Aliases for MAPK15 Gene

Aliases for MAPK15 Gene

  • Mitogen-Activated Protein Kinase 15 2 3 4 5
  • ERK7 2 3 4
  • ERK8 2 3 4
  • Extracellular Signal-Regulated Kinase 7 3 4
  • Extracellular Signal-Regulated Kinase 8 3 4
  • MAP Kinase 15 3 4
  • EC 2.7.11.24 4 50
  • MAPK 15 3 4
  • ERK-7 3 4
  • ERK-8 3 4
  • Extracellular Signal Regulated Kinase 8 2
  • Extracellular Regulated Kinase 8 Delta 3
  • EC 2.7.11 50
  • MAPK15 5

External Ids for MAPK15 Gene

Previous GeneCards Identifiers for MAPK15 Gene

  • GC08P144871
  • GC08P144798
  • GC08P140051

Summaries for MAPK15 Gene

GeneCards Summary for MAPK15 Gene

MAPK15 (Mitogen-Activated Protein Kinase 15) is a Protein Coding gene. Diseases associated with MAPK15 include Hemangioma Of Subcutaneous Tissue and Breast Mucoepidermoid Carcinoma. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK7.

UniProtKB/Swiss-Prot Summary for MAPK15 Gene

  • Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).

Gene Wiki entry for MAPK15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK15 Gene

Genomics for MAPK15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MAPK15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK15

Top Transcription factor binding sites by QIAGEN in the MAPK15 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • ATF-2
  • c-Jun
  • E2F
  • Lmo2
  • RelA

Genomic Locations for MAPK15 Gene

Latest Assembly
chr8:143,716,305-143,722,458
(GRCh38/hg38)
Size:
6,154 bases
Orientation:
Plus strand

Previous Assembly
chr8:144,798,519-144,804,628
(GRCh37/hg19 by Entrez Gene)
Size:
6,110 bases
Orientation:
Plus strand

chr8:144,798,429-144,804,628
(GRCh37/hg19 by Ensembl)
Size:
6,200 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr8(ALT_REF_LOCI_1):193,396-199,505 (+)

Genomic View for MAPK15 Gene

Genes around MAPK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK15 Gene

Proteins for MAPK15 Gene

  • Protein details for MAPK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD08-MK15_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 15
    Protein Accession:
    Q8TD08
    Secondary Accessions:
    • Q2TCF9
    • Q8N362

    Protein attributes for MAPK15 Gene

    Size:
    544 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Interacts with CSK/c-Src, ABL1, RET and TGFB1I1 (PubMed:11875070, PubMed:16484222, PubMed:16624805). Interacts with GABARAP, MAP1LC3B and GABARAPL1; controls, in a kinase-dependent fashion, both basal and starvation-induced autophagy (PubMed:22948227). Interacts with ESRRA; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity (PubMed:21190936). Interacts with PCNA; the interaction is chromatin binding- and kinase activity-dependent and prevents MDM2-mediated PCNA destruction by inhibiting the association of PCNA with MDM2 (PubMed:20733054). Interacts with DVL2 (By similarity). Interacts with CLIC3; MAPK15 does not phosphorylates CLIC3 (By similarity).
    Miscellaneous:
    • [Isoform 2]: Appears not to be a CSK- and RET-dependent activated kinase.

    Alternative splice isoforms for MAPK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK15 Gene

Selected DME Specific Peptides for MAPK15 Gene

Q8TD08:
  • YVATRWYR
  • TEYVATRWYRAPE
  • GRPLFPG
  • TRWYRAPE

Post-translational modifications for MAPK15 Gene

  • Autophosphorylated on Thr-175 and Tyr-177; activates the enzyme.
  • Ubiquitinated (PubMed:19166846). Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAPK15 Gene

Gene Families for MAPK15 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAPK15 Gene

Suggested Antigen Peptide Sequences for MAPK15 Gene

GenScript: Design optimal peptide antigens:
  • Extracellular signal-regulated kinase 8 (MK15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD08

UniProtKB/Swiss-Prot:

MK15_HUMAN :
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK15: view

Function for MAPK15 Gene

Molecular function for MAPK15 Gene

UniProtKB/Swiss-Prot Function:
Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation (PubMed:11875070, PubMed:16336213, PubMed:19166846). Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity). Phosphorylation and activation in response to DNA damaging agents, serum stimulation (PubMed:11875070, PubMed:16336213, PubMed:19166846). Constitutively actived when phosphorylated on Tyr-177. Activity depends on the relative rates of MAPK15 autophosphorylation and dephosphorylation by PTPN1 (PubMed:16336213).

Enzyme Numbers (IUBMB) for MAPK15 Gene

Phenotypes From GWAS Catalog for MAPK15 Gene

Gene Ontology (GO) - Molecular Function for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003682 chromatin binding IDA 20733054
GO:0004672 protein kinase activity IDA 26595526
GO:0004674 protein serine/threonine kinase activity IEA,IBA 21873635
GO:0004707 MAP kinase activity IBA,IDA 11875070
genes like me logo Genes that share ontologies with MAPK15: view
genes like me logo Genes that share phenotypes with MAPK15: view

Animal Models for MAPK15 Gene

MGI Knock Outs for MAPK15:
  • Mapk15 Mapk15<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for MAPK15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK15

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK15 Gene

Localization for MAPK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK15 Gene

Cytoplasm, cytoskeleton, cilium basal body. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, autophagosome. Golgi apparatus. Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936). Translocates to the nucleus upon activation (PubMed:20638370). At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity). {ECO:0000250 UniProtKB:Q80Y86, ECO:0000269 PubMed:20638370, ECO:0000269 PubMed:21190936}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK15 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
golgi apparatus 5
mitochondrion 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11875070
GO:0005634 nucleus IBA,IDA 20638370
GO:0005737 cytoplasm IBA,IDA 20638370
GO:0005776 autophagosome IEA,IDA 22948227
GO:0005794 Golgi apparatus IEA,IDA 24618899
genes like me logo Genes that share ontologies with MAPK15: view

Pathways & Interactions for MAPK15 Gene

genes like me logo Genes that share pathways with MAPK15: view

Pathways by source for MAPK15 Gene

SIGNOR curated interactions for MAPK15 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0003400 regulation of COPII vesicle coating IMP 24618899
GO:0006468 protein phosphorylation IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 19166846
GO:0007029 endoplasmic reticulum organization IMP 21847093
genes like me logo Genes that share ontologies with MAPK15: view

Drugs & Compounds for MAPK15 Gene

(4) Drugs for MAPK15 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Target 1600
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Minocycline Approved, Investigational Pharma Target, inhibitor 240
ATP Investigational Nutra 0

(1) Additional Compounds for MAPK15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with MAPK15: view

Transcripts for MAPK15 Gene

mRNA/cDNA for MAPK15 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK15

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK15 Gene

No ASD Table

Relevant External Links for MAPK15 Gene

GeneLoc Exon Structure for
MAPK15

Expression for MAPK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK15 Gene

This gene is overexpressed in Fallopian Tube (x6.0), Testis (x4.9), Cervix - Endocervix (x4.4), and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for MAPK15 Gene

This gene is overexpressed in Spinal cord (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK15 Gene



Protein tissue co-expression partners for MAPK15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK15

SOURCE GeneReport for Unigene cluster for MAPK15 Gene:

Hs.493169

mRNA Expression by UniProt/SwissProt for MAPK15 Gene:

Q8TD08-MK15_HUMAN
Tissue specificity: Widely expressed with a maximal expression in lung and kidney.

Evidence on tissue expression from TISSUES for MAPK15 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MAPK15: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK15 Gene

Orthologs for MAPK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MAPK15 29 30
  • 97.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MAPK15 29 30
  • 79.2 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MAPK15 29 30
  • 78.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mapk15 29 16 30
  • 76.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mapk15 29
  • 75.98 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MAPK15 30
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MAPK15 30
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MAPK15 29 30
  • 57.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MAPK15 30
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mapk15 29
  • 57.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii mapk15 29 30
  • 55.56 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Erk7 29 30
  • 55.02 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C05D10.2 29 30
  • 55.27 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 54 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8827 29
Species where no ortholog for MAPK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPK15 Gene

ENSEMBL:
Gene Tree for MAPK15 (if available)
TreeFam:
Gene Tree for MAPK15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK15: view image
Alliance of Genome Resources:
Additional Orthologs for MAPK15

Paralogs for MAPK15 Gene

(23) SIMAP similar genes for MAPK15 Gene using alignment to 1 proteins:

  • MK15_HUMAN
genes like me logo Genes that share paralogs with MAPK15: view

Variants for MAPK15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK15 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs151138393 Likely Benign: not provided 143,719,150(+) C/A
NM_139021.3(MAPK15):c.575C>A (p.Ser192Ter)
NONSENSE
rs56038219 -- p.Ser505Pro
rs60732298 -- p.Thr221Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MAPK15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MAPK15 Gene

Variant ID Type Subtype PubMed ID
nsv466007 CNV loss 19166990
nsv519816 CNV loss 19592680
nsv612893 CNV loss 21841781
nsv612894 CNV loss 21841781
nsv612895 CNV loss 21841781
nsv6441 CNV insertion 18451855
nsv824777 CNV loss 20364138
nsv967635 CNV duplication 23825009

Variation tolerance for MAPK15 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK15
Leiden Open Variation Database (LOVD)
MAPK15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK15 Gene

Disorders for MAPK15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPK15 Gene - From: COP

Disorder Aliases PubMed IDs
hemangioma of subcutaneous tissue
  • angioma of the subcutaneous tissue
breast mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of breast
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPK15

genes like me logo Genes that share disorders with MAPK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK15 Gene

Publications for MAPK15 Gene

  1. ERK8, a new member of the mitogen-activated protein kinase family. (PMID: 11875070) Abe MK … Rosner MR (The Journal of biological chemistry 2002) 2 3 4 22
  2. Regulation of the activity and expression of ERK8 by DNA damage. (PMID: 19166846) Klevernic IV … Cohen P (FEBS letters 2009) 3 4 22
  3. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PMID: 16624805) Saelzler MP … Abe MK (The Journal of biological chemistry 2006) 3 4 22
  4. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PMID: 16484222) Iavarone C … Chiariello M (The Journal of biological chemistry 2006) 3 4 22
  5. The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism. (PMID: 28842414) Bermingham DP … Blakely RD (The Journal of neuroscience : the official journal of the Society for Neuroscience 2017) 3 4

Products for MAPK15 Gene

Sources for MAPK15 Gene