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Aliases for MAPK15 Gene

Aliases for MAPK15 Gene

  • Mitogen-Activated Protein Kinase 15 2 3 3 5
  • Extracellular Signal-Regulated Kinase 7 3 4
  • Extracellular Signal-Regulated Kinase 8 3 4
  • MAP Kinase 15 3 4
  • MAPK 15 3 4
  • ERK-7 3 4
  • ERK-8 3 4
  • ERK7 3 4
  • ERK8 3 4
  • Extracellular Signal Regulated Kinase 8 2
  • Extracellular Regulated Kinase 8 Delta 3
  • EC 2.7.11.24 4

External Ids for MAPK15 Gene

Previous GeneCards Identifiers for MAPK15 Gene

  • GC08P144871
  • GC08P144798
  • GC08P140051

Summaries for MAPK15 Gene

GeneCards Summary for MAPK15 Gene

MAPK15 (Mitogen-Activated Protein Kinase 15) is a Protein Coding gene. Among its related pathways are MAPK Pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK7.

UniProtKB/Swiss-Prot for MAPK15 Gene

  • In vitro, phosphorylates MBP.

Gene Wiki entry for MAPK15 Gene

Additional gene information for MAPK15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK15 Gene

Genomics for MAPK15 Gene

GeneHancer (GH) Regulatory Elements for MAPK15 Gene

Promoters and enhancers for MAPK15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143716 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 658 0.0 -13 0.3 BCOR HDAC1 TFAP4 SIN3A BMI1 CTBP1 POLR2A VEZF1 RBM22 RFX1 MAPK15 ENSG00000253931 ENSG00000254574
GH08J143717 Enhancer 0.8 FANTOM5 652.6 +0.9 884 0.2 KLF1 ATF1 ZBTB6 TEAD4 ZSCAN4 KLF17 HIC1 ZFHX2 GLIS2 NCOR1 ENSG00000254548 MAPK15 FAM83H
GH08J143731 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +21.0 20989 11.1 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B E2F8 ZNF143 FAM83H ENSG00000254548 FAM83H-AS1 ENSG00000254973 PLEC MAPK15 MROH6 RHPN1 GC08P143741 MIR4664
GH08J143744 Enhancer 0.4 ENCODE 7.2 +29.0 28988 1 ZNF24 SPI1 PIR34971 PIR36953 ENSG00000254548 MAPK15 FAM83H-AS1 IQANK1 LOC105375800
GH08J143885 Enhancer 0.4 FANTOM5 1.9 +169.1 169078 0.2 SAP130 POLR2A EPPK1 MAPK15 MROH6 PIR31533
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAPK15 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • Lmo2
  • RelA
  • E2F
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta

Genomic Locations for MAPK15 Gene

Genomic Locations for MAPK15 Gene
chr8:143,716,259-143,722,463
(GRCh38/hg38)
Size:
6,205 bases
Orientation:
Plus strand
chr8:144,798,429-144,804,633
(GRCh37/hg19)
Size:
6,205 bases
Orientation:
Plus strand

Genomic View for MAPK15 Gene

Genes around MAPK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK15 Gene

Proteins for MAPK15 Gene

  • Protein details for MAPK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD08-MK15_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 15
    Protein Accession:
    Q8TD08
    Secondary Accessions:
    • Q2TCF9
    • Q8N362

    Protein attributes for MAPK15 Gene

    Size:
    544 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Interacts with CSK/c-Src, ABL1, RET and TGFB1I1.

    Alternative splice isoforms for MAPK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK15 Gene

Post-translational modifications for MAPK15 Gene

  • Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.
  • Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK15 Gene

No data available for DME Specific Peptides for MAPK15 Gene

Domains & Families for MAPK15 Gene

Gene Families for MAPK15 Gene

Protein Domains for MAPK15 Gene

Suggested Antigen Peptide Sequences for MAPK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD08

UniProtKB/Swiss-Prot:

MK15_HUMAN :
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK15: view

Function for MAPK15 Gene

Molecular function for MAPK15 Gene

UniProtKB/Swiss-Prot Function:
In vitro, phosphorylates MBP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).

Enzyme Numbers (IUBMB) for MAPK15 Gene

Phenotypes From GWAS Catalog for MAPK15 Gene

Gene Ontology (GO) - Molecular Function for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004707 MAP kinase activity IDA 11875070
GO:0005515 protein binding IPI 22948227
genes like me logo Genes that share ontologies with MAPK15: view
genes like me logo Genes that share phenotypes with MAPK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK15

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK15 Gene

Localization for MAPK15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK15 gene
Compartment Confidence
extracellular 5
nucleus 4
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11875070
GO:0005622 intracellular NAS 11875070
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005776 autophagosome IDA 22948227
genes like me logo Genes that share ontologies with MAPK15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAPK15 Gene

Pathways & Interactions for MAPK15 Gene

genes like me logo Genes that share pathways with MAPK15: view

Pathways by source for MAPK15 Gene

SIGNOR curated interactions for MAPK15 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007029 endoplasmic reticulum organization IMP 21847093
GO:0010468 regulation of gene expression IBA --
GO:0010506 regulation of autophagy IDA 22948227
genes like me logo Genes that share ontologies with MAPK15: view

Drugs & Compounds for MAPK15 Gene

(2) Drugs for MAPK15 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for MAPK15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MAPK15: view

Transcripts for MAPK15 Gene

mRNA/cDNA for MAPK15 Gene

Unigene Clusters for MAPK15 Gene

Mitogen-activated protein kinase 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK15 Gene

No ASD Table

Relevant External Links for MAPK15 Gene

GeneLoc Exon Structure for
MAPK15
ECgene alternative splicing isoforms for
MAPK15

Expression for MAPK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK15 Gene

This gene is overexpressed in Fallopian Tube (x6.0), Testis (x4.9), Cervix - Endocervix (x4.4), and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for MAPK15 Gene

This gene is overexpressed in Spinal cord (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK15 Gene



Protein tissue co-expression partners for MAPK15 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPK15 Gene:

MAPK15

SOURCE GeneReport for Unigene cluster for MAPK15 Gene:

Hs.493169

mRNA Expression by UniProt/SwissProt for MAPK15 Gene:

Q8TD08-MK15_HUMAN
Tissue specificity: Widely expressed with a maximal expression in lung and kidney.

Evidence on tissue expression from TISSUES for MAPK15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MAPK15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK15 Gene

Orthologs for MAPK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK15 34 33
  • 97.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK15 34 33
  • 79.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK15 34 33
  • 78.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk15 16 34 33
  • 76.36 (n)
rat
(Rattus norvegicus)
Mammalia Mapk15 33
  • 75.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK15 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK15 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK15 34 33
  • 57.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK15 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk15 33
  • 57.12 (n)
zebrafish
(Danio rerio)
Actinopterygii mapk15 34 33
  • 55.56 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Erk7 34 33
  • 55.02 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05D10.2 34 33
  • 55.27 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
Cin.8827 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8827 33
Species where no ortholog for MAPK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK15 Gene

ENSEMBL:
Gene Tree for MAPK15 (if available)
TreeFam:
Gene Tree for MAPK15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK15: view image

Paralogs for MAPK15 Gene

Paralogs for MAPK15 Gene

(23) SIMAP similar genes for MAPK15 Gene using alignment to 1 proteins:

  • MK15_HUMAN
genes like me logo Genes that share paralogs with MAPK15: view

Variants for MAPK15 Gene

Sequence variations from dbSNP and Humsavar for MAPK15 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000396823 -- 143,720,644(+) A/G intron_variant
rs1001132300 -- 143,719,543(+) G/A intron_variant
rs1002179257 -- 143,717,450(+) A/G intron_variant
rs1002231735 -- 143,717,629(+) G/A intron_variant
rs1002852047 -- 143,719,279(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK15 Gene

Variant ID Type Subtype PubMed ID
nsv466007 CNV loss 19166990
nsv519816 CNV loss 19592680
nsv612893 CNV loss 21841781
nsv612894 CNV loss 21841781
nsv612895 CNV loss 21841781
nsv6441 CNV insertion 18451855
nsv824777 CNV loss 20364138
nsv967635 CNV duplication 23825009

Variation tolerance for MAPK15 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK15 Gene

Disorders for MAPK15 Gene

Additional Disease Information for MAPK15

No disorders were found for MAPK15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK15 Gene

Publications for MAPK15 Gene

  1. ERK8, a new member of the mitogen-activated protein kinase family. (PMID: 11875070) Abe MK … Rosner MR (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PMID: 16484222) Iavarone C … Chiariello M (The Journal of biological chemistry 2006) 3 4 22 58
  3. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PMID: 16624805) Saelzler MP … Abe MK (The Journal of biological chemistry 2006) 3 4 22 58
  4. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. (PMID: 20395206) Xu YM … Dong Z (Cancer research 2010) 3 22 58
  5. Regulation of the activity and expression of ERK8 by DNA damage. (PMID: 19166846) Klevernic IV … Cohen P (FEBS letters 2009) 3 22 58

Products for MAPK15 Gene

Sources for MAPK15 Gene

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