Aliases for MAPK1 Gene
Aliases for MAPK1 Gene
External Ids for MAPK1 Gene
- HGNC: 6871
- Entrez Gene: 5594
- Ensembl: ENSG00000100030
- OMIM: 176948
- UniProtKB: P28482
Previous HGNC Symbols for MAPK1 Gene
- PRKM2
- PRKM1
Previous GeneCards Identifiers for MAPK1 Gene
- GC22M018815
- GC22M020441
- GC22M022108
- GC22M005071
Summaries for MAPK1 Gene
-
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
GeneCards Summary for MAPK1 Gene
MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include Chromosome 22Q11.2 Deletion Syndrome, Distal and Pertussis. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK3.
UniProtKB/Swiss-Prot for MAPK1 Gene
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
-
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
-
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.
Additional gene information for MAPK1 Gene
- Monarch Initiative
- Search for MAPK1 at DataMed
- Search for MAPK1 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1 Gene
Genomics for MAPK1 Gene
GeneHancer (GH) Regulatory Elements for MAPK1 Gene
Promoters and enhancers for MAPK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MAPK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MAPK1 gene promoter:
Regulatory Element Products
Genomic Locations for MAPK1 Gene
Genomic Locations for MAPK1 Gene
- chr22:21,754,500-21,867,680
- (GRCh38/hg38)
- Size:
- 113,181 bases
- Orientation:
- Minus strand
- chr22:22,108,789-22,221,970
- (GRCh37/hg19)
Genomic View for MAPK1 Gene
Genes around MAPK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by Ensembl
- 22q11.22 by Entrez Gene
- 22q11.22 by HGNC
MAPK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK1 Gene
Proteins for MAPK1 Gene
-
Protein details for MAPK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28482-MK01_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 1
- Protein Accession:
- P28482
- A8CZ64
Protein attributes for MAPK1 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 41390 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 (Tyr-19-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX. Interacts with CDK2AP2. Interacts with CAVIN4 (By similarity).
- SequenceCaution:
-
- Sequence=CAA77753.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MAPK1 Gene
Protein Expression for MAPK1 Gene
Selected DME Specific Peptides for MAPK1 Gene
- P28482:
-
- YVATRWYR
- MELDDLPKE
- GCILAEM
- RVAIKKISPFEHQT
- GLKYIHSA
- FPGKHYLDQLN
- AEAPFKF
- GPEMVRGQ
- YQILRGLKY
- IEQMKDV
- ILLRFRHEN
- FDVGPRY
- ALAHPYLEQYYDP
- LKICDFG
- HSANVLHRDL
- LKYIHSA
- TEYVATRWYRAPE
- HRDLKPSNLLLN
- RVAIKKI
- WSVGCILAE
- YRAPEIML
- VLHRDLK
- DDLPKEKLKELI
- DIWSVGCI
- RTLREIK
- YIGEGAYGMV
- KALDLLDKMLTFNPHKRIEVE
- TRWYRAPE
- DVYIVQDLMETDLYKLLK
- WSVGCIL
- NHILGIL
- LKICDFGLAR
- ETARFQPG
Post-translational modifications for MAPK1 Gene
- ISGylated.
- Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs.
- Ubiquitination at isoforms=2292
- Modification sites at PhosphoSitePlus
Other Protein References for MAPK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAPK1 (ERK2)
-
Custom Antibody ServicesOriGene Antibodies for MAPK1
- TA500468S
- TA700064
- TA700063
- TA700062
- TA600064
- TA600063
- CF500486
- TA500486
- CF500485
- TA500485
- CF500475
- TA500475
- CF500474
- TA500474
- CF500473
- TA500473
- CF500472
- TA500472
- CF500470
- TA500470
- CF500469
- TA500469
- CF500468
- TA500468
- CF500467
- TA500467
- TA353805
- TA347800
- TA328051
- TA326202
- TA326185
- TA326099
- TA324942
- TA324912
- TA324692
- TA309121
- TA309120
- TA302982
- AP55841PU-S
- AP55841PU-N
- AP23401PU-N
- AP09076SU-N
- AP07464PU-N
- AM09368PU-S
- AM09368PU-N
- AM08381PU-N
- AM06140PU-N
- AM00086PU-N
- AM00086BT-N
- AM00085PU-N
- AM00085BT-N
- Novus Biologicals Antibodies for MAPK1
-
Abcam antibodies for MAPK1
-
Cloud-Clone Corp. Antibodies for MAPK1
- Invitrogen Antibodies for MAPK1
- antibodies-online: Search results for 370 available ERK2 Antibodies ranked by validation data
- Compare Top ERK2 Antibodies
-
Recommended
- 1 IP Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 113 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 136 WB Antibodies (anti-mouse)
- 1 FACS Antibody (anti-human)
- 3 LMNX Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 317 WB Antibodies (anti-human)
- GeneTex MAPK1 antibody for MAPK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK1
- Sino Biological Antibodies for MAPK1
Protein Products
- R&D Systems Proteins and Enzymes for MAPK1 (ERK2)
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK1
- Origene Custom Protein Services for MAPK1
- Sino Biological Recombinant Proteins for MAPK1
- Sino Biological Cell Lysates for MAPK1
- ProSpec Recombinant Proteins for MAPK1
-
Cloud-Clone Corp. Proteins for MAPK1
- Search GeneTex for Proteins for MAPK1
-
Abcam proteins for MAPK1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for MAPK1 (MAP Kinase (MAPK) Array Kit)
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for MAPK1 (ERK2)
-
Cloud-Clone Corp. Assay Kits for MAPK1
Domains & Families for MAPK1 Gene
Gene Families for MAPK1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MAPK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P28482UniProtKB/Swiss-Prot:
MK01_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK1 Gene
Molecular function for MAPK1 Gene
- GENATLAS Biochemistry:
- mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus after activation where it phosphorylate nuclear targets
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Enzyme Numbers (IUBMB) for MAPK1 Gene
Phenotypes From GWAS Catalog for MAPK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001784 | phosphotyrosine residue binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
Phenotypes for MAPK1 Gene
- MGI mutant phenotypes for MAPK1:
-
inferred from 11 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for MAPK1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cell migration
- Decreased telomerase activity
- Decreased viability with carboplatin
Animal Models for MAPK1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK1 gene
- Search ViGene Biosciences for MAPK1
CRISPR Products
-
OriGene CRISPR knockouts for MAPK1
- genomics-online: gRNA clones - Search results for 137 available ERK2 gene related products
- Overview of 137 available ERK2 gene related products
- Applied Biological Materials CRISPR for MAPK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1
- GenScript: Design CRISPR guide RNA sequences for MAPK1
miRNA for MAPK1 Gene
- miRTarBase miRNAs that target MAPK1
-
- hsa-mir-199a-3p (MIRT003983)
- hsa-mir-28-5p (MIRT006418)
- hsa-mir-335-5p (MIRT006447)
- hsa-mir-320a (MIRT007093)
- hsa-mir-30a-5p (MIRT028452)
- hsa-mir-766-3p (MIRT039037)
- hsa-mir-769-5p (MIRT039161)
- hsa-mir-92b-3p (MIRT040549)
- hsa-mir-15b-5p (MIRT046445)
- hsa-let-7b-5p (MIRT052280)
- hsa-mir-214-3p (MIRT053000)
- hsa-mir-143-3p (MIRT053641)
- hsa-mir-132-3p (MIRT054837)
- hsa-mir-4643 (MIRT087172)
- hsa-mir-5190 (MIRT087200)
- hsa-mir-4253 (MIRT300652)
- hsa-mir-6862-5p (MIRT300654)
- hsa-mir-4796-3p (MIRT300679)
- hsa-mir-6512-3p (MIRT300692)
- hsa-mir-6720-5p (MIRT300693)
- ssc-mir-378 (MIRT437445)
- hsa-mir-378a-3p (MIRT437887)
- hsa-mir-181a-5p (MIRT438857)
- hsa-mir-20a-5p (MIRT440278)
- hsa-mir-106b-5p (MIRT440279)
- hsa-mir-498 (MIRT473700)
- hsa-mir-6869-5p (MIRT473701)
- hsa-mir-1200 (MIRT473702)
- hsa-mir-6792-3p (MIRT473703)
- hsa-mir-4691-5p (MIRT473704)
- hsa-mir-4703-3p (MIRT473705)
- hsa-mir-6829-3p (MIRT473706)
- hsa-mir-6791-3p (MIRT473707)
- hsa-mir-3653-5p (MIRT473708)
- hsa-mir-544b (MIRT473709)
- hsa-mir-4324 (MIRT473710)
- hsa-mir-660-3p (MIRT473711)
- hsa-mir-6849-3p (MIRT473712)
- hsa-mir-1244 (MIRT473713)
- hsa-mir-4689 (MIRT473714)
- hsa-mir-6858-5p (MIRT473715)
- hsa-mir-1268b (MIRT473716)
- hsa-mir-1268a (MIRT473717)
- hsa-mir-585-3p (MIRT473718)
- hsa-mir-1255b-5p (MIRT473719)
- hsa-mir-1255a (MIRT473720)
- hsa-mir-6894-5p (MIRT473721)
- hsa-mir-6853-5p (MIRT473722)
- hsa-mir-3605-5p (MIRT473723)
- hsa-mir-4784 (MIRT473724)
- hsa-mir-3150b-3p (MIRT473725)
- hsa-mir-1273f (MIRT473726)
- hsa-mir-4459 (MIRT473727)
- hsa-mir-4433a-3p (MIRT473728)
- hsa-mir-4768-3p (MIRT473729)
- hsa-mir-5000-5p (MIRT473730)
- hsa-mir-6888-5p (MIRT473731)
- hsa-mir-573 (MIRT501975)
- hsa-mir-3616-5p (MIRT501976)
- hsa-mir-185-3p (MIRT501977)
- hsa-mir-4741 (MIRT501978)
- hsa-mir-4675 (MIRT501979)
- hsa-mir-6813-5p (MIRT501980)
- hsa-mir-4795-5p (MIRT501981)
- hsa-mir-6085 (MIRT501982)
- hsa-mir-519c-3p (MIRT501983)
- hsa-mir-519b-3p (MIRT501984)
- hsa-mir-519a-3p (MIRT501985)
- hsa-mir-3936 (MIRT501986)
- hsa-mir-130a-3p (MIRT501987)
- hsa-mir-301a-3p (MIRT501988)
- hsa-mir-130b-3p (MIRT501989)
- hsa-mir-301b-3p (MIRT501990)
- hsa-mir-3666 (MIRT501991)
- hsa-mir-4295 (MIRT501992)
- hsa-mir-454-3p (MIRT501993)
- hsa-mir-19a-3p (MIRT501994)
- hsa-mir-19b-3p (MIRT501995)
- hsa-mir-4420 (MIRT506630)
- hsa-mir-181b-3p (MIRT506631)
- hsa-mir-181b-2-3p (MIRT506632)
- hsa-mir-6773-3p (MIRT506633)
- hsa-mir-668-3p (MIRT506634)
- hsa-mir-450a-2-3p (MIRT506635)
- hsa-mir-6857-5p (MIRT506636)
- hsa-mir-6763-5p (MIRT506637)
- hsa-mir-3150a-3p (MIRT506638)
- hsa-mir-6810-5p (MIRT506639)
- hsa-mir-2110 (MIRT506640)
- hsa-mir-6873-3p (MIRT506641)
- hsa-mir-6883-3p (MIRT506642)
- hsa-mir-6780b-5p (MIRT506643)
- hsa-mir-4725-3p (MIRT506644)
- hsa-mir-4271 (MIRT506645)
- hsa-mir-4708-5p (MIRT506646)
- hsa-mir-6088 (MIRT506647)
- hsa-mir-4770 (MIRT506648)
- hsa-mir-6817-3p (MIRT506649)
- hsa-mir-7110-3p (MIRT506650)
- hsa-mir-3927-5p (MIRT506651)
- hsa-mir-454-5p (MIRT506652)
- hsa-mir-487a-3p (MIRT506653)
- hsa-mir-154-3p (MIRT506654)
- hsa-mir-5590-3p (MIRT506655)
- hsa-mir-142-5p (MIRT506656)
- hsa-mir-216b-5p (MIRT506657)
- hsa-mir-106a-5p (MIRT506658)
- hsa-mir-20b-5p (MIRT506659)
- hsa-mir-519d-3p (MIRT506660)
- hsa-mir-526b-3p (MIRT506661)
- hsa-mir-93-5p (MIRT506662)
- hsa-mir-17-5p (MIRT506663)
- hsa-mir-584-5p (MIRT511190)
- hsa-mir-3157-3p (MIRT556272)
- hsa-mir-4261 (MIRT556273)
- hsa-mir-5581-5p (MIRT556274)
- hsa-mir-4297 (MIRT556275)
- hsa-mir-18b-3p (MIRT556276)
- hsa-mir-6734-3p (MIRT556277)
- hsa-mir-371b-3p (MIRT556278)
- hsa-mir-6831-5p (MIRT556279)
- hsa-mir-3927-3p (MIRT556280)
- hsa-mir-3614-3p (MIRT556281)
- hsa-mir-548ah-5p (MIRT556282)
- hsa-mir-3609 (MIRT556283)
- hsa-mir-196b-5p (MIRT556284)
- hsa-mir-196a-5p (MIRT556285)
- hsa-mir-513a-5p (MIRT623314)
- hsa-mir-494-3p (MIRT623315)
- hsa-mir-499b-3p (MIRT623316)
- hsa-mir-499a-3p (MIRT623317)
- hsa-mir-4438 (MIRT623318)
- hsa-mir-5698 (MIRT667468)
- hsa-mir-143-5p (MIRT667469)
- hsa-mir-4430 (MIRT667470)
- hsa-mir-3652 (MIRT667471)
- hsa-mir-566 (MIRT667472)
- hsa-mir-6789-3p (MIRT667473)
- hsa-mir-122-5p (MIRT667474)
- hsa-mir-504-3p (MIRT667475)
- hsa-mir-3135b (MIRT667476)
- hsa-mir-6499-3p (MIRT667477)
- hsa-mir-6786-3p (MIRT667478)
- hsa-mir-4638-5p (MIRT667479)
- hsa-mir-1307-3p (MIRT667480)
- hsa-mir-6741-3p (MIRT667481)
- hsa-mir-5693 (MIRT667482)
- hsa-mir-6808-3p (MIRT715291)
- hsa-mir-7973 (MIRT715292)
- hsa-mir-4252 (MIRT715293)
- hsa-mir-6846-3p (MIRT715294)
- hsa-mir-6859-3p (MIRT715295)
- hsa-mir-4286 (MIRT715296)
- hsa-mir-4301 (MIRT715297)
- hsa-mir-4692 (MIRT715298)
- hsa-mir-4514 (MIRT715299)
- hsa-mir-4691-3p (MIRT715300)
- hsa-mir-3157-5p (MIRT715301)
- hsa-mir-5003-5p (MIRT715302)
- hsa-mir-449b-3p (MIRT715303)
- hsa-mir-7641 (MIRT719976)
- hsa-mir-4279 (MIRT719977)
- hsa-mir-6867-3p (MIRT719978)
- hsa-mir-7111-3p (MIRT719979)
- hsa-mir-4695-3p (MIRT719980)
- hsa-mir-6845-3p (MIRT719981)
- hsa-mir-4685-3p (MIRT719982)
- hsa-mir-4287 (MIRT719983)
- hsa-mir-7113-3p (MIRT719984)
- hsa-mir-4469 (MIRT719985)
- hsa-mir-6769b-3p (MIRT719986)
- hsa-mir-4723-3p (MIRT719987)
- hsa-mir-3183 (MIRT719988)
- hsa-mir-4667-3p (MIRT719989)
- hsa-mir-1470 (MIRT719990)
- hsa-mir-6777-3p (MIRT719991)
- hsa-mir-4639-3p (MIRT719992)
- hsa-mir-4761-3p (MIRT719993)
- hsa-mir-197-3p (MIRT731741)
- hsa-mir-550a-3p (MIRT732138)
- hsa-mir-329-3p (MIRT732273)
- gga-mir-130a-3p (MIRT732609)
- hsa-mir-9-3p (MIRT732887)
- hsa-mir-129-5p (MIRT733163)
- hsa-mir-451a (MIRT733562)
miRNA Products
- Search ViGene Biosciences for MAPK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MAPK1
- Browse OriGene Inhibitory RNA Products For MAPK1
- genomics-online: shRNA clones - Search results for 137 available ERK2 gene related products
- Overview of 137 available ERK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK1 gene
Clone Products
- Sino Biological Human cDNA Clone for MAPK1
- VectorBuilder custom plasmid, inducible vectors for MAPK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK1
- Applied Biological Materials Clones for MAPK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MAPK1
-
ViGene Biosciences adenoviral particle packaged cDNA for MAPK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK1 gene
No data available for Transcription Factor Targets and HOMER Transcription for MAPK1 Gene
Localization for MAPK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK1 Gene
- Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| endoplasmic reticulum | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | TAS | 19565474 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005739 | mitochondrion | TAS | 19565474 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK1 Gene
Pathways & Interactions for MAPK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | IL-2 Pathway |
.59
.48
|
.43
.37
.36
.34
|
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 5 | Endometrial cancer |
.52
.47
|
.36
.32
|
Pathways by source for MAPK1 Gene
19 Sino Biological pathways for MAPK1 Gene
3 GeneTex pathways for MAPK1 Gene
126 BioSystems pathways for MAPK1 Gene
140 Reactome pathways for MAPK1 Gene
100 KEGG pathways for MAPK1 Gene
91 GeneGo (Thomson Reuters) pathways for MAPK1 Gene
18 R&D Systems pathways for MAPK1 Gene
135 Qiagen pathways for MAPK1 Gene
1 Cell Signaling Technology pathway for MAPK1 Gene
Interacting Proteins for MAPK1 Gene
Selected Interacting proteins:
P28482-MK01_HUMAN
ENSP00000215832
for MAPK1 Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for MAPK1 Gene
- Activates:
-
- RPS6KB1
- FOS
- ELK1
- TH
- MYC
- MAPKAPK2
- BAD
- MKNK1
- MKNK2
- RPS6KA1
- EIF2AK2
- MAPKAPK5
- RPS6KA5
- STAT5A
- ERF
- DUSP1
- GTF2I
- NCOA1
- BCL2
- PDE4D
- CDKN1B
- PTTG1
- SREBF1
- RGS19
- PLCB1
- TP53
- MAFA
- SP1
- ATF2
- SMAD2
- MCL1
- IER3
- CDK2
- ESR1
- KHDRBS1
- PTK2
- SMAD4
- THRB
- SPHK1
- IL16
- SREBF2
- CAPN2
- PML
- PITPNM1
- CIITA
- GAB2
- DAPK1
- NFATC4
- CAD
- RPS3
- GRB10
- H3F3A
- RUNX1
- MED1
- PARP1
- MAP3K5
- NCF1
- SLC9A1
- SPHK2
- EP300
- NR4A2
- SP3
- GSK3B
- HIF1A
- TPR
- PRDX6
- ARHGEF2
- RPS6KA2
- RPS6KA3
- CEBPB
- NUP50
- CSNK2A1
- SLC2A4
- CTTN
- LRP6
- NOX5
- ABI1
- TWIST1
- BMF
- STIM1
- JUND
- EXOC7
- JUN
- Inactivates:
-
- EGFR
- MBP
- SOS1
- ERF
- LIFR
- LCK
- PPARG
- SMAD1
- BCL6
- RAF1
- PDE4D
- SMAD2
- SMAD3
- ARRB1
- CALD1
- MAP2K1
- PGR
- BCL2
- MITF
- CDKN1B
- PDE4C
- UBTF
- ESPL1
- EIF4EBP1
- MAPK14
- RXRA
- TOB1
- CASP9
- THRB
- POLR2A
- CEBPA
- IRS1
- CIITA
- AMPH
- BCL2L11
- DUSP6
- PCYT1A
- TSC1
- TSC2
- GSK3B
- RUNX1
- CEP55
- DUSP1
- PPP2R5C
- BRAF
- JAK2
- RORA
- FOXO3
- AR
- MKL1
- TFCP2
- CDKN1A
- NUP50
- NOXA1
- STMN1
- CIC
- KLC1
- POU5F1
- FGFR1
- CASP8
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006468 | protein phosphorylation | TAS | 11404397 |
Drugs & Compounds for MAPK1 Gene
(101) Drugs for MAPK1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Arsenic trioxide | Approved, Investigational | Pharma | Target, inducer, inhibitor | 125 | ||
| Isoproterenol | Approved, Investigational | Pharma | Full agonist, Agonist, Target, inducer | 24 | ||
| Turpentine | Approved, Experimental | Pharma | Target | 0 | ||
| Trisenox | Approved September 2000 | Pharma | 0 | |||
| Sumatriptan | Approved, Investigational | Pharma | Full agonist, Agonist | 5-HT1 receptor agonist | 123 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(4) Tocris Compounds for MAPK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eicosapentaenoic Acid | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 10417-94-4 |
| FR 180204 | Selective ERK inhibitor | 865362-74-9 |
| Pluripotin | Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal | 839707-37-8 |
| XMD 8-92 | ERK5/BMK1 inhibitor; also BRD4 inhibitor | 1234480-50-2 |
(7) ApexBio Compounds for MAPK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DEL-22379 | inhibitor of the dimerization of ERK | 181223-80-3 |
| FR 180204 | ERK inhibitor | 865362-74-9 |
| Piperine | MAPK inhibitor | 94-62-2 |
| SCH772984 | ERK1 and ERK2 inhibitor | 942183-80-4 |
| TIC10 | Potent Akt/ERK inhibitor | 41276-02-2 |
| VRT752271 | ERK1/ERK2 inhibitor | 869886-67-9 |
| VX-11e | ERK inhibitor | 896720-20-0 |
Transcripts for MAPK1 Gene
mRNA/cDNA for MAPK1 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (622) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAPK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MAPK1
- genomics-online: gRNA clones - Search results for 137 available ERK2 gene related products
- Overview of 137 available ERK2 gene related products
- Applied Biological Materials CRISPR for MAPK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK1
- GenScript: Design CRISPR guide RNA sequences for MAPK1
miRNA Products
- Search ViGene Biosciences for MAPK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MAPK1
- Browse OriGene Inhibitory RNA Products For MAPK1
- genomics-online: shRNA clones - Search results for 137 available ERK2 gene related products
- Overview of 137 available ERK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK1 gene
Clone Products
- Sino Biological Human cDNA Clone for MAPK1
- VectorBuilder custom plasmid, inducible vectors for MAPK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MAPK1
- Applied Biological Materials Clones for MAPK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MAPK1 Gene
This gene is overexpressed in Brain (8.7) and Frontal cortex (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MAPK1 Gene:
MAPK1SOURCE GeneReport for Unigene cluster for MAPK1 Gene:
Hs.431850Evidence on tissue expression from TISSUES for MAPK1 Gene
- Nervous system(4.9)
- Blood(4.6)
- Lung(4.6)
- Liver(4.5)
- Skin(3.2)
- Heart(3)
- Muscle(2.9)
- Eye(2.8)
- Intestine(2.8)
- Kidney(2.8)
- Spleen(2.6)
- Bone marrow(2.4)
- Lymph node(2.4)
- Adrenal gland(2.3)
- Stomach(2.3)
- Bone(2.2)
- Pancreas(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for MAPK1
-
OriGene qPCR primer pairs and template standards for MAPK1
- genomics-online: primer clones - Search results for 137 available ERK2 gene related products
- Overview of 137 available ERK2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK1 Gene
Orthologs for MAPK1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | MAPK1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mapk1 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MAPK1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mapk1 33 |
|
||
| chicken (Gallus gallus) |
Aves | MAPK1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MAPK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mapk1 33 |
|
||
| Str.19446 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mapk1 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2326 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG18732 35 |
|
|
|
| rl 35 33 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009207 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mpk-1 35 33 34 |
|
||
| C05D10.2a 35 |
|
|
|||
| C05D10.2c 35 |
|
|
|||
| F09C12.2 35 |
|
|
|||
| Y51B9A.9 35 |
|
|
|||
| C49C3.10b 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KSS1 33 34 |
|
||
| FUS3 34 36 |
|
ManyToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL191C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A02497g 33 |
|