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This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
MAPK13 (Mitogen-Activated Protein Kinase 13) is a Protein Coding gene. Diseases associated with MAPK13 include Glioblastoma Mesenchymal Subtype. Among its related pathways are ATM Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK12.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IDA | 12244047 |
GO:0004707 | MAP kinase activity | IBA,IDA | 9218798 |
GO:0005515 | protein binding | IPI | 19135240 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
|
2 | 4-1BB Pathway |
4-1BB Pathway
.54
CD40 Signaling
.54
CMV and MAPK Pathways
.46
|
NF-KappaB Activation by EBV
.42
PKR Pathway
.36
SUMO Pathway
.30
|
3 | RET signaling | ||
4 | Toll-like Receptor Signaling Pathway |
.37
|
|
5 | GPCR Pathway |
Paxillin Interactions
.73
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
|
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006970 | response to osmotic stress | IDA | 9731215 |
GO:0007049 | cell cycle | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Pirfenidone | Approved, Investigational | Pharma | inhibitor | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 86 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
KC706 | Investigational | Pharma | Target, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
BIRB 796 (Doramapimod) | P38 MAPK inhibitor,cell permeable and highly selective | 285983-48-4 |
Losmapimod | 585543-15-3 | |
LY2228820 | P38 MAP kinase inhibitor | 862507-23-1 |
PH-797804 | P38 MAP kinase inhibitor, potent and selective | 586379-66-0 |
SB 203580 | P38 MAP kinase inhibitor | 152121-47-6 |
SB202190 (FHPI) | P38 MAPK inhibitor | 152121-30-7 |
Skepinone-L | P38-MAPK inhibitor,potent and selective | 1221485-83-1 |
TAK-715 | p38 MAPK inhibitor | 303162-79-0 |
VX-702 | P38α MAPK inhibitor,highly selective and ATP-competitive | 479543-46-9 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAPK13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAPK13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAPK13 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MAPK13 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mapk13 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mapk13 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAPK13 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAPK13 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mapk13 30 |
|
||
Str.3065 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | mapk13 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | p38b 32 |
|
|
|
Mpk2 32 |
|
|
|||
p38c 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | pmk-1 32 |
|
|
|
F09C12.2 32 |
|
|
|||
pmk-3 32 |
|
|
|||
Y51B9A.9 32 |
|
|
|||
C49C3.10b 32 |
|
|
|||
C49C3.10a 32 |
|
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
775077 | Benign: not provided | 36,131,273(+) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
785169 | Benign: not provided | 36,135,780(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
789745 | Benign: not provided | 36,136,653(+) | T/C | INTRON_VARIANT | |
rs41270090 | - | p.Ala300Thr | |||
rs55776345 | - | p.Ser41Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
glioblastoma mesenchymal subtype |
|
|