MAPK10 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 10

GC04M085990
GIFtS:
51
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is a... See more...

Aliases for MAPK10 Gene

Aliases for MAPK10 Gene

  • Mitogen-Activated Protein Kinase 10 2 3 4 5
  • JNK3 2 3 4
  • Stress-Activated Protein Kinase JNK3 3 4
  • Stress-Activated Protein Kinase 1b 3 4
  • C-Jun N-Terminal Kinase 3 3 4
  • MAP Kinase P49 3F12 3 4
  • MAP Kinase 10 3 4
  • EC 2.7.11.24 4 51
  • P54bSAPK 2 3
  • P493F12 2 3
  • PRKM10 3 4
  • SAPK1b 3 4
  • JNK3A 3 4
  • Stress Activated Protein Kinase Beta 3
  • JNK3 Alpha Protein Kinase 3
  • EC 2.7.11 51
  • MAPK 10 4
  • MAPK10 5
  • SAPK1B 4

External Ids for MAPK10 Gene

Previous HGNC Symbols for MAPK10 Gene

  • PRKM10

Previous GeneCards Identifiers for MAPK10 Gene

  • GC04M086878
  • GC04M087239
  • GC04M087396
  • GC04M087294
  • GC04M087156
  • GC04M082680
  • GC04M086936
  • GC04M086013

Summaries for MAPK10 Gene

Entrez Gene Summary for MAPK10 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

GeneCards Summary for MAPK10 Gene

MAPK10 (Mitogen-Activated Protein Kinase 10) is a Protein Coding gene. Diseases associated with MAPK10 include Lennox-Gastaut Syndrome and Pertussis. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK8.

UniProtKB/Swiss-Prot Summary for MAPK10 Gene

  • Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296).

Tocris Summary for MAPK10 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK10 Gene

Additional gene information for MAPK10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK10 Gene

Genomics for MAPK10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J086592 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 605.3 -0.3 -276 5.4 SP1 CTCF TEAD4 PRDM10 ZNF629 RFX1 RFX5 ZNF692 POLR2A BACH1 PTPN13 MAPK10 lnc-SLC10A6-4 ENSG00000248196 ENSG00000251411 HSD17B13 LOC107986189 SLC10A6
GH04J086357 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 +235.9 235924 4.6 CREB1 RFX1 LARP7 ZSCAN4 POLR2A RCOR1 PKNOX1 ZSCAN29 RAD21 DPF2 MAPK10 ENSG00000251411 lnc-PTPN13-3 piR-31937-157 PTPN13 lnc-SLC10A6-4 ARHGAP24
GH04J086451 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 +141.7 141725 3.1 FOXA1 ZIC2 CTBP1 YY1 PKNOX1 ZNF217 GATA3 DPF2 ELF1 KLF17 MAPK10 PTPN13 piR-31937-157 lnc-PTPN13-3 lnc-SLC10A6-4 ARHGAP24
GH04J086220 Promoter/Enhancer 0.5 EPDnew ENCODE 600 +373.4 373375 0.6 MAPK10 piR-60985-081 HSALNG0035658 PTPN13 lnc-SLC10A6-4 ARHGAP24
GH04J085827 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.2 +766.0 766016 2.8 ZNF692 FOXA1 GABPA ZNF776 ZSCAN4 PATZ1 ZNF501 ZNF600 ZNF148 SCRT2 ARHGAP24 MAPK10 WDFY3-AS2 piR-48222-254 piR-39904-015 PTPN13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK10

Top Transcription factor binding sites by QIAGEN in the MAPK10 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for MAPK10 Gene

Genomic Locations for MAPK10 Gene
chr4:85,990,007-86,594,625
(GRCh38/hg38)
Size:
604,619 bases
Orientation:
Minus strand
chr4:86,936,276-87,515,284
(GRCh37/hg19)
Size:
579,009 bases
Orientation:
Minus strand

Genomic View for MAPK10 Gene

Genes around MAPK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK10 Gene

Proteins for MAPK10 Gene

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  • Protein details for MAPK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53779-MK10_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 10
    Protein Accession:
    P53779
    Secondary Accessions:
    • A6NFS3
    • A6NG28
    • B3KQ94
    • Q15707
    • Q49AP1

    Protein attributes for MAPK10 Gene

    Size:
    464 amino acids
    Molecular mass:
    52585 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAPKBP1 (By similarity). Interacts with MAPK8IP1/JIP-1 and MAPK8IP3/JIP-3/JSAP1 (By similarity). Interacts with SPAG9/MAPK8IP4/JIP4 (PubMed:15693750). Interacts with HDAC9 (PubMed:16611996). Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5 (PubMed:18435604). Interacts with SARM1 (By similarity). Interacts with JUND; interaction is inhibited in the presence of MEN1 (PubMed:22327296).
    SequenceCaution:
    • Sequence=BAG51956.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK10 Gene

    Alternative splice isoforms for MAPK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK10 Gene

Protein Expression for MAPK10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK10 Gene

P53779:
  • PIGSGAQGIVC
  • YVENRPKY
  • MTPYVVTRYYRAPEVI
  • TVRNYVENR
  • IDQWNKV
  • DKQLDEREH
  • VNHKNII
  • KELIYKE
  • ILDFGLA
  • HSAGIIHRDLKPSN
  • RISVDDAL
  • LLNVFTPQK
  • KKLSRPFQ
  • LLSKMLVID
  • EFMKKLQPTVR
  • AKRAYRE
  • DSTFTVLKRYQ
  • LEEFQDVY
  • RDLLSKML
  • EAPPPQIYD
  • LLSKMLV
  • QARDLLS
  • VGCIMGE
  • DIWSVGCI
  • SYLLYQMLCG
  • LDFGLAR
  • VMELMDANLC
  • YINVWYD
  • LKILDFGLAR

Post-translational modifications for MAPK10 Gene

  • Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro.
  • Palmitoylation regulates subcellular location and axonal development.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAPK10

Domains & Families for MAPK10 Gene

Gene Families for MAPK10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for MAPK10 Gene

InterPro:
Blocks:
  • MAP kinase
  • JNK MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ42801 fis, clone BRCAN2001223, highly similar to Mitogen-activated protein kinase 10 (EC 2.7.11.24) (A6NG28_HUMAN)
  • c-Jun N-terminal kinase 3 (MK10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53779

UniProtKB/Swiss-Prot:

MK10_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK10: view

Function for MAPK10 Gene

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Molecular function for MAPK10 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.

Enzyme Numbers (IUBMB) for MAPK10 Gene

Phenotypes From GWAS Catalog for MAPK10 Gene

Gene Ontology (GO) - Molecular Function for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004705 JUN kinase activity TAS,ISS 8654373
GO:0004707 MAP kinase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with MAPK10: view
genes like me logo Genes that share phenotypes with MAPK10: view

Human Phenotype Ontology for MAPK10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPK10 Gene

MGI Knock Outs for MAPK10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK10

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for MAPK10 Gene

Localization for MAPK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK10 Gene

Cytoplasm. Membrane. Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 4
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK10 Gene

Pathways & Interactions for MAPK10 Gene

PathCards logo

SuperPathways for MAPK10 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
2 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-2 Pathway
.48
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
3 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
NF-KappaB Activation by EBV
.42
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
4 Toll-Like receptor Signaling Pathways
NOD-like Receptor Signaling Pathways
.59
Toll-Like receptor Signaling Pathways
.59
Inflammasome Activation Pathways
.51
IL-1 Family Signaling Pathways
.43
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with MAPK10: view

Pathways by source for MAPK10 Gene

3 Sino Biological pathways for MAPK10 Gene
1 PharmGKB pathway for MAPK10 Gene
34 GeneGo (Thomson Reuters) pathways for MAPK10 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
107 Qiagen pathways for MAPK10 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Agrin Interactions at Neuromuscular Junction
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for MAPK10 Gene
1 GeneTex pathway for MAPK10 Gene

SIGNOR curated interactions for MAPK10 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007165 signal transduction TAS 8654373
genes like me logo Genes that share ontologies with MAPK10: view

Drugs & Compounds for MAPK10 Gene

Products:

  1. Drug

(120) Drugs for MAPK10 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Magnesium Approved, Experimental, Investigational Pharma 0
Anisomycin Experimental Pharma JNK agonist, potent and specific, JNK, SAPK and p38 activator 0
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime Experimental Pharma Target 0

(65) Additional Compounds for MAPK10 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
c-JUN peptide
610273-01-3

(3) Tocris Compounds for MAPK10 Gene

Compound Action Cas Number
Anisomycin JNK, SAPK and p38 activator 22862-76-6
CEP 1347 Inhibitor of JNK signaling 156177-65-0
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3

(20) ApexBio Compounds for MAPK10 Gene

Compound Action Cas Number
AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis 63735-71-7
Anisomycin JNK agonist, potent and specific 22862-76-6
AS 602801 Jun Kinase Inhibitor 848344-36-5
AS601245 c-Jun NH2-terminal protein kinase inhibitor 345987-15-7
BI 78D3 Competitive JNK inhibitor 883065-90-5
CC-401 JNK inhibitor,ATP-competitive 395104-30-0
CC-401 hydrochloride JNK inhibitor 1438391-30-0
CC-930 JNK inhibitor,potent and selective 899805-25-5
CEP 1347 JNK inhibitor 156177-65-0
DTP3 inhibitor of GADD45β/MKK7 complex
IQ 3 312538-03-7
JIP-1 (153-163) 438567-88-5
JNK-IN-7 Selective JNK inhibitor 1408064-71-0
JNK-IN-8 JNK inhibitor, selective and irreversible 1410880-22-6
PF-03394197(Oclacitinib) Novel Janus kinase inhibitor 1208319-26-9
SP 600125 JNK1/2/3 inhibitor 129-56-6
SR 3576 1164153-22-3
SU 3327 40045-50-9
TCS JNK 5a JNK2 and JNK3 inhibitor 312917-14-9
TCS JNK 6o JNK inhibitor 894804-07-0
genes like me logo Genes that share compounds with MAPK10: view

Drug Products

Transcripts for MAPK10 Gene

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mRNA/cDNA for MAPK10 Gene

10 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
192 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10:
SP11: -

Relevant External Links for MAPK10 Gene

GeneLoc Exon Structure for
MAPK10

Expression for MAPK10 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK10 Gene

mRNA expression in normal human tissues for MAPK10 Gene
mRNA expression by GTEx for MAPK10 GenemRNA expression by BioGPS for MAPK10 Gene

mRNA differential expression in normal tissues according to GTEx for MAPK10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for MAPK10 Gene

This gene is overexpressed in Heart (33.0), Frontal cortex (16.5), Testis (8.6), and Retina (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK10 Gene



Protein tissue co-expression partners for MAPK10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK10

SOURCE GeneReport for Unigene cluster for MAPK10 Gene:

Hs.125503

mRNA Expression by UniProt/SwissProt for MAPK10 Gene:

P53779-MK10_HUMAN
Tissue specificity: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.

Evidence on tissue expression from TISSUES for MAPK10 Gene

  • Nervous system(5)
  • Kidney(2.6)
  • Heart(2.6)
  • Blood(2.5)
  • Adrenal gland(2.5)
  • Muscle(2.4)
  • Eye(2.3)
  • Thyroid gland(2.3)
  • Liver(2.3)
  • Intestine(2.2)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK10 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
genes like me logo Genes that share expression patterns with MAPK10: view

Orthologs for MAPK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK10 30 31
  • 99.86 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MAPK10 31
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MAPK10 30 31
  • 94.13 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MAPK10 31
  • 94 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MAPK10 30 31
  • 93.89 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mapk10 30 17 31
  • 91.74 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mapk10 30
  • 91.67 (n)
Chicken
(Gallus gallus)
 Aves MAPK10 30 31
  • 86.85 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MAPK10 31
  • 98 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mapk10 30
  • 85.89 (n)
Str.13873 30
Zebrafish
(Danio rerio)
 Actinopterygii mapk10 30 31
  • 81.26 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta bsk 31 32
  • 77 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea jnk-1 31 32
  • 57 (a)
 OneToMany
F09C12.2 32
  • 35 (a)
Y51B9A.9 32
  • 35 (a)
C49C3.10b 32
  • 33 (a)
C49C3.10a 32
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HOG1 31
  • 34 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 61 (a)
 OneToMany
Species where no ortholog for MAPK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MAPK10 Gene

ENSEMBL:
Gene Tree for MAPK10 (if available)
TreeFam:
Gene Tree for MAPK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAPK10: view image

Paralogs for MAPK10 Gene

Paralogs for MAPK10 Gene

(40) SIMAP similar genes for MAPK10 Gene using alignment to 15 proteins:

  • MK10_HUMAN
  • A8MPV1_HUMAN
  • A8MWW6_HUMAN
  • D6R9C1_HUMAN
  • D6RAJ0_HUMAN
  • D6RAU3_HUMAN
  • D6RBH2_HUMAN
  • D6RC26_HUMAN
  • D6RCB1_HUMAN
  • D6RDG1_HUMAN
  • D6RFX8_HUMAN
  • D6RFZ7_HUMAN
  • D6RJF9_HUMAN
  • H0Y9H3_HUMAN
  • Q499Y8_HUMAN
genes like me logo Genes that share paralogs with MAPK10: view

Variants for MAPK10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAPK10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
747293 Likely Benign: not provided 86,067,828(-) G/C SYNONYMOUS_VARIANT
763905 Likely Benign: not provided 86,107,241(-) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
764533 Likely Benign: not provided 86,101,176(-) T/C SYNONYMOUS_VARIANT
793018 Likely Benign: not provided 86,194,378(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
rs116053658 Benign/Likely Benign: Epileptic encephalopathy; not provided 86,064,323(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MAPK10 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAPK10 Gene

Variant ID Type Subtype PubMed ID
dgv1508e212 CNV loss 25503493
dgv1509e212 CNV loss 25503493
dgv25e194 CNV deletion 18987734
dgv2844n106 CNV deletion 24896259
dgv5332n100 CNV loss 25217958
dgv5333n100 CNV loss 25217958
dgv5334n100 CNV loss 25217958
dgv660n27 CNV loss 19166990
dgv9146n54 CNV loss 21841781
dgv9147n54 CNV loss 21841781
dgv9148n54 CNV loss 21841781
dgv9149n54 CNV loss 21841781
dgv9150n54 CNV loss 21841781
dgv9151n54 CNV loss 21841781
esv1427548 CNV insertion 17803354
esv2422128 CNV deletion 20811451
esv26690 CNV loss 19812545
esv2670758 CNV deletion 23128226
esv2678617 CNV deletion 23128226
esv2727930 CNV deletion 23290073
esv2727931 CNV deletion 23290073
esv2727932 CNV deletion 23290073
esv2727933 CNV deletion 23290073
esv2759263 CNV loss 17122850
esv2760917 CNV loss 21179565
esv2763374 CNV gain 21179565
esv2763854 CNV loss 21179565
esv29871 CNV gain 19812545
esv3564185 CNV deletion 23714750
esv3564186 CNV deletion 23714750
esv3564187 CNV deletion 23714750
esv3601253 CNV loss 21293372
esv3601254 CNV loss 21293372
esv5249 CNV loss 18987735
nsv1003585 CNV loss 25217958
nsv1005338 CNV loss 25217958
nsv1007891 CNV loss 25217958
nsv1008773 CNV loss 25217958
nsv1011494 CNV loss 25217958
nsv1014691 CNV loss 25217958
nsv10529 CNV loss 18304495
nsv1073348 CNV deletion 25765185
nsv1109619 CNV deletion 24896259
nsv1148441 CNV deletion 26484159
nsv1161116 CNV deletion 26073780
nsv291104 CNV deletion 16902084
nsv4408 CNV insertion 18451855
nsv442912 CNV loss 18776908
nsv461574 CNV loss 19166990
nsv471766 CNV loss 16327809
nsv477508 CNV novel sequence insertion 20440878
nsv511259 CNV loss 21212237
nsv513143 CNV loss 21212237
nsv514230 CNV loss 21397061
nsv515925 CNV loss 19592680
nsv517318 CNV loss 19592680
nsv594760 CNV loss 21841781
nsv594761 CNV loss 21841781
nsv594786 CNV gain 21841781
nsv594787 CNV gain 21841781
nsv594788 CNV loss 21841781
nsv818248 CNV loss 17921354
nsv820309 CNV gain 19587683
nsv956395 CNV deletion 24416366

Variation tolerance for MAPK10 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK10 Gene

Human Gene Mutation Database (HGMD)
MAPK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK10 Gene

Disorders for MAPK10 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MAPK10 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lennox-gastaut syndrome
  • lgs
pertussis
  • bordetella infection
opioid abuse
  • opioid-related disorders
pheochromocytoma
  • pcc
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MK10_HUMAN
  • Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. {ECO:0000269 PubMed:16249883}.

Additional Disease Information for MAPK10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MAPK10: view

No data available for Genatlas for MAPK10 Gene

Publications for MAPK10 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S … Davis RJ (The EMBO journal 1996) 2 3 4 23
  2. Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. (PMID: 16249883) Shoichet SA … Kalscheuer VM (Human genetics 2006) 3 4 23
  3. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PMID: 15693750) Jagadish N … Suri A (The Biochemical journal 2005) 3 4 23
  4. Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1. (PMID: 10715136) Lisnock J … LoGrasso P (Biochemistry 2000) 3 4 23
  5. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. (PMID: 7826642) Mohit AA … Miller CA (Neuron 1995) 3 4 23

ExternalLinks

View latest publications for MAPK10 gene in Mastermind

Products for MAPK10 Gene

Sources for MAPK10 Gene