Aliases for MAPK1IP1L Gene

Aliases for MAPK1IP1L Gene

  • Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like 2 3 5
  • MAPK-Interacting And Spindle-Stabilizing Protein-Like 3 4
  • C14orf32 3 4
  • Mitogen-Activated Protein Kinase 1-Interacting Protein 1-Like 4
  • MAPK-Interacting And Spindle-Stabilizing Protein 3
  • Chromosome 14 Open Reading Frame 32 2
  • MAPK1IP1L 5
  • C14_5346 3
  • MISS 3

External Ids for MAPK1IP1L Gene

Previous HGNC Symbols for MAPK1IP1L Gene

  • C14orf32

Previous GeneCards Identifiers for MAPK1IP1L Gene

  • GC14P054589
  • GC14P055518
  • GC14P035680

Summaries for MAPK1IP1L Gene

GeneCards Summary for MAPK1IP1L Gene

MAPK1IP1L (Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like) is a Protein Coding gene. Diseases associated with MAPK1IP1L include Cervix Erosion and Acute Stress Disorder.

Gene Wiki entry for MAPK1IP1L Gene

Additional gene information for MAPK1IP1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK1IP1L Gene

Genomics for MAPK1IP1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAPK1IP1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK1IP1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK1IP1L

Top Transcription factor binding sites by QIAGEN in the MAPK1IP1L gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • Chx10
  • FosB
  • Fra-1
  • GATA-1
  • JunB
  • JunD

Genomic Locations for MAPK1IP1L Gene

Genomic Locations for MAPK1IP1L Gene
chr14:55,051,647-55,070,194
(GRCh38/hg38)
Size:
18,548 bases
Orientation:
Plus strand
chr14:55,518,349-55,536,912
(GRCh37/hg19)
Size:
18,564 bases
Orientation:
Plus strand

Genomic View for MAPK1IP1L Gene

Genes around MAPK1IP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK1IP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK1IP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK1IP1L Gene

Proteins for MAPK1IP1L Gene

  • Protein details for MAPK1IP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDC0-MISSL_HUMAN
    Recommended name:
    MAPK-interacting and spindle-stabilizing protein-like
    Protein Accession:
    Q8NDC0
    Secondary Accessions:
    • B2RDD8
    • Q96BG5

    Protein attributes for MAPK1IP1L Gene

    Size:
    245 amino acids
    Molecular mass:
    24269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAPK1IP1L Gene

Post-translational modifications for MAPK1IP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK1IP1L Gene

No data available for DME Specific Peptides for MAPK1IP1L Gene

Domains & Families for MAPK1IP1L Gene

Gene Families for MAPK1IP1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAPK1IP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK1IP1L Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase 1-interacting protein 1-like (MISSL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NDC0

UniProtKB/Swiss-Prot:

MISSL_HUMAN :
  • Belongs to the MISS family.
Family:
  • Belongs to the MISS family.
genes like me logo Genes that share domains with MAPK1IP1L: view

Function for MAPK1IP1L Gene

Phenotypes From GWAS Catalog for MAPK1IP1L Gene

Gene Ontology (GO) - Molecular Function for MAPK1IP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAPK1IP1L: view
genes like me logo Genes that share phenotypes with MAPK1IP1L: view

Animal Model Products

CRISPR Products

miRNA for MAPK1IP1L Gene

miRTarBase miRNAs that target MAPK1IP1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1IP1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPK1IP1L Gene

Localization for MAPK1IP1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK1IP1L gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPK1IP1L Gene

Pathways & Interactions for MAPK1IP1L Gene

PathCards logo

SuperPathways for MAPK1IP1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAPK1IP1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAPK1IP1L Gene

Drugs & Compounds for MAPK1IP1L Gene

No Compound Related Data Available

Transcripts for MAPK1IP1L Gene

mRNA/cDNA for MAPK1IP1L Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1IP1L

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1IP1L Gene

No ASD Table

Relevant External Links for MAPK1IP1L Gene

GeneLoc Exon Structure for
MAPK1IP1L

Expression for MAPK1IP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK1IP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK1IP1L Gene

This gene is overexpressed in NK cells (10.8), Bone marrow stromal cell (9.7), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK1IP1L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK1IP1L

SOURCE GeneReport for Unigene cluster for MAPK1IP1L Gene:

Hs.594338

Evidence on tissue expression from TISSUES for MAPK1IP1L Gene

  • Nervous system(4.5)
  • Skin(3.8)
  • Kidney(3.6)
  • Lung(2.9)
  • Eye(2.3)
  • Heart(2.2)
  • Liver(2.2)
  • Muscle(2.2)
  • Blood(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MAPK1IP1L: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1IP1L Gene

Orthologs for MAPK1IP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAPK1IP1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAPK1IP1L 30 31
  • 99.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAPK1IP1L 30 31
  • 93.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAPK1IP1L 30 31
  • 93.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MAPK1IP1L 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mapk1ip1l 30 17 31
  • 85.06 (n)
OneToMany
Mapk1ip1 31
  • 41 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mapk1ip1l 30
  • 85.01 (n)
Chicken
(Gallus gallus)
Aves MAPK1IP1L 30
  • 74.46 (n)
Lizard
(Anolis carolinensis)
Reptilia MAPK1IP1L 31
  • 68 (a)
OneToOne
Species where no ortholog for MAPK1IP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MAPK1IP1L Gene

ENSEMBL:
Gene Tree for MAPK1IP1L (if available)
TreeFam:
Gene Tree for MAPK1IP1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK1IP1L: view image

Paralogs for MAPK1IP1L Gene

Pseudogenes.org Pseudogenes for MAPK1IP1L Gene

genes like me logo Genes that share paralogs with MAPK1IP1L: view

No data available for Paralogs for MAPK1IP1L Gene

Variants for MAPK1IP1L Gene

Additional dbSNP identifiers (rs#s) for MAPK1IP1L Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK1IP1L Gene

Variant ID Type Subtype PubMed ID
nsv977468 CNV duplication 23825009

Variation tolerance for MAPK1IP1L Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK1IP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK1IP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK1IP1L Gene

Disorders for MAPK1IP1L Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPK1IP1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix erosion
  • erosion of cervix
acute stress disorder
  • traumatic stress disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPK1IP1L

genes like me logo Genes that share disorders with MAPK1IP1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK1IP1L Gene

Publications for MAPK1IP1L Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  5. Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. (PMID: 12011110) Lefebvre C … Verlhac MH (The Journal of cell biology 2002) 2 3

Products for MAPK1IP1L Gene

Sources for MAPK1IP1L Gene