Aliases for MAPK13 Gene
Aliases for MAPK13 Gene
External Ids for MAPK13 Gene
- HGNC: 6875
- Entrez Gene: 5603
- Ensembl: ENSG00000156711
- OMIM: 602899
- UniProtKB: O15264
Previous HGNC Symbols for MAPK13 Gene
- PRKM13
Previous GeneCards Identifiers for MAPK13 Gene
- GC06P036100
- GC06P036145
- GC06P036129
- GC06P035818
- GC06P036095
- GC06P036838
- GC06P036925
- GC06P037779
- GC06P038403
- GC06P038993
- GC06P039582
- GC06P040142
- GC06P041214
Summaries for MAPK13 Gene
-
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for MAPK13 Gene
MAPK13 (Mitogen-Activated Protein Kinase 13) is a Protein Coding gene. Diseases associated with MAPK13 include Pthirus Pubis Infestation. Among its related pathways are mTOR Pathway and Melanocyte Development and Pigmentation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK12.
UniProtKB/Swiss-Prot for MAPK13 Gene
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Additional gene information for MAPK13 Gene
- Monarch Initiative
- Search for MAPK13 at DataMed
- Search for MAPK13 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK13 Gene
Genomics for MAPK13 Gene
GeneHancer (GH) Regulatory Elements for MAPK13 Gene
Promoters and enhancers for MAPK13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAPK13 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK13 gene promoter:
Regulatory Element Products
Genomic Locations for MAPK13 Gene
Genomic Locations for MAPK13 Gene
- chr6:36,127,809-36,144,524
- (GRCh38/hg38)
- Size:
- 16,716 bases
- Orientation:
- Plus strand
- chr6:36,095,586-36,107,842
- (GRCh37/hg19)
Genomic View for MAPK13 Gene
Genes around MAPK13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
- 6p21.31 by Ensembl
MAPK13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK13 Gene
Proteins for MAPK13 Gene
-
Protein details for MAPK13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15264-MK13_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 13
- Protein Accession:
- O15264
- O14739
- O15124
- Q5U4A5
- Q6FI46
- Q9UNU0
Protein attributes for MAPK13 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 42090 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with MAPK8IP2.
Three dimensional structures from OCA and Proteopedia for MAPK13 Gene
Protein Expression for MAPK13 Gene
Post-translational modifications for MAPK13 Gene
- Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAPK13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK13 (p38 delta)
-
Custom Antibody ServicesOriGene Antibodies for MAPK13
- AM00138PU-N
- AM31024PU-N
- AM31025PU-N
- AM31044PU-N
- TA350771
- TA505779
- CF505779
- TA505780
- CF505780
- TA505781
- CF505781
- TA505782
- CF505782
- TA505783
- CF505783
- TA505804
- CF505804
- TA505805
- CF505805
- TA505820
- CF505820
- TA505850
- CF505850
- TA505851
- CF505851
- TA505852
- CF505852
- TA505853
- CF505853
- TA505854
- CF505854
- TA505855
- CF505855
- TA505856
- CF505856
- TA505865
- CF505865
- TA505866
- CF505866
- TA505867
- CF505867
- TA505878
- CF505878
- Novus Biologicals Antibodies for MAPK13
- Invitrogen Antibodies for MAPK13
- GeneTex MAPK13 Antibody for MAPK13
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK13
- Sino Biological Antibodies for MAPK13
Protein Products
-
OriGene Purified Proteins for MAPK13
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK13
- Origene Custom Protein Services for MAPK13
- Sino Biological Cell Lysates for MAPK13
- Sino Biological Recombinant Proteins for MAPK13
- ProSpec Recombinant Proteins for MAPK13
- GeneTex Proteins for MAPK13
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for MAPK13 (p38 delta)
- antibodies-online: Search results for 5 available MAPK13 Elisa Kits ranked by validation data
- Compare Top MAPK13 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for MAPK13 Gene
Domains & Families for MAPK13 Gene
Gene Families for MAPK13 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAPK13 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15264UniProtKB/Swiss-Prot:
MK13_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK13 Gene
Molecular function for MAPK13 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1.
Enzyme Numbers (IUBMB) for MAPK13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 12244047 |
| GO:0004707 | MAP kinase activity | IDA | 9218798 |
| GO:0005515 | protein binding | IPI | 19135240 |
Phenotypes for MAPK13 Gene
- MGI mutant phenotypes for MAPK13:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MAPK13:
-
- Increased mitotic index
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased substrate adherent cell growth
- Wnt reporter downregulated
- G0/1 arrest
- Increased G1 DNA content
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased transferrin (TF) endocytosis
- Increased simian virus 40 (SV40) infection
- Transferrin accumulation in the perinuclear area
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for MAPK13 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MAPK13
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK13
-
CRISPR Products
-
OriGene CRISPR knockouts for MAPK13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK13
- genomics-online: gRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- Applied Biological Materials CRISPR for MAPK13
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK13
- GenScript: Design CRISPR guide RNA sequences for MAPK13
miRNA for MAPK13 Gene
- miRTarBase miRNAs that target MAPK13
-
- hsa-mir-3691-5p (MIRT462701)
- hsa-mir-6887-5p (MIRT462702)
- hsa-mir-4531 (MIRT462703)
- hsa-mir-6795-5p (MIRT462704)
- hsa-mir-5010-5p (MIRT462705)
- hsa-mir-4525 (MIRT462706)
- hsa-mir-5187-5p (MIRT462707)
- hsa-mir-5703 (MIRT462708)
- hsa-mir-4516 (MIRT462709)
- hsa-mir-4434 (MIRT462710)
- hsa-mir-8082 (MIRT462711)
- hsa-mir-3134 (MIRT462712)
- hsa-mir-4534 (MIRT462713)
- hsa-mir-6798-5p (MIRT462714)
- hsa-mir-5685 (MIRT462715)
- hsa-mir-4690-3p (MIRT462716)
- hsa-mir-4773 (MIRT462717)
- hsa-mir-5589-5p (MIRT519494)
- hsa-mir-4731-5p (MIRT519495)
- hsa-mir-6778-3p (MIRT519496)
- hsa-mir-150-5p (MIRT519497)
- hsa-mir-6814-5p (MIRT519498)
- hsa-mir-4735-3p (MIRT519499)
- hsa-mir-4761-5p (MIRT519500)
- hsa-mir-18b-5p (MIRT519501)
- hsa-mir-18a-5p (MIRT519502)
- hsa-mir-155-5p (MIRT732510)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK13
- Browse OriGene Inhibitory RNA Products For MAPK13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK13
- genomics-online: shRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for MAPK13
- Sino Biological Human cDNA Clone for MAPK13
- VectorBuilder custom plasmid, inducible vectors for MAPK13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK13
- Applied Biological Materials Clones for MAPK13
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK13
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK13 Gene
Localization for MAPK13 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 2 |
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAPK13 Gene
Pathways & Interactions for MAPK13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
.59
.48
|
.43
.36
|
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | 4-1BB Pathway |
.54
.54
|
.36
.30
|
| 4 | RET signaling | ||
| 5 | GPCR Pathway |
.62
|
.55
|
Pathways by source for MAPK13 Gene
1 Sino Biological pathway for MAPK13 Gene
13 BioSystems pathways for MAPK13 Gene
14 Reactome pathways for MAPK13 Gene
1 PharmGKB pathway for MAPK13 Gene
24 GeneGo (Thomson Reuters) pathways for MAPK13 Gene
10 R&D Systems pathways for MAPK13 Gene
4 Tocris pathways for MAPK13 Gene
89 Qiagen pathways for MAPK13 Gene
1 Cell Signaling Technology pathway for MAPK13 Gene
Interacting Proteins for MAPK13 Gene
Selected Interacting proteins:
O15264-MK13_HUMAN
ENSP00000211287
for MAPK13 Gene via
IID
UniProtKB
STRING
MINT
GPS-Prot Interaction Network for MAPK13
SIGNOR curated interactions for MAPK13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006970 | response to osmotic stress | IDA | 9731215 |
| GO:0007049 | cell cycle | IEA | -- |
Drugs & Compounds for MAPK13 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Pirfenidone | Approved, Investigational | Pharma | inhibitor | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 65 | |
| Magnesium | Approved | Nutra | 0 | |||
| PH-797804 | Investigational | Pharma | P38 MAP kinase inhibitor, potent and selective | 0 | ||
| VX-702 | Investigational | Pharma | inhibitor | P38α MAPK inhibitor,highly selective and ATP-competitive | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
(9) ApexBio Compounds for MAPK13 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BIRB 796 (Doramapimod) | P38 MAPK inhibitor,cell permeable and highly selective | 285983-48-4 |
| Losmapimod | 585543-15-3 | |
| LY2228820 | P38 MAP kinase inhibitor | 862507-23-1 |
| PH-797804 | P38 MAP kinase inhibitor, potent and selective | 586379-66-0 |
| SB 203580 | P38 MAP kinase inhibitor | 152121-47-6 |
| SB202190 (FHPI) | P38 MAPK inhibitor | 152121-30-7 |
| Skepinone-L | P38-MAPK inhibitor,potent and selective | 1221485-83-1 |
| TAK-715 | p38 MAPK inhibitor | 303162-79-0 |
| VX-702 | P38α MAPK inhibitor,highly selective and ATP-competitive | 479543-46-9 |
Transcripts for MAPK13 Gene
mRNA/cDNA for MAPK13 Gene
- (132) Selected AceView cDNA sequences:
- (18) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000211287 2052 bps (uc003ols.5)
- ENST00000373759 1036 bps (uc063odh.1)
- ENST00000373766 6196 bps (uc003olt.5)
- ENST00000476951 499 bps (uc063odg.1)
- ENST00000490334 649 bps (uc063odi.1)
Unigene Clusters for MAPK13 Gene
- Mitogen-activated protein kinase 13:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MAPK13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK13
- genomics-online: gRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- Applied Biological Materials CRISPR for MAPK13
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK13
- GenScript: Design CRISPR guide RNA sequences for MAPK13
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK13
- Browse OriGene Inhibitory RNA Products For MAPK13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK13
- genomics-online: shRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for MAPK13
- Sino Biological Human cDNA Clone for MAPK13
- VectorBuilder custom plasmid, inducible vectors for MAPK13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK13
- Applied Biological Materials Clones for MAPK13
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for MAPK13 Gene
mRNA differential expression in normal tissues according to GTEx for MAPK13 Gene
This gene is overexpressed in Esophagus - Mucosa (x5.4).
This gene is overexpressed in Cervix (17.5), Islet of Langerhans (11.2), and Skin (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK13 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK13 Gene:
MAPK13SOURCE GeneReport for Unigene cluster for MAPK13 Gene:
Hs.178695mRNA Expression by UniProt/SwissProt for MAPK13 Gene:
O15264-MK13_HUMAN
Tissue specificity:
Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Evidence on tissue expression from TISSUES for MAPK13 Gene
- Blood(4.5)
- Lung(4.5)
- Nervous system(4.4)
- Liver(4.3)
- Pancreas(4.2)
- Skin(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for MAPK13
-
OriGene qPCR primer pairs for MAPK13
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK13 Gene
Orthologs for MAPK13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK13 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAPK13 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAPK13 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAPK13 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mapk13 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mapk13 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK13 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAPK13 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MAPK13 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mapk13 33 |
|
||
| Str.3065 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mapk13 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | p38b 35 |
|
|
|
| Mpk2 35 |
|
|
|||
| p38c 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | pmk-1 35 |
|
|
|
| F09C12.2 35 |
|
|
|||
| pmk-3 35 |
|
|
|||
| Y51B9A.9 35 |
|
|
|||
| C49C3.10b 35 |
|
|
|||
| C49C3.10a 35 |
|
|
- Species where no ortholog for MAPK13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MAPK13 Gene
- ENSEMBL:
- Gene Tree for MAPK13 (if available)
- TreeFam:
- Gene Tree for MAPK13 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAPK13: view image
Paralogs for MAPK13 Gene
(62) SIMAP similar genes for MAPK13 Gene using alignment to 6 proteins:
- MK13_HUMAN
- B5BTY5_HUMAN
- Q5R3E4_HUMAN
- Q5R3E6_HUMAN
- Q5U4A5_HUMAN
- Q6FHR4_HUMAN
- MAPK14
- MAPK12
- DKFZp686M02159
- MAPK11
- MAPK10
- MAPK8
- DKFZp686O0215
- MAPK9
- MAPK3
- MAPK1
- MAPK7
- NLK
- MAPK4
- MAPK15
- MAPK6
- DKFZp434M058
- CDKL2
- CDK11A
- CDC2L2
- CDKL4
- CAMKK1
- CDC2L1
- CDK11B
- NUAK1
- RPS6KA1
- DKFZp686D0638
- CDK3
- CDK7
- GSK3B
- GSK3A
- CDKL3
- PCTK1
- MAK
- CSNK2A2
- CDK16
- CDK12
- CDK20
- CSNK2A1
- CDK1
- CDK5
- CDC2
- MOK
- CDK17
- CSNK2A3
- CDK14
- CDK9
- CHEK2
- CDK19
- DKFZp686L20222
- CDKL1
- CDKL5
- CDK6
- CDK15
- CDK4
- ICK
- CDK2
- CDK10
- PCTK3
- ULK2
- ULK1
- CDK18
- CDK13
Variants for MAPK13 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013472 | -- | 36,130,277(+) | G/A | upstream_transcript_variant | |
| rs1000203629 | -- | 36,138,311(+) | G/A | intron_variant | |
| rs1000254477 | -- | 36,144,860(+) | A/G | downstream_transcript_variant | |
| rs1000302836 | -- | 36,144,672(+) | C/G | downstream_transcript_variant | |
| rs1000940018 | -- | 36,139,615(+) | T/C | 3_prime_UTR_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.60;
30.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK13 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAPK13 Gene
Disorders for MAPK13 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pthirus pubis infestation |
|
|
Search MAPK13 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAPK13
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK13 Gene
Publications for MAPK13 Gene
- Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M … Cohen P (The EMBO journal 1997) 2 3 4 22 58
- Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. (PMID: 9295308) Wang XS … Yao Z (The Journal of biological chemistry 1997) 2 3 4 22 58
- MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. (PMID: 18367666) Zhou X … Burg MB (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22 58
- Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PMID: 10201954) Hale KK … Manthey CL (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 22 58
- Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. (PMID: 10066767) Hu MC … Tan TH (The Journal of biological chemistry 1999) 3 4 22 58
Products for MAPK13 Gene
- R&D Systems Antibodies for MAPK13 (p38 delta)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for MAPK13 (p38 delta)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAPK13
- AM00138PU-N
- AM31024PU-N
- AM31025PU-N
- AM31044PU-N
- TA350771
- TA505779
- CF505779
- TA505780
- CF505780
- TA505781
- CF505781
- TA505782
- CF505782
- TA505783
- CF505783
- TA505804
- CF505804
- TA505805
- CF505805
- TA505820
- CF505820
- TA505850
- CF505850
- TA505851
- CF505851
- TA505852
- CF505852
- TA505853
- CF505853
- TA505854
- CF505854
- TA505855
- CF505855
- TA505856
- CF505856
- TA505865
- CF505865
- TA505866
- CF505866
- TA505867
- CF505867
- TA505878
- CF505878
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAPK13
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK13
- Origene Custom Protein Services for MAPK13
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK13
- Browse OriGene Inhibitory RNA Products For MAPK13
- OriGene qPCR primer pairs and template standards for MAPK13
- OriGene qPCR primer pairs for MAPK13
- OriGene CRISPR knockouts for MAPK13
- OriGene ORF clones in human for MAPK13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAPK13
- GenScript: Custom all cDNA clones Services for MAPK13
- GenScript Custom Purified and Recombinant Proteins Services for MAPK13
- GenScript Custom Assay Services for MAPK13
- GenScript Custom overexpressing Cell Line Services for MAPK13
- GenScript: Design CRISPR guide RNA sequences for MAPK13
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAPK13
- Sino Biological Human cDNA Clone for MAPK13
- Sino Biological Cell Lysates for MAPK13
- Sino Biological Recombinant Proteins for MAPK13
- Sino Biological Antibodies for MAPK13
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MAPK13
- Novus Biologicals lysates and proteins for MAPK13
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for MAPK13
- Taconic Biosciences Mouse Models for MAPK13
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MAPK13
- ApexBio compounds for MAPK13
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK13
- VectorBuilder custom plasmid, inducible vectors for MAPK13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK13
- antibodies-online: Search results for 165 available MAPK13 Antibodies ranked by validation data
- Compare Top MAPK13 Antibodies
- antibodies-online: Search results for 5 available MAPK13 Elisa Kits ranked by validation data
- Compare Top MAPK13 Elisa Kits
- Recommended
- antibodies-online: Search results for 22 available MAPK13 Proteins ranked by validation data
- Compare Top MAPK13 Proteins
- GeneTex MAPK13 Antibody for MAPK13
- GeneTex Proteins for MAPK13
- Santa Cruz Biotechnology (SCBT) Antibodies for MAPK13
- Search Santa Cruz Biotechnology (SCBT) for MAPK13 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAPK13
- Horizon Cell Lines for MAPK13
- genomics-online: cdna clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- orf clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- genomics-online: gRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- genomics-online: primer clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- genomics-online: shRNA clones - Search results for 131 available MAPK13 gene related products
- Overview of 131 available MAPK13 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK13
- GeneCopoeia miRNA 3'UTR Target clone products for MAPK13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK13
Sources for MAPK13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio