MAPK12 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 12

GC22M050246
GIFtS:
48
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008] See more...

Aliases for MAPK12 Gene

Aliases for MAPK12 Gene

  • Mitogen-Activated Protein Kinase 12 2 3 4 5
  • ERK6 2 3 4
  • Mitogen-Activated Protein Kinase P38 Gamma 3 4
  • Extracellular Signal-Regulated Kinase 6 3 4
  • Stress-Activated Protein Kinase 3 3 4
  • MAP Kinase P38 Gamma 3 4
  • MAP Kinase 12 3 4
  • EC 2.7.11.24 4 51
  • MAPK 12 3 4
  • PRKM12 2 3
  • SAPK-3 2 3
  • ERK-6 3 4
  • SAPK3 3 4
  • Mitogen-Activated Protein Kinase 3 3
  • EC 2.7.11 51
  • P38GAMMA 3
  • P38gamma 2
  • MAPK12 5
  • ERK3 3

External Ids for MAPK12 Gene

Previous HGNC Symbols for MAPK12 Gene

  • SAPK3

Previous GeneCards Identifiers for MAPK12 Gene

  • GC22M047242
  • GC22M048873
  • GC22M048993
  • GC22M049033
  • GC22M050684

Summaries for MAPK12 Gene

Entrez Gene Summary for MAPK12 Gene

  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK12 Gene

MAPK12 (Mitogen-Activated Protein Kinase 12) is a Protein Coding gene. Diseases associated with MAPK12 include Breast Cancer. Among its related pathways are ATM Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK13.

UniProtKB/Swiss-Prot Summary for MAPK12 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

Gene Wiki entry for MAPK12 Gene

Additional gene information for MAPK12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK12 Gene

Genomics for MAPK12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK12

Top Transcription factor binding sites by QIAGEN in the MAPK12 gene promoter:
  • CRE-BP1
  • NF-kappaB
  • NF-kappaB1
  • p53
  • STAT3

Genomic Locations for MAPK12 Gene

Genomic Locations for MAPK12 Gene
chr22:50,245,450-50,261,810
(GRCh38/hg38)
Size:
16,361 bases
Orientation:
Minus strand
chr22:50,683,879-50,700,254
(GRCh37/hg19)
Size:
16,376 bases
Orientation:
Minus strand

Genomic View for MAPK12 Gene

Genes around MAPK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK12 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK12 Gene

Proteins for MAPK12 Gene

Products:

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  3. Assay

  • Protein details for MAPK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53778-MK12_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 12
    Protein Accession:
    P53778
    Secondary Accessions:
    • Q14260
    • Q6IC53
    • Q99588
    • Q99672

    Protein attributes for MAPK12 Gene

    Size:
    367 amino acids
    Molecular mass:
    41940 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP (By similarity). Interacts with PTPN4; this interaction induces the activation of PTPN4 phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for MAPK12 Gene

    Alternative splice isoforms for MAPK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK12 Gene

Protein Expression for MAPK12 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK12 Gene

P53778:
  • QTVDIWSVGCIMAE
  • LVYQMLKGL
  • EMTGYVVTRWYRAPEVIL
  • ILDFGLA
  • YRELRLLKHM
  • AKRAYRE
  • AVNEDCEL
  • DIWSVGCI
  • DFYLVMPFMGTDLGKLMK
  • HENVIGLLD
  • LDFGLAR
  • LLDVFTP
  • VGSGAYG
  • TRWYRAPE
  • HRDLKPGN
  • LKILDFGLAR

Post-translational modifications for MAPK12 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme.
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for MAPK12
  • Abcam proteins for MAPK12

Domains & Families for MAPK12 Gene

Gene Families for MAPK12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for MAPK12 Gene

InterPro:
Blocks:
  • MAP kinase
  • P38 MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK12 Gene

GenScript: Design optimal peptide antigens:
  • Stress-activated protein kinase 3 (MK12_HUMAN)
  • MAPK12 protein (Q6IC53_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53778

UniProtKB/Swiss-Prot:

MK12_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK12: view

Function for MAPK12 Gene

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Molecular function for MAPK12 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:10212242};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:10212242};.
UniProtKB/Swiss-Prot Induction:
Expression of MAPK12 is down-regulation by MAPK14 activation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=37 uM for ATP {ECO:0000269|PubMed:10212242}; KM=313 uM for EGFR substrate peptide {ECO:0000269|PubMed:10212242}; KM=254 uM for GST-ATF2 {ECO:0000269|PubMed:10212242};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha.
GENATLAS Biochemistry:
mitogen-activated protein kinase 12

Enzyme Numbers (IUBMB) for MAPK12 Gene

Phenotypes From GWAS Catalog for MAPK12 Gene

Gene Ontology (GO) - Molecular Function for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 10508788
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS 18221368
GO:0004707 MAP kinase activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with MAPK12: view
genes like me logo Genes that share phenotypes with MAPK12: view

Animal Models for MAPK12 Gene

MGI Knock Outs for MAPK12:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK12

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK12

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK12 Gene

Localization for MAPK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK12 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK12 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK12: view

Pathways & Interactions for MAPK12 Gene

PathCards logo

SuperPathways for MAPK12 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
2 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CMV and MAPK Pathways
.46
NF-KappaB Activation by EBV
.42
PKR Pathway
.36
SUMO Pathway
.30
3 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
4 RET signaling
Signalling to ERKs
.95
Signalling to RAS
.95
NGF signalling via TRKA from the plasma membrane
.87
Signalling by NGF
.81
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
5 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
Chagas disease (American trypanosomiasis)
.31
genes like me logo Genes that share pathways with MAPK12: view

Pathways by source for MAPK12 Gene

1 PharmGKB pathway for MAPK12 Gene
24 GeneGo (Thomson Reuters) pathways for MAPK12 Gene
  • Cell adhesion_Plasmin signaling
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Development A1 receptor signaling
  • Development A2A receptor signaling
  • Development A2B receptor- action via G-protein alpha s
104 Qiagen pathways for MAPK12 Gene
  • 14-3-3 and Cell Cycle Regulation
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for MAPK12 Gene

SIGNOR curated interactions for MAPK12 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006975 DNA damage induced protein phosphorylation TAS 10848581
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest TAS 10848581
genes like me logo Genes that share ontologies with MAPK12: view

Drugs & Compounds for MAPK12 Gene

Products:

  1. Drug

(29) Drugs for MAPK12 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Pirfenidone Approved, Investigational Pharma inhibitor TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 86
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
Phosphonothreonine Experimental Pharma Target 0

(2) Additional Compounds for MAPK12 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(9) ApexBio Compounds for MAPK12 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
genes like me logo Genes that share compounds with MAPK12: view

Drug Products

Transcripts for MAPK12 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK12 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK12

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - - -
SP10: - - -
SP11: -
SP12: -
SP13:

ExUns: 15b ^ 16
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MAPK12 Gene

GeneLoc Exon Structure for
MAPK12

Expression for MAPK12 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK12 Gene

mRNA expression in normal human tissues for MAPK12 Gene
mRNA expression by GTEx for MAPK12 GenemRNA expression by BioGPS for MAPK12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK12 Gene

This gene is overexpressed in Muscle - Skeletal (x15.0).

Protein differential expression in normal tissues from HIPED for MAPK12 Gene

This gene is overexpressed in Tonsil (29.1) and Peripheral blood mononuclear cells (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK12 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK12

SOURCE GeneReport for Unigene cluster for MAPK12 Gene:

Hs.432642

mRNA Expression by UniProt/SwissProt for MAPK12 Gene:

P53778-MK12_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for MAPK12 Gene

  • Muscle(4.7)
  • Heart(4.5)
  • Pancreas(4.4)
  • Nervous system(3.9)
  • Blood(3.1)
  • Kidney(2.3)
  • Intestine(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MAPK12: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK12 Gene

Orthologs for MAPK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK12 30 31
  • 93.55 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK12 30 31
  • 90.64 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPK12 30 31
  • 90.19 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk12 30
  • 86.56 (n)
Mouse
(Mus musculus)
 Mammalia Mapk12 30 17 31
  • 86.01 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPK12 31
  • 85 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MAPK12 30 31
  • 73.82 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPK12 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapk12 30
  • 70.44 (n)
Zebrafish
(Danio rerio)
 Actinopterygii mapk12a 31
  • 69 (a)
 OneToMany
mapk12b 30 31
  • 67.13 (n)
 OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Mpk2 32
  • 58 (a)
p38b 32
  • 57 (a)
p38c 32
  • 39 (a)
Worm
(Caenorhabditis elegans)
 Secernentea pmk-1 32
  • 58 (a)
pmk-3 32
  • 41 (a)
F09C12.2 32
  • 37 (a)
Y51B9A.9 32
  • 32 (a)
Species where no ortholog for MAPK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPK12 Gene

ENSEMBL:
Gene Tree for MAPK12 (if available)
TreeFam:
Gene Tree for MAPK12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK12: view image

Paralogs for MAPK12 Gene

Paralogs for MAPK12 Gene

(49) SIMAP similar genes for MAPK12 Gene using alignment to 4 proteins:

  • MK12_HUMAN
  • A8MY48_HUMAN
  • B5MDL5_HUMAN
  • Q6IC53_HUMAN
genes like me logo Genes that share paralogs with MAPK12: view

Variants for MAPK12 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK12 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
720967 Likely Benign: not provided 50,261,240(-) G/A MISSENSE_VARIANT
rs2066776 - p.Thr244Met
rs34422484 - p.Thr103Met
rs35396905 - p.Asp230Asn

Additional dbSNP identifiers (rs#s) for MAPK12 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK12 Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv1066496 CNV loss 25217958
nsv471223 CNV loss 18288195
nsv955199 CNV deletion 24416366

Variation tolerance for MAPK12 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK12 Gene

Disorders for MAPK12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPK12 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MK12_HUMAN
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is preferentially associated with basal-like and metastatic phenotypes of breast tumor samples.

Additional Disease Information for MAPK12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPK12: view

No data available for Genatlas for MAPK12 Gene

Publications for MAPK12 Gene

  1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PMID: 9169156) Goedert M … Clegg S (Genomics 1997) 2 3 4 23
  2. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PMID: 11991731) Court NW … Bogoyevitch MA (Journal of molecular and cellular cardiology 2002) 3 4 23
  3. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PMID: 10848581) Wang X … Han J (Molecular and cellular biology 2000) 3 4 23
  4. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PMID: 10212242) Hasegawa M … Goedert M (The Journal of biological chemistry 1999) 3 4 23
  5. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PMID: 8633070) Lechner C … Ullrich A (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23

ExternalLinks

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