK6
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- OriGene qPCR primer pairs for MAPK6
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- OriGene CRISPR knockouts for MAPK6
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAPK6
- GenScript: Next-day shipping of latest version cDNA ORF clones for MAPK6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MAPK6
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- GenScript: Design CRISPR guide RNA sequences for MAPK6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Sino Biological Human cDNA Clone for MAPK6
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- Sino Biological Antibodies for MAPK6
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for MAPK6
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- Novus Biologicals Tissue Microarrays
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- Abcam proteins for MAPK6
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- Invitrogen Antibodies for MAPK6 (AFLGC-MAPK6)
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- antibodies-online: Search results for available MAPK6 related products ranked by validation data
- antibodies-online: Search results for available MAPK6 related products ranked by validation data
- antibodies-online: Search results for available MAPK6 related products ranked by validation data
- GeneTex MAPK6 Antibody for MAPK6
- Search GeneTex for Proteins for MAPK6
- Santa Cruz Biotechnology (SCBT) Antibodies for MAPK6
- Search Santa Cruz Biotechnology (SCBT) for MAPK6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAPK6
- Horizon Cell Lines for MAPK6
- genomics-online: cdna clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
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- Overview of 131 available MAPK6 gene related products
- genomics-online: gRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- genomics-online: primer clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- genomics-online: shRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK6
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK6
Sources for MAPK6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
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- (8) Gene Wiki
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- (25) HMDB
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- (27) AceView
- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
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- (100) SwitchGear Genomics
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- (102) PathCards
- (103) GeneReviews
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- (105) Taconic Biosciences
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- (169) Biorbyt