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Aliases for MAP7D3 Gene

Aliases for MAP7D3 Gene

  • MAP7 Domain Containing 3 2 3 5
  • MDP3 3 4
  • MAP7 Domain-Containing Protein 3 3

External Ids for MAP7D3 Gene

Previous GeneCards Identifiers for MAP7D3 Gene

  • GC0XM135124
  • GC0XM135295
  • GC0XM124567

Summaries for MAP7D3 Gene

Entrez Gene Summary for MAP7D3 Gene

  • The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAP7D3 Gene

MAP7D3 (MAP7 Domain Containing 3) is a Protein Coding gene. Diseases associated with MAP7D3 include Scapuloperoneal Myopathy. Gene Ontology (GO) annotations related to this gene include structural molecule activity and tubulin binding. An important paralog of this gene is MAP7D2.

UniProtKB/Swiss-Prot for MAP7D3 Gene

  • Promotes the assembly and stability of microtubules.

Additional gene information for MAP7D3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D3 Gene

Genomics for MAP7D3 Gene

GeneHancer (GH) Regulatory Elements for MAP7D3 Gene

Promoters and enhancers for MAP7D3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI136250 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.4 +5.3 5286 2 SIN3A ZNF76 RFX5 ZNF335 POLR2B GLIS2 ZNF213 EGR1 ZNF366 EGR2 MAP7D3 GC0XM136223
GH0XI136256 Promoter 0.5 EPDnew 550.8 +0.1 68 0.1 MAP7D3 GC0XM136223
GH0XI136255 Enhancer 0.3 ENCODE 550.8 +0.7 705 0.2 SCRT2 MAP7D3 GC0XM136223
GH0XI136166 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.8 +87.6 87592 5.8 PKNOX1 FEZF1 ZNF2 ZNF213 FOS KLF13 SP3 RXRA REST TSHZ1 FHL1 MAP7D3 PIR45658
GH0XI136908 Promoter/Enhancer 1.5 Ensembl ENCODE 20.8 -653.6 -653633 2.6 HDGF PKNOX1 ARNT NEUROD1 SIN3A YBX1 ZBTB7B POLR2B MCM3 SP3 LOC100420958 SRRM1P3 RBMX MAP7D3 ADGRG4 RNU6-972P CD40LG RPL22P23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP7D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP7D3 gene promoter:

Genomic Locations for MAP7D3 Gene

Genomic Locations for MAP7D3 Gene
43,263 bases
Minus strand

Genomic View for MAP7D3 Gene

Genes around MAP7D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D3 Gene

Proteins for MAP7D3 Gene

  • Protein details for MAP7D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP7 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A2A2J0
    • A6NCZ7
    • A6NHR4
    • B4DWD2
    • H7BY77
    • Q5JXI5
    • Q5JXI6
    • Q6P2S1
    • Q9H9M8

    Protein attributes for MAP7D3 Gene

    876 amino acids
    Molecular mass:
    98429 Da
    Quaternary structure:
    • Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.
    • Sequence=AAH64350.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAM21578.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D3 Gene


neXtProt entry for MAP7D3 Gene

Post-translational modifications for MAP7D3 Gene

Other Protein References for MAP7D3 Gene

No data available for DME Specific Peptides for MAP7D3 Gene

Domains & Families for MAP7D3 Gene

Gene Families for MAP7D3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP7D3 Gene


Suggested Antigen Peptide Sequences for MAP7D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAP7 family.
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D3: view

Function for MAP7D3 Gene

Molecular function for MAP7D3 Gene

UniProtKB/Swiss-Prot Function:
Promotes the assembly and stability of microtubules.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.

Phenotypes From GWAS Catalog for MAP7D3 Gene

Gene Ontology (GO) - Molecular Function for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0008017 microtubule binding IDA 22142902
GO:0015631 tubulin binding IDA 22142902
genes like me logo Genes that share ontologies with MAP7D3: view
genes like me logo Genes that share phenotypes with MAP7D3: view

Animal Model Products

CRISPR Products

miRNA for MAP7D3 Gene

miRTarBase miRNAs that target MAP7D3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D3 Gene

Localization for MAP7D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7D3 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis. {ECO:0000269 PubMed:22142902}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D3 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0015630 microtubule cytoskeleton IBA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with MAP7D3: view

Pathways & Interactions for MAP7D3 Gene

SuperPathways for MAP7D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IDA 22142902
GO:0046785 microtubule polymerization IDA 24927501
genes like me logo Genes that share ontologies with MAP7D3: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D3 Gene

Drugs & Compounds for MAP7D3 Gene

No Compound Related Data Available

Transcripts for MAP7D3 Gene

Unigene Clusters for MAP7D3 Gene

MAP7 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2: - -

Relevant External Links for MAP7D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP7D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP7D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D3 Gene

This gene is overexpressed in Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for MAP7D3 Gene

This gene is overexpressed in Bone marrow stromal cell (19.5), Adipocyte (17.2), and Testis (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP7D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP7D3 Gene:


SOURCE GeneReport for Unigene cluster for MAP7D3 Gene:


Evidence on tissue expression from TISSUES for MAP7D3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MAP7D3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D3 Gene

Orthologs for MAP7D3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP7D3 33
  • 99.14 (n)
(Canis familiaris)
Mammalia MAP7D3 33 34
  • 71.31 (n)
(Bos Taurus)
Mammalia MAP7D3 33 34
  • 67.43 (n)
(Rattus norvegicus)
Mammalia Map7d3 33
  • 59.65 (n)
(Mus musculus)
Mammalia Mtap7d3 33 34
  • 58.34 (n)
Map7d3 16
(Ornithorhynchus anatinus)
Mammalia MAP7D3 34
  • 29 (a)
(Monodelphis domestica)
Mammalia MAP7D3 34
  • 25 (a)
(Gallus gallus)
Aves MAP7D3 34
  • 31 (a)
(Anolis carolinensis)
Reptilia MAP7D3 34
  • 33 (a)
(Danio rerio)
Actinopterygii map7d3 34
  • 25 (a)
Species where no ortholog for MAP7D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D3 Gene

Gene Tree for MAP7D3 (if available)
Gene Tree for MAP7D3 (if available)

Paralogs for MAP7D3 Gene

Paralogs for MAP7D3 Gene

genes like me logo Genes that share paralogs with MAP7D3: view

Variants for MAP7D3 Gene

Sequence variations from dbSNP and Humsavar for MAP7D3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000053954 -- 136,222,648(-) C/T intron_variant
rs1000086069 -- 136,236,799(-) T/A/C intron_variant
rs1000157967 -- 136,221,616(-) C/T intron_variant
rs1000224291 -- 136,249,801(-) G/A intron_variant
rs1000276577 -- 136,248,171(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D3 Gene

Variant ID Type Subtype PubMed ID
nsv1115293 CNV deletion 24896259
esv3574718 CNV loss 25503493
esv3559371 CNV deletion 23714750
esv2668671 CNV deletion 23128226

Variation tolerance for MAP7D3 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP7D3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D3 Gene

Disorders for MAP7D3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP7D3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
scapuloperoneal myopathy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP7D3

genes like me logo Genes that share disorders with MAP7D3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP7D3 Gene

Publications for MAP7D3 Gene

  1. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. (PMID: 24927501) Yadav S … Panda D (PloS one 2014) 2 3 4 58
  2. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. (PMID: 22142902) Sun X … Zhou J (Cell cycle (Georgetown, Tex.) 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for MAP7D3 Gene

Sources for MAP7D3 Gene

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