Aliases for MAPK4 Gene
External Ids for MAPK4 Gene
Previous HGNC Symbols for MAPK4 Gene
Previous GeneCards Identifiers for MAPK4 Gene
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for MAPK4 Gene
MAPK4 (Mitogen-Activated Protein Kinase 4) is a Protein Coding gene. Diseases associated with MAPK4 include Pulmonary Immaturity and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Melanocyte Development and Pigmentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAPK6.
UniProtKB/Swiss-Prot Summary for MAPK4 Gene
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).