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Aliases for MAPK1IP1L Gene

Aliases for MAPK1IP1L Gene

  • Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like 2 3 5
  • C14orf32 3 4
  • Mitogen-Activated Protein Kinase 1-Interacting Protein 1-Like 4
  • MAPK-Interacting And Spindle-Stabilizing Protein-Like 3
  • MAPK-Interacting And Spindle-Stabilizing Protein 3
  • Chromosome 14 Open Reading Frame 32 2
  • C14_5346 3
  • MISS 3

External Ids for MAPK1IP1L Gene

Previous HGNC Symbols for MAPK1IP1L Gene

  • C14orf32

Previous GeneCards Identifiers for MAPK1IP1L Gene

  • GC14P054589
  • GC14P055518
  • GC14P035680

Summaries for MAPK1IP1L Gene

GeneCards Summary for MAPK1IP1L Gene

MAPK1IP1L (Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like) is a Protein Coding gene.

Gene Wiki entry for MAPK1IP1L Gene

Additional gene information for MAPK1IP1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1IP1L Gene

Genomics for MAPK1IP1L Gene

GeneHancer (GH) Regulatory Elements for MAPK1IP1L Gene

Promoters and enhancers for MAPK1IP1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J055050 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 684.5 +0.7 675 3.2 MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 ZNF610 GLIS1 NBN MAPK1IP1L LOC105370509 WDHD1 ATG14 GC14M055058 GC14M055059 GC14M054989
GH14J055578 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.8 +529.9 529941 6.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 KTN1-AS1 KTN1 ATG14 MAPK1IP1L SOCS4 TBPL2 GC14P055652
GH14J055189 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.3 +139.2 139220 3.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS DLGAP5 LOC105370508 FBXO34 MAPK1IP1L LOC105370509 ATG14 GCH1 LGALS3 GC14M054989
GH14J054395 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 28.1 -654.4 -654380 2.7 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF416 CDKN3 MAPK1IP1L SOCS4 WDHD1 BMP4 CNIH1 GC14P054145
GH14J054487 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 26.5 -562.2 -562192 3.8 HDGF PKNOX1 CLOCK ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 GMFB ATG14 BMP4 MAPK1IP1L SOCS4 ENSG00000259318 ENSG00000258753 ATP5F1CP1 ENSG00000258050 RPL34P28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK1IP1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAPK1IP1L gene promoter:
  • AREB6
  • GATA-1
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Chx10

Genomic Locations for MAPK1IP1L Gene

Genomic Locations for MAPK1IP1L Gene
18,564 bases
Plus strand
18,564 bases
Plus strand

Genomic View for MAPK1IP1L Gene

Genes around MAPK1IP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK1IP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK1IP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK1IP1L Gene

Proteins for MAPK1IP1L Gene

  • Protein details for MAPK1IP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAPK-interacting and spindle-stabilizing protein-like
    Protein Accession:
    Secondary Accessions:
    • B2RDD8
    • Q96BG5

    Protein attributes for MAPK1IP1L Gene

    245 amino acids
    Molecular mass:
    24269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAPK1IP1L Gene

Post-translational modifications for MAPK1IP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK1IP1L Gene

Antibody Products

  • Boster Bio Antibodies for MAPK1IP1L

No data available for DME Specific Peptides for MAPK1IP1L Gene

Domains & Families for MAPK1IP1L Gene

Gene Families for MAPK1IP1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAPK1IP1L Gene


Suggested Antigen Peptide Sequences for MAPK1IP1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MISS family.
  • Belongs to the MISS family.
genes like me logo Genes that share domains with MAPK1IP1L: view

Function for MAPK1IP1L Gene

Phenotypes From GWAS Catalog for MAPK1IP1L Gene

Gene Ontology (GO) - Molecular Function for MAPK1IP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAPK1IP1L: view
genes like me logo Genes that share phenotypes with MAPK1IP1L: view

Animal Model Products

miRNA for MAPK1IP1L Gene

miRTarBase miRNAs that target MAPK1IP1L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPK1IP1L Gene

Localization for MAPK1IP1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK1IP1L gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPK1IP1L Gene

Pathways & Interactions for MAPK1IP1L Gene

SuperPathways for MAPK1IP1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAPK1IP1L Gene


No data available for Pathways by source and SIGNOR curated interactions for MAPK1IP1L Gene

Drugs & Compounds for MAPK1IP1L Gene

No Compound Related Data Available

Transcripts for MAPK1IP1L Gene

mRNA/cDNA for MAPK1IP1L Gene

Unigene Clusters for MAPK1IP1L Gene

Mitogen-activated protein kinase 1 interacting protein 1-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1IP1L Gene

No ASD Table

Relevant External Links for MAPK1IP1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAPK1IP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK1IP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK1IP1L Gene

This gene is overexpressed in NK cells (10.8), Bone marrow stromal cell (9.7), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK1IP1L Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPK1IP1L Gene:


SOURCE GeneReport for Unigene cluster for MAPK1IP1L Gene:


Evidence on tissue expression from TISSUES for MAPK1IP1L Gene

  • Nervous system(4.3)
  • Kidney(3.4)
  • Lung(2.9)
  • Skin(2.9)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with MAPK1IP1L: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1IP1L Gene

Orthologs for MAPK1IP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAPK1IP1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAPK1IP1L 34 33
  • 99.86 (n)
(Bos Taurus)
Mammalia MAPK1IP1L 34 33
  • 93.65 (n)
(Canis familiaris)
Mammalia MAPK1IP1L 34 33
  • 93.17 (n)
(Monodelphis domestica)
Mammalia MAPK1IP1L 34
  • 87 (a)
(Mus musculus)
Mammalia Mapk1ip1l 16 34 33
  • 85.06 (n)
Mapk1ip1 34
  • 41 (a)
(Rattus norvegicus)
Mammalia Mapk1ip1l 33
  • 85.01 (n)
(Gallus gallus)
Aves MAPK1IP1L 33
  • 74.46 (n)
(Anolis carolinensis)
Reptilia MAPK1IP1L 34
  • 68 (a)
Species where no ortholog for MAPK1IP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAPK1IP1L Gene

Gene Tree for MAPK1IP1L (if available)
Gene Tree for MAPK1IP1L (if available)
Evolutionary constrained regions (ECRs) for MAPK1IP1L: view image

Paralogs for MAPK1IP1L Gene Pseudogenes for MAPK1IP1L Gene

genes like me logo Genes that share paralogs with MAPK1IP1L: view

No data available for Paralogs for MAPK1IP1L Gene

Variants for MAPK1IP1L Gene

Sequence variations from dbSNP and Humsavar for MAPK1IP1L Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000195504 -- 55,053,163(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000926357 -- 55,051,870(+) C/T genic_upstream_transcript_variant, intron_variant
rs1001051329 -- 55,068,125(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001069852 -- 55,052,109(+) C/T genic_upstream_transcript_variant, intron_variant
rs1001126252 -- 55,062,029(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK1IP1L Gene

Variant ID Type Subtype PubMed ID
nsv977468 CNV duplication 23825009

Variation tolerance for MAPK1IP1L Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK1IP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK1IP1L Gene

Disorders for MAPK1IP1L Gene

Additional Disease Information for MAPK1IP1L

No disorders were found for MAPK1IP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK1IP1L Gene

Publications for MAPK1IP1L Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  5. Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. (PMID: 12011110) Lefebvre C … Verlhac MH (The Journal of cell biology 2002) 2 3 58

Products for MAPK1IP1L Gene

Sources for MAPK1IP1L Gene

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