Aliases for MAPK1IP1L Gene
Aliases for MAPK1IP1L Gene
- Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like 2 3 5
- C14orf32 3 4
- Mitogen-Activated Protein Kinase 1-Interacting Protein 1-Like 4
- MAPK-Interacting And Spindle-Stabilizing Protein-Like 3
- MAPK-Interacting And Spindle-Stabilizing Protein 3
- Chromosome 14 Open Reading Frame 32 2
- C14_5346 3
- MISS 3
External Ids for MAPK1IP1L Gene
- HGNC: 19840
- Entrez Gene: 93487
- Ensembl: ENSG00000168175
- OMIM: 617226
- UniProtKB: Q8NDC0
Previous HGNC Symbols for MAPK1IP1L Gene
- C14orf32
Previous GeneCards Identifiers for MAPK1IP1L Gene
- GC14P054589
- GC14P055518
- GC14P035680
Summaries for MAPK1IP1L Gene
GeneCards Summary for MAPK1IP1L Gene
MAPK1IP1L (Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like) is a Protein Coding gene.
Additional gene information for MAPK1IP1L Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1IP1L Gene
Genomics for MAPK1IP1L Gene
GeneHancer (GH) Regulatory Elements for MAPK1IP1L Gene
Promoters and enhancers for MAPK1IP1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAPK1IP1L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK1IP1L gene promoter:
-
- AREB6
- GATA-1
- AP-1
- c-Fos
- c-Jun
- FosB
- Fra-1
- JunB
- JunD
- Chx10
Regulatory Element Products
Genomic Locations for MAPK1IP1L Gene
Genomic Locations for MAPK1IP1L Gene
- chr14:55,051,631-55,070,194
- (GRCh38/hg38)
- Size:
- 18,564 bases
- Orientation:
- Plus strand
- chr14:55,518,349-55,536,912
- (GRCh37/hg19)
- Size:
- 18,564 bases
- Orientation:
- Plus strand
Genomic View for MAPK1IP1L Gene
Genes around MAPK1IP1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.3 by Entrez Gene
- 14q22.3 by HGNC
- 14q22.3 by Ensembl
MAPK1IP1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK1IP1L Gene
Proteins for MAPK1IP1L Gene
-
Protein details for MAPK1IP1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NDC0-MISSL_HUMAN
- Recommended name:
- MAPK-interacting and spindle-stabilizing protein-like
- Protein Accession:
- Q8NDC0
- B2RDD8
- Q96BG5
Protein attributes for MAPK1IP1L Gene
- Size:
- 245 amino acids
- Molecular mass:
- 24269 Da
- Quaternary structure:
- No Data Available
Protein Expression for MAPK1IP1L Gene
Post-translational modifications for MAPK1IP1L Gene
Other Protein References for MAPK1IP1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MAPK1IP1L
- Novus Biologicals Antibodies for MAPK1IP1L
-
Abcam antibodies for MAPK1IP1L
- Invitrogen Antibodies for MAPK1IP1L (AFLGC-MAPK1IP1L)
- GeneTex MAPK1IP1L Antibody for MAPK1IP1L
-
Boster Bio Antibodies for MAPK1IP1L
Protein Products
-
OriGene Purified Proteins for MAPK1IP1L
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- Search GeneTex for Proteins for MAPK1IP1L
Assay Products
No data available for DME Specific Peptides for MAPK1IP1L Gene
Domains & Families for MAPK1IP1L Gene
Gene Families for MAPK1IP1L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for MAPK1IP1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NDC0- Family:
-
- Belongs to the MISS family.
Function for MAPK1IP1L Gene
Phenotypes From GWAS Catalog for MAPK1IP1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for MAPK1IP1L Gene
- GenomeRNAi human phenotypes for MAPK1IP1L:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for MAPK1IP1L
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- Overview of 102 available MAPK1IP1L gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1IP1L
- GenScript: Design CRISPR guide RNA sequences for MAPK1IP1L
miRNA for MAPK1IP1L Gene
- miRTarBase miRNAs that target MAPK1IP1L
-
- hsa-mir-124-3p (MIRT002581)
- hsa-mir-374b-5p (MIRT016032)
- hsa-mir-193b-3p (MIRT041442)
- hsa-mir-100-5p (MIRT048410)
- hsa-mir-92a-3p (MIRT048984)
- hsa-mir-181a-5p (MIRT053685)
- hsa-mir-320a (MIRT279170)
- hsa-mir-320b (MIRT279172)
- hsa-mir-320c (MIRT279173)
- hsa-mir-320d (MIRT279176)
- hsa-mir-1911-5p (MIRT279177)
- hsa-mir-4429 (MIRT279180)
- hsa-mir-4726-3p (MIRT279182)
- hsa-mir-4999-5p (MIRT279183)
- hsa-mir-490-3p (MIRT368960)
- hsa-mir-6788-5p (MIRT522580)
- hsa-mir-30c-2-3p (MIRT522581)
- hsa-mir-30c-1-3p (MIRT522582)
- hsa-mir-6874-5p (MIRT522583)
- hsa-mir-3650 (MIRT522584)
- hsa-mir-8085 (MIRT522585)
- hsa-mir-6731-5p (MIRT522586)
- hsa-mir-6878-5p (MIRT522587)
- hsa-mir-6500-5p (MIRT522588)
- hsa-mir-4633-3p (MIRT522589)
- hsa-mir-4327 (MIRT522590)
- hsa-mir-8082 (MIRT522591)
- hsa-mir-4534 (MIRT522592)
- hsa-mir-1273f (MIRT522593)
- hsa-mir-3192-5p (MIRT522594)
- hsa-mir-7851-3p (MIRT522595)
- hsa-mir-607 (MIRT556270)
- hsa-mir-4693-3p (MIRT556271)
- hsa-mir-665 (MIRT680874)
- hsa-mir-887-5p (MIRT680875)
- hsa-mir-6799-5p (MIRT680876)
- hsa-mir-6883-5p (MIRT680877)
- hsa-mir-6785-5p (MIRT680878)
- hsa-mir-4728-5p (MIRT680879)
- hsa-mir-149-3p (MIRT680880)
- hsa-mir-7106-5p (MIRT680881)
- hsa-mir-7160-5p (MIRT680882)
- hsa-mir-298 (MIRT680883)
- hsa-mir-4649-3p (MIRT680884)
- hsa-mir-1282 (MIRT680885)
- hsa-mir-5707 (MIRT680886)
- hsa-mir-4478 (MIRT680887)
- hsa-mir-4419b (MIRT680888)
- hsa-mir-3929 (MIRT680889)
- hsa-mir-6511a-5p (MIRT680890)
- hsa-mir-1910-3p (MIRT680891)
- hsa-mir-1827 (MIRT763065)
- hsa-mir-3937 (MIRT767848)
- hsa-mir-3942-3p (MIRT767859)
- hsa-mir-4433a-3p (MIRT769014)
- hsa-mir-4459 (MIRT769298)
- hsa-mir-485-5p (MIRT772619)
- hsa-mir-6884-5p (MIRT781007)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK1IP1L
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- genomics-online: shRNA clones - Search results for 102 available MAPK1IP1L gene related products
- Overview of 102 available MAPK1IP1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAPK1IP1L
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- Applied Biological Materials Clones for MAPK1IP1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK1IP1L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPK1IP1L Gene
Localization for MAPK1IP1L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
- Cytosol (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPK1IP1L Gene
Pathways & Interactions for MAPK1IP1L Gene
No Data Available
Interacting Proteins for MAPK1IP1L Gene
Selected Interacting proteins:
Q8NDC0-MISSL_HUMAN
ENSP00000378851
for MAPK1IP1L Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MAPK1IP1L
No data available for Pathways by source and SIGNOR curated interactions for MAPK1IP1L Gene
Transcripts for MAPK1IP1L Gene
mRNA/cDNA for MAPK1IP1L Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (543) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000395468 6480 bps (uc001xbq.2)
- ENST00000554364 565 bps (uc059bsk.1)
- ENST00000556515 534 bps (uc059bsm.1)
- ENST00000553976 517 bps (uc059bsn.1)
- ENST00000622254 2836 bps (uc059bsl.1)
Unigene Clusters for MAPK1IP1L Gene
- Mitogen-activated protein kinase 1 interacting protein 1-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAPK1IP1L
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- genomics-online: gRNA clones - Search results for 102 available MAPK1IP1L gene related products
- Overview of 102 available MAPK1IP1L gene related products
- Applied Biological Materials CRISPR for MAPK1IP1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1IP1L
- GenScript: Design CRISPR guide RNA sequences for MAPK1IP1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK1IP1L
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- genomics-online: shRNA clones - Search results for 102 available MAPK1IP1L gene related products
- Overview of 102 available MAPK1IP1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for MAPK1IP1L
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- Applied Biological Materials Clones for MAPK1IP1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MAPK1IP1L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in NK cells (10.8), Bone marrow stromal cell (9.7), and CD4 Tcells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK1IP1L Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK1IP1L Gene:
MAPK1IP1LSOURCE GeneReport for Unigene cluster for MAPK1IP1L Gene:
Hs.594338Evidence on tissue expression from TISSUES for MAPK1IP1L Gene
- Nervous system(4.3)
- Kidney(3.4)
- Lung(2.9)
- Skin(2.9)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs for MAPK1IP1L
-
OriGene qPCR primer pairs and template standards for MAPK1IP1L
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1IP1L Gene
Orthologs for MAPK1IP1L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK1IP1L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAPK1IP1L 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAPK1IP1L 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAPK1IP1L 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mapk1ip1l 16 34 33 |
|
||
| Mapk1ip1 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Mapk1ip1l 33 |
|
||
| chicken (Gallus gallus) |
Aves | MAPK1IP1L 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MAPK1IP1L 34 |
|
OneToOne |
- Species where no ortholog for MAPK1IP1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for MAPK1IP1L Gene
- ENSEMBL:
- Gene Tree for MAPK1IP1L (if available)
- TreeFam:
- Gene Tree for MAPK1IP1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAPK1IP1L: view image
Paralogs for MAPK1IP1L Gene
Pseudogenes.org Pseudogenes for MAPK1IP1L Gene
No data available for Paralogs for MAPK1IP1L Gene
Variants for MAPK1IP1L Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000195504 | -- | 55,053,163(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000926357 | -- | 55,051,870(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1001051329 | -- | 55,068,125(+) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1001069852 | -- | 55,052,109(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1001126252 | -- | 55,062,029(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK1IP1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAPK1IP1L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK1IP1L Gene
Disorders for MAPK1IP1L Gene
Additional Disease Information for MAPK1IP1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MAPK1IP1L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK1IP1L Gene
Publications for MAPK1IP1L Gene
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
- Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. (PMID: 12011110) Lefebvre C … Verlhac MH (The Journal of cell biology 2002) 2 3 58
Products for MAPK1IP1L Gene
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- genomics-online: cdna clones - Search results for 102 available MAPK1IP1L gene related products
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Sources for MAPK1IP1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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