MAPK3 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 3

GC16M030117
GIFtS:
49
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, re... See more...

Aliases for MAPK3 Gene

Aliases for MAPK3 Gene

  • Mitogen-Activated Protein Kinase 3 2 3 4 5
  • ERK1 2 3 4
  • Extracellular Signal-Regulated Kinase 1 3 4
  • Microtubule-Associated Protein 2 Kinase 3 4
  • Insulin-Stimulated MAP2 Kinase 3 4
  • MAP Kinase Isoform P44 3 4
  • EC 2.7.11.24 4 51
  • P44-ERK1 3 4
  • P44-MAPK 3 4
  • ERK-1 3 4
  • PRKM3 3 4
  • ERT2 3 4
  • Extracellular Signal-Related Kinase 1 3
  • MAP Kinase 3 4
  • EC 2.7.11 51
  • HS44KDAP 3
  • HUMKER1A 3
  • P44ERK1 3
  • P44MAPK 3
  • P44mapk 2
  • P44erk1 2
  • MAPK 1 3
  • MAPK 3 4
  • MAPK3 5

External Ids for MAPK3 Gene

Previous HGNC Symbols for MAPK3 Gene

  • PRKM3

Previous GeneCards Identifiers for MAPK3 Gene

  • GC16P029026
  • GC16M030447
  • GC16M030123
  • GC16M030162
  • GC16M030032
  • GC16M030125
  • GC16M027786

Summaries for MAPK3 Gene

Entrez Gene Summary for MAPK3 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK3 Gene

MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Neutrophil Migration and Pertussis. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot Summary for MAPK3 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Tocris Summary for MAPK3 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Gene Wiki entry for MAPK3 Gene

Additional gene information for MAPK3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK3 Gene

Genomics for MAPK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J030119 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 617.9 +1.3 1335 5.8 HNRNPL GATAD2A TFE3 IKZF1 KDM1A CTCF ZNF692 POLR2A RCOR2 BACH1 MAPK3 RF00017-2045 YPEL3 SETD1A NPIPB13 NPIPB12 SRCAP ZNF747 INO80E CORO1A
GH16J030112 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 14.6 +8.7 8746 5.7 ARHGAP35 CEBPG HNRNPL GATAD2A CTCF ZBTB33 TEAD4 TFE3 IKZF1 NFKBIZ GDPD3 lnc-PPP4C-12 SLX1A TBX6 SRCAP INO80E SMG1P5 SMG1P2 ENSG00000235560 MAPK3
GH16J030130 Enhancer 0.8 ENCODE 21 -7.3 -7339 1.3 GATAD2A TFE3 PKNOX1 RXRB GABPA CEBPA MNT SOX13 CBX3 FOXA2 MAPK3 YPEL3 RF00017-2046 CORO1A
GH16J030131 Enhancer 0.5 Ensembl 19 -9.0 -8995 1.4 PKNOX1 GABPA ZNF530 ETV4 SMARCA4 NR2F6 GABPB1 ELF3 KAT8 MAPK3 SRCAP SETD1A KAT8 RF00017-2046 CORO1A
GH16J030165 Enhancer 0.8 ENCODE 10.9 -43.0 -42985 1 IKZF1 BACH1 IKZF2 RCOR1 TRIM22 SOX6 CEBPA MNT EED ZNF766 MAPK3 piR-55655-210 RF00017-2046 CORO1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK3

Top Transcription factor binding sites by QIAGEN in the MAPK3 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for MAPK3 Gene

Genomic Locations for MAPK3 Gene
chr16:30,114,105-30,123,506
(GRCh38/hg38)
Size:
9,402 bases
Orientation:
Minus strand
chr16:30,125,426-30,134,827
(GRCh37/hg19)
Size:
9,402 bases
Orientation:
Minus strand

Genomic View for MAPK3 Gene

Genes around MAPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK3 Gene

Proteins for MAPK3 Gene

Products:

  1. Antibody
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  3. Assay

  • Protein details for MAPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27361-MK03_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 3
    Protein Accession:
    P27361
    Secondary Accessions:
    • A8CZ58
    • B0LPG3
    • Q8NHX1

    Protein attributes for MAPK3 Gene

    Size:
    379 amino acids
    Molecular mass:
    43136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with TPR. Interacts with CDKN2AIP. Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs upon heat shock (PubMed:10747973). Interacts with CAVIN4 (By similarity).
    • (Microbial infection) Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity.

    Three dimensional structures from OCA and Proteopedia for MAPK3 Gene

    Alternative splice isoforms for MAPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK3 Gene

Protein Expression for MAPK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK3 Gene

P27361:
  • YVATRWYR
  • MELDDLPKE
  • GCILAEM
  • RVAIKKISPFEHQT
  • MRDVYIVQ
  • GLKYIHSA
  • DEPVAEE
  • FPGKHYLDQLN
  • YQILRGLKY
  • ILLRFRHEN
  • FDVGPRY
  • ALAHPYLEQYYDP
  • LKICDFG
  • HSANVLHRDL
  • LKYIHSA
  • TEYVATRWYRAPE
  • RVAIKKI
  • WSVGCILAE
  • YRAPEIML
  • VLHRDLK
  • DIWSVGCI
  • YIGEGAYGMV
  • TRWYRAPE
  • DVYIVQDLMETDLYKLLK
  • WSVGCIL
  • NHILGIL
  • LKICDFGLAR
  • ETARFQPG

Post-translational modifications for MAPK3 Gene

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.
  • Ubiquitination at Lys317
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MAPK3 Gene

Gene Families for MAPK3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for MAPK3 Gene

InterPro:
Blocks:
  • MAP kinase
  • ERK1/2 MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33690 fis, clone BRAWH2002967, highly similar to Mitogen-activated protein kinase 3 (EC 2.7.11.24) (B3KR49_HUMAN)
  • p44-ERK1 (MK03_HUMAN)
  • MAPK3 protein (Q9BWJ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27361

UniProtKB/Swiss-Prot:

MK03_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK3: view

Function for MAPK3 Gene

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Molecular function for MAPK3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9.
GENATLAS Biochemistry:
mitogen-activated protein kinase 3 (MAP kinase) (p44),insulin activated map kinase,highly expressed in lung and in head and neck squamous cell carcinoma

Enzyme Numbers (IUBMB) for MAPK3 Gene

Phenotypes From GWAS Catalog for MAPK3 Gene

Gene Ontology (GO) - Molecular Function for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001784 phosphotyrosine residue binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004707 MAP kinase activity IBA,NAS 7687743
genes like me logo Genes that share ontologies with MAPK3: view
genes like me logo Genes that share phenotypes with MAPK3: view

Animal Models for MAPK3 Gene

MGI Knock Outs for MAPK3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK3 Gene

Localization for MAPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK3 Gene

Cytoplasm. Nucleus. Membrane, caveola. Note=Autophosphorylation at Thr-207 promotes nuclear localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
mitochondrion 5
nucleus 5
endosome 5
cytosol 5
golgi apparatus 5
extracellular 3
endoplasmic reticulum 3
peroxisome 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,TAS 19565474
GO:0005635 nuclear envelope IDA 20455999
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with MAPK3: view

Pathways & Interactions for MAPK3 Gene

PathCards logo

SuperPathways for MAPK3 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
4 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
Insulin signaling pathway
.32
ErbB2/ErbB3 signaling events
.31
Signal attenuation
.01
5 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
Adipocytokines and Insulin Signaling
.34
genes like me logo Genes that share pathways with MAPK3: view

Pathways by source for MAPK3 Gene

86 GeneGo (Thomson Reuters) pathways for MAPK3 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell adhesion Integrin inside-out signaling
134 Qiagen pathways for MAPK3 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for MAPK3 Gene
1 GeneTex pathway for MAPK3 Gene

SIGNOR curated interactions for MAPK3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade NAS,TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0001934 positive regulation of protein phosphorylation IMP 19664780
GO:0002720 positive regulation of cytokine production involved in immune response IEA --
genes like me logo Genes that share ontologies with MAPK3: view

Drugs & Compounds for MAPK3 Gene

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  1. Drug

(108) Drugs for MAPK3 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inducer, inhibitor 131
Sulindac Approved, Investigational Pharma Target, inhibitor Anti-inflammatory agent;COX inhibitor 37
Aspirin Approved, Vet_approved Pharma Channel blocker, Target 1512
Cholecystokinin Approved, Investigational Pharma Target 24
Minocycline Approved, Investigational Pharma Target, inhibitor 229

(53) Additional Compounds for MAPK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(4) Tocris Compounds for MAPK3 Gene

Compound Action Cas Number
Eicosapentaenoic Acid Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 10417-94-4
FR 180204 Selective ERK inhibitor 865362-74-9
Pluripotin Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal 839707-37-8
XMD 8-92 ERK5/BMK1 inhibitor; also BRD4 inhibitor 1234480-50-2

(8) ApexBio Compounds for MAPK3 Gene

Compound Action Cas Number
DEL-22379 inhibitor of the dimerization of ERK 181223-80-3
FR 180204 ERK inhibitor 865362-74-9
Matrine Alkaloid found in Sophora plant 519-02-8
Piperine MAPK inhibitor 94-62-2
Pluripotin 839707-37-8
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
VRT752271 ERK1/ERK2 inhibitor 869886-67-9
VX-11e ERK inhibitor 896720-20-0
genes like me logo Genes that share compounds with MAPK3: view

Drug Products

Transcripts for MAPK3 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK3 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK3

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: - -
SP8: - -
SP9:

Relevant External Links for MAPK3 Gene

GeneLoc Exon Structure for
MAPK3

Expression for MAPK3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK3 Gene

mRNA expression in normal human tissues for MAPK3 Gene
mRNA expression by GTEx for MAPK3 GenemRNA expression by BioGPS for MAPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK3 Gene

This gene is overexpressed in Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK3 Gene



Protein tissue co-expression partners for MAPK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK3

SOURCE GeneReport for Unigene cluster for MAPK3 Gene:

Hs.861

Evidence on tissue expression from TISSUES for MAPK3 Gene

  • Nervous system(4.7)
  • Eye(4)
  • Heart(3.8)
  • Muscle(3.8)
  • Lung(3.6)
  • Kidney(3.6)
  • Intestine(3.6)
  • Skin(3.6)
  • Blood(3.5)
  • Adrenal gland(3.4)
  • Spleen(3.3)
  • Liver(3.3)
  • Lymph node(3.3)
  • Stomach(3.3)
  • Bone marrow(3.3)
  • Thyroid gland(3.2)
  • Pancreas(3.2)
  • Bone(2.8)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with MAPK3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK3 Gene

Orthologs for MAPK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK3 30 31
  • 97 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAPK3 31
  • 94 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK3 30 31
  • 92.82 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LOC479790 30
  • 91.92 (n)
MAPK3 31
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mapk3 30 17 31
  • 90.01 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk3 30
  • 89.55 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 73 (a)
 OneToMany
-- 31
  • 71 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia MAPK3 31
  • 87 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii mapk3 30 31
  • 78.21 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG18732 32
  • 87 (a)
rl 31 32
  • 75 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea mpk-1 31 32
  • 61 (a)
 OneToMany
C05D10.2a 32
  • 41 (a)
C05D10.2c 32
  • 41 (a)
F09C12.2 32
  • 41 (a)
pmk-3 32
  • 39 (a)
Y51B9A.9 32
  • 34 (a)
H01G02.2 32
  • 32 (a)
C49C3.10b 32
  • 31 (a)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFR019W 30
  • 59.9 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FUS3 30 31
  • 56.38 (n)
 ManyToMany
KSS1 31
  • 46 (a)
 ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E10539g 30
  • 54.04 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons MPK2 30
  • 55.62 (n)
Rice
(Oryza sativa)
 Liliopsida Os02g0148100 30
  • 55.26 (n)
Os.406 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9711 31
  • 80 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU02393 30
  • 62.99 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes spk1 30
  • 52.85 (n)
Species where no ortholog for MAPK3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MAPK3 Gene

ENSEMBL:
Gene Tree for MAPK3 (if available)
TreeFam:
Gene Tree for MAPK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK3: view image

Paralogs for MAPK3 Gene

Paralogs for MAPK3 Gene

(86) SIMAP similar genes for MAPK3 Gene using alignment to 10 proteins:

  • MK03_HUMAN
  • B3KR49_HUMAN
  • E9PBK7_HUMAN
  • E9PJF0_HUMAN
  • E9PQW4_HUMAN
  • E9PRH7_HUMAN
  • H0YDH9_HUMAN
  • H0YEX6_HUMAN
  • L7RXH5_HUMAN
  • Q9BWJ1_HUMAN
genes like me logo Genes that share paralogs with MAPK3: view

Variants for MAPK3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK3 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
710826 Benign: not provided 30,116,903(-) C/T SYNONYMOUS_VARIANT
718814 Likely Benign: not provided 30,116,944(-) C/T MISSENSE_VARIANT
720009 Likely Benign: not provided 30,123,167(-) G/A MISSENSE_VARIANT
726200 Likely Benign: not provided 30,121,850(-) C/T SYNONYMOUS_VARIANT
732826 Likely Benign: not provided 30,122,014(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MAPK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK3 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850
esv993894 CNV insertion 20482838
nsv1160384 CNV duplication 26073780
nsv1781 CNV insertion 18451855
nsv833187 CNV loss 17160897

Variation tolerance for MAPK3 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK3 Gene

Human Gene Mutation Database (HGMD)
MAPK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK3 Gene

Disorders for MAPK3 Gene

MalaCards: The human disease database

(53) MalaCards diseases for MAPK3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutrophil migration
  • nm
pertussis
  • bordetella infection
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
bile duct cancer
  • bile duct tumor
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MAPK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAPK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK3 Gene

Publications for MAPK3 Gene

  1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd JL … Denu JM (The Journal of biological chemistry 1999) 3 4 23
  2. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.