Aliases for MAPK12 Gene
Aliases for MAPK12 Gene
External Ids for MAPK12 Gene
- HGNC: 6874
- Entrez Gene: 6300
- Ensembl: ENSG00000188130
- OMIM: 602399
- UniProtKB: P53778
Previous HGNC Symbols for MAPK12 Gene
- SAPK3
Previous GeneCards Identifiers for MAPK12 Gene
- GC22M047242
- GC22M048873
- GC22M048993
- GC22M049033
- GC22M050684
Summaries for MAPK12 Gene
-
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPK12 Gene
MAPK12 (Mitogen-Activated Protein Kinase 12) is a Protein Coding gene. Diseases associated with MAPK12 include Breast Cancer. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK13.
UniProtKB/Swiss-Prot for MAPK12 Gene
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Additional gene information for MAPK12 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK12 Gene
Genomics for MAPK12 Gene
GeneHancer (GH) Regulatory Elements for MAPK12 Gene
Promoters and enhancers for MAPK12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAPK12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK12 gene promoter:
Regulatory Element Products
Genomic Locations for MAPK12 Gene
Genomic Locations for MAPK12 Gene
- chr22:50,245,450-50,261,825
- (GRCh38/hg38)
- Size:
- 16,376 bases
- Orientation:
- Minus strand
- chr22:50,683,879-50,700,254
- (GRCh37/hg19)
Genomic View for MAPK12 Gene
Genes around MAPK12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.33 by Ensembl
- 22q13.33 by Entrez Gene
- 22q13.33 by HGNC
MAPK12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK12 Gene
Proteins for MAPK12 Gene
-
Protein details for MAPK12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53778-MK12_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 12
- Protein Accession:
- P53778
- Q14260
- Q6IC53
- Q99588
- Q99672
Protein attributes for MAPK12 Gene
- Size:
- 367 amino acids
- Molecular mass:
- 41940 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP (By similarity).
Protein Expression for MAPK12 Gene
Selected DME Specific Peptides for MAPK12 Gene
- P53778:
-
- QTVDIWSVGCIMAE
- LVYQMLKGL
- EMTGYVVTRWYRAPEVIL
- ILDFGLA
- YRELRLLKHM
- AKRAYRE
- AVNEDCEL
- DIWSVGCI
- DFYLVMPFMGTDLGKLMK
- HENVIGLLD
- LDFGLAR
- LLDVFTP
- VGSGAYG
- TRWYRAPE
- HRDLKPGN
- LKILDFGLAR
Post-translational modifications for MAPK12 Gene
- Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme.
- Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAPK12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK12 (p38 gamma)
-
Custom Antibody ServicesOriGene Antibodies for MAPK12
- Novus Biologicals Antibodies for MAPK12
-
Abcam antibodies for MAPK12
-
Cloud-Clone Corp. Antibodies for MAPK12
- Invitrogen Antibodies for MAPK12
- Search GeneTex for Antibodies for MAPK12
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK12
- Sino Biological Antibodies for MAPK12
Protein Products
-
OriGene Purified Proteins for MAPK12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK12
- Origene Custom Protein Services for MAPK12
- Sino Biological Recombinant Proteins for MAPK12
- Sino Biological Cell Lysates for MAPK12
- ProSpec Recombinant Proteins for MAPK12
-
Cloud-Clone Corp. Proteins for MAPK12
- Search GeneTex for Proteins for MAPK12
-
Abcam proteins for MAPK12
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for MAPK12 (p38 gamma)
-
Cloud-Clone Corp. Assay Kits for MAPK12
-
Abcam assays for MAPK12
Domains & Families for MAPK12 Gene
Gene Families for MAPK12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MAPK12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53778UniProtKB/Swiss-Prot:
MK12_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK12 Gene
Molecular function for MAPK12 Gene
- GENATLAS Biochemistry:
- mitogen-activated protein kinase 12
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=37 uM for ATP {ECO:0000269 PubMed:10212242}; KM=313 uM for EGFR substrate peptide {ECO:0000269 PubMed:10212242}; KM=254 uM for GST-ATF2 {ECO:0000269 PubMed:10212242};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
- UniProtKB/Swiss-Prot Induction:
- Expression of MAPK12 is down-regulation by MAPK14 activation.
Enzyme Numbers (IUBMB) for MAPK12 Gene
Phenotypes From GWAS Catalog for MAPK12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 10508788 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | 18221368 |
| GO:0004707 | MAP kinase activity | IBA,TAS | -- |
Phenotypes for MAPK12 Gene
- MGI mutant phenotypes for MAPK12:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MAPK12:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell migration
- Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor
Animal Model Products
-
Taconic Biosciences Mouse Models for MAPK12
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK12
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK12 gene
- Search ViGene Biosciences for MAPK12
CRISPR Products
-
OriGene CRISPR knockouts for MAPK12
- genomics-online: gRNA clones - Search results for 131 available MAPK12 gene related products
- Overview of 131 available MAPK12 gene related products
- Applied Biological Materials CRISPR for MAPK12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK12
- GenScript: Design CRISPR guide RNA sequences for MAPK12
miRNA Products
- Search ViGene Biosciences for MAPK12
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MAPK12
- Browse OriGene Inhibitory RNA Products For MAPK12
- genomics-online: shRNA clones - Search results for 131 available MAPK12 gene related products
- Overview of 131 available MAPK12 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK12 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MAPK12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK12
- Applied Biological Materials Clones for MAPK12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK12
-
ViGene Biosciences adenoviral particle packaged cDNA for MAPK12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK12 gene
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK12 Gene
Localization for MAPK12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK12 Gene
- Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Cytosol (2)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for MAPK12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
.59
|
.48
.43
.36
|
| 2 | 4-1BB Pathway |
.54
.54
|
.36
.30
|
| 3 | GPCR Pathway |
.73
.62
|
.55
|
| 4 | RET signaling | ||
| 5 | Toll-like receptor signaling pathway | ||
Pathways by source for MAPK12 Gene
4 Sino Biological pathways for MAPK12 Gene
16 BioSystems pathways for MAPK12 Gene
20 Reactome pathways for MAPK12 Gene
1 PharmGKB pathway for MAPK12 Gene
24 GeneGo (Thomson Reuters) pathways for MAPK12 Gene
10 R&D Systems pathways for MAPK12 Gene
4 Tocris pathways for MAPK12 Gene
104 Qiagen pathways for MAPK12 Gene
1 Cell Signaling Technology pathway for MAPK12 Gene
Interacting Proteins for MAPK12 Gene
Selected Interacting proteins:
ENSP00000215659
P53778-MK12_HUMAN
for MAPK12 Gene via
STRING
IID
UniProtKB
SIGNOR curated interactions for MAPK12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006975 | DNA damage induced protein phosphorylation | TAS | 10848581 |
Drugs & Compounds for MAPK12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pirfenidone | Approved, Investigational | Pharma | inhibitor | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 65 | |
| Magnesium | Approved | Nutra | 0 | |||
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| Phosphonothreonine | Experimental | Pharma | Target | 0 | ||
| KC706 | Investigational | Pharma | Target, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(9) ApexBio Compounds for MAPK12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BIRB 796 (Doramapimod) | P38 MAPK inhibitor,cell permeable and highly selective | 285983-48-4 |
| Losmapimod | 585543-15-3 | |
| LY2228820 | P38 MAP kinase inhibitor | 862507-23-1 |
| PH-797804 | P38 MAP kinase inhibitor, potent and selective | 586379-66-0 |
| SB 203580 | P38 MAP kinase inhibitor | 152121-47-6 |
| SB202190 (FHPI) | P38 MAPK inhibitor | 152121-30-7 |
| Skepinone-L | P38-MAPK inhibitor,potent and selective | 1221485-83-1 |
| TAK-715 | p38 MAPK inhibitor | 303162-79-0 |
| VX-702 | P38α MAPK inhibitor,highly selective and ATP-competitive | 479543-46-9 |
Transcripts for MAPK12 Gene
mRNA/cDNA for MAPK12 Gene
- (150) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAPK12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MAPK12
- genomics-online: gRNA clones - Search results for 131 available MAPK12 gene related products
- Overview of 131 available MAPK12 gene related products
- Applied Biological Materials CRISPR for MAPK12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK12
- GenScript: Design CRISPR guide RNA sequences for MAPK12
miRNA Products
- Search ViGene Biosciences for MAPK12
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MAPK12
- Browse OriGene Inhibitory RNA Products For MAPK12
- genomics-online: shRNA clones - Search results for 131 available MAPK12 gene related products
- Overview of 131 available MAPK12 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK12 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MAPK12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK12
- Applied Biological Materials Clones for MAPK12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 15b | ^ | 16 |
|---|---|---|---|
| SP1: | - | ||
| SP2: | - | ||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: |
Expression for MAPK12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for MAPK12 Gene
This gene is overexpressed in Muscle - Skeletal (x15.0).
This gene is overexpressed in Tonsil (29.1) and Peripheral blood mononuclear cells (26.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK12 Gene
NURSA nuclear receptor signaling pathways regulating expression of MAPK12 Gene:
MAPK12SOURCE GeneReport for Unigene cluster for MAPK12 Gene:
Hs.432642mRNA Expression by UniProt/SwissProt for MAPK12 Gene:
P53778-MK12_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle and heart.
Evidence on tissue expression from TISSUES for MAPK12 Gene
- Muscle(4.6)
- Heart(4.3)
- Pancreas(4.2)
- Nervous system(3.6)
- Blood(2.3)
Primer Products
-
OriGene qPCR primer pairs for MAPK12
-
OriGene qPCR primer pairs and template standards for MAPK12
- genomics-online: primer clones - Search results for 131 available MAPK12 gene related products
- Overview of 131 available MAPK12 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK12 Gene
Orthologs for MAPK12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK12 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MAPK12 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MAPK12 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mapk12 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mapk12 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK12 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MAPK12 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MAPK12 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mapk12 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mapk12a 34 |
|
OneToMany | |
| mapk12b 33 34 |
|
||||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Mpk2 35 |
|
|
|
| p38b 35 |
|
|
|||
| p38c 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | pmk-1 35 |
|
|
|
| pmk-3 35 |
|
|
|||
| F09C12.2 35 |
|
|
|||
| Y51B9A.9 35 |
|
|
- Species where no ortholog for MAPK12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MAPK12 Gene
(49) SIMAP similar genes for MAPK12 Gene using alignment to 4 proteins:
- DKFZp686M02159
- MAPK14
- MAPK13
- MAPK11
- DKFZp686O0215
- MAPK1
- MAPK9
- MAPK3
- MAPK10
- MAPK8
- MAPK7
- MAPK4
- MAPK15
- NLK
- CDKL4
- RPS6KA2
- CDKL3
- CDKL1
- MOK
- CDKL2
- CDK20
- CDK11B
- CDK11A
- CDC2L2
- CDC2L1
- DKFZp686D0638
- CDKL5
- CDC2
- CSNK2A2
- MAK
- CDK12
- ICK
- GSK3B
- CDK1
- CDK9
- CDK7
- CDK6
- GSK3A
- DKFZp686L20222
- CSNK2A1
- CDK10
- PCTK3
- CDK5
- CDK3
- CDK15
- CDK17
- CDK16
- PCTK1
- CDK14
Variants for MAPK12 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000296740 | -- | 50,260,130(-) | G/A | intron_variant | |
| rs1000851417 | -- | 50,257,011(-) | G/A | intron_variant | |
| rs1001030467 | -- | 50,263,326(-) | C/G | upstream_transcript_variant | |
| rs1001294966 | -- | 50,262,995(-) | A/G | upstream_transcript_variant | |
| rs1001321934 | -- | 50,259,198(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.52;
71.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAPK12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAPK12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK12 Gene
Disorders for MAPK12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
Search MAPK12 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MK12_HUMAN- Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is preferentially associated with basal-like and metastatic phenotypes of breast tumor samples.
Additional Disease Information for MAPK12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MAPK12 Gene
Publications for MAPK12 Gene
- Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PMID: 9169156) Goedert M … Clegg S (Genomics 1997) 2 3 4 22 58
- Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PMID: 11991731) Court NW … Bogoyevitch MA (Journal of molecular and cellular cardiology 2002) 3 4 22 58
- Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PMID: 10848581) Wang X … Han J (Molecular and cellular biology 2000) 3 4 22 58
- Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PMID: 10212242) Hasegawa M … Goedert M (The Journal of biological chemistry 1999) 3 4 22 58
- ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PMID: 8633070) Lechner C … Ullrich A (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 22 58
Products for MAPK12 Gene
- R&D Systems Antibodies for MAPK12 (p38 gamma)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for MAPK12 (p38 gamma)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
- Browse cDNA Clones
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAPK12
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MAPK12
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK12
- Origene Custom Protein Services for MAPK12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK12
- Browse OriGene Inhibitory RNA Products For MAPK12
- OriGene qPCR primer pairs and template standards for MAPK12
- OriGene qPCR primer pairs for MAPK12
- OriGene CRISPR knockouts for MAPK12
- OriGene ORF clones in human for MAPK12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAPK12
- GenScript: Next-day shipping of latest version cDNA ORF clones for MAPK12 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MAPK12
- GenScript Custom Assay Services for MAPK12
- GenScript Custom overexpressing Cell Line Services for MAPK12
- GenScript: Design CRISPR guide RNA sequences for MAPK12
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAPK12
- Browse Sino Biological cDNA Clones
- Sino Biological Cell Lysates for MAPK12
- Sino Biological Recombinant Proteins for MAPK12
- Sino Biological Antibodies for MAPK12
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MAPK12
- Novus Biologicals lysates and proteins for MAPK12
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MAPK12
- Abcam proteins for MAPK12
- Abcam assays for MAPK12
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for MAPK12
- Cloud-Clone Corp. Antibodies for MAPK12
- Cloud-Clone Corp. Proteins for MAPK12
- Cloud-Clone Corp. Assay Kits for MAPK12
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for MAPK12
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MAPK12
- ApexBio compounds for MAPK12
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK12
- VectorBuilder custom plasmid, inducible vectors for MAPK12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK12
- antibodies-online: Search results for 115 available MAPK6 Antibodies ranked by validation data
- Compare Top MAPK6 Antibodies
- antibodies-online: Search results for 5 available MAPK6 Elisa Kits ranked by validation data
- Compare Top MAPK6 Elisa Kits
- Recommended
- antibodies-online: Search results for 10 available MAPK6 Proteins ranked by validation data
- Compare Top MAPK6 Proteins
- Search GeneTex for Antibodies for MAPK12
- Search GeneTex for Proteins for MAPK12
- ViGene Biosciences adenoviral particle packaged cDNA for MAPK12 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MAPK12 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MAPK12 gene
- Search ViGene Biosciences for MAPK12
- Santa Cruz Biotechnology (SCBT) Antibodies for MAPK12
- Search Santa Cruz Biotechnology (SCBT) for MAPK12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAPK12
- Horizon Cell Lines for MAPK12
- genomics-online: cdna clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- orf clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- genomics-online: gRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- genomics-online: primer clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
- genomics-online: shRNA clones - Search results for 131 available MAPK6 gene related products
- Overview of 131 available MAPK6 gene related products
Sources for MAPK12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems