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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Neutrophil Migration and Pertussis. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001784 | phosphotyrosine residue binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004707 | MAP kinase activity | IBA,NAS | 7687743 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,TAS | 19565474 |
GO:0005635 | nuclear envelope | IDA | 20455999 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Activated TLR4 signalling | ||
3 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
4 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
|
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
|
5 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | NAS,TAS | -- |
GO:0000186 | activation of MAPKK activity | TAS | -- |
GO:0000187 | activation of MAPK activity | TAS | -- |
GO:0001934 | positive regulation of protein phosphorylation | IMP | 19664780 |
GO:0002720 | positive regulation of cytokine production involved in immune response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Arsenic trioxide | Approved, Investigational | Pharma | Target, inducer, inhibitor | 131 | ||
Sulindac | Approved, Investigational | Pharma | Target, inhibitor | Anti-inflammatory agent;COX inhibitor | 37 | |
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target | 1512 | ||
Cholecystokinin | Approved, Investigational | Pharma | Target | 24 | ||
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
Eicosapentaenoic Acid | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 10417-94-4 |
FR 180204 | Selective ERK inhibitor | 865362-74-9 |
Pluripotin | Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal | 839707-37-8 |
XMD 8-92 | ERK5/BMK1 inhibitor; also BRD4 inhibitor | 1234480-50-2 |
Compound | Action | Cas Number |
---|---|---|
DEL-22379 | inhibitor of the dimerization of ERK | 181223-80-3 |
FR 180204 | ERK inhibitor | 865362-74-9 |
Matrine | Alkaloid found in Sophora plant | 519-02-8 |
Piperine | MAPK inhibitor | 94-62-2 |
Pluripotin | 839707-37-8 | |
SCH772984 | ERK1 and ERK2 inhibitor | 942183-80-4 |
VRT752271 | ERK1/ERK2 inhibitor | 869886-67-9 |
VX-11e | ERK inhibitor | 896720-20-0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAPK3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAPK3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAPK3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC479790 30 |
|
||
MAPK3 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Mapk3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mapk3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | MAPK3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | mapk3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18732 32 |
|
|
|
rl 31 32 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | mpk-1 31 32 |
|
OneToMany | |
C05D10.2a 32 |
|
|
|||
C05D10.2c 32 |
|
|
|||
F09C12.2 32 |
|
|
|||
pmk-3 32 |
|
|
|||
Y51B9A.9 32 |
|
|
|||
H01G02.2 32 |
|
|
|||
C49C3.10b 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR019W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FUS3 30 31 |
|
ManyToMany | |
KSS1 31 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E10539g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MPK2 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0148100 30 |
|
||
Os.406 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9711 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02393 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spk1 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710826 | Benign: not provided | 30,116,903(-) | C/T | SYNONYMOUS_VARIANT | |
718814 | Likely Benign: not provided | 30,116,944(-) | C/T | MISSENSE_VARIANT | |
720009 | Likely Benign: not provided | 30,123,167(-) | G/A | MISSENSE_VARIANT | |
726200 | Likely Benign: not provided | 30,121,850(-) | C/T | SYNONYMOUS_VARIANT | |
732826 | Likely Benign: not provided | 30,122,014(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758642 | CNV | gain | 17122850 |
esv993894 | CNV | insertion | 20482838 |
nsv1160384 | CNV | duplication | 26073780 |
nsv1781 | CNV | insertion | 18451855 |
nsv833187 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
neutrophil migration |
|
|
pertussis |
|
|
pancreatic adenocarcinoma |
|
|
bile duct cancer |
|
|
squamous cell carcinoma |
|