MAPK13 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 13

GC06P047452
GIFtS:
48
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines ... See more...

Aliases for MAPK13 Gene

Aliases for MAPK13 Gene

  • Mitogen-Activated Protein Kinase 13 2 3 4 5
  • SAPK4 2 3 4
  • Mitogen-Activated Protein Kinase P38 Delta 3 4
  • Stress-Activated Protein Kinase 4 3 4
  • MAP Kinase P38 Delta 3 4
  • MAP Kinase 13 3 4
  • EC 2.7.11.24 4 51
  • P38delta 2 3
  • MAPK 13 3 4
  • PRKM13 3 4
  • EC 2.7.11 51
  • MAPK-13 3
  • MAPK13 5

External Ids for MAPK13 Gene

Previous HGNC Symbols for MAPK13 Gene

  • PRKM13

Previous GeneCards Identifiers for MAPK13 Gene

  • GC06P036100
  • GC06P036145
  • GC06P036129
  • GC06P035818
  • GC06P036095
  • GC06P036838
  • GC06P036925
  • GC06P042810
  • GC06P043145
  • GC06P043357
  • GC06P046048
  • GC06P037779
  • GC06P038403
  • GC06P038993
  • GC06P039582
  • GC06P040142
  • GC06P041214
  • GC06P041896
  • GC06P042540

Summaries for MAPK13 Gene

Entrez Gene Summary for MAPK13 Gene

  • This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAPK13 Gene

MAPK13 (Mitogen-Activated Protein Kinase 13) is a Protein Coding gene. Diseases associated with MAPK13 include Glioblastoma Mesenchymal Subtype. Among its related pathways are ATM Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK12.

UniProtKB/Swiss-Prot Summary for MAPK13 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Gene Wiki entry for MAPK13 Gene

Additional gene information for MAPK13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK13 Gene

Genomics for MAPK13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK13

Top Transcription factor binding sites by QIAGEN in the MAPK13 gene promoter:
  • AP-4
  • C/EBPalpha
  • Lmo2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for MAPK13 Gene

Genomic Locations for MAPK13 Gene
chr6:36,127,809-36,144,524
(GRCh38/hg38)
Size:
16,716 bases
Orientation:
Plus strand
chr6:36,095,586-36,107,842
(GRCh37/hg19)
Size:
12,257 bases
Orientation:
Plus strand

Genomic View for MAPK13 Gene

Genes around MAPK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK13 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK13 Gene

Proteins for MAPK13 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15264-MK13_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 13
    Protein Accession:
    O15264
    Secondary Accessions:
    • O14739
    • O15124
    • Q5U4A5
    • Q6FI46
    • Q9UNU0

    Protein attributes for MAPK13 Gene

    Size:
    365 amino acids
    Molecular mass:
    42090 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAPK8IP2.

    Three dimensional structures from OCA and Proteopedia for MAPK13 Gene

    Alternative splice isoforms for MAPK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK13 Gene

Protein Expression for MAPK13 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK13 Gene

O15264:
  • QTVDIWSVGCIMAE
  • LVYQMLKGL
  • VVHRDLK
  • LKYIHSA
  • AVNEDCEL
  • GEKVAIK
  • GLKYIHSA
  • FMQTDLQKIM
  • EMTGYVVTRWYRAPEVIL
  • DIWSVGCI
  • VDEWKQHIYKEI
  • ILDFGLA
  • AAKSYIQSLPQ
  • HENVIGLLD
  • LDFGLAR
  • DLLEKML
  • LLDVFTP
  • VGSGAYG
  • KKLSRPFQ
  • QLFPRASPQA
  • TRWYRAPE
  • HSAGVVHRDLKP
  • HRDLKPGN
  • AKRAYRE
  • VHRDLKP
  • LKILDFGLAR

Post-translational modifications for MAPK13 Gene

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

  • Signalway Proteins for MAPK13
  • Abcam proteins for MAPK13

Domains & Families for MAPK13 Gene

Gene Families for MAPK13 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MAPK13 Gene

InterPro:
Blocks:
  • MAP kinase
  • P38 MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK13 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase 13 (B5BTY5_HUMAN)
  • Stress-activated protein kinase 4 (MK13_HUMAN)
  • MAPK13 protein (Q6FHR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15264

UniProtKB/Swiss-Prot:

MK13_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK13: view

Function for MAPK13 Gene

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  2. CRISPR
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  5. Clone
  6. Cell Line

Molecular function for MAPK13 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1.

Enzyme Numbers (IUBMB) for MAPK13 Gene

Phenotypes From GWAS Catalog for MAPK13 Gene

Gene Ontology (GO) - Molecular Function for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 12244047
GO:0004707 MAP kinase activity IBA,IDA 9218798
GO:0005515 protein binding IPI 19135240
genes like me logo Genes that share ontologies with MAPK13: view
genes like me logo Genes that share phenotypes with MAPK13: view

Animal Models for MAPK13 Gene

MGI Knock Outs for MAPK13:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK13

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK13

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK13 Gene

Localization for MAPK13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK13 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAPK13 Gene

Pathways & Interactions for MAPK13 Gene

PathCards logo

SuperPathways for MAPK13 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
2 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CMV and MAPK Pathways
.46
NF-KappaB Activation by EBV
.42
PKR Pathway
.36
SUMO Pathway
.30
3 RET signaling
Signalling to ERKs
.95
Signalling to RAS
.95
NGF signalling via TRKA from the plasma membrane
.87
Signalling by NGF
.81
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
4 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
Chagas disease (American trypanosomiasis)
.31
5 GPCR Pathway
Paxillin Interactions
.73
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with MAPK13: view

Pathways by source for MAPK13 Gene

2 Sino Biological pathways for MAPK13 Gene
1 PharmGKB pathway for MAPK13 Gene
24 GeneGo (Thomson Reuters) pathways for MAPK13 Gene
  • Cell adhesion_Plasmin signaling
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Development A1 receptor signaling
  • Development A2A receptor signaling
  • Development A2B receptor- action via G-protein alpha s
89 Qiagen pathways for MAPK13 Gene
  • 14-3-3 and Cell Cycle Regulation
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for MAPK13 Gene

SIGNOR curated interactions for MAPK13 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006970 response to osmotic stress IDA 9731215
GO:0007049 cell cycle IEA --
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with MAPK13: view

Drugs & Compounds for MAPK13 Gene

Products:

  1. Drug

(21) Drugs for MAPK13 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Pirfenidone Approved, Investigational Pharma inhibitor TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 86
Magnesium Approved, Experimental, Investigational Pharma 0
KC706 Investigational Pharma Target, inhibitor 0

(3) Additional Compounds for MAPK13 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(9) ApexBio Compounds for MAPK13 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
genes like me logo Genes that share compounds with MAPK13: view

Drug Products

Transcripts for MAPK13 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK13 Gene

1 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK13

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
SP1: - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - -
SP9:

Relevant External Links for MAPK13 Gene

GeneLoc Exon Structure for
MAPK13

Expression for MAPK13 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK13 Gene

mRNA expression in normal human tissues for MAPK13 Gene
mRNA expression by BioGPS for MAPK13 GenemRNA expression by GTEx for MAPK13 Gene

mRNA differential expression in normal tissues according to GTEx for MAPK13 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.4).

Protein differential expression in normal tissues from HIPED for MAPK13 Gene

This gene is overexpressed in Cervix (17.5), Islet of Langerhans (11.2), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK13 Gene



Protein tissue co-expression partners for MAPK13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK13

SOURCE GeneReport for Unigene cluster for MAPK13 Gene:

Hs.178695

mRNA Expression by UniProt/SwissProt for MAPK13 Gene:

O15264-MK13_HUMAN
Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.

Evidence on tissue expression from TISSUES for MAPK13 Gene

  • Lung(4.6)
  • Blood(4.5)
  • Pancreas(4.4)
  • Nervous system(4.4)
  • Liver(4.4)
  • Skin(2.8)
  • Intestine(2.4)
  • Kidney(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MAPK13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK13 Gene

Orthologs for MAPK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK13 30 31
  • 99.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK13 30 31
  • 92.24 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPK13 30 31
  • 91.96 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAPK13 31
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mapk13 30 17 31
  • 88.13 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk13 30
  • 88.13 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPK13 31
  • 84 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAPK13 30 31
  • 76.26 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPK13 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapk13 30
  • 68.5 (n)
Str.3065 30
Zebrafish
(Danio rerio)
 Actinopterygii mapk13 30 31
  • 65.63 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta p38b 32
  • 58 (a)
Mpk2 32
  • 57 (a)
p38c 32
  • 42 (a)
Worm
(Caenorhabditis elegans)
 Secernentea pmk-1 32
  • 56 (a)
F09C12.2 32
  • 40 (a)
pmk-3 32
  • 38 (a)
Y51B9A.9 32
  • 31 (a)
C49C3.10b 32
  • 30 (a)
C49C3.10a 32
  • 28 (a)
Species where no ortholog for MAPK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPK13 Gene

ENSEMBL:
Gene Tree for MAPK13 (if available)
TreeFam:
Gene Tree for MAPK13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK13: view image

Paralogs for MAPK13 Gene

Paralogs for MAPK13 Gene

(62) SIMAP similar genes for MAPK13 Gene using alignment to 6 proteins:

  • MK13_HUMAN
  • B5BTY5_HUMAN
  • Q5R3E4_HUMAN
  • Q5R3E6_HUMAN
  • Q5U4A5_HUMAN
  • Q6FHR4_HUMAN
genes like me logo Genes that share paralogs with MAPK13: view

Variants for MAPK13 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK13 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
775077 Benign: not provided 36,131,273(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
785169 Benign: not provided 36,135,780(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
789745 Benign: not provided 36,136,653(+) T/C INTRON_VARIANT
rs41270090 - p.Ala300Thr
rs55776345 - p.Ser41Leu

Additional dbSNP identifiers (rs#s) for MAPK13 Gene

Variation tolerance for MAPK13 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK13 Gene

Human Gene Mutation Database (HGMD)
MAPK13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAPK13 Gene

Disorders for MAPK13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPK13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
glioblastoma mesenchymal subtype
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAPK13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPK13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK13 Gene

Publications for MAPK13 Gene

  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M … Cohen P (The EMBO journal 1997) 2 3 4 23
  2. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. (PMID: 9295308) Wang XS … Yao Z (The Journal of biological chemistry 1997) 2 3 4 23
  3. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. (PMID: 18367666) Zhou X … Burg MB (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23
  4. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PMID: 10727080) Herbison CE … Price P (DNA sequence : the journal of DNA sequencing and mapping 1999) 3 4 23
  5. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PMID: 10201954) Hale KK … Manthey CL (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 23

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