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This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphory... See more...
Aliases for MAPK1 Gene
Aliases for MAPK1 Gene
External Ids for MAPK1 Gene
- HGNC: 6871
- NCBI Entrez Gene: 5594
- Ensembl: ENSG00000100030
- OMIM®: 176948
- UniProtKB/Swiss-Prot: P28482
Previous HGNC Symbols for MAPK1 Gene
- PRKM2
- PRKM1
Previous GeneCards Identifiers for MAPK1 Gene
- GC22M018815
- GC22M020441
- GC22M022108
- GC22M005071
Summaries for MAPK1 Gene
-
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
GeneCards Summary for MAPK1 Gene
MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include Noonan Syndrome 13 and Specific Learning Disability. Among its related pathways are RET signaling and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK3.
UniProtKB/Swiss-Prot Summary for MAPK1 Gene
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
-
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
-
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.
Additional gene information for MAPK1 Gene
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK1 Gene
Genomics for MAPK1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAPK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAPK1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK1
- Top Transcription factor binding sites by QIAGEN in the MAPK1 gene promoter:
-
- ATF-2
- c-Jun
- CREB
- deltaCREB
Genomic Locations for MAPK1 Gene
Latest Assembly
- chr22:21,759,657-21,867,680
- (GRCh38/hg38)
- Size:
- 108,024 bases
- Orientation:
- Minus strand
Previous Assembly
- chr22:22,113,946-22,221,970
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 108,025 bases
- Orientation:
- Minus strand
Genomic View for MAPK1 Gene
Genes around MAPK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by HGNC
- 22q11.22 by Entrez Gene
- 22q11.22 by Ensembl
MAPK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK1 Gene
Proteins for MAPK1 Gene
-
Protein details for MAPK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28482-MK01_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 1
- Protein Accession:
- P28482
- A8CZ64
Protein attributes for MAPK1 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 41390 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds both upstream activators and downstream substrates in multimolecular complexes. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX. Interacts with CDK2AP2. Interacts with CAVIN4 (By similarity). Interacts with DUSP7; the interaction enhances DUSP7 phosphatase activity (PubMed:9788880).
- (Microbial infection) Interacts with HIV-1 Nef through its SH3 domain.
- SequenceCaution:
-
- Sequence=CAA77753.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MAPK1 Gene
Protein Expression for MAPK1 Gene
Selected DME Specific Peptides for MAPK1 Gene
- P28482:
-
- YVATRWYR
- MELDDLPKE
- GCILAEM
- RVAIKKISPFEHQT
- GLKYIHSA
- FPGKHYLDQLN
- AEAPFKF
- GPEMVRGQ
- YQILRGLKY
- IEQMKDV
- ILLRFRHEN
- FDVGPRY
- ALAHPYLEQYYDP
- LKICDFG
- HSANVLHRDL
- LKYIHSA
- TEYVATRWYRAPE
- HRDLKPSNLLLN
- RVAIKKI
- WSVGCILAE
- YRAPEIML
- VLHRDLK
- DDLPKEKLKELI
- DIWSVGCI
- RTLREIK
- YIGEGAYGMV
- KALDLLDKMLTFNPHKRIEVE
- TRWYRAPE
- DVYIVQDLMETDLYKLLK
- WSVGCIL
- NHILGIL
- LKICDFGLAR
- ETARFQPG
Post-translational modifications for MAPK1 Gene
- Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs. Dephosphorylated by DUSP1 at Thr-185 and Tyr-187.
- ISGylated.
-
Ubiquitination at Lys292
- NX_P28482 (NX_P28482-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MAPK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MAPK1 / ERK2 Antibody and MAPK1 / ERK2 Monoclonal Antibody
- G Biosciences Immunotag™ MAPK1 Antibody
- SouthernBiotech Mouse Anti-Human Erk1/2-BIOT, Mouse Anti-Human Erk1/2-HRP, and Mouse Anti-Human Erk1/2-UNLB
- RayBiotech Rabbit anti-Human ERK (p202/204) (Phosph)
-
BioLegend
- ERK2 Antibody
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (675502)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (675503)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369504)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369503)
- Direct-Blot(TM) ERK1/2 Phospho (Thr202/Tyr204) Antibody
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (675504)
- PerCP/Cyanine5.5 ERK1/2 Phospho (Thr202/Tyr204) Antibody (369511)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369513)
- PerCP/Cyanine5.5 ERK1/2 Phospho (Thr202/Tyr204) Antibody (369512)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369510)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369507)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369509)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369506)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369514)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369505)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369508)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (675508)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (675507)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369515)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369518)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369520)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369519)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369516)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369517)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369502)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369501)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369522)
- ERK1/2 Phospho (Thr202/Tyr204) Antibody (369521)
-
Custom Antibody ServicesOriGene Antibodies for MAPK1
- AM00085BT-N
- AM00085PU-N
- AM00086BT-N
- AM00086PU-N
- AM06140PU-N
- AM08381PU-N
- AM09368PU-N
- AM09368PU-S
- AP07464PU-N
- AP09076SU-N
- AP23401PU-N
- AP55841PU-N
- AP55841PU-S
- CF500467
- CF500468
- CF500469
- CF500470
- CF500472
- CF500473
- CF500474
- CF500475
- CF500485
- CF500486
- TA302982
- TA309120
- TA309121
- TA324692
- TA324912
- TA324942
- TA326099
- TA326185
- TA326202
- TA328051
- TA347800
- TA354302
- TA354378
- TA354684
- TA354685
- TA354686
- TA500467
- TA500467S
- TA500468
- TA500468S
- TA500469
- TA500469S
- TA500470
- TA500470S
- TA500472
- TA500472S
- TA500473
- TA500473S
- TA500474
- TA500474S
- TA500475
- TA500475S
- TA500485
- TA500485S
- TA500486
- TA500486S
- TA600063
- TA600064
- TA700062
- TA700063
- TA700064
- Novus Biologicals Antibodies for MAPK1
-
Abcam antibodies for MAPK1
- Invitrogen Antibodies for MAPK1 (AFLGC-MAPK1)
- antibodies-online: Show 219 available ERK2 Antibodies ranked by validation data
- Compare Top ERK2 Antibodies
-
Recommended
- 301 WB Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 3 LMNX Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 126 WB Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 124 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for MAPK1
- mitogen-activated protein kinase 1 [13-090]
- mitogen-activated protein kinase 1 [13-950]
- mitogen-activated protein kinase 1 [19-110]
- mitogen-activated protein kinase 1 [48-785]
- mitogen-activated protein kinase 1 [45-551]
- mitogen-activated protein kinase 1 [49-771]
- mitogen-activated protein kinase 1 [51-396]
- mitogen-activated protein kinase 1 [54-320]
- Mitogen-activated protein kinase 1 [62-759]
- Mitogen-activated protein kinase 1 [62-760]
- mitogen-activated protein kinase 1 [70-229]
- Mitogen-activated protein kinase 1 [62-952]
- mitogen-activated protein kinase 1 [XG-6179]
- mitogen-activated protein kinase 1 [XW-7183]
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK1
- Sino Biological Antibodies for MAPK1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK1
- Origene Custom Protein Services for MAPK1
- Sino Biological Recombinant Proteins for MAPK1
- Sino Biological Cell Lysates for MAPK1
- ProSpec Recombinant Proteins for MAPK1
-
Abcam proteins for MAPK1
Assay products for research
- antibodies-online: Show 63 available ERK2 Elisa Kits ranked by validation data
- Compare Top ERK2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for MAPK1
Domains & Families for MAPK1 Gene
Gene Families for MAPK1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAPK1 Gene
- InterPro:
- Blocks:
-
- MAP kinase
- ERK1/2 MAP kinase signature
Suggested Antigen Peptide Sequences for MAPK1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58314, highly similar to Mitogen-activated protein kinase 1 (EC 2.7.11.24) (B4DHN0_HUMAN)
- Mitogen-activated protein kinase 2 (MK01_HUMAN)
- Mitogen-activated protein kinase 1, isoform CRA_a (Q1HBJ4_HUMAN)
- Mitogen-activated protein kinase 1 (Q499G7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28482UniProtKB/Swiss-Prot:
MK01_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK1 Gene
Molecular function for MAPK1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP1, DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
- GENATLAS Biochemistry:
- mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus after activation where it phosphorylate nuclear targets
Enzyme Numbers (IUBMB) for MAPK1 Gene
Phenotypes From GWAS Catalog for MAPK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001784 | phosphotyrosine residue binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
Phenotypes for MAPK1 Gene
- MGI mutant phenotypes for MAPK1:
-
inferred from 12 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for MAPK1:
-
- Decreased viability
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- no effect
- Increased cell death HMECs cells
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased substrate adherent cell growth
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased telomerase activity
- Increased viability
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased cell migration
- Increased cell death in HCC-1954 cells
- Increased cell death in HCT116 cells
- Decreased viability with carboplatin
Animal Models for MAPK1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAPK1 - Starting at $85 >
- * MAPK1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAPK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1
miRNA for MAPK1 Gene
- miRTarBase miRNAs that target MAPK1
-
- rno-miR-290 (MIRT002198)
- hsa-miR-199a-3p (MIRT003983)
- hsa-miR-28-5p (MIRT006418)
- hsa-miR-335-5p (MIRT006447)
- hsa-miR-320a (MIRT007093)
- mmu-miR-340-5p (MIRT010686)
- mmu-miR-136-5p (MIRT015105)
- hsa-miR-30a-5p (MIRT028452)
- hsa-miR-766-3p (MIRT039037)
- hsa-miR-769-5p (MIRT039161)
- hsa-miR-92b-3p (MIRT040549)
- hsa-miR-15b-5p (MIRT046445)
- hsa-let-7b-5p (MIRT052280)
- hsa-miR-214-3p (MIRT053000)
- hsa-miR-143-3p (MIRT053641)
- hsa-miR-132-3p (MIRT054837)
- hsa-miR-4643 (MIRT087172)
- hsa-miR-5190 (MIRT087200)
- hsa-miR-4253 (MIRT300652)
- hsa-miR-6862-5p (MIRT300654)
- hsa-miR-4796-3p (MIRT300679)
- hsa-miR-6512-3p (MIRT300692)
- hsa-miR-6720-5p (MIRT300693)
- ssc-miR-378 (MIRT437445)
- mmu-miR-155-5p (MIRT437847)
- hsa-miR-378a-3p (MIRT437887)
- hsa-miR-181a-5p (MIRT438857)
- hsa-miR-20a-5p (MIRT440278)
- hsa-miR-106b-5p (MIRT440279)
- hsa-miR-498 (MIRT473700)
- hsa-miR-6869-5p (MIRT473701)
- hsa-miR-1200 (MIRT473702)
- hsa-miR-6792-3p (MIRT473703)
- hsa-miR-4691-5p (MIRT473704)
- hsa-miR-4703-3p (MIRT473705)
- hsa-miR-6829-3p (MIRT473706)
- hsa-miR-6791-3p (MIRT473707)
- hsa-miR-3653-5p (MIRT473708)
- hsa-miR-544b (MIRT473709)
- hsa-miR-4324 (MIRT473710)
- hsa-miR-660-3p (MIRT473711)
- hsa-miR-6849-3p (MIRT473712)
- hsa-miR-1244 (MIRT473713)
- hsa-miR-4689 (MIRT473714)
- hsa-miR-6858-5p (MIRT473715)
- hsa-miR-1268b (MIRT473716)
- hsa-miR-1268a (MIRT473717)
- hsa-miR-585-3p (MIRT473718)
- hsa-miR-1255b-5p (MIRT473719)
- hsa-miR-1255a (MIRT473720)
- hsa-miR-6894-5p (MIRT473721)
- hsa-miR-6853-5p (MIRT473722)
- hsa-miR-3605-5p (MIRT473723)
- hsa-miR-4784 (MIRT473724)
- hsa-miR-3150b-3p (MIRT473725)
- hsa-miR-1273f (MIRT473726)
- hsa-miR-4459 (MIRT473727)
- hsa-miR-4433a-3p (MIRT473728)
- hsa-miR-4768-3p (MIRT473729)
- hsa-miR-5000-5p (MIRT473730)
- hsa-miR-6888-5p (MIRT473731)
- hsa-miR-573 (MIRT501975)
- hsa-miR-3616-5p (MIRT501976)
- hsa-miR-185-3p (MIRT501977)
- hsa-miR-4741 (MIRT501978)
- hsa-miR-4675 (MIRT501979)
- hsa-miR-6813-5p (MIRT501980)
- hsa-miR-4795-5p (MIRT501981)
- hsa-miR-6085 (MIRT501982)
- hsa-miR-519c-3p (MIRT501983)
- hsa-miR-519b-3p (MIRT501984)
- hsa-miR-519a-3p (MIRT501985)
- hsa-miR-3936 (MIRT501986)
- hsa-miR-130a-3p (MIRT501987)
- hsa-miR-301a-3p (MIRT501988)
- hsa-miR-130b-3p (MIRT501989)
- hsa-miR-301b-3p (MIRT501990)
- hsa-miR-3666 (MIRT501991)
- hsa-miR-4295 (MIRT501992)
- hsa-miR-454-3p (MIRT501993)
- hsa-miR-19a-3p (MIRT501994)
- hsa-miR-19b-3p (MIRT501995)
- hsa-miR-4420 (MIRT506630)
- hsa-miR-181b-3p (MIRT506631)
- hsa-miR-181b-2-3p (MIRT506632)
- hsa-miR-6773-3p (MIRT506633)
- hsa-miR-668-3p (MIRT506634)
- hsa-miR-450a-2-3p (MIRT506635)
- hsa-miR-6857-5p (MIRT506636)
- hsa-miR-6763-5p (MIRT506637)
- hsa-miR-3150a-3p (MIRT506638)
- hsa-miR-6810-5p (MIRT506639)
- hsa-miR-2110 (MIRT506640)
- hsa-miR-6873-3p (MIRT506641)
- hsa-miR-6883-3p (MIRT506642)
- hsa-miR-6780b-5p (MIRT506643)
- hsa-miR-4725-3p (MIRT506644)
- hsa-miR-4271 (MIRT506645)
- hsa-miR-4708-5p (MIRT506646)
- hsa-miR-6088 (MIRT506647)
- hsa-miR-4770 (MIRT506648)
- hsa-miR-6817-3p (MIRT506649)
- hsa-miR-7110-3p (MIRT506650)
- hsa-miR-3927-5p (MIRT506651)
- hsa-miR-454-5p (MIRT506652)
- hsa-miR-487a-3p (MIRT506653)
- hsa-miR-154-3p (MIRT506654)
- hsa-miR-5590-3p (MIRT506655)
- hsa-miR-142-5p (MIRT506656)
- hsa-miR-216b-5p (MIRT506657)
- hsa-miR-106a-5p (MIRT506658)
- hsa-miR-20b-5p (MIRT506659)
- hsa-miR-519d-3p (MIRT506660)
- hsa-miR-526b-3p (MIRT506661)
- hsa-miR-93-5p (MIRT506662)
- hsa-miR-17-5p (MIRT506663)
- hsa-miR-584-5p (MIRT511190)
- hsa-miR-3157-3p (MIRT556272)
- hsa-miR-4261 (MIRT556273)
- hsa-miR-5581-5p (MIRT556274)
- hsa-miR-4297 (MIRT556275)
- hsa-miR-18b-3p (MIRT556276)
- hsa-miR-6734-3p (MIRT556277)
- hsa-miR-371b-3p (MIRT556278)
- hsa-miR-6831-5p (MIRT556279)
- hsa-miR-3927-3p (MIRT556280)
- hsa-miR-3614-3p (MIRT556281)
- hsa-miR-548ah-5p (MIRT556282)
- hsa-miR-3609 (MIRT556283)
- hsa-miR-196b-5p (MIRT556284)
- hsa-miR-196a-5p (MIRT556285)
- mmu-miR-669m-3p (MIRT582532)
- mmu-miR-466n-3p (MIRT582533)
- mmu-miR-466e-3p (MIRT582534)
- mmu-miR-297b-3p (MIRT582535)
- mmu-miR-466a-3p (MIRT582536)
- mmu-miR-466d-3p (MIRT582537)
- mmu-miR-467g (MIRT582538)
- mmu-miR-467f (MIRT582539)
- hsa-miR-513a-5p (MIRT623314)
- hsa-miR-494-3p (MIRT623315)
- hsa-miR-499b-3p (MIRT623316)
- hsa-miR-499a-3p (MIRT623317)
- hsa-miR-4438 (MIRT623318)
- hsa-miR-5698 (MIRT667468)
- hsa-miR-143-5p (MIRT667469)
- hsa-miR-4430 (MIRT667470)
- hsa-miR-3652 (MIRT667471)
- hsa-miR-566 (MIRT667472)
- hsa-miR-6789-3p (MIRT667473)
- hsa-miR-122-5p (MIRT667474)
- hsa-miR-504-3p (MIRT667475)
- hsa-miR-3135b (MIRT667476)
- hsa-miR-6499-3p (MIRT667477)
- hsa-miR-6786-3p (MIRT667478)
- hsa-miR-4638-5p (MIRT667479)
- hsa-miR-1307-3p (MIRT667480)
- hsa-miR-6741-3p (MIRT667481)
- hsa-miR-5693 (MIRT667482)
- hsa-miR-6808-3p (MIRT715291)
- hsa-miR-7973 (MIRT715292)
- hsa-miR-4252 (MIRT715293)
- hsa-miR-6846-3p (MIRT715294)
- hsa-miR-6859-3p (MIRT715295)
- hsa-miR-4286 (MIRT715296)
- hsa-miR-4301 (MIRT715297)
- hsa-miR-4692 (MIRT715298)
- hsa-miR-4514 (MIRT715299)
- hsa-miR-4691-3p (MIRT715300)
- hsa-miR-3157-5p (MIRT715301)
- hsa-miR-5003-5p (MIRT715302)
- hsa-miR-449b-3p (MIRT715303)
- hsa-miR-7641 (MIRT719976)
- hsa-miR-4279 (MIRT719977)
- hsa-miR-6867-3p (MIRT719978)
- hsa-miR-7111-3p (MIRT719979)
- hsa-miR-4695-3p (MIRT719980)
- hsa-miR-6845-3p (MIRT719981)
- hsa-miR-4685-3p (MIRT719982)
- hsa-miR-4287 (MIRT719983)
- hsa-miR-7113-3p (MIRT719984)
- hsa-miR-4469 (MIRT719985)
- hsa-miR-6769b-3p (MIRT719986)
- hsa-miR-4723-3p (MIRT719987)
- hsa-miR-3183 (MIRT719988)
- hsa-miR-4667-3p (MIRT719989)
- hsa-miR-1470 (MIRT719990)
- hsa-miR-6777-3p (MIRT719991)
- hsa-miR-4639-3p (MIRT719992)
- hsa-miR-4761-3p (MIRT719993)
- hsa-miR-197-3p (MIRT731741)
- hsa-miR-550a-3p (MIRT732138)
- hsa-miR-329-3p (MIRT732273)
- gga-miR-130a-3p (MIRT732609)
- hsa-miR-9-3p (MIRT732887)
- hsa-miR-129-5p (MIRT733163)
- hsa-miR-451a (MIRT733562)
- mmu-miR-378a-3p (MIRT733653)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK1
- Browse OriGene Inhibitory RNA Products For MAPK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1
Clone products for research
- Applied Biological Materials (abm): Clones for MAPK1 - Starting at $45 >
- * MAPK1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227633
- MR227633
- MR227633L3
- MR227633L4
- MR229471
- RC204703
- RC204703L1
- RC204703L2
- RC204703L3
- RC204703L4
- RC210493
- RC210493L1
- RC210493L2
- RC210493L3
- RC210493L4
- RG204703
- RG210493
- RR209609
- RR209609L3
- RR209609L4
- MR227633L3V
- MR227633L4V
- RC204703L1V
- RC204703L2V
- RC204703L3V
- RC204703L4V
- RC210493L1V
- RC210493L2V
- RC210493L3V
- RC210493L4V
- RR209609L3V
- RR209609L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAPK1
- Addgene plasmids for MAPK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK1
Cell Lines for research
-
Horizon Cell Lines for MAPK1
No data available for Transcription Factor Targets and HOMER Transcription for MAPK1 Gene
Localization for MAPK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK1 Gene
- Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| lysosome | 4 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA,TAS | 19565474 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA,ISS | -- |
| GO:0005739 | mitochondrion | TAS | 19565474 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK1 Gene
Pathways & Interactions for MAPK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
|
Cell adhesion PLAU signaling
.35
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
|
| 5 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
|
|
Pathways by source for MAPK1 Gene
12 Sino Biological pathways for MAPK1 Gene
128 BioSystems pathways for MAPK1 Gene
140 Reactome pathways for MAPK1 Gene
9 PharmGKB pathways for MAPK1 Gene
115 KEGG pathways for MAPK1 Gene
91 GeneGo (Thomson Reuters) pathways for MAPK1 Gene
- Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
- Apoptosis and survival BAD phosphorylation
- Apoptosis and survival Role of CDK5 in neuronal death and survival
- Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
- Cell adhesion Integrin inside-out signaling
18 R&D Systems pathways for MAPK1 Gene
135 Qiagen pathways for MAPK1 Gene
- 14-3-3 Induced Apoptosis
- 14-3-3 Induced Intracellular Signaling
- 4-1BB Pathway
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
1 Cell Signaling Technology pathway for MAPK1 Gene
3 GeneTex pathways for MAPK1 Gene
Interacting Proteins for MAPK1 Gene
Selected Interacting proteins:
P28482-MK01_HUMAN
ENSP00000215832
for MAPK1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAPK1
SIGNOR curated interactions for MAPK1 Gene
- Activates:
-
- FOS
- ABI1
- EIF2AK2
- PRDX6
- TPR
- ARHGEF2
- ATF2
- BCL2
- BMF
- CAPN2
- CDK2
- CDKN1B
- CEBPB
- CIITA
- CSNK2A1
- CTTN
- DAPK1
- DUSP16
- DUSP1
- ELK1
- EP300
- ERF
- ESR1
- EXOC7
- GAB1
- GAB2
- GRB10
- GTF2I
- H3-3A
- HIF1A
- IER3
- IL16
- JUND
- JUN
- KHDRBS1
- LCK
- LIPE
- LRP6
- MAFA
- MAP3K5
- MAPK1
- MAPKAPK2
- MCL1
- MED1
- MKNK1
- MKNK2
- MYC
- NCF1
- NCOA1
- NDE1
- NEFH
- NFATC4
- NOX5
- NR4A1
- NR5A1
- PARP1
- PITPNM1
- PLCB1
- PML
- PPARA
- PTPN7
- PTPRR
- PTTG1
- RCAN1
- RGS19
- RPS3
- RPS6KA1
- RPS6KA2
- RPS6KA3
- RPS6KA5
- RPS6KB1
- RUNX1
- SLC2A4
- SLC9A1
- SMAD2
- SMAD4
- SP1
- SP3
- SPHK1
- SPHK2
- SREBF1
- SREBF2
- STAT5A
- STIM1
- TH
- CAD
- GSK3B
- MAPKAPK5
- NR4A2
- PDE4D
- TWIST1
- RSPH3
- AEBP1
- PCBP2
- KCND2
- RPTOR
- IRX2
- Inactivates:
-
- POLR2A
- BCL2L11
- PDE4D
- RXRA
- SMAD2
- AMPH
- AR
- ARRB1
- BAD
- BCL6
- BRAF
- CALD1
- CASP8
- CASP9
- CDKN1B
- CEBPA
- CEP55
- DUSP1
- DUSP6
- EGFR
- EIF4EBP1
- ERF
- ESPL1
- ETV6
- FGFR1
- FOXO3
- GJA1
- IRS1
- JAK2
- KLC1
- LCK
- LIFR
- MAP2K1
- MAPK14
- MAPT
- MBP
- MITF
- MRTFA
- NOXA1
- PAK1
- PCYT1A
- PDE4C
- PGR
- POU5F1
- PPARG
- PPP2R5C
- RAF1
- RORA
- SCNN1B
- SCNN1G
- SMAD1
- SMAD3
- SOS1
- STMN1
- TCF3
- TFCP2
- TFEB
- TNFRSF1A
- TOB1
- TSC1
- TSC2
- CIC
- CIITA
- GSK3B
- THRB
- UBTF
- ETV3
- GORASP1
- TPPP
- ATP1A1
- CDKN1A
- DAZAP1
- XPO5
- NR3C1
- NUP50
- RUNX1
- STK11
- LIMA1
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0006468 | protein phosphorylation | TAS | 11404397 |
| GO:0006915 | apoptotic process | TAS,IEA | -- |
Drugs & Compounds for MAPK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Arsenic trioxide | Approved, Investigational | Pharma | Target, inducer, inhibitor | 137 | ||
| Isoproterenol | Approved, Investigational | Pharma | Target, inducer | 31 | ||
| Aspirin | Approved, Vet_approved | Pharma | Target | 1600 | ||
| Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 240 | ||
| Turpentine | Approved, Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
(4) Tocris Compounds for MAPK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eicosapentaenoic Acid | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 10417-94-4 |
| FR 180204 | Selective ERK inhibitor | 865362-74-9 |
| Pluripotin | Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal | 839707-37-8 |
| XMD 8-92 | ERK5/BMK1 inhibitor; also BRD4 inhibitor | 1234480-50-2 |
(7) ApexBio Compounds for MAPK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DEL-22379 | inhibitor of the dimerization of ERK | 181223-80-3 |
| FR 180204 | ERK inhibitor | 865362-74-9 |
| Piperine | MAPK inhibitor | 94-62-2 |
| SCH772984 | ERK1 and ERK2 inhibitor | 942183-80-4 |
| TIC10 | Potent Akt/ERK inhibitor | 41276-02-2 |
| VRT752271 | ERK1/ERK2 inhibitor | 869886-67-9 |
| VX-11e | ERK inhibitor | 896720-20-0 |
Transcripts for MAPK1 Gene
mRNA/cDNA for MAPK1 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215832 5881 nts (view in UCSC)
- ENST00000398822 1487 nts (view in UCSC)
- ENST00000491588 491 nts (view in UCSC)
- ENST00000544786 951 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MAPK1 - Starting at $85 >
- * MAPK1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MAPK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAPK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAPK1
- Browse OriGene Inhibitory RNA Products For MAPK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1
Clone products for research
- Applied Biological Materials (abm): Clones for MAPK1 - Starting at $45 >
- * MAPK1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227633
- MR227633
- MR227633L3
- MR227633L4
- MR229471
- RC204703
- RC204703L1
- RC204703L2
- RC204703L3
- RC204703L4
- RC210493
- RC210493L1
- RC210493L2
- RC210493L3
- RC210493L4
- RG204703
- RG210493
- RR209609
- RR209609L3
- RR209609L4
- MR227633L3V
- MR227633L4V
- RC204703L1V
- RC204703L2V
- RC204703L3V
- RC204703L4V
- RC210493L1V
- RC210493L2V
- RC210493L3V
- RC210493L4V
- RR209609L3V
- RR209609L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAPK1
- Addgene plasmids for MAPK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAPK1
Relevant External Links for MAPK1 Gene
- GeneLoc Exon Structure for
- MAPK1
Expression for MAPK1 Gene
This gene is overexpressed in Brain (8.7) and Frontal cortex (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK1
SOURCE GeneReport for Unigene cluster for MAPK1 Gene:
Hs.431850Evidence on tissue expression from TISSUES for MAPK1 Gene
- Nervous system(4.9)
- Lung(4.6)
- Liver(4.6)
- Blood(4.6)
- Skin(3.5)
- Intestine(3.1)
- Kidney(3.1)
- Heart(3)
- Eye(3)
- Muscle(3)
- Spleen(2.9)
- Lymph node(2.7)
- Adrenal gland(2.7)
- Pancreas(2.6)
- Stomach(2.6)
- Bone marrow(2.6)
- Thyroid gland(2.6)
- Bone(2.2)