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Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
MAPK12 (Mitogen-Activated Protein Kinase 12) is a Protein Coding gene. Diseases associated with MAPK12 include Breast Cancer. Among its related pathways are ATM Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 10508788 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | TAS | 18221368 |
GO:0004707 | MAP kinase activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
|
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
|
2 | 4-1BB Pathway |
4-1BB Pathway
.54
CD40 Signaling
.54
CMV and MAPK Pathways
.46
|
NF-KappaB Activation by EBV
.42
PKR Pathway
.36
SUMO Pathway
.30
|
3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
4 | RET signaling | ||
5 | Toll-like Receptor Signaling Pathway |
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006975 | DNA damage induced protein phosphorylation | TAS | 10848581 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007050 | cell cycle arrest | TAS | 10848581 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Pirfenidone | Approved, Investigational | Pharma | inhibitor | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 86 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
Phosphonothreonine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
BIRB 796 (Doramapimod) | P38 MAPK inhibitor,cell permeable and highly selective | 285983-48-4 |
Losmapimod | 585543-15-3 | |
LY2228820 | P38 MAP kinase inhibitor | 862507-23-1 |
PH-797804 | P38 MAP kinase inhibitor, potent and selective | 586379-66-0 |
SB 203580 | P38 MAP kinase inhibitor | 152121-47-6 |
SB202190 (FHPI) | P38 MAPK inhibitor | 152121-30-7 |
Skepinone-L | P38-MAPK inhibitor,potent and selective | 1221485-83-1 |
TAK-715 | p38 MAPK inhibitor | 303162-79-0 |
VX-702 | P38α MAPK inhibitor,highly selective and ATP-competitive | 479543-46-9 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 15b | ^ | 16 |
---|---|---|---|
SP1: | - | ||
SP2: | - | ||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: | |||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MAPK12 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MAPK12 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MAPK12 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mapk12 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mapk12 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MAPK12 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MAPK12 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MAPK12 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mapk12 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mapk12a 31 |
|
OneToMany | |
mapk12b 30 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mpk2 32 |
|
|
|
p38b 32 |
|
|
|||
p38c 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | pmk-1 32 |
|
|
|
pmk-3 32 |
|
|
|||
F09C12.2 32 |
|
|
|||
Y51B9A.9 32 |
|
|
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
720967 | Likely Benign: not provided | 50,261,240(-) | G/A | MISSENSE_VARIANT | |
rs2066776 | - | p.Thr244Met | |||
rs34422484 | - | p.Thr103Met | |||
rs35396905 | - | p.Asp230Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|