MAPK1 Gene (Protein Coding)

Mitogen-Activated Protein Kinase 1

GC22M021754
GIFtS:
51
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphory... See more...

Aliases for MAPK1 Gene

Aliases for MAPK1 Gene

  • Mitogen-Activated Protein Kinase 1 2 3 4 5
  • ERK2 2 3 4
  • Extracellular Signal-Regulated Kinase 2 3 4
  • Mitogen-Activated Protein Kinase 2 3 4
  • MAP Kinase Isoform P42 3 4
  • MAP Kinase 1 3 4
  • MAP Kinase 2 3 4
  • EC 2.7.11.24 4 51
  • P42-MAPK 3 4
  • P41mapk 2 3
  • MAPK 2 3 4
  • ERK-2 3 4
  • MAPK2 2 3
  • PRKM1 3 4
  • PRKM2 3 4
  • ERT1 3 4
  • ERK 2 3
  • Protein Tyrosine Kinase ERK2 3
  • EC 2.7.11 51
  • P42MAPK 3
  • MAPK 1 4
  • MAPK1 5
  • P38 3
  • P40 3
  • P41 3

External Ids for MAPK1 Gene

Previous HGNC Symbols for MAPK1 Gene

  • PRKM2
  • PRKM1

Previous GeneCards Identifiers for MAPK1 Gene

  • GC22M018815
  • GC22M020441
  • GC22M022108
  • GC22M005071

Summaries for MAPK1 Gene

Entrez Gene Summary for MAPK1 Gene

  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

CIViC Summary for MAPK1 Gene

GeneCards Summary for MAPK1 Gene

MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include Chromosome 22Q11.2 Deletion Syndrome, Distal and Pertussis. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK3.

UniProtKB/Swiss-Prot Summary for MAPK1 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
  • Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Tocris Summary for MAPK1 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Gene Wiki entry for MAPK1 Gene

Additional gene information for MAPK1 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAPK1 Gene

Genomics for MAPK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MAPK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAPK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAPK1

Top Transcription factor binding sites by QIAGEN in the MAPK1 gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for MAPK1 Gene

Genomic Locations for MAPK1 Gene
chr22:21,759,657-21,867,680
(GRCh38/hg38)
Size:
108,024 bases
Orientation:
Minus strand
chr22:22,108,789-22,221,970
(GRCh37/hg19)
Size:
113,182 bases
Orientation:
Minus strand

Genomic View for MAPK1 Gene

Genes around MAPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK1 Gene

Proteins for MAPK1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28482-MK01_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 1
    Protein Accession:
    P28482
    Secondary Accessions:
    • A8CZ64

    Protein attributes for MAPK1 Gene

    Size:
    360 amino acids
    Molecular mass:
    41390 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX. Interacts with CDK2AP2. Interacts with CAVIN4 (By similarity). Interacts with DUSP7; the interaction enhances DUSP7 phosphatase activity (PubMed:9788880).
    • (Microbial infection) Interacts with HIV-1 Nef through its SH3 domain.
    SequenceCaution:
    • Sequence=CAA77753.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK1 Gene

    Alternative splice isoforms for MAPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK1 Gene

Protein Expression for MAPK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK1 Gene

P28482:
  • YVATRWYR
  • MELDDLPKE
  • GCILAEM
  • RVAIKKISPFEHQT
  • GLKYIHSA
  • FPGKHYLDQLN
  • AEAPFKF
  • GPEMVRGQ
  • YQILRGLKY
  • IEQMKDV
  • ILLRFRHEN
  • FDVGPRY
  • ALAHPYLEQYYDP
  • LKICDFG
  • HSANVLHRDL
  • LKYIHSA
  • TEYVATRWYRAPE
  • HRDLKPSNLLLN
  • RVAIKKI
  • WSVGCILAE
  • YRAPEIML
  • VLHRDLK
  • DDLPKEKLKELI
  • DIWSVGCI
  • RTLREIK
  • YIGEGAYGMV
  • KALDLLDKMLTFNPHKRIEVE
  • TRWYRAPE
  • DVYIVQDLMETDLYKLLK
  • WSVGCIL
  • NHILGIL
  • LKICDFGLAR
  • ETARFQPG

Post-translational modifications for MAPK1 Gene

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs. Dephosphorylated by DUSP1 at Thr-185 and Tyr-187.
  • ISGylated.
  • Ubiquitination at Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAPK1

Domains & Families for MAPK1 Gene

Gene Families for MAPK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAPK1 Gene

InterPro:
Blocks:
  • MAP kinase
  • ERK1/2 MAP kinase signature
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58314, highly similar to Mitogen-activated protein kinase 1 (EC 2.7.11.24) (B4DHN0_HUMAN)
  • Mitogen-activated protein kinase 2 (MK01_HUMAN)
  • Mitogen-activated protein kinase 1, isoform CRA_a (Q1HBJ4_HUMAN)
  • Mitogen-activated protein kinase 1 (Q499G7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28482

UniProtKB/Swiss-Prot:

MK01_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK1: view

Function for MAPK1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MAPK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP1, DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
GENATLAS Biochemistry:
mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus after activation where it phosphorylate nuclear targets

Enzyme Numbers (IUBMB) for MAPK1 Gene

Phenotypes From GWAS Catalog for MAPK1 Gene

Gene Ontology (GO) - Molecular Function for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001784 phosphotyrosine residue binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with MAPK1: view

Phenotypes for MAPK1 Gene

MGI mutant phenotypes for MAPK1:
inferred from 12 alleles
GenomeRNAi human phenotypes for MAPK1:
genes like me logo Genes that share phenotypes with MAPK1: view

Human Phenotype Ontology for MAPK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPK1 Gene

MGI Knock Outs for MAPK1:

Animal Model Products

CRISPR Products

miRNA for MAPK1 Gene

miRTarBase miRNAs that target MAPK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1

No data available for Transcription Factor Targets and HOMER Transcription for MAPK1 Gene

Localization for MAPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK1 Gene

Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
endosome 5
cytosol 5
golgi apparatus 5
lysosome 4
peroxisome 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,TAS 19565474
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with MAPK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAPK1 Gene

Pathways & Interactions for MAPK1 Gene

PathCards logo

SuperPathways for MAPK1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
4 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
Insulin signaling pathway
.32
ErbB2/ErbB3 signaling events
.31
Signal attenuation
.01
Class IB PI3K non-lipid kinase events
.01
5 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
Adipocytokines and Insulin Signaling
.34
genes like me logo Genes that share pathways with MAPK1: view

Pathways by source for MAPK1 Gene

91 GeneGo (Thomson Reuters) pathways for MAPK1 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Apoptosis and survival BAD phosphorylation
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell adhesion Integrin inside-out signaling
135 Qiagen pathways for MAPK1 Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for MAPK1 Gene
3 GeneTex pathways for MAPK1 Gene

SIGNOR curated interactions for MAPK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0006468 protein phosphorylation TAS 11404397
GO:0006915 apoptotic process TAS,IEA --
genes like me logo Genes that share ontologies with MAPK1: view

Drugs & Compounds for MAPK1 Gene

Products:

  1. Drug

(107) Drugs for MAPK1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inducer, inhibitor 131
Isoproterenol Approved, Investigational Pharma Agonist, Full agonist, Target, inducer 31
Aspirin Approved, Vet_approved Pharma Channel blocker, Target 1512
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Turpentine Approved, Experimental Pharma Target 0

(68) Additional Compounds for MAPK1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(4) Tocris Compounds for MAPK1 Gene

Compound Action Cas Number
Eicosapentaenoic Acid Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 10417-94-4
FR 180204 Selective ERK inhibitor 865362-74-9
Pluripotin Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal 839707-37-8
XMD 8-92 ERK5/BMK1 inhibitor; also BRD4 inhibitor 1234480-50-2

(7) ApexBio Compounds for MAPK1 Gene

Compound Action Cas Number
DEL-22379 inhibitor of the dimerization of ERK 181223-80-3
FR 180204 ERK inhibitor 865362-74-9
Piperine MAPK inhibitor 94-62-2
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
TIC10 Potent Akt/ERK inhibitor 41276-02-2
VRT752271 ERK1/ERK2 inhibitor 869886-67-9
VX-11e ERK inhibitor 896720-20-0
genes like me logo Genes that share compounds with MAPK1: view

Transcripts for MAPK1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAPK1 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAPK1

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1 Gene

No ASD Table

Relevant External Links for MAPK1 Gene

GeneLoc Exon Structure for
MAPK1

Expression for MAPK1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK1 Gene

mRNA expression in normal human tissues for MAPK1 Gene
mRNA expression by GTEx for MAPK1 GenemRNA expression by BioGPS for MAPK1 Gene

Protein differential expression in normal tissues from HIPED for MAPK1 Gene

This gene is overexpressed in Brain (8.7) and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPK1 Gene



Protein tissue co-expression partners for MAPK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAPK1

SOURCE GeneReport for Unigene cluster for MAPK1 Gene:

Hs.431850

Evidence on tissue expression from TISSUES for MAPK1 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Blood(4.7)
  • Liver(4.7)
  • Skin(3.7)
  • Intestine(3.5)
  • Heart(3.5)
  • Kidney(3.4)
  • Muscle(3.4)
  • Spleen(3.3)
  • Eye(3.3)
  • Lymph node(3.2)
  • Bone marrow(3.1)
  • Pancreas(3)
  • Stomach(2.9)
  • Adrenal gland(2.9)
  • Thyroid gland(2.8)
  • Bone(2.8)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • chin
  • ear
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • heart
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • skin
genes like me logo Genes that share expression patterns with MAPK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK1 Gene

Orthologs for MAPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MAPK1 30 31
  • 100 (n)
 OneToOne